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This is a timely compilation of new concepts in the molecular pathogenesis and molecular therapy of acute myelogenous leukemia (AML). The focus is on selected critical molecular determinants of AML pathogenesis and pathophysiology and the exploitation of these factors by diverse therapeutic agents and modalities. There is an emphasis throughout on the bidirectional flow of knowledge between the clinical and laboratory arenas.

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From the original publisher, Alfred A. Knopf...

In this extraordinary chronicle, Terry Pringle, telling of his four-year-old son's battle with leukemia, so fully captures this "ordinary" child's achievement of amazing courage and grace that his book transcends its burden of pain to fill us with wonder and pride at the gallantry of which the human spirit is capable.

From reviews...

"Pringle has balanced his account perfectly.He employs neither sympathy-card sentimentality nor gruesome close-up."--Time Magazine

"A profoundly stirring book, This Is the Child is one of the finer contributions to inspirational literature."--Dallas Morning News

"With this book Pringle has clearly found his professional calling.We'll hear from him again.But life will never serve the writer with a more heartfelt story."--Texas Monthly

"This Is the Child is a story of victory of courage over fear, peace over turmoil, spirit over flesh."--New York Times Book Review

"The reader experiences a wonderful feeling of elation at the indomitability of the human spirit." --Fort Worth Star-Telegram


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Customer Reviews (3)

Get the tissues ready!!
I read this book in 1 day because I could not put it down!From the 1st sentence, the author captivated me and made me feel part of his family through the end.The story is heart-warming and heart-wrenching at the same time.It is extremely well-written and shows the family with all of their flaws as well as their great strengths.I could not stop crying while reading this book and recommend it as long as you are prepared to leave a piece of your heart with the author and his family.

ERIC'S LAST ROUND-UP
Eric Pringle, (1974 - 1981) was a bright, engaging boy who loved candy, cowboys, television and superheroes.He loved making up stories and playing with dogs.Creative and artistic, Eric loved to draw and was quite adept at drawing detailed cowboys.He enjoyed a good joke on his brother Michael who was 2 years his senior.In short, Eric (nicknamed "E") was a normal boy.

At 4, Eric was diagnosed with leukemia.His distraught parents and brother sought ways to make the treatments Eric underwent more palatable.One clever method they devised was to tell him that his medications were like "superheroes" that warded off the evil illness.Michael, to his credit continued treating Eric like a healthy sibling and the pair displayed refreshingly normal bouts of sibling rivalry.

I was not too fond of the author and I didn't like the way he would brush Michael off when Michael expressed resentment over the extra attention Eric was receiving.In one memorable scene, the author tells the resentful Michael to "shut up" and that he went outside to get away from the boy.Ouch!I also didn't like the way he criticized Michael for describing a nightmare he had had shortly after Eric's death in October, 1981.Nightmares were a normal response to the tragedy and trauma this child had undergone.A bright, imaginative child, it was only natural that this young boy's subconscious would conjure up frightful images after losing a brother.

The part that really soured me on the author was when he told a story with Eric as the hero and Michael as the villain.Although Michael outwardly took it in stride, one could not help but wonder what message such a story sent to Michael.I thought it was cruel to make him the villain in the story.

Pringle captivates with a smile

He enjoyed his "Any-M's," those miniature candy-coated chocolates which refuse to melt in your hands.He laughed with his brother and parents, often dressing up as a cowboy before galloping around the house, or giving mock-interviews to his dad's tape recorder.He smiled, when smiles were at a premium.Eric Pringle was a young boy battling leukemia, and spinal taps weren't as much fun as Star Wars figures--but he smiled anyway.

Terry Pringle's THIS IS THE CHILD is Eric's story, revealed through his father's emotional exploration of a tight Texas family.From a rattlesnake coiled in the dining room of a new house to countless I-Spy games during countless journeys to countless doctors in Houston, "E" takes it all in stride.

Here, as in subsequent novels THE PREACHER'S BOY and A FINE TIME TO LEAVE ME, Pringle is adept at depicting the minutiae of family life--the television shows (and everything else) that kids bicker over; the kids (and everything else) that adults bicker over.He i ... Read more

Product Description
International experts not only review the state-of-the-art in managing children and adults with acute leukemia, but also debate the pros and cons of current controversial and problematic issues. The book summarizes the best diagnostic and treatment practices for acute leukemias in children, adolescents, and adults. Among the therapies discussed are methotrexate, asparaginase, antipurines, epipodophyllotoxins, hematopoietic stem cell transplantation, hematopoietic growth factors, and immunotherapy. ... Read more

