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         Spina Bifida Hydrocephalus Genetics:     more detail

21. Jays Pitcher's Family Rally Back From Spina Bifida
There's no single cause of spina bifida but nutrition, genetics and environmentall play a role. Facts about spina bifidahydrocephalus What are they?
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Monday, May 31, 1999 Jays pitcher's family rally back from spina bifida By MARLENE HABIB The Canadian Press Canada Health Profile
  • Health Expectancy
  • Life expectancy
  • Health Expenditures
  • Exercise frequency ...
  • Health Chat TORONTO (CP) As a pitcher, Bill Risley of the Toronto Blue Jays has keen balance. Risley's young son Kaleb, on the other hand, has trouble with balance even with splints. Kaleb has spina bifida , a neural-tube defect that will affect about one in 750 children born in Canada this year. Risley and his wife Brenda consider themselves lucky even though they were thrown yet another medical curve. Risley has a history of back problems. A few years ago, their daughter Sage scalded her throat when she put her mouth over a steaming pot of tea. The relief pitcher said an ultrasound on his pregnant wife revealed Kaleb's spine wasn't forming properly. But the early diagnosis gave the couple time to prepare for the challenges ahead.
  • 22. Centre For Research Into Psychological Development
    Stevenson,J. (2002).The genetics of ADHD. Peer relations and neuropsychologicalabilities in children with hydrocephalus and/or spina bifida.

    23. Centre For Research Into Psychological Development
    The genetics of ADEHD and reading disability. and parent report on behavioural problemsand selfesteem in children with spina bifida and hydrocephalus.

    24. Spina Bifida The Resource Network At Kennedy Krieger Institute
    hydrocephalus is controlled by a surgical procedure called Most children born withspina bifida live well into Mental Hygiene, Office of genetics and Children
    Spina Bifida
    Spina bifida results from the failure of the spine to close properly during the first month of pregnancy. In severe cases, the spinal cord protrudes through the back and may be covered by skin or a thin membrane. Surgery to close a newborn's back is generally performed within 24 hours after birth to minimize the risk of infection and to preserve existing function in the spinal cord.
    Because of the paralysis resulting from the damage to the spinal cord, people born with spina bifida may need surgeries and other extensive medical care. The condition can also cause bowel and bladder complications. A large percentage of children born with spina bifida have hydrocephalus, the accumulation of fluid in the brain. Hydrocephalus is controlled by a surgical procedure called "shunting" which relieves the fluid build up in the brain by redirecting it into the abdominal area. Most children born with spina bifida live well into adulthood as a result of today's sophisticated medical techniques. Spina Bifida Glossary of Terms Additional Resources Diagnoses List

    25. Spina Bifida: Additional Resources The Resource Network At Kennedy Krieger Insti
    Additional Resources Anencephaly Support Foundation; hydrocephalus Association of SpinaBifida Central; SB Teens. Mental Hygiene, Office of genetics and Children
    Spina Bifida: Additional Resources
    Fact Sheets
    Additional Resources
    Related Organizations

    26. Professionals' Site Builder MyDr Members' Login
    2. Continence in spina bifida. Click Here To Find Out More. 3. hydrocephalus.Click Here To Find Out More. 4. Neural tube defects genetics and prevention.

    QUEENSLAND CLINICAL genetics SERVICE Royal Children’s Hospital, Herston myDr ArticlesAZ of myDr articles about spina bifida and hydrocephalus. myDr Health

    28. Patient Informatics Consult Servics: Pathfinder Database
    The possible genetics component of the cause may show who is most at risk forthese problems. hydrocephalus caused by spina bifida can be treated and

