Product Description
Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.

* Critical reviews of the previous year's literature in many topics of interest to medicinal chemists
* Highlights major developments in medicinal chemistry
* Includes a comprehensive set of cumulative indices to easily locate topics in all published volumes ... Read more

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This is Volume 2: Drug Discovery and Drug Development, of Burger's Medicinal Chemistry and Drug Discovery, 6th Edition. This new volume contains critical new chapters on Combinational Chemistry and Multiple Parallel Synthesis, High Throughput Pharmacology, and Retrometabolism-Based Drug Design and Targeting.

To purchase the entire 6 volume set, please refer to ISBN 0-471-37032-0. ... Read more

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Chemogenomics brings together the most powerful concepts in modern chemistry and biology, linking combinatorial chemistry with genomics and proteomics.

The first reference devoted to the topic, this up-to-date resource covers all stages of the early drug discovery process, from target selection to compound library and lead design.

With the combined expertise of 20 research groups from academia and from leading pharmaceutical companies, this book is a must-have for every drug developer and medicinal chemist applying the powerful methods of chemogenomics to speed up the drug discovery process. ... Read more

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MEDICINAL CHEMISTRY: PRINCIPLES AND PRACTICES, 2/E introduces the principles and practices of modern medicinal chemistry, and covers all aspects of drug discovery from the initial lead to final development. It teaches how to convert a lead compound into a potential drug and provides recent case histories as examples of successes. References to specialist monographs and reviews supplement this breadth of coverage, where the reader can find more detail on specific topics of interest if required. For this new edition, the material has been extensively revised to reflect the advances in the methods used in drug discovery over recent years.

SOME PRAISE FOR THE PREVIOUS EDITION:

TALANTA"Overall an excellent book for those making a move into pharmaceutical/medicinal chemistry research and for those who wish to broaden their knowledge of all disciplines involved in this area." ... Read more

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The selection of plants studied in this treatise is based on its significance, and its representation of members of different taxonomic families as well as of different classes (and subclasses) of compounds. All the available data on the chemical compounds and the pharmacological studies on these plants/compounds have been incorporated. The plants are arranged by the type and nature of chemical compounds they contain. Secondary metabolites have been included in this volume due to their great therapeutic role. ... Read more

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BURGER'S MEDICINAL CHEMISTRY AND DRUG DISCOVERY, FIFTH EDITION, Volume 1: Principles and Practice

This new edition of Dr. Alfred Burger's internationally celebrated classic helps researchers acquaint themselves with both traditional and state-of-the-art principles and practices governing new drug research and development. Completely updated and revised to reflect the many monumental changes that have occurred over the past decade and a half in medicinal chemistry and new drug development, this latest edition of Volume 1: Principles and Practice now:
* Covers the latest methods of drug discovery, including such "hot" topics as computational chemistry and peptidomimetrics
* Has added emphasis on preclinical development issues
* Offers the most timely information on a broad range of important regulatory, management, legal, and financial issues
* Features in-depth coverage of important factors in the discovery process, including ADME, toxicity and drug allergy, and clinical trials
* Updates readers on recent advances in the understanding of the structural biology of drug action
* Explores the cutting-edge technologies for drug discovery now in use around the world
* Is more than twice the size of its predecessor
* Brings together contributions by experts in a wide range of related fields from North America and Europe ... Read more

Customer Reviews (1)

medicinal chemistry
to see the new discovery & practice of bulk dru ... Read more

Product Description
The success of any drug discovery project relies upon the quality of the lead that initiates the lead optimization process. What defines a 'quality lead', where these 'quality leads' come from and how one discovers them has been the subject of intense debate within the pharmaceutical industry, relies upon defining those properties that historically have led to successful drug discovery. This volume addresses these questions and specifically discusses diabetes, obesity and tuberculosis.

*Presents the latest research in the field of drug discovery
*Publishes on an annual basis to bring you the most innovative updates in medicinal chemistry
*Available as an online resource via ScienceDirect ... Read more

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Annual Reports in Medicinal Chemistry continues to focus on providing timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.