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Dr. Talpaz has assembled top experts to write state-of-the art reviews on the management of chronic myelogenous leukemia. Some of the articles that will be of most interest include  Selection of Therapy: Rational Decisions Based on Molecular Events; Is There a Potential Cure for CML in Current Therapies?; Hurdles Toward a Cure for CML: The CML Stem Cell; The CML Stem Cell in the Chronic and Advanced Disease; CML Disease Progression; Management of Ph+ ALL and CML Blast Crisis; BMT in CML in the Era of Targeted Therapy; Pharmacoeconomics: The Cost of Staying Alive; and The Significance of CML Prognostic Factors in the Era of Targeted Therapy. ... Read more

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A panel of internationally recognized research scientists and clinical investigators brings together a diverse collection of readily reproducible methods for identifying and quantifying a large number of specific genetic abnormalities associated with the broad spectrum of myeloid malignancies. Highlights include techniques for the detection of BCR-ABL mutations and resistance to imatinib mesylate, detection of the FIP1L1-PDGFRA fusion in idiopathic hypereosinophilic syndrome and chronic eosinophilic leukemia, classification of AML by DNA-oligonucleotide microarrays, and detection of the V617F JAK2 mutation in myeloproliferative disorders. In addition to gene rearrangments, other prognostically relevant molecular lesions such as FLT3 mutations and WT-1 overexpression are covered. ... Read more

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For the most honest, objective opinion, HealthScouter provides a patient's view of the most common medical problems. Including hundreds of quotes, questions, and answers from patients themselves, this guide provides comprehensive information about a single condition for from perspective that matters: the patient's perspective. Understand how current patients approach their medical challenges, and help overcome your own. This reference will help you see through obscure medical jargon and limited treatment options and empower you to better understand the issues that really matter: Diagnosis + Symptoms + What to Expect + Treatment Options + Medical Terminology ... Read more

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Childhood leukemias represent nearly one third of all cancers in children and present a unique challenge to oncologists, pediatricians, hematologists, and other health professionals. Ching-Hon Pui has assembled an expert team of authors to develop the most comprehensive, clinically-oriented, and authoritative reference dedicated to these diseases. The volume moves from the laboratory bench to the patient bedside in four easily-accessible sections. Fully referenced and up-to-date, it is an absolute 'must-have' for any physician or investigator who deals with leukemias in childhood. ... Read more

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Adult Leukemia summarizes advances in leukemia biology and treatment. It discusses the most successful treatments currently available and examines the remaining obstacles to a cure. Dr. Wiernik's team at New York Medical College has done seminal work in clinical investigation as well as patient management in the leukemias. The subject lends itself particularly well to color illustrations, a key feature of the American Cancer Society Atlas of Clinical Oncology series. This book is an essential reference tool for medical and radiation oncologists and for hematologists. ... Read more

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The current explosion of new areas of controversy in the treatment of acute lymphocytic leukemia in adults and young adults makes this comprehensive book a much needed reference for hematologists and oncologists.This book assembles leading authorities from around the globe to cover the full spectrum of ALL subtypes and their treatments.Specific topics of discussion include indications for allogeneic bone marrow transplant in first complete remission, the role of minimal residual disease in making treatment decisions, the treatment of young adults, and the treatment of Philadelphia chromosome positive ALL with the advent of the tyrosine kinase inhibitors. This is the first book to focus exclusively on the adult ALL patient.It provides a complete overview of diagnosis, molecular pathogenesis, evaluation, and treatment for this important patient population. ... Read more

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This book has been created for parents who have decided to make education and research an integral part of the treatment process. Although it also gives information useful to doctors, caregivers and other health professionals, it tells parents where and how to look for information covering virtually all topics related to childhood acute myeloid leukemia (also Acute granulocytic leukemia; Acute myeloid leukemia; Acute nonlymphoblastic leukemia; Acute nonlymphocytic leukemia; child Acute myeloid leukemia; child Acute nonlymphocytic leukemia), from the essentials to the most advanced areas of research. The title of this book includes the word official. This reflects the fact that the sourcebook draws from public, academic, government, and peer-reviewed research. Selected readings from various agencies are reproduced to give you some of the latest official information available to date on childhood acute myeloid leukemia. Given parents' increasing sophistication in using the Internet, abundant references to reliable Internet-based resources are provided throughout this sourcebook. Where possible, guidance is provided on how to obtain free-of-charge, primary research results as well as more detailed information via the Internet. E-book and electronic versions of this sourcebook are fully interactive with each of the Internet sites mentioned (clicking on a hyperlink automatically opens your browser to the site indicated). Hard-copy users of this sourcebook can type cited Web addresses directly into their browsers to obtain access to the corresponding sites. In addition to extensive references accessible via the Internet, chapters include glossaries of technical or uncommon terms. ... Read more

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Better therapy of acute leukemias depends ultimately on better understanding of the distinction between leukemic and normal progenitor cells. Thus, several chapters in this volume describe current knowledge of acute leukemia biology and discuss new classification systems that have arisen consequent to emerging insights into pathogenesis. Treatment has also improved for particular types of acute leukemia. Given our intention that the book be useful to clinicians, we pay particular attention to these advances, to management of acute leukemia in general, and to development of new therapies.

