21. Activated Protein C Resistance Test Menu activated protein c resistance, Primary Name, activated protein c resistance.Synonym, Screen for factor V Leiden. Synonym, . Contraction, APC resistance. http://peir.path.uab.edu/coag/article_19.shtml

Front Page Announcements Contact Us Clinical Conditions ... Test Order Form Search All Categories Front Page Announcements Contact Us Clinical Conditions Guidelines Links Patient Education Test Menu Test Order Form Test Menu Activated protein C resistance Email this article Printer friendly page Primary Name Activated protein C resistance Synonym Screen for factor V Leiden Synonym Contraction APC resistance Contraction APCR Contraction UAB Procedure Number CPT Code Specimen Collect one (1) blue-stopper tube (3.2% sodium citrate), filled to specified volume. Do not underfill or overfill. * If follow-up factor V Leiden mutation test is indicated, collect one (1) lavender-stopper tube (EDTA) whole blood. Specimen Management Centrifuge blue-stopper tube within 1 hour of collection, separate plasma and test or quick-freeze at -70°C. The lavender-stopper tube may be refrigerated up to 72 hours before shipping. Ship overnight at ambient temperature or on wet ice. Specimen Accepted Daily including weekends Times Available Test Performed Twice weekly Available Stat?

22. Activated Protein C Resistance Test Menu activated protein c resistance. Primary Name, activated protein c resistance.Synonym, Screen for factor V Leiden. Synonym, . Contraction, APC resistance. http://peir.path.uab.edu/coag/printer_19.shtml

From UAB Coagulation Service (http://coag.path.uab.edu) Test Menu Activated protein C resistance Primary Name Activated protein C resistance Synonym Screen for factor V Leiden Synonym Contraction APC resistance Contraction APCR Contraction UAB Procedure Number CPT Code Specimen Collect one (1) blue-stopper tube (3.2% sodium citrate), filled to specified volume. Do not underfill or overfill. * If follow-up factor V Leiden mutation test is indicated, collect one (1) lavender-stopper tube (EDTA) whole blood. Specimen Management Centrifuge blue-stopper tube within 1 hour of collection, separate plasma and test or quick-freeze at -70°C. The lavender-stopper tube may be refrigerated up to 72 hours before shipping. Ship overnight at ambient temperature or on wet ice. Specimen Accepted Daily including weekends Times Available Test Performed Twice weekly Available Stat? Pathologist's approval required. Description APC resistance is a thrombotic risk factor caused by the factor V Leiden mutation that is found in 3 to 8% of Caucasians. Factor V Leiden mutation confers a 2- to 8-fold increased risk of venous thrombosis. The APC resistance assay is performed as a screen before ordering the confirmatory factor V Leiden mutation assay. Reference Interval Ratio: 1.8 - 3. A pathology interpretation accompanies the report.

23. ACTIVATED PROTEIN C RESISTANCE activated protein c resistance. TEST CODEAPRTC CPT CODE85335 SYNONYMSTEST INCLUDES LABORATORY HematologyCoagulation SPECIMEN http://hsc.virginia.edu/medicine/clinical/pathology/labtests/handbook/aprtc.htm

ACTIVATED PROTEIN C RESISTANCE TEST CODE: APRTC CPT CODE: SYNONYMS: TEST INCLUDES: LABORATORY: Hematology-Coagulation SPECIMEN: Blue Top, 4.5 mL citrated blood MINIMUM VOLUME: Small Blue Top, 2.7 mL citrated blood AVAILABILITY: By consultation only TURNAROUND TIME: Final report pending Pathologist review. Contact laboratory at 924-8007 for STAT testing and STAT results. SPECIAL INSTRUCTIONS: REFERENCE RANGE:

24. Alpha Laboratories - ACTIVATED PROTEIN C RESISTANCE GO! News activated protein c resistance. activated protein c resistance(APCr). In patients with recurring thrombotic episodes the http://www.alphalabs.co.uk/APCr.htm

