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This book presents proven approaches for studying the secretory and endocytic paths in animal cells. The range of methods covers initial events of translocation into the rough endoplasmic reticulum through to events of vesicular traffic at the cell surface. The chapters have been selected from three recent "Methods in Cell Biology" volumes as those with broad appeal for an expanded audience of students and researchers. Features and benefits include a convenient bench-top format; vectorial transport in the rough endoplasmic reticulum; accessing the cytoplasm; analysis of vesicle fusion; and electron microscopic immunocytochemistry. ... Read more

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Russells Hall Hospital, West Midlands, UK. Demonstrates the simplicity and versatility of capillary electrophoresis over conventional methods. Offers new techniques, a range of practical CE methods, and productive assays standard in many laboratories. For researchers. Expanded-outline format. DNLM: Electrophoresis, capillary. ... Read more

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Thanks to recent advancements, optimization is now recognized as a crucial component in research and decision-making across a number of fields. Through optimization, scientists have made tremendous advances in cancer treatment planning, disease control, and drug development, as well as in sequencing DNA, and identifying protein structures.

Optimization in Medicine and Biology provides researchers with a comprehensive, single-source reference that will enable them to apply the very latest optimization techniques to their work. With contributions from pioneering international experts this volume integrates strong foundational theory, good modeling techniques, and efficient and robust algorithms with relevant applications

Divided into two sections, the first begins with mathematical programming techniques for medical decision making processes and demonstrates their application to optimizing pediatric vaccine formularies, kidney paired donation, and the cost-effectiveness of HIV programs. It also presents recent advances in cancer treatment planning models and solution algorithms, including three-dimensional conventional conformal radiation therapy (3DCRT), intensity modulated radiation therapy (IMRT), tomotherapy, and proton therapy.

Part two focuses on optimization in biology and discusses computational algorithms for genomic analysis; probe design and selection, properties of probes, and various algorithms and software packages to aid in probe selection and design. Subsequent chapters introduce a new dihedral angle measure for protein secondary prediction, and an optimization approach for tumor virotherapy with recombinant measles viruses. The editors include a short tutorial appendix on Integer Programming (IP).

Highlighting the most recent advances in optimization techniques for solving complex problems in medical research, this book facilitates strong collaborative environments among optimization researchers and medical professionals for future medical research. ... Read more

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In recent years cell-based technologies have gained significantscientific attention, and have become a matter of intense publicdebate as well. Namely, (i) tissue engineering, the construction oftissues and whole organs using molecularly-designed resorbablebiomaterials to create new tissue de novo with or withouttransplanting cells; (ii) the potential use of human embryonic stemcells for transplantation and regenerative medicine (with similarpotential for adult-derived stem cells); (iii) and gene therapy, inrelation with cell transplantation, have taken their places as themost discussed biomedical issues of the day. New findings inbiomimetic materials, cell signalling pathways, extracellular matrixreceptors and ligands, growth factors, and the human genome projectare motivating the developments in these challenging research areas.

This book includes manuscripts on tissue engineering, stem cells andgene therapies authored by world-renowned scientists of the field. Thefirst section of the volume consists of four chapters givingperspectives for the current status and potential future of tissueengineering and stem cell technologies. The second section of thevolume includes five chapters based on experimental and clinical data.In this section, the role of stem cells in liver tissue engineering,cell-based therapies in diabetes mellitus, and chronic degenerativediseases of the central nervous system, and adult-derived stem celltherapies are discussed. The two chapters of the third section focuson the biomarkers for tissue-engineered products, namely fortissue-engineered skin. The eight chapters of the fourth sectiondiscuss novel biomaterials developed for neural-, vascular-, aortic-,bone-, cartilage- and endocrine pancreas-tissue engineeringapplications. The last section of the book includes chapters onpractical gene targeting applications, controlled release in genetherapy and tissue engineering, antibodies in cancer, acute-phasegenes and phage-displayed peptide libraries. Proceedings of BIOMED 2002 -- The 9th International Symposium onBiomedical Science and Technology, held September 19-22, 2002, inAntalya, Turkey ... Read more

