Product Description
This volume highlights the main procedures for assessing theregional risks resulting from dangerous goods storage, andtransportation by means of different systems (i.e., road, rail, ship,and pipeline).
The information in the book is based on a wide range of references andstudies. The main procedural steps involved in quantitative riskanalysis for transportation systems are supported by relevant methodsof risk assessment, as recognized at an international level. The bookgives an overview of the criteria and guidelines applicable to theimplementation of risk assessments and management at different stages.
Chapter 1 describes the environmental and safety factors to considerwhen performing a transportation risk analysis for a region. Chapter 2presents risk definitions and the methodology for analyzingtransportation risks in a complex area. Chapter 3 presents generalinformation about truck accidents and their consequences, and reviewsthe risk presented by road tunnels. Chapter 4 deals withtransportation of hazardous materials by rail. Chapter 5 is concernedwith the assessment of transportation risks on water ways. Chapter 6furnishes a description of the transport pipelines for natural gas andpetroleum products and describes the situation in Switzerland. Chapter7 presents a compilation of statistical data related to accidents andthe movement of dangerous goods. Chapter 8 is devoted to thedescription of data bases and computer support for risk assessment.Chapter 9 deals with integrated approaches for regional riskassessment and safety management with special emphasis to thetransportation of hazardous materials. Chapter 10 presents severalrelevant case studies and miscellaneous information. ... Read more

Product Description
There are many different chemicals and materials in use today.These are subject to stringent regulations, which include a requirement for physico-chemical and toxicity testing.In some countries existing chemicals are also undergoing safety checks.The aim is to determine their hazardous properties and the risks involved in using substances.

Health and safety of the environment and the individual are becoming of prime importance to society and extensive legislation has been developed.To the R&D chemist this is a maze to negotiate when trying to introduce a new material or chemical into a different market place. What tests are required and for which markets? What do the test results mean?Who are the key organisations in each global region?Legislation varies between applications and often the quantity of chemical in use is critical to determining the level of testing required.

A Practical Guide to Chemical Safety Testing describes the different tests that must be performed on new chemicals and other materials to demonstrate to the regulatory authorities that they are safe for use.Tests vary from physico-chemical, measuring properties such as melting point and density, through genetic toxicity studies, to mammalian toxicology and studies to investigate effects on the environment.Animal testing is carried out to look for potential irritants, harmful substances, corrosive agents, allergens, cancer causing potential, etc.Each test type is described here and the validity of the test methods is debated.For example, there are sometimes major differences between simple model systems using cell lines or bacteria, effects in laboratory animals and, most importantly, with effects on humans.This can give rise to misleading interpretation of results.

There is a chapter devoted to alternatives to animal testing for safety evaluation.Many non-animal screening tests are available.It is also becoming increasingly possible to cross-match many new chemicals with existing toxicity data to predict potential carcinogenicity, allergenicity, etc.These approaches can reduce the test requirements for the chemical, although a structural alert showing the presence of a suspect chemical moiety can trigger definitive toxicological assessment.

Ecotoxicological testing is carried out to determine the level of hazard to organisms in the environment.Important properties used to estimate environmental fate include the solubility of the test material in water, its ability to adsorb to soil and its potential for accumulation in animals.

Regulations vary depending on the intended purpose of a material, and this book describes the requirements for general chemicals, polymers, food contact materials, medical devices and biocides.Often the quantity imported into a region determines the stringency of the testing required.The EU, the USA, Japan and other geographical regions each has its own set of regulations.These are outlined here.In some instances approval of a chemical in one country will lead to automatic approval in a second country.In other cases new testing is required.This is a very complex situation.The second half of this book sets out to untangle the web of legal issues facing manufacturers and suppliers.

