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1. Human Genetics and Genomics (HUMAN
2. Here Is a Human Being: At the
3. Human Genome Epidemiology, 2nd
4. Genomic Imprinting and Kinship
5. Drawing the Map of Life: Inside
6. The Genomic Revolution: Unveiling
7. Genomics: The Science and Technology
8. Essentials of Medical Genomics
9. Annual Review of Genomics and
10. Genomic Diversity - Applications
11. Politics in the Laboratory: The
12. Genomics: Applications in Human
13. Pathogen Genomics: Impact on Human
14. Inside the Human Genome: A Case
15. Genomics of Disease (Stadler Genetics
16. An International System for Human
17. Human Genetics: Proceedings of
18. Frontiers in Human Genetics: Diseases
19. Human Genome Project: An entry
20. Genomics Protocols (Methods in

by Bruce R. Korf MDPhD
Paperback: 288 Pages (2006-12-22)
list price: US$68.95 -- used & new: US$50.62
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Asin: 0632046562
Average Customer Review: 4.0 out of 5 stars
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Human Genetics and Genomics, 3rd edition, the new rendition of the classic textbook Human Genetics: A Problem-Based Approach, merges basic genetic principles with clinical applications of genetics in medical practice. By presenting the core concepts of human genetics while maintaining an emphasis on a problem-based learning and clinical approach, the third edition of Human Genetics and Genomics acts both as a textbook for genetics courses, and a bridge into the clinical environment.

Features include enhanced emphasis on microbiology content, a chapter devoted to laboratory techniques, and a vast array of new pedagogy, such as:

Recommended readings for each chapter "Clinical snapshots" covering major genetic disorders and integrating a clinical approach Ethics boxes covering ethical implications in genetics Key points at the beginning of each chapter for a quick summary and Q&As at the end of each chapter for self-testing "Hot topics" sections at the ends of chapters covering new and emerging areas in genetics ... Read more

Customer Reviews (6)

3-0 out of 5 stars Human Genetics Text
This is the text my instructor uses for our class. It doesn't contain enough practice problems with solutions. I need to get another book that has more practice problems like we get tested on.

5-0 out of 5 stars Korf (2007). Human Genetics and Genomics.
The book that I received was in very good condition initially.As I started reading the book the pages started falling out because of poor binding quality.I immediately notifed Sandra V. and she quickly responded and asked me to return to her for a full refund.She even let me keep the book until I finished my midterm since I had to order a new book.I am giving her 5 stars because of her phenomenal customer service.Sandra originally e-mailed me asking if I was satisfied and immediately responded to my binding issue.I have nothing but excellent comments about her customer service and responsiveness to my book problems.I highly recommend her to other customers.

4-0 out of 5 stars Book is an easy read but I found several mistakes.
Book is an easy read but I found several mistakes, so be aware of that.

5-0 out of 5 stars Great clinically-based format.
Clear and compelling, each topic presented in a clincal setting

4-0 out of 5 stars Good for medical doctor or students
When I read this book, I was very excited the plot of it. Start with patient case, end with resonable explaination of genetic base of disease. I think it is highly recommandable to the doctors andmedical students whowant to connect basic and clinical aspect of medical genetics. ... Read more

2. Here Is a Human Being: At the Dawn of Personal Genomics
by Misha Angrist
Hardcover: 352 Pages (2010-11-01)
list price: US$26.99 -- used & new: US$17.81
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Asin: 0061628336
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The first in-depth look at personal genomics: its larger-than-life research subjects; its entrepreneurs and do-it-yourselfers; its technology developers; the bewildered and overwhelmed physicians and regulators who must negotiate it; and what it means to be a "public genome" in a world where privacy is already under siege

In 2007, Misha Angrist became the fourth subject in the Personal Genome Project, George Church's ambitious plan to sequence the entire genomic catalog: every participant's twenty thousand–plus genes and the rest of his or her 6 billion base pairs. Church hopes to better understand how genes influence our physical traits, from height and athletic ability to behavior and weight, and our medical conditions, from cancer and diabetes to obesity and male pattern baldness. Now Angrist reveals startling information about the experiment's participants and scientists; how the experiment was, is, and will be conducted; the discoveries and potential discoveries; and the profound implications of having an unfiltered view of our hardwired selves for us and for our children.

DNA technology has already changed our health care, the food we eat, and our criminal justice system. Unlocking the secrets of our genomes opens the door not only to helping us understand why we are the way we are and potentially fixing what ails us but also to many other concerns: What exactly will happen to this information? Will it become just another marketing tool? Can it help us understand our ancestry, or will it merely reinforce old ideas of race? Can personal genomics help fix the U.S. health care system?

