Product Description
Fluorine chemistry is an expanding area of research that is attracting international interest, due to the impact of fluorine in drug discovery and in clinical and molecular imaging (e.g. PET, MRI). Many researchers and academics are entering this area of research, while scientists in industrial and clinical environments are also indirectly exposed to fluorine chemistry through the use of fluorinated compounds for imaging. This book provides an overview of the impact that fluorine has made in the life sciences. In the first section, the emphasis is on how fluorine substitution of amino acids, peptides, nucleobases and carbohydrates can provide invaluable information at a molecular level. The following chapters provide answers to the key questions posed on the importance of fluorine in drug discovery and clinical applications. For examples, the reader will discover how fluorine has found its place as a key element improving drug efficacy, with reference to some of the best-selling drugs on the market.Finally, a thorough review on the design, synthesis and use of 18F-radiotracers for positron emission tomography is provided, and this is complemented with a discussion on how 19F NMR has advanced molecular and clinical imaging. ... Read more

Product Description
Massachusetts College of Pharmacy and Allied Health Sciences, Boston. Fourth edition of a major reference/textbook for pharmacy students. Previous edition 1989. New topics include molecular modeling, pharmaceutical biotechnology, and anti-AIDS agents. 52 contributors, 46 U.S. ... Read more

Customer Reviews (1)

A thourogh comprehensive view of medicinal chemistry
This volume is everything that one can ask for those wondering how drugs perform the functions that they do. The baseline for Foye's explanation lies in the description of the receptor involved. From there he can explain how the natural substrate fits either the active or allosteric site of the target molecule. From this point the authors are able to elucidate chemically how the functional groups of the pharmicological compound interact with the receptor evoking the desired response. ... Read more

Product Description
The extraordinary potential of fluorine-containing molecules in medicinal chemistry and chemical biology has been recognized by researchers outside of the traditional fluorine chemistry field, and thus a new wave of fluorine chemistry is rapidly expanding its biomedical frontiers. With several of the best selling drugs in the world crucially containing fluorine atoms, the incorporation of fluorine to drug leads has become an essential practice in biomedical research, especially for drug design and discovery as well as development.

Focusing on the unique and significant roles that fluorine plays in medicinal chemistry and chemical biology, this book reviews recent advances and future prospects in this rapidly developing field. Topics covered include:

• Discovery and development of fluorine containing drugs and drug candidates.
• New and efficient synthetic methods for medicinal chemistry and the optimisation of fluorine-containing drug candidates.
• Structural and chemical biology of fluorinated amino acids and peptides.
• Fluorine labels as probes in metabolic study, protein engineering and clinical diagnosis.
• Applications of 19F NMR spectroscopy in biomedical research.

An appendix presents an invaluable index of all fluorine-containing drugs that have been approved by the US Food and Drug Administration, including information on structure and pharmaceutical action.

Fluorine in Medicinal Chemistry and Chemical Biology will serve as an excellent reference source for graduate students as well as academic and industrial researchers who want to take advantage of fluorine in biomedical research.

... Read more

Product Description
Oregon State Univ., Corvallis. Blends the chemical and pharmaceutical principles necessary for understanding structure-activity relationships and molecular mechanisms of drug action. Offers new information on emerging trends and advances and the challenges posed by new diseases. Features a new chapter on combinatorial chemistry. Previous edition: c1998. DNLM: Chemistry, Pharmaceutical. ... Read more

Customer Reviews (1)

Exactly what I ordered.
The product was exactly what I ordered and I got it in a timely manner. Thank! ... Read more

Product Description
The gold standard for industrial research now completely revised in line with current trends in the field, with all contributions extensively updated or rewritten.
In 21 chapters readers can benefit from the key working knowledge of today's leading pharmaceutical companies, including Pfizer, AstraZeneca, and Roche. Drug developers from industry and academia present all the factors governing drug bioavailability, complete with practical examples and real-life data.
Part I focuses on in vitro and in vivo measurements of physicochemical properties, such as membrane permeability and ionization. Part II discusses solubility and gastrointestinal absorption, while the third part is devoted to metabolism and excretory mechanisms. The much revised and expanded part IV surveys current in silico approaches to predict drug properties needed to estimate the bioavailability of any new drug candidate. The final part shows how poor bioavailability may be improved by various approaches during the development process.
No other publication offers the same level of treatment on this crucial topic in modern drug development. ... Read more