    29. Spina Bifida
    Neurulation disorders are associated with genetics, teratogens, and nutritional deficiencies. Manychildren with spina bifida have hydrocephalus which may
  • Definition Epidemiology Pathophysiology Etiology ... Reference Page
  • Definition:
    Spina bifida (SB) a type of myelodysplasia is the most common neural tube defect. SB caused by the failure of the fetus's spine to close properly during the first month of fetal development. The Spina Bifida Association of America reports that spina bifida is the most common permanently disabling birth defect.48 Spina bifida may be categorized into 2 type (some texts include spina bifida cystica in which a CSF filled sac protrudes f rom the spinal column. Spina bifida aperta includes 2 main types: myelomeningocele and meningocele. Myelomeningocele is the severest form in which the spinal cord and the meninges protrude from an opening in the spine. Meningocele is a less severe form in which the only the meninges and nonfunctional nerves protrude in a sac wall. Spina bifida occulta, the mildest form, is typically only a vertebral defect in which the vertebral arches do not fuse.
    Spina bifida affects 0.5 to 1 out of 1,000 infants born in the United States. The group with the lowest incidence is African blacks with 1 in 10,000. There is a sibling

    30. Glossary Of Genetics Terminology The Genetics Center, Inc.
    The geneticists at The genetics Center are boardcertified. spina bifida due to aneural tube defect typically in paralysis as well as hydrocephalus ( water on
    GLOSSARY OF GENETICS TERMINOLOGY Alpha-fetoprotein - The predominant protein present in fetal blood. Small amounts are present in the maternal circulation during pregnancy, and the values change as the fetus grows. Abnormally high or low values are associated with increased risks of spina bifida and Down syndrome, respectively.
    Amniocentesis - A procedure for prenatal diagnosis in which about one tablespoon of amniotic fluid surrounding the fetus is withdrawn from the amniotic sac using a very fine needle. Genetic amniocentesis is performed at The Genetics Center. Continuous ultrasound guidance during the amniocentesis makes the 60 to 90 second procedure as safe and painless as possible.
    Autosomal recessive / dominant - Patterns of inheritance in which females are as likely to be affected as males. In recessive disorders, one gene (of the pair) needs to function properly to prevent the disorder. For a dominant disorder, one gene functioning abnormally is sufficient to cause the disorder.
    BRCA1 and BRCA2 - Two genes that are important in breast cancer. Certain changes in either BRCA1 or BRCA2 result in an increased risk of developing breast, ovarian, or certain other cancers. BRCA1 was identified in 1994, and BRCA2 was discovered in 1996.

    31. Spina Bifida Association Of America - Publications, Products, And Services
    A Guide to hydrocephalus. The spina bifida Association of Ontario, Canada. AgentOrange and spina bifida. *Educational Issues. *genetics and spina bifida.
    SBAAWeb Resources Home Donate Online
    Parent's Tributes

    Facts About Spina Bifida
    Search SBAAWeb
    SBAA Publications
    *Non-Member Price GENERAL
    Folic Acid Counseling Kit Counseling information for health professionals.
    Plan Ahead Do What You Can
    Folic acid information for women at risk for recurrence.
    *available in Spanish
    Introduction to Spina Bifida (1998). David McLone, M.D., Ph. D. Answering your questions about Spina Bifida Catherine Shaer, M.D, Provides information to help you understand the basic medical, educational and social issues. (Also Available in Spanish) Living with Spina Bifida : A Guide for Families and Professionals Adrian Sandler, M.D. A Guide to Hydrocephalus The Spina Bifida Association of Ontario, Canada Confronting the Challenges of Spina Bifida (Curriculum for 8-13 year olds) Accessible Gardening for People with Physical Disabilities:
    A Guide to Methods, Tools, and Plants.
    Janeen R Adil A 300-page guide to accessible and barrier free gardening. Children with Spina Bifida: A Parents' Guide. Edited by Marlene Lutkenhoff, MS, RN, et al.