Here Is a Human Being explores these complicated questions while documenting Angrist's own fascinating journey—one that tens of thousands of us will soon make.

... Read more

3. Human Genome Epidemiology, 2nd Edition: Building the evidence for using genetic information to improve health and prevent disease
Hardcover: 704 Pages (2010-01-20)
list price: US$69.95 -- used & new: US$53.00
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Asin: 0195398440
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The first edition of Human Genome Epidemiology, published in 2004, discussed how the epidemiologic approach provides an important scientific foundation for studying the continuum from gene discovery to the development, applications and evaluation of human genome information in improving health and preventing disease. Since that time, advances in human genomics have continued to occur at a breathtaking pace.

With contributions from leaders in the field from around the world, this new edition is a fully updated look at the ways in which genetic factors in common diseases are studied. Methodologic developments in collection, analysis and synthesis of data, as well as issues surrounding specific applications of human genomic information for medicine and public health are all discussed. In addition, the book focuses on practical applications of human genome variation in clinical practice and disease prevention. Students, clinicians, public health professionals and policy makers will find the book a useful tool for understanding the rapidly evolving methods of the discovery and use of genetic information in medicine and public health in the 21st century. ... Read more

4. Genomic Imprinting and Kinship (The Rutgers Series in Human Evolution, edited by Robert Trivers, Lee Cronk, Helen Fisher, and Lionel Tiger)
by David Haig
Paperback: 238 Pages (2002-02-20)
list price: US$29.00 -- used & new: US$4.45
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Asin: 081353027X
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Until twenty years ago we had no idea which of our genes came from our father and which came from our mother. We took it for granted that our genes expressed themselves identically and that there was a 50/50 chance that they came from either parent. We also assumed that they worked in cooperation with each other. The biggest breakthrough in genetics in the past two decades has been the discovery of genomic imprinting, which allows us to trace genes to the parent of origin. David Haig has been at the forefront of theorizing these developments. He argues that these "paternally and maternally active genes" comprise less than one percent of our total gene count and are far from being cooperative. In fact, they have been shown to be in competition with one another. If Haig's theory holds true, imprinted genes exemplify an extraordinary within-individual conflict, while shaking up our fundamental ideas of what it means to be an individual. This collection of Haig's papers represents a unique comprehensive overview of the state of evolutionary biology. The pages are linked by a commentary that provides background, and brings readers up-to-date on developments that occurred after the paper's original publication. Since genomic imprinting touches on many areas in the life sciences, including evolutionary biology and developmental genetics, Haig's work is scattered through the literature. This volume brings his work together for the first time.A volume in the Rutgers Series in Human Evolution, edited by Robert Trivers.David Haig is an associate professor of organismic and evolutionary biology at Harvard University. ... Read more

5. Drawing the Map of Life: Inside the Human Genome Project (A Merloyd Lawrence Book)
by Victor K. McElheny
Hardcover: 384 Pages (2010-06-22)
list price: US$28.00 -- used & new: US$14.39
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Asin: 046504333X
Average Customer Review: 5.0 out of 5 stars
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Drawing the Map of Life is the dramatic story of the Human Genome Project from its origins, through the race to order the 3 billion subunits of DNA, to the surprises emerging as scientists seek to exploit the molecule of heredity. It’s the first account to deal in depth with the intellectual roots of the project, the motivations that drove it, and the hype that often masked genuine triumphs.

Distinguished science journalist Victor McElheny offers vivid, insightful profiles of key people, such as David Botstein, Eric Lander, Francis Collins, James Watson, Michael Hunkapiller, and Craig Venter. McElheny also shows that the Human Genome Project is a striking example of how new techniques (such as restriction enzymes and sequencing methods) often arrive first, shaping the questions scientists then ask.

Drawing on years of original interviews and reporting in the inner circles of biological science, Drawing the Map of Life is the definitive, up-to-date story of today’s greatest scientific quest. No one who wishes to understand genome mapping and how it is transforming our lives can afford to miss this book.

