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The complement system plays a major role in the host's defenceagainst infections and in immune complex diseases. Although it isknown to consist of a number of serum and membrane proteins thatinteract through a cascade, there is still a poor understanding of theexact nature of the components and their complex interaction. Many ofthe biological consequences of complement activation also awaitelucidation.This fully revised edition of Complement in Health and Diseaseprovides an up-to-date account of how the system works and its effectson the host. Key topics covered include the history, phylogeny andevolution of the system; genetics and biochemistry; deficiency statesand infection; immune complex diseases; complement and angioedema;anaphylatoxins; and diseases of the nervous system.The book is valuable both for those wanting an introduction to thiscomplex area of immunology as well as those requiring a more detailedupdate on developments in specific topics. ... Read more

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Based on the proceedings of the International Convocation on Immunology held recently at the State University of New York at Buffalo, this up-to-date resource provides a state-of-the-art examination of blood transfusion practice and its future possibilities.Explains the immunological effects of blood transfusion as well as its immunological and microbiological hazards and offers potential remedies! ... Read more

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This issue, Guest Edited by Dr. Mark Boguniewicz, will feature topics such as:  Role of Fungi in Atopic Dermatitis; The Infectious Aspects of Atopic Dermatitis; Contact Allergy in Atopic Dermatitis; Role of the Nurse Educator in Atopic Dermatitis; Investigational and Unproven Therapies in Atopic Dermatitis; Addressing Psychosocial Aspects of Atopic Dermatitis; Complementary and Alternative Treatments in Atopic Dermatitis; Quality of Life in Atopic Dermatitis. ... Read more

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Infection with the human immunodeficiency virus ischaracterized by the destruction of the host immune system as alsoreflected by a progressive loss of CD4-positive T-cells. This finallyresults in the host's incapacity to deal with opportunistic infectionsand the immune surveillance of tumors, a clinical status known as theAcquired Immunodeficiency Syndrome (AIDS).
The book AIDS Pathogenesis provides the reader with a completeoverview of the clinical course of HIV-1 infection. It describes theclinical aspects of primary infection, the different clinical outcomesof HIV-1 infection, and strategies for anti-viral treatment. Inaddition, more fundamental aspects of HIV-1 infection are reviewed.These include the biology of the virus and the novel insights in AIDSpathogenesis. Not only is the significance of an HIV-specific cellularand humoral immune response discussed, but also the possibleincapacity of the adult human host to deal with T-cell destruction.Finally, the book discusses the currently used laboratory markers thatallow for monitoring of the clinical course of infection. ... Read more

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This issue will focus on treatments for Chronic Rhinosinusitis. Dr. Wyste Fokkens guest edits topics such as: "Inflammatory mechanisms in chronic rhinosinusitis with or without nasal polyposis," "European versus Asian Chronic rhinosinusitis. What did it teach us and what do we want to know," "Epithelium, cilia and mucus, their importance in chronic rhinosinusitisNoam Cohen Noam," "Aspirin intolerance: does desensitization alter the course of the disease," "Anti-inflammatory effects of macrolides: applications in CRS," and more! ... Read more

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Autoimmunity is the most common cause of endocrine disorders.This volume provides an up-to-date summary of recent advances in thisimportant field. In addition, it describes developments in ourunderstanding of conditions such as vitiligo and pernicious anaemiawhich are frequently associated with autoimmune endocrinopathies.There is a detailed review of animal models of endocrine disease whichhave contributed greatly to current knowledge. Furthermore, theaetiology, pathogenesis and treatment of the clinical disorders arediscussed in depth. The book will be of interest to anyone working inthe areas of endocrinology and immunology. ... Read more

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Schering-Plough, Dardilly, France.June 19-23, 1994, Annecy, France. Research on the role of dendritic cells in immunology. For researchers. Multiple international contributors. ... Read more

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The immune system has evolved in large part to enable organismsto resist microbial infection. Microorganisms have long been used asexperimental tools by immunologists, and the study of the immuneresponse to viruses and bacteria has contributed much to ourunderstanding of basic immunological mechanisms. There are also important practical and clinical reasons for attemptingto understand the immunology of infections -- these include therational design of vaccines, the pathogenesis of infectious diseases,the advent of AIDS, the rise in drug-resistant mycobacterialinfections and the recognition of the infectious aetiology of pepticulcer disease. The contributors to this book are all chosen for their activeinvolvement and expertise in the fields. It bridges the divide betweenbasic immunological research and clinical practice. ... Read more

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The contributions to this book examine the role of the immuneresponse in liver disease. The book is divided into three sections andthere are two introductory chapters: one discussing viralimmunopathology and the other autoimmune disease. Three chapters aredevoted to viral hepatitis infections, the immune responses engenderedby each virus and the pathogenesis of the diseases they cause. Oneauthor reviews the use of immunotherapy in hepatocellularcarcinoma.Two chapters then review the recent advances in the identification andcharacterisation of autoantibodies and their cytoplasmic antigens.These concentrate on new experimental approaches using molecularbiological techniques to identify the structures recognised bydisease-specific autoantibodies.The third section has a chapter reviewing the immune mechanisms inalcoholic liver disease and a chapter examining the immune reactionsprovoked by hepatotoxic drugs. ... Read more

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The neuromuscular diseases comprise the disorders of peripheralnerves, the neuromuscular junction, and muscle. Both pre andpost-synaptic elements of the neuromuscular junction may becometargets of autoimmune attack in different diseases. This book addresses the immunologically mediated neuromusculardiseases, including Guillain--Barre syndrome and otherautoimmune neuropathies, the Lambert--Eaton myasthenic syndrome,myasthenia gravis, and the autoimmune diseases of muscle. Two chaptersare devoted to the vasculitic and HIV-mediated neuromuscular diseases.The experimental models of neuritis and myasthenia gravis areaddressed in separate chapters. An introductory chapter provides ageneral background to autoimmunity. This book is a useful overview for all neurologists, rheumatologistsand immunologists both in research and clinical practice. ... Read more