61. Mississippi Challenge For Rett Syndrome & Adrenoleukodystrophy (ALD) The Mississippi River. adrenoleukodystrophy (ALD) What Is adrenoleukodystrophy(ALD)? ALD is one of a group of genetic disorders http://www.mississippichallenge.org/ald.html

A World Record Attempt and Film Documentary The Mississippi River Challenge for Rett Syndrome And Leukodystrophy - Beginning May 10, 2003 - The Mississippi River Adrenoleukodystrophy (ALD) The Mississippi River Challenge for Rett Syndrome And Leukodystrophy What Is Adrenoleukodystrophy (ALD)? ALD is one of a group of genetic disorders called the leukodystrophies that cause damage to the myelin sheath, the fatty covering, on nerve fibers in the brain and leads to progressive neurological disability and death. It is probably best know to Americans as the disease that afflicts the young boy Lorenzo Odone, whose story is told in the 1993 film 'Lorenzo's oil'. Who Gets ALD? ALD does not recognize racial, social, economic, or religious boundaries. It does, however, manifest preferentially in males. Diagnosing ALD For ALD, very accurate diagnostic testing is available. However, there is a tremendous lack of awareness among both laypersons and physicians in terms of requesting these studies.  An ALD diagnosis can be done on a blood sample by either looking at the level of very long chain fatty acids (VLFCAs) in the blood, or by DNA analysis. There are several forms of ALD Onset of the classic childhood form, which is the most severe and affects only boys, may occur between ages 4 and 10. Features of this form may include visual loss, learning disabilities, seizures, dysphagia, deafness, disturbances of gait and coordination, fatigue, intermittent vomiting, and progressive dementia. The most common symptoms are usually behavioral changes such as abnormal withdrawal or aggression, poor memory, and poor school performance.

62. Ask NOAH About: Neurological And Neuromuscular Disorders adrenoleukodystrophy adrenoleukodystrophy National Center for Biotechnology Informationadrenoleukodystrophy - National Institute of Neurological Disorders http://www.noah-health.org/english/illness/neuro/neuropg.html

Ask NOAH About: Neurological and Neuromuscular Disorders Specific Neurological and Neuromuscular Disorders Alzheimer's Disease and Dementia Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) Arnold Chiari Malformation Batten Disease ... Information Resources Neurological and Neuromuscular Disorders Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) The Basics ALS - National Institute of Neurological Disorders and Stroke ALS, MS, MD: What's the Difference - Center for Neurological Study ALS Dictionary - ALS Survival Guide Amyotrophic Lateral Sclerosis (ALS) - Methodist Health Care System, Houston TX (also in Spanish Amyotrophic Lateral Sclerosis: Lou Gehrig's Disease - AAFP Fact Sheet: ALS - Family Caregiver Alliance Facts About Amyotrophic Lateral Sclerosis (ALS) - Muscular Dystrophy Association ... What You Need to Know About Amyotrophic Lateral Sclerosis - Cleveland Clinic Foundation Diagnosis ALS Diagnosis - North Shore-Long Island Jewish Health System, NY ALS Diagnosis - Neurology Channel.com Initial Symptoms of the Disease - ALS Association Diagnosis of ALS - ALS Association Care and Treatment Alternative Medicine - ALS Survival Guide Approved Drugs - ALS Survival Guide Clinical Trials ALS: Drug Trials - Baylor School of Medicine Amyotrophic Lateral Sclerosis - ClinicalTrials.gov

63. Adrenoleukodystrophy adrenoleukodystrophy. Moser, H, et al. adrenoleukodystrophy, Endocrinology and MetabolismClinics of North America, 202; 297318 (june 1991). Moser, H, et al. http://www.clevelandclinic.org/health/health-info/docs/1200/1242.asp?index=6030

64. Boys With Adrenoleukodystrophy Or ALD - Aldboys.org Site Designed with LOVE and HOPE by MagicBus.com, Inc. http://www.aldboys.org/

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65. ALD Family Support Trust To Drive a Train. But all our dreams were over before they began, the onlything we all have in common now is that we have adrenoleukodystrophy. http://www.aldfst.org.uk/

WELCOME YOU TO OUR WEB SITE We Had A Dream To be Football Players in the Premier League. To Fly a Plane. To Drive a Train. But all our dreams were over before they began, the only thing we all have in common now is that we have Adrenoleukodystrophy. Adrenoleukodystrophy Family Support Trust is a national registered charity, specifically for children like us who are victims of the life threatening genetic disease called Adrenoleukodystrophy, better known as ALD for short. Please use the following pages and links to find out more about the work of the ALD Family Support Trust, and for information on how you can help us. Thank You So Much. Home Home