GO! News - ACTIVATED PROTEIN C RESISTANCE ACTIVATED PROTEIN C RESISTANCE (APCr) In patients with recurring thrombotic episodes the prevalence of APCr is 25-40% making it an essential assay in any thrombophilia panel. The kit is based on a modified APTT so is easy to run on most automated coagulometers. Our kit for detecting APCr is changing its name, with immediate effect the Bioclot aPC sensitivity becomes Bioclot Fva-aPC Resistance Ordering details remain the same as do the excellent CV when comparing within and between run precision. Whilst the kit contains controls, additional vials can be purchased, click on the catalogue number below to obtain more information Catalogue Number Description Pack Bioclot Fva-aPC Resistance 2 x 20 Tests Bioclot Fva-aPC Control Plasma Set 2 x 5 x 0.5ml

25. Activated Protein C Resistance - Best Activated Protein C Resistance Site On The activated protein c resistance best activated protein c resistance site onthe net. activated protein c resistance - activated protein c resistance. http://www.walnutstgospelhall.org/activated_protein_c_resistance.html

activated protein c resistance - activated protein c resistance activated protein c resistance Welcome to nutritional supplements store - the place where you can find out the best information and rates for health, nutrition, sport and wellness supplement under the sun. activated protein c resistance - operating since 1998, Nutritionalsupplementsstore gives you non biased information and recommendations of web sites on the internet where you can buy nutritional supplements online, b6 b6 deficiency vitamin vitamin health benefit of vitamin e food gram in protein vitamin b 100 ... combination complete food protein or find out more information about the type of activated protein c resistance you are looking for. nutritional supplements store activated protein c resistance is excited to announce our latest listings, updated Daily. For activated protein c resistance we have listings of over 100 sites, descriptions of their content and services, and remember we have been to each site, talked to the owners and we only recommend the highest quality sites, protein shake recipe low protein food high protein pasta protein science journal ... allowance daily mineral recommended vitamin with the most secure are reputable systems for activated protein c resistance. Thousands of activated protein c resistance customers rely on us to find the best value health and wellbeing nutrient providers. Enjoy your activated protein c resistance the security and safety of our recommendations as all sites are tested and approved by us. activated protein c resistance has an unique program geared for Internet users who have want to purchase online, but are concerned about the security of their credit card details. We have tried and tested all sites and recommend only the ones that pass out stringent testing. In addition activated protein c resistance we only recommend sites that have a huge range of products, a range of shipping options, and are truly reputable.

26. Annals Of Internal Medicine: Abstract ARTICLES activated protein c resistance and Factor V Leiden MutationAre Independent Risk Factors for Venous Thromboembolism. Francesco http://www.annals.org/issues/v130n8/abs/199904200-00004.html

20 April 1999 Volume 130 Number 8 ARTICLES Activated Protein C Resistance and Factor V Leiden Mutation Are Independent Risk Factors for Venous Thromboembolism Francesco Rodeghiero, MD; and Alberto Tosetto, MD Pages Background: Resistance to activated protein C due to the factor V R506Q (Leiden) mutation is the most common clotting abnormality in patients with venous thromboembolism. Objective: To evaluate the risk for venous thromboembolism associated with the factor V Leiden mutation or with resistance to activated protein C in the general population. Design: Cross-sectional survey. Setting: General community of Vicenza, Italy. Patients: A population-based sample of 15 109 white persons 18 to 65 years of age who were randomly selected from the census list. Measurements: Sequential validated approach based on participants' reports and Doppler ultrasonography. Resistance to activated protein C was investigated in all participants; 2134 participants with resistance to activated protein C were screened for the factor V Leiden mutation. Results: Carriers of the factor V Leiden mutation had a relative risk of 3.3 (95% CI, 1.7 to 6.1) for venous thromboembolism before 65 years of age. The fraction of cases attributable to the factor V Leiden mutation was 6.6%. By 65 years of age, 5.7% of carriers of the mutation had had venous thromboembolism, mostly after surgery. Participants with a reduced response to activated protein C were at higher risk even if they did not carry the mutation (odds ratio, 1.7 [CI, 1.0 to 2.7]); the attributable risk for venous thromboembolism was 5.1%.

