61. Acromegaly Endocrinology. acromegaly. What is acromegaly? Untreated, the disease canlead to severe illness and death. What are the symptoms of acromegaly? http://www.mcghealthcare.org/endocrinology/pithub/acromegaly/acromegaly.htm

MCG Health System Phone Numbers: (706) 721-CARE 1-800-736-CARE Request an Appointment Online Endocrinology Acromegaly What is acromegaly? Acromegaly is the Greek word for "extremities" and "enlargement." When the pituitary gland produces excess growth hormones, this results in excessive growth, called acromegaly. The excessive growth occurs first in the hands and feet, as soft tissue begins to swell. Acromegaly affects mostly middle-aged adults. Untreated, the disease can lead to severe illness and death. What are the symptoms of acromegaly? Symptoms of acromegaly vary depending on how long the patient has had the disease. The following are the most common symptoms. However, each individual may experience symptoms differently: swelling of the hands and feet facial features become course as bones grow body hair becomes course as the skin thickens and/or darkens increased perspiration accompanied with body odor protruding jaw voice deepening enlarged lip, nose, and tongue

62. Healthology Acromegaly Sign Up For acromegaly Updates . acromegaly acromegaly. http://www.advancesinoncology.com/focus_index.asp?f=aio_acromegaly

63. MDchoice.com The Ultimate Medical Information Finder Acromegaly page. acromegaly. height. What Causes acromegaly? acromegaly is causedby prolonged overproduction of GH by the pituitary gland. http://mdchoice.com/Pt/consumer/acromegaly.asp

Sign up for a FREE disease newsletter: Select Disease Allergies Arthritis Cholesterol Depression Diabetes Hypertension Medical Information Arthritis Center Allergy Center Kid's Health Cancer Center ... Health News Interactive Education Simulators PhotoRounds Medical Databases MEDLINE CancerLit AIDSLine Healthcare Employment About Us Editorial Board Our Company Contact Us We subscribe to the HONcode principles of the Health On the Net Foundation Spell Checker Search the Web's best medical sites Searches over 6,000 Medical Journals Health Information Sunday, March 30, 2003 Find more information about this topic from either the Web or the world's best medical journals by using the search boxes at the top of this page. Acromegaly What Causes Acromegaly? How Common is Acromegaly? How is Acromegaly Diagnosed? How is Acromegaly Treated? ... Other Resources Acromegaly is a hormonal disorder that results when the pituitary gland produces excess growth hormone (GH). It most commonly affects middle-aged adults and can result in serious illness and premature death. Once recognized, acromegaly is treatable in most patients, but because of its slow and often insidious onset, it frequently is not diagnosed correctly. The name acromegaly comes from the Greek words for "extremities" and "enlargement" and reflects one of its most common symptoms, the abnormal growth of the hands and feet. Soft tissue swelling of the hands and feet is often an early feature, with patients noticing a change in ring or shoe size. Gradually, bony changes alter the patient's facial features: the brow and lower jaw protrude, the nasal bone enlarges, and spacing of the teeth increases.

64. AACE Program Advances Care Of Acromegaly AACE Program Advances Care of acromegaly JACKSONVILLE, Fla., May 2, 1996 Workingfrom the premise that treating a rare disorder should not be hampered by http://www.pslgroup.com/dg/82BA.htm

65. Acromegaly. The Columbia Encyclopedia, Sixth Edition. 2001 2001. acromegaly. acromegaly is usually caused by a tumor of the pituitary;treatment consists of irradiation or surgical removal of the tumor. http://www.bartleby.com/65/ac/acromega.html