    32. Center For Genetics - Genetic Disorders
    Center for genetics Infants with spina bifida may have medical problems involvingweakness or and bladder control, chronic infection, hydrocephalus (water on

    33. SBAV Links And Resources
    Petty, 1997 Extensive coverage of genetics, hereditity, preand a guide to education/ Association for spina bifida and hydrocephalus Peterborough ASBAH
    Other Resources
    11th International Conference on Hydrocephalus and Spina Bifida 23 to 26th September 1999 in: Caliper: Official Journal of the Spina Bifida Association of Western Australia Issue No. 4/99
    11th International Conference on Hydrocephalus and Spina Bifida 23 to 26th September 1999 in: Calipher: official journal of the Spina Bifida Association of Western Australia Issue no. 4/99
    SB 616.043 INT (1999) Bowel Continence and Spina Bifida
    Bowel Continence and Spina Bifida / Leibold, Susan Braun, Pat Cole, Jeane Peterson, Paula Henry-Atkinson, Jeanete (ed)
    Washington, DC: Spina Bifida Association of America, 1995
    SB 616.043 BOWa Children With Disabilities
    Chldren With Disabilities 4th / Batshaw, Mark, L (M.D). ed.
    Extensive coverage of genetics, hereditity, pre-and postnatal development, specific disabilities, family roles and intervention. Also includes chapters on substance abuse, AIDS, Autism, Neural Tube Defects (Spina Bifida and Folate Information), Down Syndrome, fragile X syndrome, behaviour management includes case studies and comprehensive list of references for each chapter.
    R618.92 CHI

    Teratology Society Public Health genetics Society Society of Craniofacial geneticsSociety for Research into hydrocephalus and spina bifida Society for the
    Genetics Societies (National and Regional)

    35. ETenet - Library
    genetics also seems to play a role. (Back to Top). Questions to Ask Your Doctor.Which form of spina bifida is involved? Is hydrocephalus present?

    36. Lorber-references.html
    MH Anencephaly/genetics MH - hydrocephalus/*genetics MH - spina bifida Occulta/geneticsSO - Z Kinderchir 1984 Dec;39 Suppl 294-5 AU - Jackson PH AU
    web contact: go back to ShuffleBrain Main Menu
    The Late Emeritus Professor John Lorber
    Neurological Publications
    Photo reproduced from The University of Sheffield Newsletter go to ShuffleBrain Main Menu web contact:

    37. Chapter 24: Links | Course Companion For Children With Disabilities, Fifth Editi
    SANDI) Project, with information on spina bifida, hydrocephalus, Chiari malformation,genetics, life with spina bifida, coping, and other resources.
    1: Chromosomes and Heredity 2: Birth Defects 3: Growth Before Birth 4: Having a Baby 5: The First Weeks of Life 6: Premature and Small-for-Dates Infants 7: Substance Abuse 8: HIV Infection in Children 9: Nutrition 10: Vision 11: Hearing 12: Communication 13: The Brain and Nervous System 14: Muscles, Bones, and Nerves 15: Mental Retardation 16: Down Syndrome 17: Fragile X Syndrome 18: PKU 19: Dual Diagnosis 20: Pervasive Developmental Disorders 21: Attention Deficits and Hyperactivity 22: Specific Learning Disabilities 23: Cerebral Palsy 24: Neural Tube Defects 25: Epilepsy 26: Traumatic Brain Injury 27: Feeding 28: Dental Care 29: Early Intervention 30: Special Education Services 31: Promoting Adaptive Behavior 32: Technological Assistance 33: Rehabilitation 34: Exercise, Sports, and Recreation 35: Ethical Dilemmas 36: Providing Family-Centered Services 37: Future Expectations 38: Health Care and Finance 24: Cerebral Palsy
    Position statement from the American Academy of Pediatrics on folic acid for the prevention of neural tube defects (NTDs).
    A prevention model and resource guide with information about NTDs, folic acid, community involvement, program development, examples of program development, a glossary, and more.
    Spina bifida fact sheet
    from National Information Center for Children and Youth with Disabilities (NICHCY).