27. Activated Protein C Resistance Information Page Diseases Database activated protein c resistance Information Page. Activated protein Cresistance aka/or APC resistance aka/or Factor V Leiden disease http://www.diseasesdatabase.com/sieve/item1.asp?glngUserChoice=154

28. Activated Protein C Resistance In Antiphospholipid Thrombosis Syndrome activated protein c resistance in Antiphospholipid Thrombosis Syndrome. 7Bokarewa MI Blomback M.Combination of activated protein c resistance. http://www.cmj.org/806.htm

Activated protein C resistance in Antiphospholipid Thrombosis Syndrome Wu Jingsheng£¬Zhou Zhizhong, Li Xiangpei, Li Xiaomei, Cheng Yuihua, Wang Guosheng, Wang Zuyi. Anhui Provincial Hospital , Hefei 230001 Abstract Objective To explore the correlation between antiphospholipid antibodies (APA) £¬activated protein C resistance(APC) and antiphospholipid thrombosis (APL-T) syndrome and, further investigate the occurring mechanism of thrombosis in APL-T syndrome. Methods ELISA, PTT-LA and APTT+/-APC methods were used respectively to detect anticardiolipin antibodies (ACA), lupus anticoagulants(LA) and APC R in 20 APL-T syndrome patients. Results 20 patients were diagnosed as APL-T. The ACA-IgG,M and LA are strongly associated with APL-T. The incidence of APCR in APL-T(75%) was significantly higher than that of the normal group(5%), Conclusion There was high prevalence of APCR in APL-T,and was stongly associated with LA.It is proposed that the acquired APCR inducing by APA is the important reason for thrombosis in Chinese APL-T . [Key Words] Antiphospholipid antibodies Antiphospholipid Thrombosis (APL-T) Syndrome Activated Protein C Resistance Antiphospholipid syndrome (APS) is a disorder of recurrent arterial or venous thrombosis, pregnancy losses, and /or thrombocytopenia associated with persistently positive results of anticardiololipin or lupus anticoagulant tests[1,2]. The basic change of pathology is thrombosis in vascular. Thrombosis at every grade of vascular may induce corresponding symptom, such as fetal loss caused by it in placental. Because thrombosis is the most prominent presentation, APS was also named as antiphospholipid thrombosis (APL-T) syndrome [3,4]. It is shown that there was a strong relationship between APA and the occurrence of APS, but the exact mechanism is still not clear. In recent years, The study on the thrombosis caused by APA by inhibiting protein C pathway attracted the attention of many authors[5,6]. To investigate the mechanism of thrombosis occurrence in APL-T syndrome, APA, APCR were measured for twenty patients with APL-T Syndrome.

29. NEJM -- Resistance To Activated Protein C As A Basis For Venous Thrombosis activated protein c resistance in patients with central retinal vein occlusion.Br. Cerebral Venous Thrombosis and activated protein c resistance. http://dx.doi.org/10.1056/NEJM199402243300801

HOME SEARCH CURRENT ISSUE PAST ISSUES ... HELP Volume 330:517-522 February 24, 1994 Number 8 Next Resistance to Activated Protein C as a Basis for Venous Thrombosis Peter J. Svensson, and Bjorn Dahlback Table of Contents Full Text of this article Related Letters to the Editor Find Similar Articles in the Journal ... Related Articles in Medline Articles in Medline by Author: Svensson, P. J. Dahlback, B. Medline Citation ABSTRACT Background In three families with various forms of venous thrombosis, we observed an apparently inherited poor response to the anticoagulant activated protein C (APC). The condition was due to a deficiency in a previously unrecognized anticoagulant factor that functioned as a cofactor to activated protein C. Methods We conducted the present study to determine the prevalence of resistance to APC in patients with venous thrombosis. We compared 104 consecutive patients with venous thrombosis confirmed by objective tests with 130 controls. In addition, 211 members of 34 families of persons with resistance to APC were studied. The anticoagulant response to APC was measured with a modified version of the activated partial-thromboplastin time test; the

30. Untitled Utilization of testing for activated protein c resistance in a reference laboratory.Am J Clin Pathol. activated protein c resistance and inherited thrombosis. http://www.medal.org/docs_ch4/doc_ch4.07.html

