Book Description
Human Genetics and Genomics, Third Edition, is the new rendition of the classic textbook Human Genetics: A Problem-Based Approach. Thoroughly updated and restructured, this brand new edition uses both a classic didactic approach to teach basic genetic concepts and a problem-based approach to demonstrate the clinical applications of genetics in medical practice. By combining both these approaches, Human Genetics and Genomics is suitable both as a textbook for genetics courses, and as a bridge into the clinical environment.

The third edition features greater emphasis on cutting edge technologies and the latest genetic issues, and a vast array of new pedagogy, such as:

• Clinical snapshots covering major genetic disorders
• Ethical Implications boxes discussing related ethical issues
• Key summary points at the beginning of each chapter and Q&As at the end of each chapter for self-assessment
• Hot topics covering new and emerging areas in genetics
• Recommended reading for each chapter
• A companion website ... Read more

Customer Reviews (3)

Great clinically-based format.
Clear and compelling, each topic presented in a clincal setting

Good for medical doctor or students
When I read this book, I was very excited the plot of it. Start with patient case, end with resonable explaination of genetic base of disease. I think it is highly recommandable to the doctors andmedical students whowant to connect basic and clinical aspect of medical genetics.

A good supplement.
This text would make a wonderful supplement to a more detailed moleculargenetics text.The book's strength is that it uses a case-study approach,using specific disorders as models of genetic concepts.The weakness ofthe book is how it deals with biochemistry.I feel it assumes the readerhas a pretty good prior understanding of everything from DNA structure andmolecular dogma to molecular genetic analysis and lab technique.Overall,a very readable book. ... Read more

Book Description
Ira Carmen seeks a fusion of experimental biological research and political science research as he explores the important and controversial realm of human genomics.
Politics in the Laboratory takes a close look at the ethical, legal, social, constitutional, and political implications of modern biological research. It addresses both biopolicy issues and basic science—including cloning, embryonic stem cell investigations, and experimentation involving the human germline—from the perspective of a political scientist. ... Read more

Customer Reviews (1)

Well worth examining
This is an ambitious book, and one well worth reading.The effort to demonstrate the linkage of knowledge from the areas of biology and political science is a daunting task.Some may be unconvinced with Carmen's use of what he terms a constitutional approach, since it is different than standard views of this matter.Others may be put off with Carmen's dismissal of political science as a discipline.The reader will certainly know the positions that the author is taking; he is straightforward and unequivocal in his stances and some of his outspoken comments will surely not go down well with some proportion of the book's readers.

However, those who persevere and take seriously the contention that the worlds of genomics and politics cannot and should not be kept separate will find many thought-provoking arguments and new ways of looking at both human genomic research as well as the roots of human social and political behavior.In the final analysis, this is a book that will reward those who persist and read it all the way through.I recommend this book strongly.
... Read more

Book Description

L. Luca Cavalli-Sforza and his collaborators Paolo Menozzi and Alberto Piazza have devoted fourteen years to one of the most compelling scientific projects of our time: the reconstruction of where human populations originated and the paths by which they spread throughout the world. In this volume, the culmination of their research, the authors explain their pathbreaking use of genetic data, which they integrate with insights from geography, ecology, archaeology, physical anthropology, and linguistics to create the first full-scale account of human evolution as it occurred across all continents. This interdisciplinary approach enables them to address a wide range of issues that continue to incite debate: the timing of the first appearance of our species, the problem of African origins and the significance of work recently done on mitochondrial DNA and the popular notion of an "African Eve," the controversy pertaining to the peopling of the Americas, and the reason for the presence of non-Indo-European languages--Basque, Finnish, and Hungarian--in Europe.

The authors reconstruct the history of our evolution by focusing on genetic divergence among human groups. Using genetic information accumulated over the last fifty years, they examined over 110 different inherited traits, such as blood types, HLA factors, proteins, and DNA markers, in over eighteen hundred, primarily aboriginal, populations. By mapping the worldwide geographic distribution of the genes, the scientists are now able to chart migrations and, in exploring genetic distance, devise a clock by which to date evolutionary history: the longer two populations are separated, the greater their genetic difference should be. This volume highlights the authors' contributions to genetic geography, particularly their technique for making geographic maps of gene frequencies and their synthetic method of detecting ancient migrations, as for example the migration of Neolithic farmers from the Middle East toward Europe, West Asia, and North Africa.