Product Description
In March 2001, the National Institutes of Health issued the following warning: "The number of Web sites offering health-related resources grows every day. Many sites provide valuable information, while others may have information that is unreliable or misleading."Furthermore, because of the rapid increase in Internet-based information, many hours can be wasted searching, selecting, and printing.This book was created for medical professionals, students, and members of the general public who want to conduct medical research using the most advanced tools available and spending the least amount of time doing so. ... Read more

Product Description
In March 2001, the National Institutes of Health issued the following warning: "The number of Web sites offering health-related resources grows every day. Many sites provide valuable information, while others may have information that is unreliable or misleading."Furthermore, because of the rapid increase in Internet-based information, many hours can be wasted searching, selecting, and printing.This book was created for medical professionals, students, and members of the general public who want to conduct medical research using the most advanced tools available and spending the least amount of time doing so. ... Read more

Customer Reviews (3)

A compelling and needed story
This is a well-written, moving narrative about one family's struggle with childhood cancer. The negative review for this book is puzzling, if not simply a plug for another book. It criticizes this one for not covering medical protocols in sufficient depth, which is unfair because the author does not purport to do that. I agree with the previous reviewer. A focus on medical details misses the forest for the trees. Protocols change, and are mostly the province of doctors. Which is not to say one shouldn't pay attention to the medicine and become reasonably educated on treatment options. But understanding the course of treatment is just one aspect of the ordeal, and not the most important when you consider the human beings involved. Hope, attitude, living and enjoying life; such choices are absolutely within the families' control, and they can make all the difference. Conveying that is the purpose of this gem.

Wise and warm guide
Cynthia Krumme's book was not meant as a guide for parents about what kind of treatment to expect. Of course the description of treatment is out of date, but the treatment varies from year to year and from country to country anyway. Krumme wrote about how to cope with a very ill child, how to treat his or her siblings, how to enjoy life in spite of everything awful that was happening, and how to let the child enjoy it. And all this is timeless. It is best to get a description of treatment from the doctor who is dealing with the child and to read as much as possible about how other people coped with similar situation.And Cynthia Krumme is a very wise, warm guide.

A heartfelt saga, but dated from a medical standpoint.
As the mother of a daughter with leukemia, I found this a moving tale of one family's struggle with leukemia, but for those whose children have been recently diagnosed (1998-99), keep in mind that the author describesmedical protocols, procedures, even family activities that are out-of-datewith current philosophy. Many of the family's experiences are no longercommon or allowed by responsible pediatric oncologists. For this reason,the book may be misleading and inaccurate to some families. A much betterguide to leukemia is Nancy Keene's book, "Childhood Leukemia." ... Read more

Product Description

Chronic Myeloid Leukemia (CML) remains a key model for the improved understanding of the pathophysiology of a malignancy at a molecular level and has been used by researchers to develop a variety of therapies and therapeutic assessment methods. This concise, readable guide assembles and synthesizes the latest developments and trends in the treatment of CML and provides an authoritative and convenient summary of the latest progress in imatinib trials, the molecular monitoring of CML responses, and the engineering of new therapies to overcome resistance and improve patient care.

Providing critical insight and exploration of models that will enhance the cancer community at large, this source:

• stands as the only source to focus on post-Gleevec developments in CML therapeutics
• collects information from the forefront of the field—helping busy clinicians make informed management decisions
• supplies critical research from recognized opinion leaders on the topic
• provides an overview of the current status of new transplant modalities
• contains a vivid selection of color photographs

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Acute myelogenous leukemia (AML), is the most common form of leukemia in adults. AML is a deadly form of malignancy, the prognosis for which has not improved in the last two decades. More importantly, it is a malignancy that is seen in older adults, therefore the number of cases is likely to rise as the population ages. Over the past 15 years, genetic mechanisms underlying AML have begun to unfold. Additional research in this area has helped identify key components and characteristics. Consequently, targeted therapy of AML is receiving much attention. It is the hope of researchers that as with chronic myelogenous leukemia (CML), and the drug, Gleevec, a targeted therapy for AML will be discovered.