66. Adrenoleukodystrophy adrenoleukodystrophy. adrenoleukodystrophy International Research Group. GeneClinicsX-linked adrenoleukodystrophy. adrenoleukodystrophy. adrenoleukodystrophy. http://www.ability.org.uk/Adrenoleukodystrophy.html

Our Aims Services Stats ... Z Adrenoleukodystrophy Adrenoleukodystrophy - International Research Group GeneClinics: X-linked Adrenoleukodystrophy Adrenoleukodystrophy Cerebral adrenoleukodystrophy ... Webmaster . Site Design by Ability "see the ability, not the disability" Acknowledgments

67. Adrenoleukodystrophy (ALD) adrenoleukodystrophy (ALD). Case Study A A 35year-old woman was referredto a neurology clinic for evaluation of a slowly progressive http://www.athenadiagnostics.com/site/content/diagnostic_ed/case_studies/ald.asp

Adrenoleukodystrophy (ALD) Case Study A A 35-year-old woman was referred to a neurology clinic for evaluation of a slowly progressive spastic paraparesis that had begun three years earlier. At that time she had been given a tentative diagnosis of multiple sclerosis. The woman complained of recently acquired bowel and bladder problems. Inquiries regarding family history revealed that the woman had a son who had died at 10 years of age of an undiagnosed leukodystrophy. Her mother had been diagnosed with rheumatoid arthritis and also was paraparetic. The patient also had a niece who was described as "clumsy." The patient was found to have hyperreflexia of the lower extremities and decreased vibration sense. Adrenal function was normal. CSF analysis and cranial MRI were unremarkable. Analysis of the woman's plasma very long chain fatty acids revealed increased concentrations of C26:0 and increased ratios of C24:0/C22:0 and C26:0/C22:0, consistent with a diagnosis of heterozygosity for X-linked Adrenoleukodystrophy. There would be a 50% chance that this woman's male offspring would be affected with X-linked Adrenoleukodystrophy and a 50% chance that her female offspring would be carriers. Genetic counseling and analysis of very long chain fatty acids in first-degree family members were suggested. Neurological Disorders Alzheimer's Neurogenetic Paraneoplastic ... Accreditations and Licensing

68. Adrenoleukodystrophy adrenoleukodystrophy. adrenoleukodystrophy (ALD) is a member of a group of diseases,leukodystrophies, that cause damage to the myelin sheath of nerve cells. http://www.healthatoz.com/healthatoz/Atoz/ency/adrenoleukodystrophy.html

Encyclopedia Index A Home Encyclopedia Encyclopedia Index A Adrenoleukodystrophy Definition Adrenoleukodystrophy is a rare genetic disease characterized by a loss of myelin surrounding nerve cells in the brain and progressive adrenal gland dysfunction. Description Adrenoleukodystrophy (ALD) is a member of a group of diseases, leukodystrophies, that cause damage to the myelin sheath of nerve cells. Approximately one in 100,000 people is affected by ALD. There are three basic forms of ALD: childhood, adult-onset, and neonatal. The childhood form of the disease is the classical form and is the most severe. Childhood ALD is progressive and usually leads to total disability or death . It affects only boys because the genetic defect is sex-linked (carried on the X chromosome). Onset usually occurs between ages four and ten and can include many different symptoms, not all of which appear together. The most common symptoms are behavioral problems and poor memory. Other symptoms frequently seen are loss of vision, seizures, poorly articulated speech, difficulty swallowing, deafness, problems with gait and coordination, fatigue , increased skin pigmentation, and progressive dementia The adult-onset form of the disease, also called adrenomyeloneuropathy, is milder, progresses slowly, is usually associated with a normal life span, and usually appears between ages 21-35. Symptoms may include progressive stiffness, weakness, or

69. Experts, Consultants, Authorities - Adrenoleukodystrophy Specialty adrenoleukodystrophy. AMFS, Inc. (American Medical Forensics).2640 Telegraph Avenue Berkeley, California 94704 Tel 800 http://www.hgexperts.com/listing/Medical-Experts-Adrenoleukodystrophy.asp

