Product Description
Big ideas made simple -- six books in an incredible new series that explains important scientific ideas more clearly than ever before.

One of the greatest achievements of the age, the sequencing of the human genome is here explored and explained in detail, from the work of the earliest geneticists to the publication of the genome itself, with all the implications it has for the future.This stimulating new series uses an innovative mix of graphics, artwork, and photographs to explain and illuminate the most important scientific topics of the day. Unique in popular science guides, Essential Science uses bright, full-color images to make traditionally "difficult" subjects more accessible. Each title focuses on a scientific or technological topic that is currently provoking debate and is likely to have a widespread impact on our lives. Lively, readable text from top science writers ensures all readers -- from 14+ schoolchildren to academics -- gain a full understanding of the facts and related issues. Under the direction of renowned science writer John Gribbin, expert authors describe, in lively, jargon-free text, the principles and discoveries behind each subject, summarize what is currently known, and predict future issues and trends. ... Read more

Product Description
Human Molecular Biology Laboratory Manual offers a hands-on, state-of-the-art introduction to modern molecular biology techniques as applied to human genome analysis. In eight unique experiments, simple step-by-step instructions guide students through the basic principles of molecular biology and the latest laboratory techniques. This laboratory manual’s distinctive focus on human molecular biology provides students with the opportunity to analyze and study their own genes while gaining real laboratory experience.

• A Background section highlighting the theoretical principles for each experiment.


• Safety Precautions.
  
• Technical Tips.
  
• Expected Results.
  
• Simple icons indicating tube orientation in centrifuge.
  
• Experiment Flow Charts
  
• Spiral bound for easy lab use

Product Description
Recent work in quantitative biology has shown theoretically whyFisher's Fundamental Theorem of Natural Selection does not precludegenetic influences on fertility, sexuality, and related processes.Genetic Influences on Human Fertility and Sexuality takes thenext step, and presents a number of successful empirical searches forsuch genetic influence on a broad range of processes, such as puberty,marriage, sexual behavior, and twinning. Employing a broad range ofmethodological approaches, including molecular and behavioralgenetics, this book weaves a new theoretical framework that shows howgenes can help relate fertility planning to fertility outcome, and howpuberty, sexuality, marriage, and reproduction can be conceptuallylinked through the genes that contribute to individual differences inthe human process. ... Read more

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A report of the National Research Council's Committee on Life Sciences on the assessment of the scientific value, technical aspects, and organizational requirements of a systematic worldwide survey of human genetic variability and the ethical, legal, and social issues it would raise. Softcover. ... Read more

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The goal of this book is neither to provide a basic introduction to imprinting, nor to provide a comprehensive survey of the current state of the field. Rather, the book covers more recent advances, drawing attention to the emerging subtleties and complexities associated with imprinted genes. Genomic imprinting refers to a recently discovered phenomenon in which the expression pattern of an allele depends on whether that allele was inherited from the mother or the father.

Product Description
This digital document is an article from Human Ecology, published by Cornell University, Human Ecology on December 1, 2002. The length of the article is 464 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Potential link found between lung health and levels of HDL. (Brief Reports: Nutrition, Health, and Genomics).
Author: Susan S. Lang
Publication: Human Ecology (Refereed)
Date: December 1, 2002
Publisher: Cornell University, Human Ecology
Volume: 30Issue: 4Page: 24(1)

Distributed by Thomson Gale ... Read more

Product Description
This digital document is an article from Human Ecology, published by Cornell University, Human Ecology on December 1, 2003. The length of the article is 1139 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Preventing childhood obesity at school, at home, and in the community: Cornell nutritional sciences expert presents legislative testimony on the childhood obesity epidemic in the state.(Nutrition, Health, and Genomics)
Publication: Human Ecology (Refereed)
Date: December 1, 2003
Publisher: Cornell University, Human Ecology
Volume: 31Issue: 2Page: 23(1)