Select Search All Bartleby.com All Reference Columbia Encyclopedia World History Encyclopedia World Factbook Columbia Gazetteer American Heritage Coll. Dictionary Roget's Thesauri Roget's II: Thesaurus Roget's Int'l Thesaurus Quotations Bartlett's Quotations Columbia Quotations Simpson's Quotations English Usage Modern Usage American English Fowler's King's English Strunk's Style Mencken's Language Cambridge History The King James Bible Oxford Shakespeare Gray's Anatomy Farmer's Cookbook Post's Etiquette Bulfinch's Mythology Frazer's Golden Bough All Verse Anthologies Dickinson, E. Eliot, T.S. Frost, R. Hopkins, G.M. Keats, J. Lawrence, D.H. Masters, E.L. Sandburg, C. Sassoon, S. Whitman, W. Wordsworth, W. Yeats, W.B. All Nonfiction Harvard Classics American Essays Einstein's Relativity Grant, U.S. Roosevelt, T. Wells's History Presidential Inaugurals All Fiction Shelf of Fiction Ghost Stories Short Stories Shaw, G.B. Stein, G. Stevenson, R.L. Wells, H.G. Reference Columbia Encyclopedia PREVIOUS NEXT ... BIBLIOGRAPHIC RECORD The Columbia Encyclopedia, Sixth Edition. acromegaly m l KEY ) , adult endocrine disorder resulting from hypersecretion of growth hormone produced by the pituitary gland. Since the bones cannot increase in length after full growth is attained, there is a disproportionate thickening of bones, predominantly in the skull and small bones of the hands and feet. Fingers and toes become broadened and spadelike, the skull increases in size, and the cheek bones and jaws protrude. Many of the soft tissues, such as the tongue and liver, enlarge. Frequently glucose metabolism is disturbed, leading to diabetes mellitus. Acromegaly is usually caused by a tumor of the pituitary; treatment consists of irradiation or surgical removal of the tumor. Onset of the disease can also occur in children, before the epiphyses of the bones are closed. In such cases the disorder leads to

66. Acromegaly. The American Heritage® Dictionary Of The English Language: Fourth E acromegaly. The American Heritage® Dictionary of the English Language FourthEdition. 2000. 2000. acromegaly. SYLLABICATION ac·ro·meg·a·ly. http://www.bartleby.com/61/53/A0065300.html

Select Search All Bartleby.com All Reference Columbia Encyclopedia World History Encyclopedia World Factbook Columbia Gazetteer American Heritage Coll. Dictionary Roget's Thesauri Roget's II: Thesaurus Roget's Int'l Thesaurus Quotations Bartlett's Quotations Columbia Quotations Simpson's Quotations English Usage Modern Usage American English Fowler's King's English Strunk's Style Mencken's Language Cambridge History The King James Bible Oxford Shakespeare Gray's Anatomy Farmer's Cookbook Post's Etiquette Bulfinch's Mythology Frazer's Golden Bough All Verse Anthologies Dickinson, E. Eliot, T.S. Frost, R. Hopkins, G.M. Keats, J. Lawrence, D.H. Masters, E.L. Sandburg, C. Sassoon, S. Whitman, W. Wordsworth, W. Yeats, W.B. All Nonfiction Harvard Classics American Essays Einstein's Relativity Grant, U.S. Roosevelt, T. Wells's History Presidential Inaugurals All Fiction Shelf of Fiction Ghost Stories Short Stories Shaw, G.B. Stein, G. Stevenson, R.L. Wells, H.G. Reference American Heritage Dictionary acrolein ... BIBLIOGRAPHIC RECORD The American Heritage Dictionary of the English Language: Fourth Edition. acromegaly SYLLABICATION: PRONUNCIATION k r -m g -l NOUN: A chronic disease of adults marked by enlargement of the bones of the extremities, face, and jaw that is caused by overactivity of the pituitary gland.

67. Acromegaly & Octreotide Neuroendocrine Clinical HomeMedical Management of acromegalywith Octreotide by Larry Katznelson, MD. http://neurosurgery.mgh.harvard.edu/NeuroEndocrine/E-F-943.HTM

Medical Management of Acromegaly with Octreotide by Larry Katznelson, M.D. Referrals Neuroendocrine Bulletin Archive Guestbook Neurosurgery Home ... Links The pulsatile release of growth hormone (GH) by normal somatotroph cells is regulated by growth hormone releasing hormone (GHRH), which stimulates GH secretion, and somatostatin, which decreases secretion. At the liver, GH stimulates secretion of somatomedin C, also known as insulin-like growth factor 1 (IGF-1), which mediates many of the peripheral somatic effects of GH. IGF-1 feeds back at the level of the hypothalamus and pituitary resulting in a reduction in GH secretion. The diagnosis of acromegaly is based on three key findings: 1) clinical evidence, 2) demonstration of an elevated IGF-1 level, and 3) inability to suppress serum GH to less than 2 ng/ml following an oral glucose challenge (OGTT). In patients who do not have a significant reduction in GH levels in response to intermittent octreotide injections, more frequent dosing of octreotide may result in a greater clinical response. Octreotide may be administered continuously by a subcutaneous pump to patients with refractory acromegaly to prevent escape of GH between injections. In addition, studies using a long-acting injectable form of octreotide that is administered once a month are underway in Europe and are likely to be initiated here in the near future.