... Read more

Customer Reviews (1)

5-0 out of 5 stars A powerful pick for any science or general collection
DRAWING THE MAP OF LIFE: INSIDE THE HUMAN GENOME PROJECT offers a fine case study for how science is done in the real world, considering the scientific surprises that have overturned ideas of what a gene or genome is and does. From ongoing conflicts in definitions and approaches to new applications made possible by the Human Genome Project, this is a powerful pick for any science or general collection.
... Read more

6. The Genomic Revolution: Unveiling the Unity of Life
Hardcover: 272 Pages (2002-07-15)
list price: US$27.95 -- used & new: US$8.88
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Asin: 0309074363
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From the discoveries of Watson and Crick to the appearance of Dolly the Sheep, the last fifty years have ushered in a revolution of knowledge in how organisms develop, function, and replicate. Scientists are now engaged in an epic task that will catapult the revolution to new heights: the sequencing of the human genome.

Consider the scope of such a discovery. How different are we from one another? Does race have a scientific meaning? Is there such a thing as a disease gene? What are the potential risks of genetically modified food? Does a clone have a soul? The Human Genome Project will inevitably lead to landmark changes in medicine, agriculture, and the study of evolution--and will ultimately define the course of human history.

The Genomic Revolution: Unveiling the Unity of Life takes readers on a fascinating journey through genomics--from the basic presentation of ideas about heredity through the essential principles of molecular biology, including an exploration of the ethical implications of the genome project for individuals and society.

Some of the world's leading experts in genomics--Harold Varmus, Leroy Hood, Daniel Kevles, and Craig Venter, to name just a few--contribute their assessments of the state of current scientific research. Written for anyone wondering why we are the way we are, The Genomic Revolution is a timely and important collection that spans the science, the promise, and the potential pitfalls of a field moving so quickly that its achievements may alternately delight and trouble us, but almost always surprise us. ... Read more

7. Genomics: The Science and Technology Behind the Human Genome Project
by Charles R. Cantor, Cassandra L. Smith
Hardcover: 624 Pages (1999-02-02)
list price: US$190.00 -- used & new: US$97.69
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Asin: 0471599085
Average Customer Review: 3.5 out of 5 stars
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A unique exploration of the principles and methods underlying the Human Genome Project and modern molecular genetics and biotechnology-from two top researchers

In Genomics, Charles R. Cantor, former director of the Human Genome Project, and Cassandra L. Smith give the first integral overview of the strategies and technologies behind the Human Genome Project and the field of molecular genetics and biotechnology. Written with a range of readers in mind-from chemists and biologists to computer scientists and engineers-the book begins with a review of the basic properties of DNA and the chromosomes that package it in cells. The authors describe the three main techniques used in DNA analysis-hybridization, polymerase chain reaction, and electrophoresis-and present a complete exploration of DNA mapping in its many different forms. By explaining both the theoretical principles and practical foundations of modern molecular genetics to a wide audience, the book brings the scientific community closer to the ultimate goal of understanding the biological function of DNA. Genomics features:

  • Topical organization within chapters for easy reference
  • A discussion of the developing methods of sequencing, such as sequencing by hybridization (SBH) in which data is read through words instead of letters
  • Detailed explanations and critical evaluations of the many different types of DNA maps that can be generated-including cytogenic and restriction maps as well as interspecies cell hybrids
  • Informed predictions for the future of DNA sequencing
... Read more

Customer Reviews (2)

4-0 out of 5 stars Genomics
So far I heard that this is the one of the best book containing all informations and instructions about genome project. I love to review this book throgh e-mail.
I can't afford myself to buy this book. but so far i can say if it is really very much helpful to me i recommend evybody of my class (MSC Bioinformatics) to go for buying that book.

with thanks

3-0 out of 5 stars a 'Gene VI' in Postgenome era
as good as GENE VI by Lewis ... Read more

8. Essentials of Medical Genomics
by Stuart M. Brown, John G. Hay, Harry Ostrer
Hardcover: 452 Pages (2008-10-20)
list price: US$94.95 -- used & new: US$63.70
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Asin: 0470140194
Average Customer Review: 5.0 out of 5 stars
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  • Six new chapters on vital topics of interest such as multilocus SNP genotyping (SNP chips), RNAi, ChIP-chip, and genomic tiling arrays
  • New edition responds to reviewers' and users' desire for greater coverage—now the most useful handbook on the market!
  • Practical, concise summary of everything about genomics and emerging technologies a busy physician or medical student should know
  • Covers concepts and techniques that are in use in medicine now, as well as those on the cutting-edge of science relevant to medicine, from bioinformatics to DNA diagnostics and proteomics
  • NEW: Includes chapter-end exercises, enhancing the utility of the new edition as a textbook
  • NEW: PowerPoint slides of images available at instructor website
... Read more

Customer Reviews (7)

4-0 out of 5 stars many potential gains in treatment
If you are not a biologist or MD, and want to see where the application of genomics to medicine is going, try Brown's book. In clear language, he and other writers explain the key ideas and promises in this field. Like what can be done with massive genomic databases, by aiding the search for inherited diseases, and isolating these to certain places in the DNA.