This book is essential reading for chemical and material manufacturers and suppliers.It describes clearly the process of obtaining approval for use in a variety of global regions and across different applications.It also explains why different tests are performed and the implications of the results. ... Read more

Product Description
"The goal is to provide a comprehensive reference book for the preclinicaldiscovery and development scientist whose responsibilities span target identification, lead candidate selection, pharmacokinetics, pharmacology, and toxicology, and for regulatory scientists whose responsibilities include the evaluation of novel therapies."
—From the Afterword by Anthony D. Dayan

Proper preclinical safety evaluation can improve the predictive value, lessen the time and cost of launching new biopharmaceuticals, and speed potentially lifesaving drugs to market. This guide covers topics ranging from lead candidate selection to establishing proof of concept and toxicity testing to the selection of the first human doses. With chapters contributed by experts in their specific areas, Preclinical Safety Evaluation of Biopharmaceuticals: A Science-Based Approach to Facilitating Clinical Trials:

• Includes an overview of biopharmaceuticals with information on regulation and methods of production
• Discusses the principles of ICH S6 and their implementation in the U.S., Europe, and Japan
• Covers current practices in preclinical development and includes a comparison of safety assessments for small molecules with those for biopharmaceuticals
• Addresses all aspects of the preclinical evaluation process, including: the selection of relevant species; safety/toxicity endpoints; specific considerations based upon class; and practical considerations in the design, implementation, and analysis of biopharmaceuticals
• Covers transitioning from preclinical development to clinical trials

Product Description
Liquefied Natural Gas (LNG) is the only viable way to extract and transport natural gas from areas not serviceable by a pipeline, but it also poses safety risks. This book examines the safety concerns regarding LNG, and examines the debate between its advocates and its opponents. The text considers risks on the extraction, transportation, and maintenance of LNG; includes discussion of case studies and LNG-related accidents over the past half-century; and summerizes the findings of the Governmental Accountability Office's (GAO) survey of nineteen LNG experts from across North America and Europe. ... Read more

Product Description

This book brings into focus the hot topics of life science for which mass spectrometry is becoming THE tool of analysis, and provides a comprehensive review of the research topics most pertinent to the advancement of mass spectrometry and its general applications. The volume gathers the contributions from eminent international researchers in the field, covering various aspects ranging from the fundamentals of MALDI and ESI to their applications to most actual omics (proteomics, lipidomics, glycomics) or to immunology. The large group of small molecules analyzed with mass spectrometry technique is also represented by brominates and keratins, or plant extracts.

It is hoped that this volume will also add stimulus for further progress in the field, where major challenges still remain and great potential exists for new breakthroughs. The ability of mass spectrometry for becoming a sound diagnosis technique of neurodegenerative diseases like Alzheimer, and for being a useful tool in immunotherapy is a fertile ground for further innovation and exploitation in the future.

Product Description
The value of the critical temperature (Tc), below which the thermal explosion of a chemical cannot occur, is indispensable to prevent such a chemical from exploding. In order to determine the Tc it has so far been necessary to measure the value in explosion experiments. Because of the inherent hazards, only few Tc values are available at present.

Critical Temperatures for the Thermal Explosion of Chemicals introduces new and simple procedures to calculate the Tc. As a result Tc can be calculated for a range of chemicals, many of which are listed in this new volume. The calculated values of Tc are shown to be in agreement with experimentally determined values.

The data and methods presented in Critical Temperatures for the Thermal Explosion of Chemicals will be of use to research laboratories as well as in the chemical industry.

* Introduces new and simple procedures for calculating critical temperatures
* Lists the T(c) values of chemicals in tables
* Explains mathematical expressions in clear simple terms ... Read more

Customer Reviews (1)

Product Never Recieved
If I could give this product zero stars, I would. I never received the product and was forced to buy it from an alternate source in order to have it for my Chemistry course. Beware of undelivered items. ... Read more

Product Description
The process industry has developed integrated process safety management programs to reduce or eliminate incidents and major consequences, such as injury, loss of life, property damage, environmental harm, and business interruption. Good documentation practices are a crucial part of retaining past knowledge and experience, and avoiding relearning old lessons. Following an introduction, which offers examples of how proper documentation might have prevented major explosions and serious incidents, the 21 sections in this book clearly present aims, goals, and methodology in all areas of documentation. The text contains examples of dozens of needed forms, lists of relevant industry organizations, sources for software, references, OSHA regulations, sample plans, and more. ... Read more

Product Description
The assessment and management of risk to society from the operation of chemical process plants and other industrial activities in which dangerous substances are produced, used, handled or stored will remain a topic of great importance in the next decade. In order to evaluate this specific risk on a qualitative and/or quantitative basis, the concepts of risk analyses are linked together in this book.