Product Description
Hardbound. Leading researchers in pharmacology and medicinal chemistry continue this esteemed series with recent advances in five important areas including:• A comprehensive account of inhibitors of the caspase family of proteolytic enzymes that represent a new class of anti-inflammatory and antiapoptotic agents of potential value in rheumatoid arthritis, and other peripheral and central indications.• A well documented survey of semi-synthetic and totally synthetic antibiotics and anti HIV agents and their sites of interaction.• Inhibitors of the intracellular enzyme acyl-CoA: cholesterol O-acyltransferase (ACAT) developed for the treatment of hypercholesterolemia.• Recent progress in growth hormone secretagogues is described, with the focus on strategies to improve oral bioavailability and duration of action.• Inhibition of the proteolytic enzyme, hepatitis C protease N-3(NS3), required for viral replicati ... Read more

Product Description
Univ. of Texas, Austin. Textbook for pharmacy students. Illustrated and well-referenced. DNLM: Chemistry, Pharmaceutical. ... Read more

Customer Reviews (2)

seller lied that the book looks like new but it does not.
this seller is a lier because a claim was made that the book looks like new but it is the oldest book i've ever bought.

wilson and gisvolds textbook of pharmaceutical and
Wilson and Gisvold's textbook of Organic medicinal and pharmaceutical chemistry is an excellent textbook for medicinal chemistry, pharmacetical chemistry and pharmacy degree students. The book is scientifically well written and enjouyable to read. he graphic images of molecules integrate well with the written aspects of book. ... Read more

Product Description
Now in its seventh edition, Burger's Medicinal Chemistry, Drug Discovery and Development provides an established, recognized, authoritative and comprehensive source on medicinal chemistry and drug discovery and development. This flagship reference for medicinal chemists and pharmaceutical professions has been thoroughly updated and expanded across 8 volumes to incorporate the entire process of drug development (preclinical testing, clinical trials, etc.) alongside the traditional strengths in medicinal chemistry and drug discovery. ... Read more

Product Description
Now in its third edition, this classic reference is the one-stop-shop for information on the foundations of medicinal chemistry for pharmaceutical researchers who are involved in drug development & discovery but who do not have a background in medicinal chemistry. Wermuth aids pharmaceutical researchers and chemists in making faster, more accurate identifications of the active substances that could potentially treat the disorder they are researching. New chapters on Drug Absorption & Transport give pharmaceutical scientists information on how potential drugs can move through the drug discovery/development phases more quickly. This third edition still stands as the only source for practical aspects of medicinal chemistry by focusing on the daily problems met by the medicinal chemist in drug discovery.

NEW TO THIS EDITION:
* Focus on chemoinformatics and drug discovery
* Enhanced pedagogical features
* New chapters including:
- Drug absorption and transport
- Multi-target drugs
* Updates on hot new areas:
NEW! Drug discovery and the latest techniques
NEW! How potential drugs can move through the drug discovery/ development phases more quickly
NEW! Chemoinformatics ... Read more

Customer Reviews (1)

Very good book
I think this is one of the most comprehensive and user-friendly books in the Medicinal Chemistry field ... Read more

Product Description
(BIOS)Concise medicinal chemistry text for undergraduates. Concentrates on the fundamental principles of the subject and assumes no more than elementary background of chemistry or biology. Softcover. ... Read more

Product Description
This is Volume 1: Drug Discovery, of Burger's Medicinal Chemistry and Drug Discovery, 6th Edition. This new volume contains critical new chapters on Virtual Screening, Bioinformatics and Chemical Information Computing Systems in Drug Discovery.