One chapter looks at gene therapy. Currently, still mostly speculative. Much remains to be done to make it viable for many people. But this chapter is perhaps the most far reaching, if its potential can be fully realised. Related to this is another chapter about proteomics, which is another buzzword. We see that protein structures are another field, closely related, that also holds big promises for understanding and treatments.

5-0 out of 5 stars Highly Recommended
"...this book was exactly what I was looking for: a high-level overview of genomic technologies and their application...Brown's book is highly recommended..." (Pharmaceutical Research, Vol. 20, No. 6, June 2003)

5-0 out of 5 stars Recommended Book
"readable account of the underpinnings of genomics and its medical applications...a clearly written book that makes a complex discipline understandable..." (New England Journal of Medicine, July 24, 2003)

5-0 out of 5 stars Good Book
"...a good purchase for...academic or medical libraries as well as large public ones." (E-Streams, Vol. 6, No. 5, May 2003)

5-0 out of 5 stars Useful Book
"It will be quite useful to anyone from other fields who is interested in a taste of what emerging technologies in genomics, proteomics, and bioinformatics can bring to bear on questions of potential importance in biomedical research." --American Journal of Human Genetics ... Read more

9. Annual Review of Genomics and Human Genetics, Volume 7, 2006
by Chakravarti; Green (eds.)
 Paperback: Pages (2006)

Asin: B003ZQLFLE
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10. Genomic Diversity - Applications in Human Population Genetics
by Surinder Singh Papiha, Ranajit Chakraborty, Ranjan Deka
Hardcover: 248 Pages (1999-11-01)
list price: US$249.00 -- used & new: US$158.40
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Asin: 0306462958
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One of the major themes of human population genetics isassaying genetic variation in human populations. The ultimate goal ofthis objective is to understand the extent of genetic diversity andthe use of this knowledge to reconstruct our evolutionary history. Thediscipline had undergone a revolutionary transition with the advent ofmolecular techniques in the 1980s. With this shift, statisticalmethods have also been developed to perceive the biological andmolecular basis of human genetic variation. Using the new perspectives gained during the above transition, thisvolume describes the applications of molecular markers spanning theautosomal, Y-chromosomal and mitochondrial genome in the analysis ofhuman diversity in contemporary populations. This is the firstreference book of its kind to bring together data from these diversesets of markers for understanding evolutionary histories andrelationships of modern humans in a single volume. ... Read more

11. Politics in the Laboratory: The Constitution of Human Genomics
by Ira H. Carmen
Hardcover: 360 Pages (2005-01-03)
list price: US$35.00 -- used & new: US$20.48
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Asin: 0299202100
Average Customer Review: 5.0 out of 5 stars
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Ira Carmen seeks a fusion of experimental biological research and political science research as he explores the important and controversial realm of human genomics.

Politics in the Laboratory takes a close look at the ethical, legal, social, constitutional, and political implications of modern biological research. It addresses both biopolicy issues and basic science--including cloning, embryonic stem cell investigations, and experimentation involving the human germline--from the perspective of a political scientist. ... Read more

Customer Reviews (1)

5-0 out of 5 stars Well worth examining
This is an ambitious book, and one well worth reading.The effort to demonstrate the linkage of knowledge from the areas of biology and political science is a daunting task.Some may be unconvinced with Carmen's use of what he terms a constitutional approach, since it is different than standard views of this matter.Others may be put off with Carmen's dismissal of political science as a discipline.The reader will certainly know the positions that the author is taking; he is straightforward and unequivocal in his stances and some of his outspoken comments will surely not go down well with some proportion of the book's readers.

However, those who persevere and take seriously the contention that the worlds of genomics and politics cannot and should not be kept separate will find many thought-provoking arguments and new ways of looking at both human genomic research as well as the roots of human social and political behavior.In the final analysis, this is a book that will reward those who persist and read it all the way through.I recommend this book strongly.
... Read more

12. Genomics: Applications in Human Biology
by Sandy B. Primrose, Richard Twyman
Paperback: 232 Pages (2004-02-06)
list price: US$89.95 -- used & new: US$20.70
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Asin: 1405108193
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Written by the successful author team of Sandy Primrose and Richard Twyman, Genomics: Applications in Human Biology is a topical book showing how the new science of genomics is adding impetus to the advances in human health provided by biotechnology.