68. Welcome To ENH.org - Health Encyclopedia: Acromegaly acromegaly. Definition acromegaly is a chronic metabolic disordercaused by the presence of too much growth hormone. It results http://www.enh.org/Encyclopedia/ency/article/000321.asp

Disease Reference Injury Reference Test Reference Nutrition Reference ... Symptoms Reference Acromegaly Disease Injury Nutrition Poison ... Z Definition: Acromegaly is a chronic metabolic disorder caused by the presence of too much growth hormone. It results in gradual enlargement of body tissues including the bones of the face, jaw, hands, feet, and skull. Alternative Names: Somatotroph adenoma; Growth hormone excess Causes, incidence, and risk factors: Acromegaly occurs in about 6 of every 100,000 adults. It is caused by abnormal production of growth hormone after normal growth of the skeleton and other organs is complete. Excessive production of growth hormone in children causes gigantism rather than acromegaly. The cause of the increased hormone secretion is usually a benign tumor of the pituitary gland. The pituitary gland, which is located just below the brain, controls the production and release of several different hormones including growth hormone. There are no known risk factors for acromegaly other than a prior history of a pituitary tumor. Symptoms: enlarged hands enlarged feet widened fingers or toes due to skin overgrowth with swelling , redness, and pain enlarged jaw (prognathism) and tongue enlarged facial bones thickening of the skin, skin tags

69. Acromegaly & Octreotide Medical Management of acromegaly with Octreotide by Larry Katznelson, MD. http://pituitary.mgh.harvard.edu/e-f-943.htm

Referrals Neuroendocrine Bulletin Archive Guestbook Links Medical Management of Acromegaly with Octreotide by Larry Katznelson, M.D. Referrals Neuroendocrine Bulletin Archive Guestbook Neurosurgery Home ... Links The pulsatile release of growth hormone (GH) by normal somatotroph cells is regulated by growth hormone releasing hormone (GHRH), which stimulates GH secretion, and somatostatin, which decreases secretion. At the liver, GH stimulates secretion of somatomedin C, also known as insulin-like growth factor 1 (IGF-1), which mediates many of the peripheral somatic effects of GH. IGF-1 feeds back at the level of the hypothalamus and pituitary resulting in a reduction in GH secretion. The diagnosis of acromegaly is based on three key findings: 1) clinical evidence, 2) demonstration of an elevated IGF-1 level, and 3) inability to suppress serum GH to less than 2 ng/ml following an oral glucose challenge (OGTT). In patients who do not have a significant reduction in GH levels in response to intermittent octreotide injections, more frequent dosing of octreotide may result in a greater clinical response. Octreotide may be administered continuously by a subcutaneous pump to patients with refractory acromegaly to prevent escape of GH between injections. In addition, studies using a long-acting injectable form of octreotide that is administered once a month are underway in Europe and are likely to be initiated here in the near future.

70. Acromegaly And Gigantism acromegaly and gigantism. In children whose bony growth plates have not closed, thechemical changes of acromegaly result in exceptional growth of long bones. http://www.healthatoz.com/healthatoz/Atoz/ency/acromegaly_and_gigantism.html

Encyclopedia Index A Home Encyclopedia Encyclopedia Index A Acromegaly and gigantism Definition Acromegaly is a disorder in which the abnormal release of a particular chemical from the pituitary gland in the brain causes increased growth in bone and soft tissue, as well as a variety of other disturbances throughout the body. This chemical released from the pituitary gland is called growth hormone (GH). The body's ability to process and use nutrients like fats and sugars is also altered. In children whose bony growth plates have not closed, the chemical changes of acromegaly result in exceptional growth of long bones. This variant is called gigantism, with the additional bone growth causing unusual height. When the abnormality occurs after bone growth stops, the disorder is called acromegaly. Description Acromegaly is a relatively rare disorder, occurring in approximately 50 out of every one million people (50/1,000,000). Both men and women are affected. Because the symptoms of acromegaly occur so gradually, diagnosis is often delayed. The majority of patients are not identified until they are middle aged. Causes and symptoms The pituitary is a small gland located at the base of the brain. A gland is a collection of cells that releases certain chemicals, or hormones, which are important to the functioning of other organs or body systems. The pituitary hormones travel throughout the body and are involved in a large number of activities, including the regulation of growth and reproductive functions. The cause of acromegaly can be traced to the pituitary's production of GH.