Table of Contents, Chap. 4 (APC) Resistance Ratio Overview: Activated protein C (APC) normally has an anticoagulant effect. Some patients with recurrent venous thrombosis do not show the expected anticoagulant effect when activated protein C (APC) is added to clotting tests and these persons were termed "resistant" to the anticoagulant effect of APC. Many of these patients have an hereditary disorder (autosomal dominant inheritance) related to a mutation in factor V (Factor V Leiden) which resists proteolysis by APC when activated to factor Va. APC resistance ratio = = (modified aPTT with APC added) / (modified aPTT without APC added) normalized APC resistance ratio = = (patient's APC resistance ratio) / (APC resistance ratio for pooled normal plasma) Interpretation: • the lower limit of the reference range for the APC resistance ratio varies with each laboratory but is typically 2 • an APC resistance ratio less than the lower limit for the reference range is seen in patients with APC resistance References: Bertina RM Koeleman BPC et al. Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature. 1994; 369:64-67.

31. Arch Ophthalmol -- Page Not Found activated protein c resistance, Factor V Leiden, and Central Retinal Vein Occlusionin Young Adults Author Information Justin L. Gottlieb, MD; Jeffrey P. Blice http://archopht.ama-assn.org/issues/v116n5/abs/ecs7724.html

Select Journal or Resource JAMA Archives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology Surgery MSJAMA Science News Updates Meetings Peer Review Congress The page you requested was not found. The JAMA Archives Journals Web site has been redesigned to provide you with improved layout, features, and functionality. The location of the page you requested may have changed. To find the page you requested, click here HOME CURRENT ISSUE PAST ISSUES ... HELP Error 404 - "Not Found"

32. Resistance To Activated Protein C As A Pathogenic Factor Of Thrombophilia of identifiable causes of familial thrombophilia has increased from 510% to 60-70%since the identification of activated protein c resistance (aPCR) in http://www.imbiomed.com/Innsz/Nnv48n3/english/Znn63-07.html

Ruiz-Argüelles GJ Resistencia a la proteína C activada como causa de trombofilia Rev Invest Clin Resistance to activated protein C as a pathogenic factor of thrombophilia ABSTRACT The proportion of identifiable causes of familial thrombophilia has increased from 5 10% to 60 70% since the identification of activated protein C resistance aPCR in February 1993 by Dahlbäck et al. A mutation in the factor V gene G A, 1691 leads to the so called Leiden mutation R 506 Q that produces a mutated factor V resistant to the catalytic action of activated protein C aPC , yet normal in its procoagulant properties. This recently identified aPCR is in Nordic populations the most prevalent and well defined genetic defect associated with disease so far described. Its prevalence in the general population ranges from 0% to up to 15% and suggests that a positive genetic selection pressure has been involved. The aPCR phenotype can be assessed in vitro by measurement of the prolongation of the activated partial thromboplastin time in the presence of aPC, whereas the aPCR genotype is studied using polymerase chain reaction searching for the Arg to Gln mutation in the coagulation factor V gene. Some acquired conditions such as the presence of lupus anticoagulants, antiphospholipid antibodies, pregnancy, liver disease and contraceptives may lead into the aPCR phenotype. The aPCR search must be the initial step in the study of a patient with thrombophilia, either inherited or acquired; aPCR together with protein C, protein S and antithrombin III explain 60 to 70% of cases of familial thrombophilia.