Aimed at advanced undergraduates, it assumes a basic knowledge of the principles of recombinant DNA technology and will form an excellent basis for further study into human disease, cancer, and new therapies.

* Written to provide the necessary overview of the subject, covering technological developments, applications and (where necessary) their ethical implications
* Divided into three sections, the first section introduces the role of biotechnology and genomics in medicine and sets out some of the technological advances that have been the basis of recent medical breakthroughs
* The second section takes a closer look at how biotechnology and genomics are influencing the prevention and treatment of different categories of disease
* Finally the contribution of biotechnology and genomics to the development of different types of therapy is described, including conventional drugs, recombinant proteins and gene/cell therapies
* References to appropriate sections in two other popular books, authored by Sandy Primrose and Richard Twyman, are included - Principles of Gene Manipulation and Principles of Gene Analysis and Genomics
* Features several categories of boxed text, including history boxes (describing the origins and development of particular technologies or treatments), molecular boxes (featuring the molecular basis of diseases or treatments in more detail) and ethics boxes (which discusses the ethical implications of technology development and new therapies) ... Read more

13. Pathogen Genomics: Impact on Human Health (Infectious Disease)
Hardcover: 309 Pages (2002-06-15)
list price: US$104.50 -- used & new: US$10.01
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Asin: 1588290263
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Johnson and Johnson Pharmaceutical Research and Development, L.L.C., San Diego, CA. Offers specialists an analysis of the new genomic technologies and their productive application to drug discovery, vaccine development, and diagnostics. Covers the genomics of infectious viruses, bacteria, fungi, and protozoa. DNLM: Microbiologic Phenomena--genetics. ... Read more

14. Inside the Human Genome: A Case for Non-Intelligent Design
by John C. Avise
Hardcover: 240 Pages (2010-02-12)
list price: US$19.95 -- used & new: US$13.99
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Asin: 0195393430
Average Customer Review: 4.0 out of 5 stars
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Humanity's physical design flaws have long been apparent--we get hemorrhoids and impacted wisdom teeth, for instance--but do the imperfections extend down to the level of our genes? Inside the Human Genome is the first book to examine the philosophical question of why, from the perspectives of biochemistry and molecular genetics, flaws exist in the biological world. Distinguished evolutionary geneticist John Avise offers a panoramic yet penetrating exploration of the many gross deficiencies in human DNA--ranging from mutational defects to built-in design faults--while at the same time offering a comprehensive treatment of recent findings about the human genome. The author shows that the overwhelming scientific evidence for genomic imperfection provides a compelling counterargument to intelligent design. He also develops a case that theologians should welcome rather than disavow these discoveries.The evolutionary sciences can help mainstream religions escape the shackles of Intelligent Design, and thereby return religion to its rightful realm--not as the secular interpreter of the biological minutiae of our physical existence, but rather as a respectable philosophical counselor on grander matters of ultimate concern. ... Read more

Customer Reviews (5)

5-0 out of 5 stars Avise's "The Iliad and Theodicy"
Avise, a Distinguished Professor of Ecology & Evolutionary Biology at UC Davis, holds a PhD in Genetics, has written 20 books, and has authored/coauthored more than 300 scientific articles in his field.

He wastes no time and minces no words. From the very first paragraphs of his Preface, he challenges the basic premise of Intelligent Design. He says: "...explaining biological systems that are complex and function well is easy, at a cursory level." [but] "The greater conceptual challenge--for scientists and ID proponents alike--is to explain complex biological traits that show profound structural or functional flaws." [and] "Flawed biotic features nonetheless abound in species, including humans." Avise posits that while the original design may have been intelligent, subsequent flaws reflect implementations that are far from intelligent and are accordingly more reasonably attributed to evolution's non-sentient design.

ID rejects macro-evolution, thus requires special creations, which brings the issue of theodicy to the fore, placing on God the entire responsibility for all the suffering caused by design and implementation flaws. But by attributing genetic flaws to evolution's less than perfect implementations, God is placed at least one remove from responsibility for them.

In Chapter 1 Avise fleshes out his thesis that an error-riddled genome, as implemented, does not reflect intelligent design: implementation by evolution does, and evolution lessens the burden of theodicy.