To purchase the entire 6 volume set, please refer to ISBN 0-471-37032-0. ... Read more

Product Description
Fully updated and rewritten by a basic scientist who is also a practicing physician, the third edition of this popular textbook remains comprehensive, authoritative and readable. Taking a receptor-based, target-centered approach, it presents the concepts central to the study of drug action in a logical, mechanistic way grounded on molecular and principles.Students of pharmacy, chemistry and pharmacology, as well as researchers interested in a better understanding of drug design, will find this book an invaluable resource.

Starting with an overview of basic principles, Medicinal Chemistry examines the properties of drug molecules, the characteristics of drug receptors, and the nature of drug-receptor interactions. Then it systematically examines the various families of receptors involved in human disease and drug design. The first three classes of receptors are related to endogenous molecules: neurotransmitters, hormones and immunomodulators.Next, receptors associated with cellular organelles (mitochondria, cell nucleus), endogenous macromolecules (membrane proteins, cytoplasmic enzymes) and pathogens (viruses, bacteria) are examined. Through this evaluation of receptors, all the main types of human disease and all major categories of drugs are considered.

There have been many changes in the third edition, including a new chapter on the immune system. Because of their increasingly prominent role in drug discovery, molecular modeling techniques, high throughput screening, neuropharmacology and genetics/genomics are given much more attention. The chapter on hormonal therapies has been thoroughly updated and re-organized.Emerging enzyme targets in drug design (e.g. kinases, caspases) are discussed, and recent information on voltage-gated and ligand-gated ion channels has been incorporated.The sections on antihypertensive, antiviral, antibacterial, anti-inflammatory, antiarrhythmic, and anticancer drugs, as well astreatments for hyperlipidemia and peptic ulcer, have been substantially expanded. One new feature will enhance the book's appeal to all readers: clinical-molecular interface sections that facilitate understanding of the treatment of human disease at a molecular level. ... Read more

Customer Reviews (1)

Better than Goodman and Gilman for pharmacy students
I have taken two pharmacological type classes. One was pharmacology and the other was simply med chem. We used Goodman and Gilman in the pharmacology class and its just too dense. It has much information, but in my opinion, its not appropriate for a textbook. I thought that this book, by Nogrady is alot more managable. However, you need to have a background in biochemistry and organic chemistry to understand some of the topics in this book. It does a good job of explaining underlying mechanisms of pharmaceutical actions. Towards the end, it adopts a Goodman and Gilman approach and just starts listing drugs and their mechanism of action. However, Nogrady doesn't go on for 5 pages like Goodman and Gilman do. Its a bit more concise. Anyway, I don't mean to say that Goodman and Gilman is a bad book, quite the contrary, its an amazing book with more information than one could ever possibly want. Its just that if you want to understand pharmacology for a class, and are not browsing the pages for fun over a cup of tea, Nogrady may be the way to go. ... Read more

Product Description

This volume will first review existing cholinesterase inhibitors prescribed for Alzheimer’s disease (AD) patients followed by some target mechanisms with ongoing clinical trials. It offers a glimpse of what our future medicine cabinets may look like for AD patients. This volume is part of a series that covers hot topics of frontier research summarized by reputed scientists in the field.

Product Description
Appropriate selection of biochemical targets is one of the most important drivers of cost effectiveness in the discovery of new medicines. Despite the many advances in genetics, genomics and systems biology, 'validation' of a target is not achieved until therapeutic efficacy is demonstrated by a drug candidate. Volume 46 of this series reviews the medicinal chemistry aimed at six diverse targets from which important new medicines are emerging:
* HIV integrase (discovery of the first-in-class inhibitor drug raltegravir)
* 11-beta-Hydroxysteroid dehydrogenase (new approach to glucocorticoid regulation)
* Nicotinic a7 choline receptor (agonists and positive allosteric modulators).
* Bradykinin receptor (new approach to pain therapy)
* Histone deacetylase (new drugs for cancer)
* 5-HT2c receptor modulators (various CNS indications)

*Presents the latest research in the field of drug discovery
*Publishes on an annual basis to bring you the most innovative updates in medicinal chemistry
*Available as an online resource via ScienceDirect ... Read more

