81. Sickle Cell Anemia sickle cell anemia is an inherited chronic anemia in which the redblood cells become sickle or crescentshaped. sickle cell anemia. http://www.mycustompak.com/healthNotes/Concern/Sickle_Cell_Anemia.htm

Sickle Cell Anemia Also indexed as: Crescent Cell Anemia, Sickle Cell Disease Introduction Checklist Symptoms Treatments ... References Anemia is a deficiency of the oxygen-carrying capacity of red blood cells. Sickle cell anemia is an inherited chronic anemia in which the red blood cells become sickle or crescent-shaped. The symptoms of sickle cell anemia are caused by the clogging of small blood vessels by the sickle cells or by poor delivery of oxygen to the tissues due to the anemia itself. A sickle cell crisis is a painful episode that occurs when the body becomes severely deprived of oxygen. The disease and the trait occur in people of African descent, as well as in people from Mediterranean countries, India, and the Middle East, but rarely in people of European descent. Checklist for Sickle Cell Anemia Rating Nutritional Supplements Herbs Fish oil Folic acid (for lowering homocysteine levels) Vitamin B12 (for sickle cell patients with diagnosed B12 deficiencies) Zinc Beta-carotene and other carotenoids Magnesium Vitamin A Vitamin B2 ... Garlic Reliable and relatively consistent scientific data showing a substantial health benefit.

82. NIH: Health Information Home Health Information Blood/Lymphatic System. sickle cell anemia. Resources. NHLBIlogo NHLBI. sickle cell anemia PDF. Call 301592-8573 for more information. http://health.nih.gov/result.asp?disease_id=593&category_id=1

83. NIH: Health Information Home Health Information Genetics/Birth Defects. sickle cell anemia. Resources.NHLBI. NHGRI. Clinical Trials. NHLBI logo NHLBI. sickle cell anemia PDF. http://health.nih.gov/result.asp?disease_id=593&category_id=9

84. Hematology/Oncology - Sickle Cell Syndromes NEJM 1993;328816. 6 patients (beta thal or sickle cell anemia)- 3 malesand 3 females. 4 patients received a continuous IV infusion X 2 weeks. http://www.mc.vanderbilt.edu/peds/pidl/hemeonc/sickle1.htm

PIDL Home/ Contents Development Nutrition Acute Illness ... Psychosocial Hematology/Oncology SICKLE CELL SYNDROMES Background and Introduction Genetics Pathophysiology Diagnosis ... Prevention or?cure BACKGROUND AND INTRODUCTION SICKLING DISORDERS are syndromes associated with presence of Hgb S which has adverse effects on the health of the individual. These include SS disease, and other disease states where Hgb S is associated with other abnormalities - eg, SC, SD, S- thalassemia - which enhances or promotes sickling phenomenon. The predominant disorder in incidence and clinical importance is Hgb SS disease - homozygous SS or sickle cell disease. One of the first human diseases to be characterized at the molecular level with biochemistry and pathophysiology well delineated, SS disease is well characterized; however, therapeutic interventions have been mainly symptomatic and supportive until recently. The terms Hgb SS disease and sickle cell disease are usually synonymous.

85. Sickle Cell Disease / Family Village The American sickle cell anemia Association 10300 Carnegie Avenue Cleveland Clinic/ East Office Building (EEb18) Cleveland, Ohio 44106 Phone 216229-8600 Web http://www.familyvillage.wisc.edu/lib_scd.htm

Sickle Cell Disease Who to Contact Where to Go to Chat with Others Learn More About It Web Sites ... Search Google for "Sickle Cell" Who to Contact Sickle Cell Disease Association of America 200 Corporate Pointe, Suite 495 Culver City California 90230-8727 (310) 216-6363 Office (310) 215-3722 Fax (800) 421-8453 General Public E-Mail: scdaa@sicklecelldisease.org Website: http://sicklecelldisease.org/ Sickle Cell Disease Association of America, Inc. is helping to promote finding a universal cure for sickle cell disease, and helping to improve the quality of life for individuals and families where sickle cell disease related conditions exist. Sickle Cell Parent and Family Network P.O. Box 19854 Cincinnati, Ohio 45219 513-398-9620 (fax) E-mail: muhjahmarshall@sprintmail.com Web: http://www.cintishares.com/sickle_cell_parent.htm Sickle Cell Parent and Family Network works to find a cure for sickle cell disease and to help families and individuals lead full lives until a cure is found. Our activities center on communication, education, advocacy, support and emergency assistance. The members of the network collaborate with medical, educational, community and religious institutions to meet the many needs of individuals with sickle cell disease and other chronic conditions and disabilities. Through learning programs designed by and for impacted families, our members are empowered to make wise decisions in meeting their life challenges. The American Sickle Cell Anemia Association