Sections I-IV are disease orientated and generally report on specific medicinal agents.

Sections V and VI continue to emphasize important topics in medicinal chemistry, biology, and drug design.

* Annual comprehensive reviews of the past year literature in many topics of interest to medicinal chemists
* Includes a comprehensive set of indices to easily locate topics in Volumes 1-38 of this series
* Provides critical review on hot topics in medicinal chemistry ... Read more

Product Description
Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies. Sections I-IV are disease orientated and generally report on specific medicinal agents. Sections V and VI continue to emphasize important topics in medicinal chemistry, biology, and drug design. Section VII looks at Trends and Perspectives in the pharmaceuticals market.

* Critical reviews of the previous year's literature in many topics of interest to medicinal chemists
* Highlights major developments in medicinal chemistry
* Includes a comprehensive set of cumulative indices to easily locate topics in all published volumes ... Read more

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The DuPont Merck Pharmaceutical Company, Wilmington, Delaware.Pharmacological research on the role of the renin-angiotensin system in hypertension and other cardiovascular disease. 46 contributors, 34 U.S. ... Read more

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This is Volume 3: Cardiovascular Agents and Endocrines, of Burger's Medicinal Chemistry and Drug Discovery, 6th Edition. This new volume contains critical new chapters on Endogenous Vasoactive Peptides, Iron Chelators and Therapeutic Uses, and Fundamentals of Steroid Chemistry and Biochemistry.

To purchase the entire 6 volume set, please refer to ISBN 0-471-37032-0. ... Read more

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This volume reviews advances in cancer chemotherapy research over the last 10 years. Chapters written by leading experts in their field reflect a range of current medicinal chemistry approaches to small molecule drugs. Each chapter covers the drug target and biological rationale, chemotypes, clinical status and future prospects in this rapidly developing area of drug research.

Product Description
Hardbound. This volume features:

• A comprehensive account of in vitro and in vivo models and in silico approaches for the prediction of oral absorption and bioavailability.

• The application of virtual screening of virtual libraries as a means of identifying lead molecules for drug discovery programmes.

• The development of molecular probes targeted to inhibit &ggr;-secretase, a key enzyme involved in the production of &bgr;-amyloid proteins the accumulation of which has been implicated as a cause of Alzheimer's disease.

• The discovery and evaluation of 5-HT terminal autoreceptor antagonists, an approach that may provide a novel treatment of depression.

• A survey of orally acting &bgr;3-agonists for the treatment of type II diabetes and obesity from early compounds active only in rodent models to recent drugs with therapeutic potential in man.

• Antagonists ... Read more

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Hardbound. This volume reviews recent advances in five important areas of medicinal chemistry which will be of interest both to chemists and to scientists of other disciplines engaged in medicines research and development. Included are accounts of successful drug discovery programmes, disease targets of unmet medical need, and recent progress in new technologies which are considered by many to hold the key to future developments in medicinal chemistry.

The style and organisation of chapters follow a similar pattern to previous volumes but references, where appropriate, now include website addresses of the World Wide Web. ... Read more

Product Description
Volume 4 of Advances in Medicinal Chemistry is comprised of six chapters on a wide range of topics in medicinal chemistry, including molecular modeling, structure-based drug design, organic synthesis, peptide conformational analysis, biological assessment, structure-activity correlation, and lead optimization. Chapter 1 presents an account about amino acid-based peptide mimetics corresponding to b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. Chapter 2 addresses new facets of the medicinal chemistry of the important anticancer drug Taxol® (paclitaxel). Chapter 3 relates an account of the search for new drugs for the treatment of malaria based on the natural product artemisinin. Chapter 4 applies computational chemistry to the evaluation of compound libraries for biological testing. Chapter 5 describes the construction of a 3-dimensional molecular model of the human thrombin receptor, the first protease-activated G-protein coupled receptor (PAR-1), as a means to explore the intermolecular contacts involved in agonist peptide recognition. Finally, Chapter 6 describes the research conducted at Merck on inhibitors of farnesyl transferase as a potential treatment for human cancers.
... Read more

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Divided into the three main sections of synthesis, analysis and drug development, this handbook covers all stages of the drug development process, including large-scale synthesis and purification of chirally pure pharmaceuticals.
The two editors from academia and a major pharmaceutical company have assembled an experienced, international team who provide first-hand practical advice and report previously unpublished data.