Product Description
This is the third edition of a book written to serve both as a useful textbook for undergraduate courses in medicine and pharmacology, and also as a handy reference title for industry professionals. Each of the 27 chapters is sub-divided into 3 sections: (i) an introduction to the subject, (ii) a chemical or pharmacological classification -– each category of compound importantly contains International Non-proprietory Names (INN), British Approved Names (BAN) and United States Approved Names (USAN) wherever applicable, chemical names and proprietory names. (iii) the synthesis of various important members treated individually, a brief description of the synthesis, therapeutic applications of each compound, the necessary dosage applied in various diseases, and routes of administration. The book also deals well with the comprehensive mechanism of actions of the structure -– activity -– relationships (SARs); thus aiding the students' understanding. Clearly written, well referenced and fully up to date with recommended readings and self assessment questions, Prof. Kar has provided an accessible textbook for students of medicinal chemistry.

Also available:

Heterocyclic Chemistry - ISBN 1848290012
Illustrated Medical Biochemistry - ISBN 1904798322

Anshan Publishers is a publisher of fine medical, scientific, and technical books. We find the best titles from our worldwide publishing partners and bring them to the global marketplace.

We publish in a wide range of fields, including:-

Anatomy
Anesthesia
Cardiology
Dermatology
Hospital Acquired Infections/Epidemiology
Obstetrics & Gynecology
Ophthalmology
Orthopedics
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Pathology
Pediatrics
Pharmacy
Radiology
Surgery
Ultrasound, ECG, and Echo
... Read more

Product Description
Most medicinal chemists working in the pharmaceutical industry are organic synthetic chemists with little or no background in medicinal chemistry.These chemists must acquire a good knowledge of medicinal chemistry during their firstyears in the pharmaceutical/drug discovery industry. This bookaims to be their practical handbook - a complete guide to the drug discovery process.

The book reviews practical aspects of Medicinal Chemistry, emphasising the daily problems met by the medicinal chemist when dealing with lead discovery/identification methodologies, with structure-activity relationship studies aimed to scale up potency and target selectivity, and when optimising pharmacokinetic and pharmaceutical properties by means of ultimate chemical modifications.

This is the second edition of The Practice of Medicinal Chemistry, the first edition being published in February 1996.The new edition is thoroughly revised, with around 30% new material, and refocussed to reflect the recent developments in genomics, proteomics, high throughput screening of compounds and drug solubilisation.An effort has been made to remove the overlap that exists in the previous edition and four new chapters have been introduced.

* Written by experts in the field
* The first edition of The Practice of Medicinal Chemistry, published in 1996, was nicknamed 'The Bible' by medicinal chemists.
* The only available book dealing with the practical aspects of medicinal chemistry, from conception of the molecules through to the production of drugs
* An essential practical handbook for the medicinal chemist, working in the pharmaceutical industry, withlittle or no background in medicinal chemistry-a complete guide to the drug discovery process. ... Read more

Customer Reviews (1)

Pls help me to get this book.
I want to buy this book. I am in Japan. Would you pls tell me how I can get this book. ... Read more

Product Description
This work brigdges the compartmentalized undergraduate organic and biochemistry and biology subjects to the pharmacology and the clinical areas a modern pharmacy practice requires. The changes and constantly increasing responsibilities of today's pharmacist have dictated a restructuring of the pharmacy curriculum, including individual course content. This book reflects and addresses these developments. This is a well-written work that covers most major areas of pharmaceutical research. The text is presented in a logical and concise fashion being divided into chapters based upon therapeutic topic. This makes the work very useful for teaching a course in medicinal chemistry since therapeutic areas can be separately covered without having to make use of the entire book which overall contains a tremendous amount of information. This book is a significant contribution to understanding what medicinal chemistry is and how this science is used to develop new therapeutic agents. ... Read more

Customer Reviews (4)

a perfect place to buy some important books
hello everyone,
amazon is really a very good website to buy some important books. the service is perfect and everythings goes well for boating the book. I got my boook just one week after my ordering on internet. can you imagine that its scheduled arriving date is in three weeks? so I am really satisfied with amazon and I support it.