The "performance based" and "goal oriented" regulatory requirements of the European Council's new "Seveso II Directive" for the identification of large scale industrial hazards, prevention of sudden and uncontrolled releases of dangerous substances from industrial plants and mitigation of serious consequences of industrial accidents to people and the environment are examined. The fact that risk assessment and management are key elements to such forms of regulation is also demonstrated.

While the "Seveso II Directive" defines "what" has to be achieved on the control of major hazards involving dangerous substances within the European Union, the methods of risk assessment and management give guidance on "how" to achieve it. The text provides a practical guide for decision-makers in regulatory bodies and companies with a non-technical background. Scientists and engineers who are not yet familiar with the concepts of risk assessment and who want a survey of some fundamentals of, and principal results from, risk assessment studies and approaches primarily for applications in the context defined by the "Seveso Directives" will also find this book invaluable. ... Read more

Customer Reviews (1)

I read with great interest; a very concise summary
I read with great interest; a very concise summary, most recommendable overview of historical development and scope of EU industrial safety control measures. ... Read more

Product Description
Young people today grow up in a world where the media bombard them with information about the effect of various factors on their health, the safety of everything from household items to nuclear waste, and the risks associated with them. These ideas of health, safety and risk are often poorly understood. Health, Safety and Risk has been produced in order to help teachers bring about a better understanding of these concepts in their students and so that, as young people growing up in a scientific and technological society, they can be properly aware of the risks associated with the world in which they live, and of attempts to minimise them. This resource includes a range of activities for 11-19 year old students designed to promote an understanding of health, safety and risk within the world of school and work. It contains teachers' notes, background information, photocopiable student worksheets and answers. ... Read more

Product Description
The construction of new laboratory buildings or the renovation of existing ones requires close communication between laboratory users, project engineers, architects, construction engineers, and health and safety personnel. All too often, health and safety considerations are overlooked or slighted and are not sufficiently incorporated into designs. Guidelines for Laboratory Design: Health and Safety Considerations, Third Edition provides reliable design information related to specific health and safety issues that need to be considered when building or renovating laboratories.

With an increase in the number of laboratory renovations due to lower costs and faster end results compared to constructing new buildings, the latest edition of Guidelines for Laboratory Design, which includes new chapters on laboratory renovation, is particularly timely. This well-established and respected volume also includes a vital section on design guidelines for commonly used laboratories and features separate chapters on a wide array of laboratory types.  In addition, the updated material contains:

-A new section on design for environmental preservation through the operation and maintenance of health and safety
-The latest information on laboratory ventilation and safety systems
-Incorporation of "green" laboratory design techniques
-Discussions on the architectural, engineering, regulatory, and health and safety aspects unique to the renovation process

A wide range of professionals–including those in industrial hygiene, chemical health and safety, laboratory management, and architectural and engineering firms handling laboratory construction and renovation–will find the latest edition of Guidelines for Laboratory Design: Health and Safety Considerations essential reading. ... Read more

Product Description
The Behavior-Based Safety Process Since the behavior-based approach to accident prevention was launched in 1980 by the author and his associates, safety performance is increasingly prominent on the agendas of many companies. Several powerful factors contribute to this trend. The widespread reorganization of personnel into work-groups that are leaner and more self-directed, the increasing importance of international competition, the growing awareness of critical environmental issues—these and related factors highlight the value of any mechanism that promotes continuous improvement in safety performance. Detailing a step-by-step approach to just such a mechanism for continuous improvement, The Behavior-Based Safety Process is a path-breaking guide that represents an important resource for anyone concerned with performance related issues in the workplace. As the title indicates, the focus is on process versus programs. The reason is simple: off-the-shelf safety imposed from the top down does not meet the safety needs of most organizations. This fact has been abundantly demonstrated in facility after facility throughout the 1970s and 1980s. In genuinely meeting the need for continuous improvement in safety performance, the behavior-based approach presents many parallels with the quality improvement process. Both of these approaches use scientific methods to identify, measure, and provide feedback on upstream factors of excellence. In the case of the behavior-based approach to safety, these upstream factors are critical behaviors that are the leading indicators of safety performance in the organization, targeting areas of concern in advance of even first-aid incidents. For an in-depth treatment of how to integrate behavioral and statistical methodologies, see the authors companion volume from Van Nostrand Reinhold: Employee-Driven Systems for Safe Behavior. In addition to presenting these parallels with quality. The Behavior-Based Safety Process also provides powerful techniques aimed at implementation issues: organizational development, trainer-training, and employee involvement. The author and his associates developed these techniques over a decade of consultation with a variety of industries, working closely in that time with such safety leaders as Monsanto, Shell Chemical Company, ARCO Chemical, ALCOA, Rohm and Haas, Scott Paper Company, Georgia Gulf Corporation, The Pillsbury Company, and Chevron U.S.A. ... Read more