In the first section, the isolation of chiral drugs from natural sources, their production in enzymatic processes and the resolution of racemic mixtures in preparative chromatography are outlined in separate chapters. For the section on qualitative and quantitative analysis, enantioselective chromatographic methods are presented as well as optical methods and CE-MS, while the final section deals with the pharmacology, pharmacokinetics and metabolic aspects of chiral drugs, devoting whole chapters to stereoselective drug binding and modeling chiral drug-receptor interactions.

With its unique industry-relevant aspects, this is a must for medicinal and pharmaceutical chemists. ... Read more

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The final volume in the standard-setting reference on therapeutic designed drugs . . .

BURGER'S MEDICINAL CHEMISTRY AND DRUG DISCOVERY, FIFTH EDITION, Volume 5: Therapeutic Agents

This volume on Therapeutic Agents completes Burger's incisive, systematic examination of the fascinating new world of custom-designed therapeutic agents. Volume 5 highlights the link between chemical structure and biological activity, and explores chemotherapeutic agents, CNS and endocrine drugs, and radiological agents. It continues the authoritative coverage begun in earlier volumes and contains a comprehensive index for the entire edition.
* Antimalarial agents
* Agents affecting the action of
* Cognition enhancers, agents, and prostaglandins pharmacodynamic models for
* Agents affecting the action of Alzheimer's disease leukotrienes and thromboxanes
* Antidepressant agent
* Histamine H1 receptor antagonists
* Antianxiety agents
* Antiviral agents, RNA viruses
* Antipsychotic agents other than HIV
* Antihistamines, topical ocular
* Radiopaques
* Antiinflammatory steroids

Essential to research in drug discovery and design, Volume 5 of Burger's Medicinal Chemistry and Drug Discovery is a cornerstone reference for professionals in the biopharmaceutical industry and academic research.

Burger's Medicinal Chemistry, Fifth Edition consists of five volumes:
* Volume 1: Principles and Practice (0-471-57556-9) 1994
* ". . . an essential addition to the libraries of any medicinal chemist . . . an outstanding work . . . highly praised as a fountain of information in drug studies and research."--Journal of Medicinal Chemistry
* Volume 2: Therapeutic Agents (0-471-57557-7) 1996
* Volume 3: Therapeutic Agents (0-471-57558-5) 1996
* Volume 4: Therapeutic Agents (0-471-57559-3) 1997
* Volume 5: Therapeutic Agents (0-471-57560-7) 1997 ... Read more

Customer Reviews (1)

the ultimate book
I have seen many books on medicinal chemistry, but this book is an outstanding publication. It covers all chemistry, pharmacology, history and approach to new drug design. It gives complete information required for ascientist.

This is the best book for medicinal chemistry. ... Read more

Product Description
Hardbound. Highlights of this volume include comprehensive accounts of the biological rationale, design and clinical potential of new drug molecules; valuable summaries of structure-activity relationships in topical areas of medicinal chemistry; and expert evaluation of new technologies in their application to drug action and design.The seven chapters of this volume describe exciting advances in new drug molecules and in the application of new technologies to drug discovery and development.

Chapter 1 provides a comprehensive account of p38 mitogen-activated protein kinase inhibitors, a new class of anti-inflammatory agents with potential application to rheumatoid arthritis, inflammatory bowel disease and psoriasis, as well as other disorders with an inflammatory component.

A timely review on ligands for adenosine A3 receptors in Chapter 2 focuses on potent and selective agonists and partial agonists derived from adenosine, but demons ... Read more