Great book for begining medicinal chemistry
Having Dr. Gringauz as a professor in pharmacy school back in 1985 was an honor, wish we had this book for his class. Thanks Alex.

minimal coverage of medicinal chemistry
Anyone wishing a more comprehensive treatment should utilize Foye's Medicinal Chemistry or Goodman and Gillmans work.

Almost Perfect!
This book is very good introduction in the major aspects of the chemistry of the drugs. It explains with good schemes the reactions of drugs and others important mechanisms. But in my opinion it is necessary a chapter toexplains the analytical methods that are being used nowadays in this fieldlike HPLC,NMR,Mass spectroscopy and so on, for searching the drugs processthru the living system. ... Read more

Product Description
Current discoveries and research into bioactive natural products

Medicinal Chemistry of Bioactive Natural Products provides a much-needed survey of bioactive natural products and their applications in medicinal chemistry. This comprehensive reference features articles by some of the world's leading scientists in the field on discovery, structure elucidation, and elegant synthetic strategies--developed for natural products--with an emphasis on the structure activity relationship of bioactive natural products. The topics have been carefully chosen on the basis of relevance to current research and to importance as clinicially useful agents.

Rather than attempting to be a comprehensive encyclopedia of bioactive natural products, Medicinal Chemistry of Bioactive Natural Products guides the reader to the key developments in the field. By providing not only practical detail but a historical perspective on the chemistry and biology of the compounds under consideration, the book serves as a handy resource for researchers in their own work developing pharmaceuticals, and as an inspiring introduction for young scientists to the dynamic field of bioactive natural products research.

Enhanced by examples with updated research results, the discussion covers such topics as:
* The chemistry and biology of epothilones
* Vancomycin and other glycopeptide antibiotic derivates
* Antitumor and other related activities of Taxol and its analogs
* The antimalarial properties of the traditional Chinese medicine, Quinghaosu (artemisinin)
* Huperzine A: A natural drug for the treatment of Alzheimer's disease
* The medicinal chemistry of ginkgolides from Ginkgo biloba
* Recent progress in Calophyllum coumarins as potent anti-HIV agents
* Plant-derived anti-HIV agents and analogs
* Chemical synthesis of annonaceous acetogenins and their structurally modified mimics ... Read more

Product Description
Massachusetts College of Pharmacy and Health Sciences, Boston. Textbook, for pharmacy students, now includes an overview of the drug development process from the perspective of an industrial research scientist. Also new to this edition: an overview of drug receptors, case studies, selected readings, and a companion web page. Previous edition: c1995. ... Read more

Customer Reviews (6)

Professors: please don't get this book for your class!
It amazes me that a book in its 6th edition would still have so many errors.In chapter 2 alone I found 5 errors.As a student, it makes me wonder how many more errors there are that I am just accepting as fact.It provides sparse case studies, but the answers are not given in the book, and many of the answers are not given online either to the students, and are only available for professors to see.Perhaps wait for the 7th edition to come out, and hope that they iron out the mistakes they made in this one.

Med Chem Text
I haven't actually used this book yet (so far the professor has given us excellent notes), but it is full of information that I'll probably use when I need to review everything. Very comprehensive for reviewing a specific topic, but a bit boring to just read.

It's the recommended book for my program.
What can I say, this book is great. A terrific resource for the study of Medicinal Chemistry. It's what the faculty recommend using for my Medicinal Chemistry program, and it is often referenced by professors.

AWESOMEEE!
this book came much earlier than expected, within like 2 days!
awesome quality & great service.
highly recommended, would buy from again anyday.

Good product, poor handling
The book itself was a required text for one of my college courses and it fulfills it's purpose adequately. My only problem was with the condition that it arrived in.I paid for a brand new product and it arrived with a huge gouge in the front cover and binding as a result of poor handling by Amazon.It was obviously not a result of shipping as the packaging it came in was not damaged at all.It was damaged by Amazon prior to shipping it out. With such poor merchandise treatment, I will definately rethink using Amazon as a future supplier. ... Read more