86. Division Of Genetics: Hemoglobinopathies 2,3,4, URMC sickle cell anemia (SS) results from the homozygous state for the sickle gene whilesickle cell disease includes also those disorders which result from the http://www.urmc.rochester.edu/genetics/hemo.htm

Home Services Counseling Services Sickle Cell Clinic Newsletters OncoGene News Sickle Selections Staff Department of Medicine Hemoglobinopathies Hemoglobinopathies are inherited disorders of hemoglobin and could involve either the heme or globin part of the molecule. The most common hemoglobinopathies include the sickling disorders resulting from structural changes in the globin gene, and the thalassemias , resulting from the reduced rate of production of one or more globin chains. An individual with one normal globin gene and one globin variant gene is referred to as being a carrier or having a trait. Trait individuals are asymptomatic. For example: An individual with one gene for normal hemoglobin (HbA) and one gene for sickle hemoglobin (HbS) will have sickle cell trait.(AS) Sickle cell trait is rarely associated with any clinical abnormality Hemoglobin Variants There are over 400 structural variants of normal hemoglobin. The 4 most common structural variants (all chain variants) are: Sickle hemoglobin - the first variant to be discovered (1949) . Its main reservoir is Central Africa where the carrier rate approximates 20%. Approximately 8% of African-Americans will carry one sickle gene. Persons from Mediterranean countries, the Middle East or East India less frequently carry the gene.

87. Sickle-Cell Anemia--Knowledge Is The Best Defense - Jehovah's Witnesses Official An article about sicklecell anemia with an explanation, the symptoms, treatment, prevention and how it is passed on. http://www.watchtower.org/library/g/1996/10/8/anemia_knowledge_defense.htm

Related topics: The Mystery of Ill Health Pestilence Will It Ever End? Knowledge Is the Best Defense BY AWAKE! CORRESPONDENT IN NIGERIA THERE were 32 people in the conference room, mostly women and children. Six-year-old Tope, frail, dressed in pink, sat quietly beside her mother, on a wooden chair. She listened as the nurse spoke to them about what to do when the pain comes. "She is my firstborn," said her mother. "From the beginning she was always sick. I went to many churches, and they prayed over her. But she still got sick. Finally, I took her to the hospital. They tested her blood and found she was a 'sickler.'" What Is It? At the Center for Sickle-Cell Anemia in Benin City, Nigeria, Tope's mother learned that sickle-cell anemia is a disorder of the blood. Contrary to superstitious beliefs, it has nothing to do with witchcraft or spirits of the dead. Children inherit sickle-cell anemia from both parents. It is not contagious. There is no way you can catch the disorder from another person. Either you are born with it or you are not. Tope's mother also learned that while there is no cure, the symptoms can be treated. Sickle-cell anemia occurs mostly in those of African descent. Dr. I. U. Omoike, director of the Center for Sickle-Cell Anemia, told

88. Sickle Cell Information Center Home Page Summary Article2002; The Georgia Comprehensive sickle cell Center Research Summarywith Publications and Presentations; Disorders of Red cells - anemia Work-up http://www.emory.edu/PEDS/SICKLE/toc.htm

The Sickle Cell Information Center has moved to http://www.SCInfo.org Please update your link. You will be automatically transferred in 5 seconds. If not click here

89. Human Gene Testing - Summary Article by Drs. Stuart Orkin and Gary Felsenfeld describing how basic research led to genetic testing, including how the discoveries of DNA, restriction enzymes, cloning, PCR (polymerase chain reaction) make tests for diseases like sicklecell anemia and breast cancer possible. http://www.beyonddiscovery.org/content/view.article.asp?a=239

90. Sickle Cell Society A UK-based charity which provides care and information. Site includes research findings, pain management Category Health Conditions and Diseases Blood Disorders sickle cell......sickle cell Society UK based charity which provides care and information on sicklecell anaemia (anemia) and other sickle cell disorders to sufferers, health http://www.sicklecellsociety.org/

Sickle Cell Society Information, Counselling and Caring for those with Sickle Cell Disorders and their families What Is Sickle Cell? Day to Day Care Employee Information Employer Information Health Profession Information Society News Diary of Events Teaching Resources Inheritance Prenatal Testing Directory of Centres More about the Society Membership and Donations Latest Reports and Research Publications Issues in the News Contacting Us Adventurous People Image Gallery Welcome to the Sickle Cell Society, Britain's premier African Caribbean health charity. Our highly acclaimed web-site is continually updated to provide a valuable resource for news, health issues, events, research, membership and ways to support our work. E-mail us at sicklecellsoc@btinternet.com Tel. 020 8961 7795 A special site for young people with Sickle Cell Please read our Site produced and maintained by Marjen Media