Distributed by Thomson Gale ... Read more

Product Description
This digital document is an article from Human Ecology, published by Cornell University, Human Ecology on September 1, 2002. The length of the article is 571 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Nutritionists attribute postpartum weight loss to daily exercise and positive attitude: intention and confidence, researchers say, are the strongest predictors as to whether women will exercise frequently and lose weight after giving birth.(Nutrition, Health, and Genomics)
Author: Susan S. Lang
Publication: Human Ecology (Refereed)
Date: September 1, 2002
Publisher: Cornell University, Human Ecology
Volume: 30Issue: 3Page: 24(1)

Distributed by Thomson Gale ... Read more

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Focusing on the roles of different segments of DNA, Statistics in Human Genetics and Molecular Biology provides a basic understanding of problems arising in the analysis of genetics and genomics. It presents statistical applications in genetic mapping, DNA/protein sequence alignment, and analyses of gene expression data from microarray experiments.

The text introduces a diverse set of problems and a number of approaches that have been used to address these problems. It discusses basic molecular biology and likelihood-based statistics, along with physical mapping, markers, linkage analysis, parametric and nonparametric linkage, sequence alignment, and feature recognition. The text illustrates the use of methods that are widespread among researchers who analyze genomic data, such as hidden Markov models and the extreme value distribution. It also covers differential gene expression detection as well as classification and cluster analysis using gene expression data sets.

Ideal for graduate students in statistics, biostatistics, computer science, and related fields in applied mathematics, this text presents various approaches to help students solve problems at the interface of these areas.

Customer Reviews (1)

Looking for what DNA does.
Aimed at the beginning graduate student in statistics, biostatistics, computer science, and related fields in applied mathematics this book is positioned at an interesting place. It presumes that the student has had a good grounding in linear algebra and basic calculus along with some study of general statistics where calculus is used. It then presents a graduate level course in statistics, but specialized in those statistical procedures which have proven useful in the biological sciences.

As such the book spends time on just those techniques rather than being a general course in statistics. The unifying theme revolves around the basic questions: What does this segment of DNA do and which segment of DNA does that.

Along the way the book gives the student some background in biology, computer science, statistics and bioinformatics that enables him to understand just what it is that he is trying to accomplish and that subsequently he can use this knowledge when facing actual problems found in research. ... Read more

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This collection of articles by internationally recognized researchers highlights the major questions and accomplishment of modern physiological research and demonstrates that modern molecular methods can well be incorporated and strengthen the original integrative perspectives of physiology set out by Claude Bernard's concept of the "milieu interieur."Among the critical issues discussed are the place of functional genomics in regulatory physiology, the role of model systems in integrative physiology, the function of neural circuits in behavior and consciousness, and the influence of external challenges to the whole body and the environment on genes. Perceptive and timely, Integrative Physiology in the Proteomics and Post-Genomics Age bridges the gap between molecular biology and whole body function, establishing the future of physiology as an integrative science based on new molecular insights. ... Read more

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Well-recognized computational geneticists review and assess both currently available and developing tools for the rapid identification of the genetic basis for susceptibility to disease. The authors introduce a new computational approach that makes it possible to identify the genetic basis for differences in physiologic or pathologic responses among inbred mouse strains, thus facilitating more rapid genetic discovery. The focus is on the haplotype-based computational genetic analysis method and its application to inbred mouse strains. Reviewing murine models of asthma, lung disease, osteoporosis, and substance abuse, the contributors provide an overview of available mouse models, what has been learned from them, and which new models must be developed to advance our understanding of these diseases. They also describe how genetic analysis of human populations has yielded information on the genetic basis for susceptibility to asthma and other inflammatory diseases. ... Read more

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Written as a platform for researchers, scientists, educators, and policy makers to discuss the current status of nutritional genomic research, this book contains the latest scientific findings on the mechanisms underlying diet-genome interactions. With contributions from renowned experts, it covers information on transforming dietary signals into disease-preventing changes in gene expression, gene-linked networks of chronic disease and cancer, and the role of food science and nutrition to meet individual genomic health needs. The book identifies future directions for research and challenges and opportunities for improving global health and wellness by preventing, delaying, or mitigating chronic diseases with diet.

