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This book explains and reviews some of the significant events involved in human implantation and the establishment of the placenta in the uterus. This critical phase in human reproduction has proved to be an elusive and challenging area of research, not least because of the immunological and genetic interactions between the mother and fetus. The volume focuses on the most recent advances in our understanding of the basic mechanisms involved, with a particular emphasis on cell biology and immunology. This lucid volume will benefit all those studying and undertaking research in reproductive biology and immunology, perinatal pathology, fetal medicine and obstetrics. ... Read more

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Cervical cancer is a major disease worldwide, with 500,000 new cases diagnosed every year.Through etiological studies, an association has been established with HPV infection throughout the pathological spectrum of this disease. A timely review of HPV infection in cervical cancer, this book provides the background to the potential for immunological intervention. Basic background is provided, ensuring the book's accessibility to all. Each chapter is integrated so that the book as a whole provides a detailed insight into the most relevant scientific issues of HPV and cervical cancer.This book will provide an interface for students, scientists and clinicians with a realistic and critical evaluation of the advances and problems in the implementation of immunologically based prophylactic and therapeutic strategies in HPV-associated disease. ... Read more

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Hardbound. This book presents an integration of recent knowledge of virology, molecular biology and immunology focusing on intractable liver diseases.It reports on mechanisms of liver injury e.g. viral hepatitis, fulminant hepatic failure, autoimmune hepatitis, and hepatocarcinogenesis based on the evidence from both clinical and basic research e.g. genetic diversities or transgenic mice models. It also explains current concepts and new strategies to treat alcoholic liver diseases, interferon resistant hepatitis C virus, liver cirrhosis, fulminant hepatic failure, and hepatocellular carcinoma e.g. new drugs, immunotherapy, gene therapy or living related liver transplantation.The authors are all front runners in current hepatology and give us proper information on each topic.The book will be of interest to all clinicians and basic scientists devoted to hepatology and will be a useful guide to reveal what we can do now and what we should do to treat ... Read more

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Host defense against infectious microorganisms is becoming an intensively studied topic; recent advances in immunology and microbiology have resulted in a substantially improved understanding of the pathways used by a variety of microorganisms to infect humans.

This resource provides up-to-date reviews of the invasion strategies utilized by selected bacteria and then shows how these microorganisms can be manipulated to generate potential vaccines. The book begins with a comprehensive review of the relationship between bacterial life-styles and immune responsiveness to bacterial antigens. The book is divided into two parts: Part 1 describes basic research intended primarily for academic scientists. Included in this section are chapters describing the use of Listeria monocytogenes, Salmonella typhimurium and Bacillus Calmette-Guerin (BCG) to invoke different types of immune response. Part 2 describes the application of the engineered Listeria monocytogenes as a vaccine against specific tumors and the use of recombinant Salmonella and BCG in clinical trials for HIV and TB ... Read more

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Immune responses result from the activation of an elaborate network of interacting cells occurring in specific microenvironments. Attention in recent years has been focussed intensively on a number of issues. Included among these are: the developmental pathways of the two major types of lymphocytes, T and B cells; the nature of their specific receptors for antigen and of their various accessory surface molecules; the subsequent fate of the cells following encounter with antigen presented as such or on a variety of cells; and the function of the effector molecules produced after successful activation by antigen. The present volume is concerned with some of these issues, and also with their potential application to the control of autoimmune phenomena and parasitic infestations.
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The amazing world of the mononuclear phagocytes keeps expanding at a truly awesome pace. As a result, maintaining currency with the latest developments and controversies that pertain to this cell type is increasingly difficult. The aspects covered in this volume have been selected to provide an overview of subject areas that either have recently become much better understood or hold the promise of new levels of understanding as they are developed in the future. The scope of topics ranges from how these cells develop, through the means that are used to regulate them, to the roles that they have in different tissues and in a variety of infectious diseases. ... Read more

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The biological bases of invertebrate immune responses have interested scientists for decades. This book summarizes aspects of invertebrate immune responses on the cellular, biochemical and molecular levels. Some chapters try to find unified patterns between phyla, others concentrate on one specific group of organisms. Concurrently, these review chapters present some of the rapid progress recently achieved in invertebrate immunity, placing this discipline as a fast-growing and important field in the biological sciences. ... Read more

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Schering-Plough, Dardilly, France.June 19-23, 1994, Annecy, France. Research on the role of dendritic cells in immunology. For researchers. Multiple international contributors. ... Read more

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Molecular Biology and Immunology of Allergens explores the characteristics of natural allergens and allergens produced by recombinant DNA techniques. The book covers important inhalant allergens such as pollen, mites, molds, and pet dander, as well as insect venoms and Chironomid hemoglobin allergens. Biological functions of allergens; the structural definition of allergens by NMR, crystallography, and computer modeling; and the production of recombinant allergens are discussed. Special attention is given to the search for the most effective expression systems in prokaryotic and eukaryotic organisms and the purification of recombinant allergens as fusion and non-fusion proteins. Other topics addressed include the production of allergen-specific T cell clones, the discovery of T cell epitopes by stimulation with overlapping peptides, and methods to induce T cell anergy by tolerogenic allergen-derived peptides. Molecular Biology and Immunology of Allergens will be an excellent reference for all researchers and clinicians in allergology, immunology, molecular biology, allergen extracting, and immunotherapy. ... Read more

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Basel Institute for Immunology, Switzerland. Advanced research on the benefits of chickens as animal models in developmental and hematopoietic research. For the investigator. 40 international contributors. ... Read more

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Genetech, San Francisco, CA. Presents an overview for the chemokine and chemokine receptor gene family, explores the role of chemokines in a variety of chronic and acute inflammatory diseases, discusses the role of chemokines in noninflammatory processes, and their emerging role in viral biology. For researchers. Expanded-outline. DNLM: Cytokines--physiology. ... Read more

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This volume is the third edition of a well known and successful reference work. Arranged by organism, the book surveys and evaluates new and existing knowledge in the field of parasitic immunology and molecular biology. This new edition has been revised and expanded, and new material on the relevance of molecular biology in diagnosis and vaccine development has been included. ... Read more

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Proceedings of the 4th International Symposium held October 5-10, 1996, in Venice, Italy. DNLM: Dendritic Cells--congresses. ... Read more