Beginning with an explanation of their major sources of data and concepts, the authors give an interdisciplinary account of human evolution at the world level. Chapters are then devoted to evolution on single continents and include analyses of genetic data and how these data relate to geographic, ecological, archaeological, anthropological, and linguistic information. Comprising a wide range of viewpoints, a vast store of new and recent information on genetics, and a generous supply of visual elements, including 522 geographic maps, this book is a unique source of facts and a catalyst for further debate and research.

Customer Reviews (10)

What I got out of this book
I learned who the people closest genetically to Basques are. The French! Makes sense the French have a a portion of Basque country in their political nation of France. I'm of French background myself. French-Canadian that is.

Great book, if you can get through it...
This book is very hard to get through as someone with no backing in genetics or biology, but it is very interesting, and it shows how we humans are really just like a couple thousand breeds of dogs, all slightly different, but with the same ancestor, our distant ancestor though was probably no wolf. It is interesting when they mention the little unexplainable historical abnormalities (african genes and caucasian genes in latin american indigenous populations, perhaps?) that they see in the genes of some groups of humans.

I allmost want to dedicate my life to genetics because of all the damn interesting knowledge that could be spawned from the information presented by the authors of this book. If you know anyone studying in this field, you must give them this book for christmas or something, please.

It is now my theory that human language has been the driving force behind human evolution, how often do two parents without a common language stay together 18+ years to raise a family? Just think about that, and it explains the human diaspora pretty well. Humans very rarely mate outside of their language group. You have a group of people in africa that speak the same language, then later on, two languages develop, or three or four, these people migrate off, and form a tribe, this tribe doesnt mate with other tribes because romance and love just dont work without a common language. Tribal names and language names are usually connected anyway, and this is why. When you read this book, you need to view humanity as an animal group pretty much, its very objective without any feeling. Human beings are creatures of communication, communication has driven our evolution forward. Writing started cities, before even that farming started widespread language and trading. It seems that the natural path this should take is more communication, but most people dont like to talk, fewer like to read and write, though that is our path of destiny as humans. The average american spends more money on lottery tickets every year than books. TV is far too widespread now, the love for books is dying, though civilization has allways been built upon thelibraries of past civilizations, the histories of the victors.

Anyway,
The things that could be done if these scientists who wrote this book could get together to do research with the people that are at the tip of the spear in supercomputer research...

If you want to have some mental fun/anguish, then this book should be read in conjunction with 'Forbidden Archaeology' by Michael Cremo.

Try it =)

Note that this book is not made for the layman, but if you are a layman, and have a biology textbook laying around, you can get through it no problem.

Any one who is thinking of reading this book, or anyone who has should really do a bit of research on National Geographic's Genographic project that is collecting genetic information all over the world right now (the same migratory route tracing that is in this book) and building a huge database...The cool thing though is that you can send National Geographic $100, and they will send you a kit, you send a cheek swab back, and later on, they tell you everything that you ever wanted to know about your ancestors, and their migratory routes, back 60,000 years...
The database is also building daily, so the information that you will first get about your genes will get more comprehensive as time goes on, and more genetic samples are collected from 10's or 100's of thousands of people all over the planet...
Anyone who reads this book actually MUST do a google search on this National Geographic Genographic Project, right now =)

History and Geography of Homan Genes
This work, in hardback, is written with the advanced researcher in mind. The author is world famous for his pioneering efforts in identifying traits in particular traits in ethnic groups with unique genetic markers. The color plates in the index section can be helpful to those who know how to intrepret them.
It's a scholarly treatment of a highly technical subject and a thorough one as well.This is ground-breaking work collected from many samples and analyzed in detail. I think this should be required reading for college students in the field of genetic research.

A review of everything
Cavalli-Sforza presents the nearest approximation possible to the correlation of all measurable human genes, markers and attributes.You might think of the work as the "unified field theory" for evloutionary biology, culture and linguistics.