33. Allina Medical Labs Collections Manual ACTIVATED PROTEIN C Test Name activated protein c resistance. Test Number 2969. Specimen1 Full Citrate (blue) Top Tube. Container Blue Top Tube (Citrate). http://www.allina.com/ahs/allinalabs.nsf/ad88a4dd4aa66fe086256a47004f30e8/3a5d24

34. ACTIVATED PROTEIN C RESISTANCE IN PATIENTS WITH CENTRAL VENOUS THROMBOSIS activated protein c resistance IN PATIENTS WITH CENTRAL VENOUS THROMBOSIS.K. Greiner, B. Stoffelns, B. Dick, N. Pfeiffer. Factors http://www.dog.org/engl/abstract97/P560.html

ACTIVATED PROTEIN C RESISTANCE IN PATIENTS WITH CENTRAL VENOUS THROMBOSIS K. Greiner, B. Stoffelns, B. Dick, N. Pfeiffer Factors of thrombophilia play an important role in the etiology of retinal venous thrombosis. In 1993, a new kind of coagulation disorder, activated protein C resistance (APC), was described far the first time. Molecular genetic analysis demonstrated a mutation in the gene of factor V (Arg506-flu) causing a delay in the enzymatic degradation of factor V. The kequency of this mutation within the European population is estimated to be 5%. Case report; We describe two patients with central venous thrombosis caused by APC resistance. In the second case we saw a patient who suFenxl a right sided central venous thrombosis with permanent reduction of visual acuity to hand movements in 1985. The patient presented again with a leA sided venous thrombosis in 1987. The visual acuity of the left eye improved from 0.3 to 0.63 with pentoxyphylline infusions and panretinal laser photocoagulation because of neovascularizations. The diagnostic procedure did not show any risk factors apart from increased serum cholesterol levels. The patients sister had died from pulmonary embolism. Because of this family history and the bilateral involvement permanent treatment with phenprocoumon was initiated. We screened for APC resistance and found a significantly low value of 1.5 . The therapy with phenprocoumon is continued. Conclusions: Due to the high prevalence of APC resistance in the general population screening for this defect gained attention in the diagnosis of retinal venous thrombosis. We theref«e routinely test for APC resistance in patients presenting with retinal venous thrombosis.

35. CAP In The News - CAP TODAY Coagulation Case Study evaluation. We tested for activated protein c resistance, the prothrombinG20210A mutation, and obtained a homocysteine level. In http://www.cap.org/captoday/CaseStudy/coag5.html

January 2000 Coagulation Case Study How to work up hypercoagulability Michael Laposata, MD, PhD Elizabeth M. Van Cott, MD Figure 1 Figure 2 Figure 3 Figure 4 ... Figure 6 This is the fifth in a periodic series of articles written by members of the CAP Coagulation Resource Committee and focusing on laboratory evaluation of coagulation disorders A 28-year-old man was repairing a sink in his home when he became acutely short of breath. He was taken to the emergency room, where medical personnel established a diagnosis of pulmonary embolism. Two years earlier, the patient had suffered a deep vein thrombosis and was anticoagulated with warfarin for six months. He was evaluated around the time of his deep vein thrombosis and found to have normal values for what his primary care physician believed was the full battery of laboratory tests appropriate for identifying acquired or congenital hypercoagulation risk factors. However, the patient was tested only for antiphospholipid antibodies, protein C, protein S, and antithrombin. He was not evaluated for factor V Leiden, the prothrombin G20210A mutation, or homocysteine. Because the patient's antiphospholipid antibody tests and protein C, protein S, and antithrombin levels were normal, his physician terminated his Coumadin therapy at six months, in accordance with published guidelines for treating a spontaneous venous clot in the absence of identifiable risk factors. After his second thrombotic event (the pulmonary embolism), the patient was referred to our practice for further evaluation. We tested for activated protein C resistance, the prothrombin G20210A mutation, and obtained a homocysteine level. In this evaluation, the patient was found to be heterozygous for the prothrombin G20210A mutation and heterozygous for factor V Leiden and had no evidence of hyperhomocysteinemia.

