Book Description
The central thesis of this book is that Volvox and its unicellular and colonial relatives provide a wholly unrivaled opportunity to explore the proximate and ultimate causes underlying the evolution from unicellular ancestors of multicellular organisms with fully differentiated cell types.A major portion of the book is devoted to reviewing what is known about the genetic, cellular and molecular basis of development in the most extensively studied species of Volvox: V. cateri, which exhibits a complete division of labor between mortal somatic cells and immortal germ cells. However, this topic has been put in context by first considering the ecological conditions and cytological preconditions that appear to have fostered the evolution of organisms of progressively increasing size and with progressively increasing tendency toproduce terminally differentiated somatic cells.The book concludes by raising the question of whether the germ-soma dichotomy may have evolved by similar or different genetic pathways in different species of Volvox. ... Read more

Book Description
In all eukaryotic cells, each fundamental process cycle progression andits control, protein secretion and targeting, transcription and itsregulation, mRNA processing, and DNA replication accomplished byessentially identical cellular machinery composed of essentially identical protein components. This conservation of function has catapulted theyeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe fromparochial backwaters to the forefront of experimental molecular biology:What is true for a yeast is true for an elephant, and in experiments youcan get the answer a lot faster from a yeast. This burgeoning appreciation of yeasts as model systems for the study of fundamental cellular processes has highlighted the need for an update of the seminal 1981 monograph TheMolecular Biology of the Yeast Saccharomyces. This need is now met by thepublication of a three-volume series to serve as the authoritative sequel. The first volume focuses on the genome organization of the yeastSaccharomyces as well as protein translation and its regulation and energy metabolism. Subsequent volumes emphasize such topics as the cell cycle,secretion, and transcription. Together, these volumes provide acomprehensive survey of the molecular and cellular biology ofSaccharomyces and Schizosaccharomyces, serving not only as a currentsummary of every significant area of investigation, but also as a thorough reference source. These volumes are required reading for everyone in thefield and anyone curious about the state of the art of molecular andcellular biology. ... Read more

Book Description
Cellular Proteolytic Systems Edited by Aaron J. Ciechanover & Alan L. Schwartz Within cells, regulation of protein degradation, or proteolysis, is critical to dynamic control of protein levels. Cellular Proteolytic Systems is the first book to provide a detailed and comprehensive summary of advances in the biochemistry, cellular biology, molecular genetics, and physiology of the major proteolytic processes. The field of cellular proteolysis is advancing rapidly and has great potential impact in a variety of research and clinical areas, including AIDS and cancer research and treatment. The editors, pioneers in the field of cellular and protein research, describe our current understanding of the three major cellular proteolytic systems: the ubiquitin system, the lysosomal and vacuolar systems, and physiological and pathophysiological cellular proteolysis. Individual chapters cover topics from the molecular genetics of the ubiquitin system to regulation of autophagy to antigen processing and presentation. Cellular Proteolytic Systems will provide an excellent foundation in the biological basis of protein turnover for cellular, developmental, and molecular biologists. ... Read more

Book Description
Cardiac cell biology has come of age.
Recognition of activated or modified signaling molecules by specificantibodies, new selective inhibitors, and fluorescent fusion tags arebut a few of the tools used to dissect signaling pathways andcross-talk mechanisms that may eventually allow rational drug design.Understanding the regulation of cardiac hypertrophy in all itscomplexity remains a fundamental goal of cardiac research. Since theadvancement of adenovirally mediated gene transfer, transfectionefficiency is no longer a limiting factor in the study ofcardiomyocytes. A limiting factor in considering cell transplantion asa strategy to repair the damaged heart is cell availability at theright time. Cardiac gap junctions, intercellular communicationchannels that allow electrical and metabolic coupling and play animportant role in arrhythmogenesis are now understood to be exquisitesensors of cardiac change.
The reports in this volume incLude elegant studies that made use ofcutting edge technological advances and many specialized reagents toaddress these issues. ... Read more

Book Description
This first textbook of its kind provides an ideal introduction to the field for students of biology and bioinformatics. Carefully designed study exercises -- with corresponding answers -- offer excellent support for those preparing for exams in these subjects, and help introduce the more technical aspects of the topic while keeping maths to a minimum. In particular the text focuses on a network-based approach to the study of cellular systems. ... Read more

Book Description
This book examines the genetic circuitry of the well-known "fruit fly," tackling questions of cell assemblage and pattern formation, of the hows and the whys behind the development of the fly. After an initial examination of the proximity versus pedigree imperatives, the volume delves into bristle pattern formation and disc development, with entire chapters devoted to the leg, wing, and eye. Extensive appendices include a glossary of protein domains, catalogs of well-studied genes, and an outline of signaling pathways. More than 30 wiring diagrams among over 60 detailed schematics clarify the text. ... Read more

Book Description
Univ. of North Carolina, Chapel Hill. Focus on progress made in the study of yeastmolecular and cellular biology. Numerous contributors. Softcover notpublished simultaneously. ... Read more