Product Description
This digital document is an article from Science News, published by Science Service, Inc. on July 4, 2009. The length of the article is 3447 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available immediately after purchase. You can view it with any web browser.

Citation Details
Title: Seeking genetic fate: personal genomics companies offer forecasts of disease risk, but the science behind the packaging is still evolving.
Author: Patrick Barry
Publication: Science News (Magazine/Journal)
Date: July 4, 2009
Publisher: Science Service, Inc.
Volume: 176Issue: 1Page: 16(6)

Distributed by Gale, a part of Cengage Learning ... Read more

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Today’s consumer can send a company a DNA sample and receive a detailed set of genetic test results in return all without ever visiting a health care provider. Although knowing one’s personal risk for serious disease may lead some individuals to make more informed health choices, an ever-growing set of questions remains: Are predictive genetic tests meaningful? Can the results be harmful as well as helpful? In what ways can genetic information be used by health care providers to predict disease risk and optimize medical management within concerned families? Most important, how might the landscape of genetic testing affect the care of children’s health?

Although there are no easy answers, the Handbook of Genomics and the Family details in one authoritative volume the challenges entailed by the latest genetic advances and offers insights into the potential translation of this knowledge in pediatric and family practice and public health. This timely and comprehensive reference introduces readers to the study of how genes, singly and in combination with each other and the environment, affect health and behavior; summarizes current findings on genetics and genomics in disease etiology and prevention; and provides family-focused perspectives relating to genetic counseling and education.

Key features of the Handbook include:

- In-depth background in genetics and genomics in relationship to disease etiology and epidemiology.

- Integrative frameworks for understanding genetics and genomics in the context of families.

- Considerations for communicating genetic and genomic information.

- Individual chapters on genetic and familial risks for specific diseases and conditions, including cancer, obesity, and Type 1 diabetes among children and adolescents.

- Training, ethics, and other emerging issues and controversies.

- Contemporary policies on genetic testing in children and families.

The Handbook of Genomics and the Family is essential reading for clinical child and pediatric psychologists and psychiatrists, pediatricians and nurses, clinical geneticists and genetic counselors, and public health specialists as advances in genetics lead the way to more personalized models of health.

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Univ. of Bath, UK. Brings together the essential molecular, genetic, and embryological methods used in today's laboratories for the identification and analysis of imprinted genes. Each technique is described in detail. Outline format. ... Read more

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"Who are the mutants? We are all mutants. But some of us are more mutant than others."

Variety, even deformity, may seem like an unlikely route by which to approach normality, even perfection. Yet much of what we know about the mechanisms of human development, growth, and aging comes from the study of people who are afflicted with congenital diseases, most of which have genetic causes. Congenital abnormalities reveal not only errors within the womb, but also our evolutionary history.

In Mutants, Armand Marie Leroi gives a brilliant narrative account of our genetic grammar and the people whose bodies have revealed it, balancing both the science and the stories behind some of history's most captivating figures-including a French convent girl who found herself changing sex upon puberty; children who, echoing Homer's Cyclops, are born with a single eye in the middle of their foreheads; a village of long-lived Croatian dwarves; a hairy family who was kept at the Burmese royal court for four generations (and from whom Darwin took one of his keenest insights into heredity); and the ostrich-footed Wadoma of the Zambezi River Valley.