In Chapters 2-4, Avise supports his contention that flawed biotic features abound. He notes the many inborn errors of metabolism that take countless lives, gratuitous genomic complexities that routinely compromise human health, byzantine mechanisms of gene regulation, and much more - and all these imperfections are consistent with evolutionary expectations, not intelligent design. While he describes only a few representative genomic flaws, he does provides numerous tables categorizing and enumerating many more, and cites other documents that describe yet more, such as the "Human Genome Mutation Database", which as of 2010 describes more than 100,000 mutations!

In Chapter 5 Avise details his argument from imperfection. Since his argument is based on microbiological data, he chooses, appropriately, to challenge Behe: "I will use Behe's 1996 treatise [Darwin's Black Box] as a touchstone for discussion because it remains the preeminent book-length endorsement of Intelligent Design from a professional molecular biologist."

Point by point, Avise shows evolution's non-sentient design is far superior to ID's special creations in explaining the diversity of life on earth. Behe was aware that there are "apparent" molecular imperfections, but tried to deflect an argument from imperfection on the basis that we can't know the mind of the designer and whether he would consider them imperfections. Avise notes: `Ironically, Behe's dismissal of the argument from imperfection in effect demolishes Intelligent Design as a testable scientific hypothesis..."

Regarding special-creations Avise says: "When fine details of molecular errors appear in phylogenetically related species, special-creation explanations for such errors are thus effectively eliminated (unless we suppose that a bumbling Creator made the same molecular mistakes time and again when directly forging different species)."

Avise finishes with a brief epilogue - essentially an apologetic for science.

In summary, the preceding is just a taste: Avise delivers much, much more. He provides a passionate defense of science in general and evolution theory in particular. In the process, he demonstrates that ID is without scientific merit and is of questionable religious merit, being unsupportive of religion relative to theodicy.

5-0 out of 5 stars Render unto evolution that which is evolution's...
In one of its pivotal confrontations, the New Testament shows a wry Jesus responding to the challenge of critics concerning what defference to give to Rome (and along with it, temporal human authority).

By way of reply, Jesus holds up a coin (presumably showing the face of Tiberius Caesar) and asks whose face is on it.Noting the reply that the image depicts Caesar, Jesus famously suggests that followers render to Caesar that which is Caesar's and that to God, which is God's.

I think Professor Avise's book can best be understood as making a much similar point, albeit with respect to science.

And though fundamentalist's may certainly differ, the liberation from having to force religion to explain natural phenomenon and thereby be placed in competition with it, dissaudes it from its more proper historical mission.And what is that proper role of religion? By its own religious texts, much of the message of organized religion concerns itself with proseltyzing moral values rather than imparting factual truths (separate and apart of course that those facts which specifically relate to its myth of beginning).In this sense, I think the particularly religious as well as the majority stream can welcome this book as a breath of fresh air.

But for the mainstream, this book is fascinating reading.Contrary to what one may think, an examination of our genetics clearly shows a more Rube Goldberg structure than one bearing the imprint of some mastermind intelligent designer. The points Avise makes in support of this thesis do run to the very technical but fortunately he periodically reduces his more complex explanations to more simple layman's language.

And significantly, the examples Avise points out are merely the tip of the iceberg to show the often flawed and self destructive ways in which our genetics can fail us.

3-0 out of 5 stars 5 for content, 1 for formatting...
The author does an excellent job of presenting evidence against Intelligent Design at the genomic level.It's a relatively short book, packed with facts.As a biologist I was fine, but it may be slightly too technical for the casual reader.

Unfortunately the Kindle formatting was atrocious.I doubt that anyone actually checked it.Only the first chapter link works on the table of contents.And none of the endnotes are clickable.Plus many of the tables are broken up by text or unreadable.I feel bad for the author to have the publisher mangle his book like this.

3-0 out of 5 stars Much-needed book; appreciated brevity; but very difficult for non-specialists.
Some material is irreducibly complex.I mean in genetics.There is only so far that an author can go in simplifying the material for a non-scientist like me before she ends up not even saying things that are accurate any more.So I sympathize with Avise's challenge in writing a book like this, but...I found some of his efforts to be more "popular" in his tone sort of amusing.I mean, he says that he is trying to produce a work for a "broad audience."Effort noted and appreciated, but then the next couple of chapters had between them perhaps four or five paragraphs that I could follow fully.And sometime's Avise helpfully provides a definition for a term that might not be familiar to the reader (ironically, it was more often than not these terms that I WAS familiar with...so perhaps one of his guiding principles was only to define the terms that were essential to an understanding of the overall subject matter even if in the context of other less-well-understood terms), followed by an onslaught of three or four paragraphs in a row of genetic arcana that I find it very hard to believe anyone without a solid grounding in genetics could follow.