91. Human Gene Testing - Honing The Search For Dis... Yuet Wai Kan and AndreeMarie Dozy were studying patients with sickle-cell anemia,a hereditary disease in which a single change in DNA gives rise to a http://www.beyonddiscovery.org/content/view.asp?I=244

92. Synthetic Theory Of Evolution: Natural Selection However, these individuals usually die in childhood from sicklecell anemia clickthis icon to hear the preceding term pronounced and related health problems. http://anthro.palomar.edu/synthetic/synth_7.htm

Natural Selection N atural selection is usually the most important mechanism of evolution. We now know that its effect on individuals depends on their phenotypes which in turn are determined mostly by their genotypes. The environment ultimately selects individuals with the best suited genotypes to survive to adulthood and to reproduce. Those who have more surviving offspring pass on more of their genes to the next generation. F or natural selection to cause evolution, it must select for or against one or more of the genotypes for a trait. In the case of a trait that is determined by a single gene with two alleles, their are five combinations of genotypes that nature can select either homozygote ( AA or aa but not both) both homozygotes ( AA and aa either homozygote and the heterozygote ( AA and Aa or aa and Aa the heterozygote ( Aa all alleles ( AA Aa , and aa Selection Against One Of The Homozygotes F or traits that are controlled by a single gene that has two alleles, selection against one of the homozygotes ( AA or aa ) will result in a progressive decrease in the allele of which that unsuccessful homozygote consists.

93. Texas Department Of Health-Sickle Cell Disease Homozygous Beta Thalassemia Major also known as Cooley's anemia. sickle cell Diseaseand sickle cell Trait. sickle cell Disease A Resource for the Educator. http://www.tdh.state.tx.us/newborn/sickle.htm

Newborn Screening Case Management Program Sickle Cell Disease Information Sickle Cell Disease in Children and Adolescents: Diagnosis, Guidelines for Comprehensive Care, and Protocols for Management of Acute and Chronic Complications© Homozygous Beta Thalassemia Major also known as Cooley's Anemia So Your Baby Has The Sickle Cell Trait Con Que Su Bebé Tiene El Rasgo de Glóbulos Falciformes ... La Anemia Falciforme (Sickle Cell) en Bebés y Niños Pequeños Newsletter The Sickle Cell Rapper - The Children's Sickle Center, San Antonio, Texas Summer 2002 Fall 2001 Spring 2001 Fall 2000 ... Fall, 1998 Abstract Universal Screening for Sickle Hemoglobinopathies Abstract Publications Newborn Screening Publications Order Form Practitioner's Guide Related Sites The fourth edition of The Management of Sickle Cell Disease developed by physicians, nurses, psychologists, and social workers who specialize in the care of children and adults with sickle cell diseasedescribes the current approach to counseling and also to management of many of the medical complications of sickle cell disease. Sickle Cell Association of Austin - Marc Thomas Chapter The Sickle Cell Information Center Please note: External links to other sites are intended to be informational and do not have the endorsement of the Texas Department of Health. These sites may also not be accessible to persons with disabilities.

94. Information Center For Sickle Cell And Thalassemic Disorders Overview of hemoglobin disorders, iron overload, and their treatment http://sickle.bwh.harvard.edu/

Kenneth R. Bridges, M.D. [Welcome] [Sickle Cell Disease] [Thalassemia Information] Kenneth R. Bridges, M.D. [Welcome] [Sickle Cell Disease] [Thalassemia Information] ... [Links]

95. FAQs Frequently Asked Questions Ask a question contact the sickle cell Center staff at aplatt@emory.edu. Copyright© 1997 sickle cell Information Center Last modified June 11, 2002. http://www.scinfo.org/faq.htm

Frequently Asked Questions (FAQs) - Questions submitted to the Web site by patients, clinicians, and others Click on a Topic Category: Sickle Cell Disease Bone Marrow and Stem Cell Transplant Sickle Cell Trait and G6PD Students and Teachers ... Sickle Cell Newborn Screening Ask a question - contact the Sickle Cell Center staff at aplatt@emory.edu Send mail to aplatt@emory.edu with questions or comments about this web site. Sickle Cell Information Center Last modified: June 11, 2002

96. Sickle Cell Disease Overview. Brief History of sickle cell Disease Hemoglobin Basics Hemoglobin SynthesisHow Does sickle Cause Disease? Why is sickle cell Disease so Variable? http://sickle.bwh.harvard.edu/menu_sickle.html