Customer Reviews (3)

A very good book
This book is a very good investment! I'm using this book for my course of safety management and it's giving to me a lot of new ideas and examples.

Best job investment I have ever made
This is a must book to anyone that is frustrated with injury rates. Once I picked the book up I couldn't put it down. It not only explains things well but gives examples, charts and figures to refer back to. I can't wait to get the new program going at work.

An Overview of BBS
I use the book for my course in Behavioral safety at Western Michigan University, and I recommend it.Strengths: broad coverage of issues invoved in BBS; examples of it practice; some coverage of scientificprinciples behind the techniques.Weaknesses:It could be organized tomake it more user-friendly; written at a rather advanced level; not a verygood "how-to" book (T. McSween's "The Values-Based SafetyProcess" book is better at "how to" - I also use that one.) ... Read more

Product Description
The completely revised and updated Third Edition of the benchmark On the Practice of Safety thoroughly covers subjects that must be mastered by anyone seeking to attain professional status in the practice of safety. Like its predecessors, the Third Edition provides a solid foundation for the study of the practice of safety in degree programs. Additionally, it serves as a basis for self-analysis by those safety professionals who seek to improve their performance, gain recognition from management for providing value, and achieve professional status.
On the Practice of Safety’s distinctive essay format provides a penetrating exploration of a variety of subjects not possible in a standard reference. The Third Edition expands on the content of the former edition, adding updated statistics to reflect recent trends and developments in the field. In addition to a greatly extended chapter on quality and safety, author Fred Manuele contributes four new chapters:

-Heinrich Revisited: Truisms or Myths
-Addressing Severe Injury Potential
-Acceptable Risk
-Behavior-Based Safety

Each chapter is a self-contained unit that offers comprehensive coverage of a particular topic. All of the chapters in the Third Edition reflect the increasing professional incidence of safety, occupational health, and environmental affairs falling under a common management, and address each issue accordingly. ... Read more

Product Description
Light end materials, such as LNG or LPG, have poor safety reputation because of a few famous incidents such as Cleveland, Feyzin, Los Alfaques and Mexico City but when handled properly by well-trained personnel in correctly design installations, they present no more risk than other energy sources. This booklet raises the awareness of operators, engineers and technicians to the main hazards of light ends (methane to penthane). Using examples of actual accidents, enabling operators to spot and rectify potential hazards before incidents occur.

IChemE, the Institution of Chemical Engineers, is the center for chemical, biochemical and process engineering professionals worldwide.

We are the heart of the process community, promoting competence and a commitment to sustainable development, advancing the discipline for the benefit of society and supporting the professional development of members.

Some of the areas we publish in include:

-Safety in the process industries - the BP Process Safety series

-Consultancy for chemical engineers

-Project management in the process industries

-Contract management in the process industries - International Forms Of Contract series

-Communication skills for engineers ... Read more

Product Description
Analyzes health and hazard risk assessment in commercial, industrial, and refining industries. ... Read more

Product Description
Provides reference information covering all aspects of food safety-science, regulation, and labeling requirements-integrating major developments in the fields of toxicology, analytical chemistry, microbiology, hygiene, and nutrition. DLC: Food adulteration and inspection. ... Read more