Having said all that, I still think the book is valuable and I think it's compelling...even kind of fun in its way, because the genome and its workings are such a freak show.The chapters where Avise comes up for air and makes pronouncements on what we've just read are lucid and cogent.Avise plays painfully fair with theism, but I do wish he could have followed Jerry Coyne's example in "Why Evolution is True" and just not addressed much of the theistic stuff at all.It's not necessary to make some sort of atheistic rant or to try to make up some soothing excuses for theism either one.The science speaks for itself, quite loudly, and any dispassionate examination of the evidence can only lead one to conclude that an all-powerful, all-good being cannot be behind the human genome.As Avise says in the section on mitochondria, not only is the design of it suboptimal, it is ludicrous.'Nuff said, frankly.Efforts at reconciliation with religion seem necessarily hollow once the truth of that sinks in.

There are other books that walk a similar path and are much easier to read.I'm thinking especially of Survival of the Sickest: A Medical Maverick Discovers Why We Need Disease, which has an interesting take on, for example, malaria.But for sophisticated, scientifically credible material one could use to counter the work of, for example, some recent books that try to make the claim that Intelligent Design is evident in DNA, "Inside" is invaluable.Not light reading, mind you, but invaluable.

5-0 out of 5 stars A timely reminder that Evolution still rules supreme.
Published on February 12, 2010, presumably in celebration of the 201st anniversary of the birth of Charles Darwin, "Inside the Human Genome: A Case for Non-Intelligent Design" is yet another book convincingly pointing out that the "modern" Creationist theory of Intelligent Design has no explanatory or predictive power, and therefore fails.

I don't recommend the Kindle edition though.The formatting of the tables and illustrations is very poor, and almost completely unreadable, and after a while I gave up on them.The text is very clear though.It would have been better if it had been formatted for the larger screen of the Kindle DX or the Kindle computer version.

Instead of examining biological structures that work very well and are very beautiful, John Avise examines plain ugly and barely functional elements of ID's latest poster child, DNA.He shows that DNA looks exactly the way it should, after a long process of evolution and tinkering, and not the masterwork of a loving and caring Intelligent Designer.

It's often forgotten, that for all its design faults, the vertebrate eye still works extremely well.Both Intelligent Design and Evolution have little trouble in explaining perfection or almost perfection.

John Avise, in less than 240 pages (in the Kindle version, the main text finishes 72% through the book before the "Notes and References"), discusses exhaustively the many design faults of the human genome.I'm not certain for whom this book is written.Certainly not the common run-of-the mill ID proponent who waxes enthusiastically over Stephen Meyer's 600+ page "Signature in the Cell".The information is presented in a very dense form, fact after fact, almost without respite.

To give two examples John Avise uses.In malarial areas, sickle cell trait provides increased resistance to malaria.Individuals are heterozygous for Haemoglobin S, a variant form of Haemoglobin A, and have a survival advantage.Individuals with sickle cell anaemia, homozygous for HbS, have a nasty and short life.They pay the price for the increased survival of heterozygotes, and the die is cast at conception.Hardly the deed of a loving and caring Intelligent Designer.So, the malarial parasite is intelligently designed, and the stop-gap measure of sickle cell trait is also intelligently designed, or at least according to ID.

He also discusses my favourite example of bad design, the mitochondrial genome.Mitochondria were originally symbiotic bacteria, and as such had a complete bacterial genome.Most of the mitochondrial genes have been moved out of harm's way to the nucleus, but the mitochondria still retains a circular bacterial chromosome, with a small number of genes, including 13 genes for components of the oxidative phosphorylation pathway.In mitochondria, exposed to free radicals of oxygen, they mutate at 5 to 10 times the rate of nuclear genes, so the end result is steadily decreasing energy production with ageing, and "brownouts" followed by "blackouts", and death.

The human genome contains 3 billion base pairs.Most of it is definitely "junk", without function.ID proponents have faith that all of it will eventually be found to have a function, but they are certain to be disappointed.Almost all genes consist of alternating exons (which code for the protein product) and introns (which don't).The trouble is, is that the the non-coding introns are 30 times as long as the coding exons.So the cell has to take a lot of effort transcribing a much larger mRNA molecule than necessary, and then has to expend a lot more effort splicing the non-coding RNA out to get a functional mRNA molecule.Not very efficient, and very wasteful.Bacteria have a much more efficient genome (actually, I wonder, does the Intelligent Designer love bacteria more than us?)