While the heft even of the abridged version is imposing, the component parts are manageable for those who already have basic statistical knowledge or who are willing to pay attention to the author's explanations.The world's populations are addressed in geographic chunks, and then at various appropriate points, more general conclusions drawn from the pieces.

Given the advances in genetic research acheived since publication, the model may ultimately prove more valuable than the particular contents...but for this decade the contents are fascinating.

Good Book, but Martel is Wrong
The book provided a great deal of information about genetic distances and the relationships between populations. However, Mr. Martel's review includes lies and these lies must be addressed. First of all, the native North Africans were not "very blonde" or "nordic". In fact, the ORIGINAL population was as black as their rock art depictions of themselves (which just so happen to span the Sahara and date back nearly 10000yrs). Many of these Ancient Saharans were, however, completely abosorbed by an incoming of migrants from the Middle East. Perhaps these migrants are the people Mr. Martel is speaking of??? At any rate, with the dessication of the Sahara, most of the original Saharans (blacks) migrated South into The Sudan. In fact, they can still be found in West Africa today. They (especially the Fulani and Dogon) can be recognized in person as easily as they can be recognized in the Ancient Saharan depictions drawn by their ancestors.

Thus, despite Mr. Martel's comments to the contrary, the admixture seen in North Africans today is not so much the result of slaves (modern admixture) as it is the result of both modern admixture as well as ancient admixture - admixture which took place LONG before the Arabs ventured anywhere near the region. As for the Egyptians, they were from the same stock as the rest of North Africa and they almost always depicted themselves as brown and intermediate between and separate from both the white people of the North (Europe), the light skinned Semites (Middle East), and the darker, more Sudanese people of the South (Nubia).

Mr. Martel is not completely wrong in so far as SOME of these Middle Eastern migrants had blonde hair and light eyes (a few individual Lybians were depicted this way). But, such features were most probably seen at the same rate theyre seen in Middle Easterners and North Africans today. Neither people, however, are "Nordics", and to assume they descend from Nordics based on hair color alone is ridiculous. Blondism occurs in Aborigines... are we to believe they descend from Nordics as well? Somehow, I think not. ... Read more

Book Description
Written by the successful author team of Sandy Primrose and Richard Twyman, Genomics: Applications in Human Biology is a topical book showing how the new science of genomics is adding impetus to the advances in human health provided by biotechnology.

• Written to provide the necessary overview of the subject, covering technological developments, applications and (where necessary) the ethical implications.
  
• Divided into three sections, the first section introduces the role of biotechnology and genomics in medicine and sets out some of the technological advances that have been the basis of recent medical breakthroughs.
  
• The second section takes a closer look at how biotechnology and genomics are influencing the prevention and treatment of different categories of disease.
  
• Finally the contribution of biotechnology and genomics to the development of different types of therapy is described, including conventional drugs, recombinant proteins and gene/cell therapies.
  
• References to appropriate sections in other two popular books, authored by Sandy Primrose and Richard Twyman, are included - Principles of Gene Manipulation and Principles of Gene Analysis and Genomics.
  
• Features several categories of boxed text, including history boxes (describing the origins and development of particular technologies or treatments), molecular boxes (featuring the molecular basis of diseases or treatments in more detail) and ethic boxes (which discusses the ethical implications of technology development and new therapies).

Book Description
One of the major themes of human population genetics isassaying genetic variation in human populations. The ultimate goal ofthis objective is to understand the extent of genetic diversity andthe use of this knowledge to reconstruct our evolutionary history. Thediscipline had undergone a revolutionary transition with the advent ofmolecular techniques in the 1980s. With this shift, statisticalmethods have also been developed to perceive the biological andmolecular basis of human genetic variation.
Using the new perspectives gained during the above transition, thisvolume describes the applications of molecular markers spanning theautosomal, Y-chromosomal and mitochondrial genome in the analysis ofhuman diversity in contemporary populations. This is the firstreference book of its kind to bring together data from these diversesets of markers for understanding evolutionary histories andrelationships of modern humans in a single volume. ... Read more

Book Description
A unique exploration of the principles and methods underlying the Human Genome Project and modern molecular genetics and biotechnology-from two top researchers