EXPERT WITNESSES MEDICAL EXPERTS MEDIATORS ARBITRATORS LEGAL CONSULTANTS Appraisal Banking Case Management Employment ... SPEAKERS BUREAU Medical Experts - Advanced Search Search for any word(s) in Companies' Description and Expertises Company Name City State/Province Country Alabama Alaska Alberta Arizona Arkansas British Columbia California Colorado Connecticut Delaware District of Columbia Florida Georgia Guam Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Manitoba Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Brunswick New Hampshire New Jersey New Mexico New York Newfoundland North Carolina North Dakota Northwest Territory Nova Scotia Ohio Oklahoma Ontario Oregon Pennsylvania Prince Edward Island Puerto Rico Quebec Rhode Island Saskatchewan South Carolina South Dakota Tennessee Texas U.S. Virgin Islands Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming Yukon Territory United States of America Afghanistan Albania Algeria American Samoa Andorra Angola Anguilla Antigua Argentina Armenia Aruba Australia Austria Azerbaijan Bahamas Bahrain Bangladesh Barbados Belarus Belgium Belize Benin Bermuda Bhutan Bolivia Bosnia and Herzegovina Botswana Brazil British Virgin Islands Brunei Brunei Darussalam Bulgaria Burkina Faso Burma Burundi Cambodia Cameroon Canada Canary Islands Cayman Islands Central African Republic Chad Channel Islands Chile China Colombia Comoros Congo Congo (Dem. Rep.)

70. Ae Click on small image to see full size. adrenoleukodystrophy. Findings AxialCT images show patchy diffuse posterior white matter hypodensity. http://www.med.uc.edu/neurorad/webpage/fda.html

Click on small image to see full size. Adrenoleukodystrophy Findings: Axial CT images show patchy diffuse posterior white matter hypodensity. Multiple MR images show predominant signal abnormalities in the parieto-occipital white matter and splenium of corpus callosum with symmetric enhancement along the periphery. The signal abnormalities extend into the brainstem. Differential Diagnosis: The signal characteristics are most consistent with ADL. Globoid cell leukodystrophy may also have predominant abnormalities in the parietal regions, but this characteristic enhancement pattern would be unusual. MS and ADEM could rarely have this appearance, and would not likely be this symmetric. Discussion: ADL represents a deficiency of lignoceroyl CoA ligase, with accumulation of very long chain fatty acids in brain, adrenals, and blood elements. It is inherited as x-linked recesive or autosomal recessive. Pathologically, there is demyelination which advances in zones, with the peripheral zone showing no inflammatory response. The intermediate zone has active demyelination and inflammatory response, with the inner zone showing necrosis, gliosis, and possible calcification. Numerous phenotypes exist, the most common of which has clinical onset between 5-10 years, with rapidly progressive neurologic decline and death. Imaging features include symmetric posterior white matter involvement including the splenium, with a rind of enhancement along the advancing edges. reference: Osborn, A; Tong, K. Handbook of Neuroradiology: Brain and Skull. 1996: Mosby Year Book. pp. 521-523.

71. Free Essays On Adrenoleukodystrophy Abstract adrenoleukodystrophy (ALD) is a rare genetic disorder that affectsthe adrenal gland and white matter of the brain. adrenoleukodystrophy. http://www.freeforessays.com/show_essay/7630.html

March 30, 2003 FREE STUFF CATEGORIES Acceptance Arts ... Top 25 Essays MEMBER LOGIN LINKS Top 75 Essays Direct Essays Top 50 Essays Mega Essays ... essays at Direct Essays! This is only the first few lines of this paper. If you would like to view the entire paper you need to register for free here. If you are already a member then login here. Category: Science Word Count: Featured Papers Summary of Lorenzo Adrenoleukodystrophy Abstract Tired of looking through thousands of essays by hand? Try Searching through 80,000 essays quickly (not freeforessays.com)!

72. Health Library - Adrenoleukodystrophy adrenoleukodystrophy. Synonyms atrophy). adrenoleukodystrophy that is inheritedas an Xlinked genetic trait may begin in childhood or adulthood. http://health_info.nmh.org/Library/HealthGuide/IllnessConditions/topic.asp?hwid=

73. X-linked Adrenoleukodystrophy http://www.peroxisome.org/Scientist/Biochemistry/XALD.html

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74. InteliHealth: Adrenoleukodystrophy Featuring Harvard Medical School, Aetna InteliHealth. Entire Site. Home. http://www.intelihealth.com/IH/ihtIH/WSIHW000/9339/9416.html

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75. Adrenoleukodystrophy The summary for this Bihari page contains characters that cannot be correctly displayed in this language/character set. http://www.healthnet.in.th/cyber_board/room1/messages/79.html