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This volume comprises a selection of papers presented at ANNIMAB-1, the first conference to focus specifically on the topics of ANNs in medicine and biology. It covers three main areas: The medical applications of ANNs, such as in diagnosis and outcome prediction, medical image analysis, and medical signal processing; The uses of ANNs in biology outside clinical medicine, such as in data analysis, in molecular biology, and in simulations of biological systems; The theoretical aspects of ANNs, examining recent developments in learning algorithms and the possible role of ANNs in the medical decision process. Summarising the state-of-the-art and analysing the relationship between ANN techniques and other available methods, it also points to possible future biological and medical uses of ANNs. Essential reading for all neural network theorists, it will also be of interest to biologists and physicians with an interest in modelling and advanced statistical techniques. ... Read more

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To understand the molecular mechanisms of XP, XP mouse models have been used, and mice deficient in XPA, XPC, XPD, XPG, XPF, and XPA/CSB have been produced and analysed. A recent elegant technique of targeting gene replacement in mouse embryonic stem cells has provided researchers with the ability to generate mutant mice defective in any specific gene(s). 32 Animals generated in this way display phenotypes and symptoms of XP patients, and have provided valuable tools to understand how and where the deficiency in DNA repair may lead to tumor formation, and also in studies of developmental biology and the aging process. Mouse studies have recently contributed to our understanding of the role of ink4a-Arf in increasing the risk of melanoma photocarcinogenesis in an XPC mutant background. As with many other genetic defects, the distribution of XP globally is not uniform. In most cases the frequency of mutation of a particular trait depends when and where a specific mutation arose, and the longer ago that is, the greater the frequency of mutant in the population unless some selective pressure prevailed. Another factor responsible for the high incidence of any mutation is consanguinity. One of the last chapters analyzes the world distribution of XP and shows that Japan has the highest incidence of XP and of varying complementation groups. After Japan perhaps Egypt suffers most from this inborn error. Here it is also shown that the most common complementation groups are XPA and XPC followed by XPV. XPB and XPE are least frequent. In a recent publication, however, 16 Japanese patients with XPV have been diagnosed and confirmed both clinically and at the cellular level. There is no evidence that interest in XP is waning, and this book should provide both the expert and novice researcher in the field with an excellent overview of the current status of research and pointers to future research goals.

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Biomaterials: From Molecules to Engineered Tissue gives examples of the application areas of biomaterials involving molecules at one end of the spectrum and finished devices in the other. It covers molecular approaches as well as molecules functional in preparing and modifying biomaterials, medical devices and systems, tissue engineering and artificial organs. Chapters on biomedical informatics and ethics complement the design and production aspects with their contribution in informatics and ethical concerns of biomedical research.This is a reference book for the advanced graduate student eager to learn the biomaterials area and for all researchers working in medicine, pharmacy, engineering and basic sciences in universities, hospitals, and industry involved in biomaterials and biomedical device production. ... Read more

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Brown Univ., Providence, RI. Summarizes current developments in long-term mechanical ventilation use and reviews applications, complications, and care of breathing disorders affecting ventilation-assisted individuals. Covers invasive and non-invasive ventilation techniques and procedures. ... Read more

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This volume examines the application of NMR techniques to molecular biology, including gene cloning and expression, site- specific mutagenesis, and biosynthetic isotopic labelling. It describes the broad-ranging applications of NMR techniques to the elucidation of structures at atomic resolution for moderately large systems. Investigators from a variety of disciplines cover the analysis of conformation, dynamics and interactions for a variety of molecules, including DNA, RNA, carbohydrates, peptides and proteins. Throughout the text, the contributors demonstrate the success of multi-dimensional NMR studies of biopolymers in solution. The book also examines possible NMR approaches for investigating systems where the molecule of interest does not reorient rapidly in solution. These systems possess molecules in the crystalline or hydrated solid state, part of supramolecular structures in solution, or are simply too large to reorient. ... Read more