Overview Brief History of Sickle Cell Disease Hemoglobin Basics Hemoglobin Synthesis How Does Sickle Cause Disease? ... Sickle Cell Trait Management Considerations Development of a Comprehensive Care Program for Patients with Sickle Cell Disease Management Overview Outpatient Management Issues Newborn Screening ... Bone Marrow Transplantation Children's Hospital Oakland Cord Blood Program Transition of Patients with Sickle Cell Disease from Pediatric to Adult Care Research Red Cell Hydration and Sickle Cell Disease

97. Sickle Cell Disease Association Of America Home, Bookmark This Site (IE Only). Historic sickle cell Disease Webcast! Get toknow your neighbors in the sickle cell community by plugging into the Forum. http://www.sicklecelldisease.org/default.htm

Home Bookmark This Site (IE Only) Historic Sickle Cell Disease Webcast! View the Opening Plenary Session of the 30th Anniversary Convention Our History Dr. Roland B. Scott: Pioneer Passes On

98. DEFIERS.COM Patient-oriented information.Category Health Conditions and Diseases Blood Disorders sickle cell......sickle cell defier (noun, plural defiers) a person with sickle cell diseasedefiers.com The Website For The sickle cell Community Click To Enter. http://www.defiers.com/

sickle cell defier (noun, plural defiers) - a person with sickle cell disease defiers.com The Website For The Sickle Cell Community Click To Enter

99. Comprehensive Sickle Cell Centers of the National Heart, Lung, and Blood Institute (NHLBI), National Institutes ofHealth (NIH), supports grants for the Comprehensive sickle cell Centers to http://www.rhofed.com/sickle/

Back To Home To CSCC-SDMC web site Program Description The Division of Blood Diseases and Resources (DBDR) of the National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), supports grants for the Comprehensive Sickle Cell Centers to focus on multi-disciplinary programs of basic, applied, and clinical research, and also to include relevant service activities in diagnosis, counseling and education concerning sickle cell disease and related disorders. The NIH established the Comprehensive Sickle Cell Center Program in 1972, in response to a Presidential initiative and Congressional mandate. After an open competition, ten Centers were funded in 1972 and five additional Centers in 1973. Subsequent RFA's were announced in 1976, 1981, 1986, 1991, and 1996, and the next RFA will be released in 2001. Ten Comprehensive Sickle Cell Centers are currently funded (as of 4/1/98), and they are: San Francisco General Hospital/Children's Hospital Oakland, University of Southern California (Los Angeles), Children's Hospital Cincinnati, University of South Alabama, University of Alabama-Birmingham, Thomas Jefferson University (Philadelphia), Children's Hospital of Philadelphia, Columbia University, Albert Einstein College of Medicine, and Boston University. Sickle Cell Center grants are identifiable units within sponsoring institutions that are organized around a group of investigators and other health professionals engaged in ongoing basic and clinical research and community service related to sickle cell disease. Centers provide support for multi - disciplinary programs of basic, clinical and behavioral research; for core resources such as laboratory and data analysis; and for quality service activities including diagnosis, counseling, and education.

100. Wadsworth-Newborn Screening-Sickle Cell What does it mean? Is the baby sick? Can it develop into sickle CellAnemia? Can other members of my family get it? . Your Baby is Not Sick. http://www.wadsworth.org/newborn/scell/scell.htm

The Family Connection SICKLE CELL TRAIT If you've been told, as the result of a blood test, that your child has Sickle Cell Trait, quite naturally, you're concerned. Questions are tumbling through your head. "What does it mean?" "Is the baby sick?" "Can it develop into Sickle Cell Anemia?" "Can other members of my family get it?" Your Baby is Not Sick First of all let us assure you that Sickle Cell Trait will not affect your baby's health. YOUR INFANT DOES NOT HAVE SICKLE CELL ANEMIA AND WILL NEVER DEVELOP THIS DISEASE. Your Baby Inherited the Trait Sickle Cell Trait, like hair color, general body build and other physical characteristics is passed down in the family from parent to child through the genes. Genes are the tiny bits of information contained in the father's sperm and the mother's egg that form a blueprint for the new life. Genes come in pairs; for each characteristic there is one gene from the mother and one form the father. One of these pairs of genes determines hemoglobin the substance that carries oxygen in your blood and gives it its red color. If your baby has Sickle Cell Trait, it means that the baby inherited a normal hemoglobin gene from one parent and a changed or altered hemoglobin gene from the other parent. We refer to the usual gene as "All and the changed gene as 'IS." Your baby, therefore, has AS hemoglobin.

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