Stepping effortlessly from myth to molecular biology, this elegant, humane, and illuminating book is about us all. ... Read more

Customer Reviews (29)

Normal defined by the abnormal
This would have been an excellent companion book for the developmental biology text that I had in graduate school. Obvious instances of development gone awry and determination of their underlying causes help elucidate the normal order of things. Leroi did a wonderful job of setting up chapters, presenting many sad, but interesting stories of "mutants" treated as curiosities for the amusement of the elite, or as subjects for medical dissection. As a result, they have their pictures taken, portraits painted, and skeletons preserved. This accounts for many of the figures and stories in the book and all are fascinating. Leroi's book loses a little momentum in the last two chapters: the chapter on aging has a long set-up for only a brief mention of conditions, like Werner's Syndrome, and unlike in other chapters, lacks explanation to any of its definitive causes; and the final chapter waxes poetic about genetic variety and really changes the focus of the book from its developmental biology beginnings to more of a book on genetic variation in natural selection. Maybe it was a literary device to illustrate mutation. Regardless, I would recommend this book to people who want to be amazed by nature creating forms that are stranger than fiction and learn about themselves in the process.

"The monstrous, the strange, and the deviant..."
A story about cyclops, mermaids, giants, pygmies, hermaphrodites, albinos, lobster-claw appendages, castrati, cretins, suicidal cells, sonic hedgehogs, glass bone men - in other words, mutants.

And it's true!

Oh, the drama of an embryo, the suspense of fetal development!

Mutants is a fascinating book about genetic mutations explained with substantive but not overwhelming scientific-ese, as well as historical details and occasional pictures. It is not a "freak show" type of book. Leroi handles his subject matter with respect, for the story of mutation is the story of human biology. What can and does go wrong reveals the wondrous ways in which our bodies develop inside and outside the womb.

Do not read this if you are pregnant or thinking of having kids because:


"Each new embryo has about a hundred mutations that its parents did not have...of these hundred mutations, about four will alter the meaning of genes...and of these four...about three will be harmful. To be precise, they will affect the ultimate reproductive success of the embryo, at least enough to ensure that, with time, natural selection will drive them to extinction."


That's right, I'm a mutant, and you, yes, you, are a mutant too. We have been mutants since before we were even born.


"We are all mutants. But some of us are more mutant than others."

Awsome.
Great book on what we know and what we still do not know about genetics and how mutations and change the out come of somethings in a big way.

Great Book
This was an excellent, if disturbing, book. It was informative and morbidly interesting to read. At some points, it got dryly scientific, and if you don't know anything about biology or genetics, you may end up spending time doing side research. A great insight into not only what can happen to us inside the womb, but a good insight into our historical views of what it once meant to be a "Mutant". Fascinating.

Exploring the definition of humanity
I originally met most of the diseases covered in this book during medical school. I found my academic knowledge of these disorders matured into a much greater understanding with the help of the history and personal stories provided by Leroi. Mutants is well-written, entertaining, and well-cited. The scientific and medical information is well presented and explained in a way that should be understandable to lay people but is not obnoxious to those more familiar with the subjects. Leroi brings to light the interplay between genetics and society, how we define humanity and normality. I was surprised to learn from many of the personal stories that people suffering from incredibly rare and often debilitating or stigmatizing diseases lived normal or even charmed lives during many times in the past. I wonder today if we do too much categorizing, if we try too hard to make every person live up to an arbitrary standard of humanity. ... Read more

Product Description
High Quality Content by WIKIPEDIA articles! Genome projects are scientific endeavours that ultimately aim to determine the complete genome sequence of an organism (be it an animal, a plant, a fungus, a bacterium, an archaean, a protist or a virus). The genome sequence for any organism requires the DNA sequences for each of the chromosomes in an organism to be determined. For bacteria, which usually have just one chromosome, a genome project will aim to map the sequence of that chromosome. Humans, with 22 pairs of autosomes and 2 sex chromosomes, will require 46 separate chromosome sequences in order to represent the completed genome. The Human Genome Project was a landmark genome project and some have argued that the era of genomics is one of the more fundamental advances in human history. ... Read more