In Genomics, Charles R. Cantor, former director of the Human Genome Project, and Cassandra L. Smith give the first integral overview of the strategies and technologies behind the Human Genome Project and the field of molecular genetics and biotechnology. Written with a range of readers in mind-from chemists and biologists to computer scientists and engineers-the book begins with a review of the basic properties of DNA and the chromosomes that package it in cells. The authors describe the three main techniques used in DNA analysis-hybridization, polymerase chain reaction, and electrophoresis-and present a complete exploration of DNA mapping in its many different forms. By explaining both the theoretical principles and practical foundations of modern molecular genetics to a wide audience, the book brings the scientific community closer to the ultimate goal of understanding the biological function of DNA. Genomics features:

• Topical organization within chapters for easy reference
• A discussion of the developing methods of sequencing, such as sequencing by hybridization (SBH) in which data is read through words instead of letters
• Detailed explanations and critical evaluations of the many different types of DNA maps that can be generated-including cytogenic and restriction maps as well as interspecies cell hybrids
• Informed predictions for the future of DNA sequencing

Customer Reviews (2)

Genomics
So far I heard that this is the one of the best book containing all informations and instructions about genome project. I love to review this book throgh e-mail.
I can't afford myself to buy this book. but so far i can say if it is really very much helpful to me i recommend evybody of my class (MSC Bioinformatics) to go for buying that book.

with thanks

a 'Gene VI' in Postgenome era
as good as GENE VI by Lewis ... Read more

Book Description
Leading infectious disease researchers and pharmaceutical scientists comprehensively review the latest genomic technologies and their application to the prevention, diagnosis, and treatment. The authors' cross-disciplinary approach, with expertise acquired from studying disease-causing viruses, bacteria, fungi, and protozoa, reveals how sequence information from diverse pathogens has uncovered novel targets for drug discovery, antigenic determinants for vaccine development, as well as diagnostic tools. The authors also discuss the application of DNA micoarrays and the impact of genome sequencing comparisons on the discovery and choices of novel drug targets. The result is a better understanding how genomic information can reveal the fundamentals of microbial pathogenesis and how organisms interact with their host environment. ... Read more

Customer Reviews (1)

18 Articles that represent the state of the art.
This is the sixth annual version of this book which publishes these peer reviewed articles that represent the state of the art as it exists today. This is a science that is changing so fast that in order to keep up it is necessary to go to this approach rather than a single author writing a book as will happen when it settles down.

This edition contains 18 articles written by a who's who of the field. They come from virtually every major research institution in the country and there are several entries from other countries.

I particularly enjoyed the look back over sixty years of medical genetics written by Alfred Knudson. In medical school during World War II, he was in at the beginning of the modern era of genetics research and specialized in cancer research.

The other articles are all of high caliber. Some of course, more interesting than others. But all are worth reading, you never know when you will pick up a useful idea. ... Read more

Book Description
This digital document is an article from Human Ecology, published by Cornell University, Human Ecology on March 22, 2001. The length of the article is 514 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Genomics and Human Ecology.(Brief Article)
Publication: Human Ecology (Refereed)
Date: March 22, 2001
Publisher: Cornell University, Human Ecology
Volume: 29Issue: 2Page: 1

Article Type: Brief Article

Distributed by Thomson Gale ... Read more

Book Description
This digital document is an article from Journal of Law and Health, published by Cleveland Marshall College of Law on March 22, 2001. The length of the article is 3877 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Genomic medicine: the human genome project from a healthcare provider's perspective.(Is There a Pink Slip in Your Genes? Genetic Discrimination in Employment and Health Insurance)(Transcript)
Publication: Journal of Law and Health (Refereed)
Date: March 22, 2001
Publisher: Cleveland Marshall College of Law
Volume: 16Issue: 1Page: 33(6)

Article Type: Transcript

Distributed by Thomson Gale ... Read more

Book Description
This digital document is an article from Human Ecology, published by Cornell University, Human Ecology on March 22, 2001. The length of the article is 3102 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Genomics: The Frontier Within.
Author: Metta Winter
Publication: Human Ecology (Refereed)
Date: March 22, 2001
Publisher: Cornell University, Human Ecology
Volume: 29Issue: 2Page: 2

Distributed by Thomson Gale ... Read more