Towards the end, the author points out that Darwin liberated both science and theology with "Origin of the Species".No longer do religious people have to try to explain the theodicy of genetic defects, as the action of a loving and caring Creator.

The author finishes, with a re-writing of Darwin's famous conclusion to "Origin";"... There is grandeur in this view of the genome, with its several powers, having perhaps been originally breathed by the Creator into one or a few primordial molecular forms; and ... from so simple a beginning most beautiful, sometimes most awful, but always wondrous genomic features have been, and are being evolved".

I think I still prefer the original, which still excites me whenever I hear it. ... Read more

15. Genomics of Disease (Stadler Genetics Symposia Series)
Paperback: 222 Pages (2010-11-02)
list price: US$149.00 -- used & new: US$149.00
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Asin: 1441926364
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This title develops from the 24th Stadler symposium. It explores the general theme "GENOME EXPLOITATION: Data Mining the Genomes". The idea behind the theme is to discuss and illustrate how scientists are going to characterize and make use of the massive amount of information being accumulated about plant and animal genomes. The book presents a state-of-the-art picture on mining the Genome databases. Its chapters are authored by key stars in the field.

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16. An International System for Human Cytogenetic Nomenclature: Iscn (1985) : Report of the Standing Committee on Human Cytogenetic Nomenclature (1985 Report ... Committee on Human Cytogenetic Nomenclature)
by D. G. Harnden, Harold P. Klinger
 Paperback: 124 Pages (1985-12)
list price: US$60.00
Isbn: 3805538707
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17. Human Genetics: Proceedings of the Sixth International Congress of Human Genetics, September 13-18, 1981, Jerusalem (Progress in Clinical and Biological Research, V. 103)
by International Congress of Human Genetics 1981 (Jerusalem), Richard Goodman, Batsheva Bonne-Tamir, Tirza Cohen
 Hardcover: 1238 Pages (1982-08)
list price: US$186.00
Isbn: 084510103X
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18. Frontiers in Human Genetics: Diseases and Technologies. Expanded and Updated Proceedings of the International Symposium on Human Genetics and Gene Therapy Held in Singapore 1999
by International Symposium on Human Genetics and Gene Therapy (1999 : Singapore)
Hardcover: 396 Pages (2001-07)
list price: US$104.00 -- used & new: US$104.00
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Asin: 9810244584
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With the completion of human genome sequencing, human genetics is poised for major developments in functional genomics, molecular diagnostics, pathogenesis of complex multifactorial diseases and gene-based therapy. This book includes manuscripts from an international symposium on human genetics and gene therapy as well as articles written by a selection of young researchers in the Asia Pacific region who are actively involved in a diverse range of medical problems, including cancers, infections, hypertension and myopia. New technologies being developed in gene therapy, lab-on-chips and bioinformatics are reported. The book provides a snapshot of the diverse approaches and solutions being developed at the frontiers of human genetics. It should be useful to researchers and students in molecular genetics and the life sciences, professionals in the biotechnology and pharmaceutical industries, as well as clinicians who are interested in molecular medicine and gene therapy. ... Read more

19. Human Genome Project: An entry from Macmillan Reference USA's <i>Macmillan Reference USA Science Library: Genetics</i>
by Ralph R. Meyer
 Digital: 8 Pages (2003)
list price: US$6.90 -- used & new: US$6.90
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Asin: B002676OHI
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This digital document is an article from Macmillan Reference USA Science Library: Genetics, brought to you by Gale®, a part of Cengage Learning, a world leader in e-research and educational publishing for libraries, schools and businesses.The length of the article is 2702 words.The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase.You can view it with any web browser.A comprehensive collection of articles on all aspects of genetics, from Mendel to the decoding of the human genome. Explains the workings of genes and chromosomes, genetic diseases, and biotechnology. Covers the ethical, legal, and social issues connected to genetic science and includes coverage of careers in the field. ... Read more

20. Genomics Protocols (Methods in Molecular Biology)
Paperback: 425 Pages (2010-11-02)
list price: US$109.00 -- used & new: US$109.00
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Asin: 1617378186
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Since the first edition, published in 2001, genomics research has taken great strides. In this updated second edition, a team of expert researchers share the most current information in a field that has recently switched emphasis from gene identification to functional genomics and the characterization of genes and gene products. This volume approaches its subject with a broad perspective to supply its reader with a vital overview of genomics and its derivative fields.

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