36. Activated Protein C Resistance Control Kit Translate this page activated protein c resistance Control Kit. Kontrollsatz für dasactivated protein c resistance Sensitivity Kit enthält je 5 x http://www.progen.de/prod_templates/Activated_Protein_C_Resistance_Control_Kit.h

Activated Protein C Resistance Control Kit Kontrollsatz für das Activated Protein C Resistance Sensitivity Kit enthält je 5 x Normal, 5 x Abnormal Kontrollen. Hier klicken um zum Produkt zu kommen

37. Activated Protein C Resistance Sensitivity Kit Translate this page activated protein c resistance Sensitivity Kit. Reagenziensatz zumfunktionellen Nachweis der hereditären und erworbenen Resistenz http://www.progen.de/prod_templates/Activated_Protein_C_Resistance_Sensitivity_K

Activated Protein C Resistance Sensitivity Kit Reagenziensatz zum funktionellen Nachweis der hereditären und erworbenen Resistenz des Gerinnungsfaktors V gegenüber aktiviertem Protein C (APC) beim Vorliegen der Faktor V Leiden-Mutation oder erworbener Resistenzen (Schwangerschaft, Inhibitoren ...). Hier klicken um zum Produkt zu kommen

38. Resistance To Activated Protein Ca Novel Risk Factor For Venous Status Published. Abstract activated protein c resistance (APC resistance)is the most common hereditary condition associated with venous thrombosis. http://eprints.lub.lu.se/archive/00009740/

39. Factor V Leiden Information, Living With Thrombophilia VR506Q(factor V Leiden) RESISTANCE TO ACTIVATED PROTEIN C AS PATHOGENIC FACTOR OFVENOUS THROMBOEMBOLISM FVLactivated protein c resistance Information on the http://www.fvleiden.org/links.htm

Your browser does not support script Links Relating to Thrombophilia Nine years ago when I searched the web for the first time, I only found one article on fvl. Now if you search, you'll find many articles. This list is not exhaustive or comprehensive. It is a sampling of what's out there. If you want to read up on APC, APS, FVL or any other clotting disorder go to one of the major search engines and put in a variety of spellings for the disorder. You will find many articles. Finding a doctor in your state that knows how to treat FVL-Just click on your state Links for FVL: Venous Thrombosis and the Factor V (Leiden) Mutation University of Illinois-Factor V Leiden Patient Information (excellent graphics and explanations) Coumadin information from CardioDoc.net Pregnancy, Clotting, and Factor V Leiden: An Overview ... Factor V Leiden Mutation Analysis APC and Protein S Deficiency articles: Resistance to activated protein C due to Factor V R506Q (Factor V Leiden) Protein S Deficiency and Thrombophilia web page from the UK EMedicine Protein S Deficiency Resistance to activated protein C due to Factor VR506Q(factor V Leiden) ... Resistance to activated protein C due to Factor V Leiden Prothrombin 20210A: Genotype Testing: Prothrombin G20210a references- this link leads to several others on the same subject General links regarding clotting and/or thrombosis information:

40. Activated Protein C Resistance (APCR) (117762) activated protein c resistance (APCR) (117762). CPT Jenson R, ActivatedProtein C Resistance, Clin Hemostasis Rev, 1995. Svensson http://www.labcorp.com/datasets/labcorp/html/chapter/mono/cf003300.htm

Activated Protein C Resistance (APCR) (117762) CPT Synonyms APCR Special Instructions The patient should be at rest for 10 minutes before sampling. The APTT should be within the normal range. Specimen Plasma, frozen Volume 2 mL Minimum Volume 1 mL Container Blue-stopper (sodium citrate plasma) tube Collection When specimen is collected for multiple tests, the order of draw is 1) culture tubes, 2) nonadditive (red-stopper) tubes, 3) coagulation (sodium citrate [blue-stopper] tubes, and 4) other additive (EDTA [lavender-stopper], heparin [green-stopper], etc) tubes. If only coagulation tests are being drawn, draw 5 mL into another tube, discard, and then collect coagulation tests. This collection procedure eliminates contamination of the specimen with tissue thromboplastins and cross-contamination from additives such as heparin and EDTA. Collect nine parts whole blood to one part 3.2% sodium citrate using plastic collection material, or draw one blue-stopper (sodium citrate) tube until the vacuum is depleted to ensure a 9:1 ratio. Centrifuge immediately at 3500 rpm for 15 minutes. Carefully remove the plasma, aliquot a minimum of 2 mL of plasma into a plastic transport tube, and quick freeze Storage Instructions Freeze Patient Preparation Causes for Rejection Tubes improperly filled; tubes improperly labeled; hemolysis; clotted specimen; thawed specimen

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