71. SupportPath.com: Acromegaly SupportPath.com, acromegaly. Other topics of interest on SupportPath.comRare Disorders. Clinical Trials Research on acromegaly http://www.supportpath.com/sl_a/acromegaly.htm

Acromegaly Other topics of interest on SupportPath.com: Rare Disorders About Us Add-A-Link Email ... here Online Communities / Message Boards... Main Pituitary Forum Website: http://www.pituitary.org/PituitaryBulletinBoard.htm Description: Bulletin Board on the Pituitary Tumor Network Association Website. Date Added: 03/28/2002 Online Chats... Note: Regularly scheduled chats are listed on our NEW Online Events Calendar Links in this section are primarily to chat rooms open 24/7 which may or may not be moderated. None Listed Usenet Groups... Note: Your browser must be properly configured to access Usenet groups from this site. None Listed Mailing Lists... None Listed National / International Organizations... INTERNATIONAL Pituitary Network Association (PNA) Website: http://www.pituitary.com/ Description: Their Mission: "To support, pursue, encourage, promote and where possible, fund research on pituitary tumors and related pituitary disorders in a sustained and full-time effort to find a cure for these illnesses." Website features include bulletin boards, links, articles on diseases, and a glossary of terms. Date Added: 03/28/2002 Note: Groups are listed alphabetically by U.S. state and then country.

72. Health Library Find Information On Acromegaly At MerckSource Find information on acromegaly at MerckSource. Learn more about acromegaly,acromegaly acromegaly. Definition acromegaly is a chronic metabolic http://www.mercksource.com/pp/us/cns/cns_hl_adam.jspzQzpgzEzzSzppdocszSzuszSzcns

73. Acromegaly acromegaly Guide picks. acromegaly If this growth hormone disorder begins in puberty,it causes gigantism (the wrestler Andre the Giant was affected by it). http://rarediseases.about.com/cs/acromegaly/

zfp=-1 About Rare/Orphan Diseases Search in this topic on About on the Web in Products Web Hosting Rare/Orphan Diseases with Mary Kugler Your Guide to one of hundreds of sites Home Articles Forums ... Help zmhp('style="color:#fff"') Subjects BUYER'S GUIDE Before You Buy Top Picks Sites for Online Specialty Shopping ... All articles on this topic Stay up-to-date! Subscribe to our newsletter. Advertising Free Credit Report Free Psychics Advertisement Acromegaly Guide picks A hormonal disorder most commonly affecting adults in which an overproduction of growth hormone causes body changes. Acromegaly If this growth hormone disorder begins in puberty, it causes gigantism (the wrestler Andre the Giant was affected by it). Most often it begins in middle age due to a tumor of the pituitary gland and causes abnormal growth of the hands and face. From the About.com Guide to Rare/Orphan Diseases. NIDDK: Acromegaly UMM: Acromegaly Information from University of Maryland Medicine. University of Iowa: Acromegaly Photographs of the hands of a person affected by acromegaly, from the Department of Dermatology, University of Iowa College of Medicine. The Pituitary Foundation (UK): Acromegaly Comprehensive information and personal story about acromegaly.

74. Endocrinology - Acromegaly acromegaly What is acromegaly ? acromegaly affects mostly middleaged adults.Untreated, the disease can lead to severe illness and death. http://www.stjohnsmercy.org/healthinfo/adult/endocrin/acromegaly.asp

Search Health Information Adult Health Endocrine System Printable Version Acromegaly What is acromegaly Acromegaly is the Greek word for "extremities" and "enlargement." When the pituitary gland produces excess growth hormones, this results in excessive growth called acromegaly. The excessive growth occurs first in the hands and feet, as soft tissue begins to swell. Acromegaly affects mostly middle-aged adults. Untreated, the disease can lead to severe illness and death. What are the symptoms of acromegaly Symptoms of acromegaly vary depending on how long the patient has had the disease. The following are the most common symptoms of acromegaly. However, each individual may experience symptoms differently. Symptoms may include: swelling of the hands and feet facial features become coarse as bones grow body hair becomes coarse as the skin thickens and/or darkens increased perspiration accompanied with body odor protruding jaw voice deepening enlarged lip, nose, and tongue

75. Ipsen Limited - Information For Patients With Acromegaly Information for patients with acromegaly, Company, Products, Patients, Contacts,Medical Dictionary, Links. What is acromegaly? Management of acromegaly. http://www.ipsen.ltd.uk/patients/acromegaly/

Information for patients with acromegaly Company Products Patients Contacts ... Links Educational Services What is acromegaly? Management of acromegaly Diagnosis Surgery Radiotherapy Medical treatment Taking Control Advice for patients Self-help organisations and patient information 1990-EX-11-03