    38. Crusader Online - Run Aids Spina Bifida
    have begun to link it with genetics, environmental factors and a to causing paralysisin some cases, spina bifida can also result in hydrocephalus, or the
    April 12, 2002
    Vol. 43, No. 20 Top Stories

    Web Forum

    SU Home

    Run aids spina bifida The Crusader/Kelly Gerrity WALKING FOR DYLAN - Sophomores Sarah Clark and Karen Littlefield and senior Shana Hull enjoy the warm weather during the Dylan's 5K run/walk for spina bifida on Sunday. By Kim Hollenbush
    Staff Writer Susquehanna hosted the second annual Dylan’s Run at Nicholas A. Lopardo Stadium Sunday, April 7 at 1:30 p.m.
    The 5K run/walk raised awareness and money for the fight against spina bifida. Dylan’s Run benefited The Spina Bifida Association of the Delaware Valley.
    “I’m really glad to see that they’re raising awareness of spina bifida, it means a lot to me because my older brother was born with spina bifida and hydrocephalus,” Sarah Stout, junior, said. “Knowing that this is one of the most common birth defects, I think that people need to be more educated about spina bifida, and I think that Dylan’s Run is a great way to make people more knowledgeable.”
    It is estimated that the 5K run/walk raised about $1800 for The Spina Bifida Association of the Delaware Valley. Seventy-five people participated in the race. Registration for the race cost $12. Teams of eight or more people registered for $10 per person. Each participant received a free T-shirt.

    39. Capital Health - Spina Bifida
    genetics/Birth Defects. hydrocephalus, a buildup of cerebrospinal fluidwithin the skull, occurs in many babies with spina bifida. Services/Health Topics/Body Location Systems/Genetic
    Hospitals Capital Health Link Site Map Media Desk ... Quick Links Genetics/Birth Defects Capital Health Home Your Health Health Topics Body Location Systems ... Genetics/Birth Defects Spina Bifida Audio File Spina bifida is a birth defect caused by failure of the lower spine to close properly during the first month of pregnancy. The severity of the defect can range from so mild that it causes no impairment to so severe that the child is unable to walk and has no bladder or bowel control. The degree and type of disability depends upon which nerves are affected and how much. The outlook for each child depends upon the number of abnormalities and their severity. Most children with spina bifida who get proper care live well into adulthood. Spina bifida is a neural tube defect. These are serious birth defects in which there is incomplete development of the brain, spinal cord and/or their protective coverings. Neural tube defects tend to run in families and are thought to result from a combination of genetic and environmental factors. Spina bifida has been linked to a lack of the B vitamin folic acid in early pregnancy. Many cases of spina bifida could be eliminated if all women of childbearing age took 0.4 mg of folic acid daily before becoming pregnant. A health care provider can usually detect spina bifida during pregnancy. If high levels of a certain protein are present in the mother’s blood, other tests can be done to identify and confirm the defect.

    40. Hydrocephalus
    Trauma from accidents. genetics. Premature birth. Brain infections (viral/ bacteria). 8090%of babies with spina bifida develop hydrocephalus.
    Hydrocephalus Causes
  • Birth trauma Trauma from accidents Genetics Premature birth Brain infections (viral/ bacteria) Anomalies of the brain
  • The development of excess fluid in the ventricles (fluid spaces) of the brain. this is treated by placement of a shunt to drain the excess fluid. 80-90% of babies with spina bifida develop hydrocephalus. Reason for shunt placement:
  • Allow for normal brain development Allow for normal head growth Prevent progressive hydrocephalus
  • Placement of a shunt does not repair brain damage that may have already occurred due to the presence of congenital hydrocephalus nor bleeds that have occurred as a the result of prematurity or birth trauma. Related Conditions Cerebral palsy Spastic diplegia Seizure disorder Neuro Treatment Shunt placement See also What is Spina Bifida? Home What Is Spina Bifida? [ Hydrocephalus ] Medical Definitions News Page Medical Staff Services ... Funding
    Phone: 423-778-2222, FAX: (423) 778-6191. Last Updated 03/07/03

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