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Here's the first state-of-the-art design reference on artificial implant surfaces. It takes you to the cutting-edge of efforts to understand and control the constant interactions taking place between biomaterials and biological media. The book explores processes and surface modifications that occur in various bio/non bio interfaces, and provides the latest performance-enhancing design, materials selection, and manufacturing guidance--including nanotechnology breakthroughs that are ushering in a new age of biomaterial design and applications.

After an extensive discussion of biomedical surfaces attributes, the book addresses design issues that arise where materials and biofluids interface and the suppression or selective adsorption of biomacromolecules is a key objective. Implant lubrication and wear issues are covered, including adsorption of lubricants on surfaces and the tribology of the surfaces themselves. The book explores interaction issues crucial to predicting biomaterial interactions with body tissues, including protein adsorption and desorption processes, immune cell response, the assimilation and interaction of cells like osteocytes, and bacterial infection risks, and includes a chapter on biomedical surfaces manufacturing which emphasizes practical design issues. The volume also examines emerging nano-engineered materials including "smart" surfaces that are responsive to host cells and tissues, as well as novel drug delivery surfaces developed with nano- and microtechnologies. Complete with techniques for measuring surface properties, this well-illustrated resource helps you design or select implants that deliver ever-higher levels of performance and durability. ... Read more

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The present Syllabus provides an integrated view of the set-up, processing and interpretation of magnetic resonance imaging and magnetic resonance spectroscopy experiments. There are specialized sections on spectroscopy, methodology and clinical MRI. Several chapters in each section provide authoritative descriptions, ranging from the physical basis to the most recent developments. The volume offers both a useful introduction to MR methods for the non-experienced reader and can be an advanced reference book for physicists, biologists and physicians actively working in MR. ... Read more

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A state-of-the-art presentation of the technology for studying human chromosomes, this book serves as a basic techniques manual designed to present the current working protocols in cytogenetics. Beginning with a description of tissue culture procedures for all tissue types from blood to solid tumors, subsequent chapters provide extensive coverage of chromosome preparations, differential staining techniques, chromosome sorting, high-resolution banding, fragile X analysis, sister chromatoid exchanges and DNA replication. A new chapter entitled "Molecular cytogenetic techniques" covers the latest fluorescent in-site hybridization (FISH) procedures illustrated by 20 colour plates. ... Read more

Customer Reviews (1)

an excellent book
This is one of the best books available on the techniques and principles of Human Genetics. This book should be accessible in all laboratories dealing with the human chromosome. It has helped millions of people aroundthe world. I strongly recommend this book. ... Read more

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Modelling the genesis and propagation of electrical activity in the heart in quantitative terms is one of the most important recent applications of mathematical modelling in biology. The main research direction, and the most important for biological and medical applications, is the development of realistic models of electrical activity in cardiac tissue and the whole mammalian heart. Recent progress in nonlinear dynamics, advances in computer technology and experiments on cardiac tissue have made feasible the construction of such models. Computational Biology of the Heart is the first book to provide a comprehensive survey of recent research together with a systematic overview of the subject. The contributions, all written by experts in the different areas of the subject, cover all main aspects of whole heart modelling: from excitation in single cells, to two and three dimensional models of cardiac tissue and the whole heart. Various computational models and techniques are described and then applied to reconstruct and visualise modelled activity in both normal and pathological heart tissues. The models are nonlinear and use techniques of ordinary differential equations, partial differential equations and eikonal equations. The book also provides a review of modelling cardiac contraction, mapping electrical activity from electrocardiograms, and recent experimental observations of wave propagation in the whole heart. Graduate students and researchers in such areas as applied mathematical biology, clinical physiology and cardiology will find this book to be an invaluable resource for their work. ... Read more