76. Ipsen Limited - What Is Acromegaly? What is acromegaly? such as diabetes. Symptoms of acromegaly. Changesin facial features, Joint stiffness, arthritis. Enlargement of http://www.ipsen.ltd.uk/patients/acromegaly/acromegaly1.html

What is Acromegaly? Company Products Patients Contacts ... Next - about the pituitary gland Acromegaly is the term used for a rare clinical condition in adults that is caused by the prolonged, excess release of growth hormone from the pituitary gland . It affects men and women equally, and in most cases, is not hereditary, so it cannot be passed onto children. The excess release of growth hormone promotes the growth of both skeletal and soft tissues, as well as causing metabolic changes that can result in symptoms such as diabetes Symptoms of acromegaly Changes in facial features Joint stiffness, arthritis Enlargement of hands, feet, jaw (separation of teeth) Tingling in the fingers and hands (carpal tunnel syndrome) Excessive sweating and / or abnormal hairiness Ear, nose (snoring), throat or dental problems Tiredness and lethargy Some loss of vision Increased frequency and / or severity of headaches Impaired glucose tolerance or diabetes Enlargement of the thyroid gland Hypertension Irregular menstrual cycle Loss of libido Back Next - about the pituitary gland 1992-EX-11-03

77. Acromegaly And Gigantism acromegaly and gigantism. In children whose bony growth plates have not closed, thechemical changes of acromegaly result in exceptional growth of long bones. http://www.hendrickhealth.org/healthy/000015.htm

MAIN SEARCH INDEX Acromegaly and gigantism Definition Description Causes and symptoms Diagnosis ... Resources Definition Acromegaly is a disorder in which the abnormal release of a particular chemical from the pituitary gland in the brain causes increased growth in bone and soft tissue, as well as a variety of other disturbances throughout the body. This chemical released from the pituitary gland is called growth hormone (GH). The body's ability to process and use nutrients like fats and sugars is also altered. In children whose bony growth plates have not closed, the chemical changes of acromegaly result in exceptional growth of long bones. This variant is called gigantism, with the additional bone growth causing unusual height. When the abnormality occurs after bone growth stops, the disorder is called acromegaly. Description Acromegaly is a relatively rare disorder, occurring in approximately 50 out of every one million people (50/1,000,000). Both men and women are affected. Because the symptoms of acromegaly occur so gradually, diagnosis is often delayed. The majority of patients are not identified until they are middle aged. Causes and symptoms The pituitary is a small gland located at the base of the brain. A gland is a collection of cells that releases certain chemicals, or hormones, which are important to the functioning of other organs or body systems. The pituitary hormones travel throughout the body and are involved in a large number of activities, including the regulation of growth and reproductive functions. The cause of acromegaly can be traced to the pituitary's production of GH.

78. Treating Acromegaly Endocrinology Medicine J A H Wass Treating acromegaly Endocrinology Medicine JAH Wass. Subject EndocrinologyMedicine Title Treating acromegaly Author JAH Wass. http://www.bookssource.co.uk/J-A-H-Wass-Treating-Acromegaly-1898099057.html

Treating Acromegaly Endocrinology Medicine J A H Wass Subject: Endocrinology Medicine Title: Treating Acromegaly Author: J A H Wass Robert Chote International Sto... L Alan Winters Foundations of ... Riccardo Faini European Union ... Javier Andres Spanish Unemploy... ... Gehrke Rudolf Anekdoten von F...

79. Acromegaly acromegaly. Image URL Acromegalic heart, Image URL acromegaly, ImageURL Adenoma in acromegaly, Image URL Adenoma in acromegaly, http://www.brisbio.ac.uk/ROADS/subject-listing/acromegaly.html

A collection of medical, dental and veterinary images for use in teaching. Home About the Archive FAQ Terms and Conditions ... Help Acromegaly Acromegalic heart Acromegaly Adenoma in acromegaly Adenoma in acromegaly Left ventricular hypertrophy and acromegaly Pneumothorax and acromegaly

80. Acromegaly acromegaly acromegaly, IGFI . Serial growth hormone after 75 g oral glucoseload (growth hormone suppression test) is a satisfactory alternative. http://www.rcpa.edu.au/pathman/acromega.htm

Acromegaly Acromegaly IGF-I . Serial growth hormone after 75 g oral glucose load (growth hormone suppression test) is a satisfactory alternative. Pituitary tumour See Pituitary hormone excess

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