adrenoleukodystrophy ·ÒºÁÒÇèÒ ¾.¨ØÌÒÁÕá¾·Âì·ÕèÊÒÁÒ¶µÇ¨áÅÐÑ¡ÉÒ adrenoleukodystrophy ä´é¨Ö§ÍÂÒ¡·Òºª×èͧ͢ᾷÂì¼Ùé¹Ñé¹ áÅÐÍÂÒ¡·ÒºÊ¶ÔµÔ¡Ò¾ºâ¤¹Õéã¹àÁ×ͧä·Â auayporna@hotmail.com ʶԵԢͧ¡Ò¾ºâ¤ adrenoleukodystrophy ã¹àÁ×ͧä·Â·èÒ¹ÊÒÁÒ¶¢Í·Òº¢éÍÁÙÅä´é¨Ò¡á¼¹¡àǪÐàºÕ¹ ¢Í§â§¾ÂÒºÒŨØÌÒŧ¡³ì Adrenoleukodystrophy à»ç¹â¤·Õèà¡Ô´¨Ò¡¤ÇÒÁ¼Ô´»¡µÔ·Ò§¡Á¾Ñ¹¸ìº¹ chromosome X ·Ò§¨ØÌÒ µÑǼÙéà¢Õ¹ä´éѺ¤ÇÒÁ¡Ø³Ò¨Ò¡ÍÒ¨ÒÂìÇÈÑ¡´Ôì áÅÐ American National Institute of Health 㹡ÒÇÔ¹Ô¨©ÑÂâ´Â¡ÒµÇ¨ very long chain fatty acid àÒ¾º¼Ùé»èǨӹǹ ËéÒÒÂã¹àÇÅÒËéÒ»Õ·Õè¼èÒ¹ÁÒ áÅÐä´é·´Åͧà»ÅÕè¹䢡´Ù¡ä»áÅéÇ˹Öè§ÒÂâ´Â¤ÇÒÁ¡Ø³Ò¨Ò¡ÍÒ¨ÒÂì ¹¾ »Õ´ÒáÅÐÊÀÒ¡ÒªÒ´ä·Â㹡ÒãËéà§Ô¹Ê¹ÑºÊ¹Ø¹¡Òà»ÅÕ蹶èÒÂÍÇÑÂÇÐ ¡ÒÑ¡ÉÒ´éÇÂÂÒÅ´ä¢ÁѹäÁè¤èÍÂä´é¼Å¹Ñ¡ ¡Òãªé¹ÓéÁѹ¾ÔàÈÉàÒäÁèÊÒÁÒ¶ËÒä´éã¹»Ðà·Èä·Â¤Ñº â§àÕ¹ᾷÂìÍ×è¹æ àªè¹ ÒÁÒ ÈÔÔÒª áÅÐʧªÅÒ¡çÁÕÒ§ҹ¤Ñº àºÍì ICQ:

76. Adrenoleukodystrophy adrenoleukodystrophy. (See LEUKODYSTROPHY, TAYSACHS DISEASE). Home Hot-Lines Resources Printed Guide Child Care for the '90's Links. http://www.childhealthinfo.com/a/adrenoleukodystrophy.htm

ADRENOLEUKODYSTROPHY (See LEUKODYSTROPHY, TAY-SACHS DISEASE) [Home] [Printed Guide] [Child Care for the '90's] [Links] ... MoreInfo@ChildHealthInfo.com

77. What Is Adrenoleukodystrophy? adrenoleukodystrophy (ALD) falls into a group of disorders known asleukodystrophies. This disease is diagnosed with a plasma test http://www.ikm.jmu.edu/Buttsjl/ISAT493/Adrenoleukodystrophy/aldintro.html

Main X-linked page Symptoms Incidence Severity ... "Lorenzo's Oil" Adrenoleukodystrophy (ALD) falls into a group of disorders known as leukodystrophies This disease is diagnosed with a plasma test to determine the level of very long chain fatty acids, regardless of symptomatology. It is a very specialized test, so it is only performed in a few laboratories worldwide. These very long chain fatty acids accumulate, due to absence of peroxisomes in the liver, and damage the ability of the adrenal gland to convert cholesterol to steroid hormones. The characteristic of the disease is progressive cognitive and behavioral impairment. This impairment is due to the myelin degeneration that occurs within these patients' central nervous system. Without the myelin sheath, nerve fibers are damaged and cease to function properly. Click the above graphic to hear the pronunciation of the disease. When prompted, choose 'open from current location.' The figure above shows the location of the Adrenoleukodystrophy gene on the x chromosome. It was borrowed from

78. NORD - National Organization For Rare Disorders, Inc. adrenoleukodystrophy. View Cart/Checkout. Copyright 1985, 1986, 1988, 1989,1990, 1993, 1994, 1997, 1998, 1999 Synonyms of adrenoleukodystrophy http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Adrenoleukody

79. Adrenoleukodystrophy | BluePrint For Health You are here Home Health A to Z adrenoleukodystrophy.adrenoleukodystrophy. Lohr, John T. http://blueprint.bluecrossmn.com/topic/topic100586401

Search COMPLEMENTARY CARE Acupuncture Massage therapy Fitness centers ... SITE AWARDS You are here: Home Health A to Z Adrenoleukodystrophy Adrenoleukodystrophy Lohr, John T. Below: Definition Description Causes and symptoms Diagnosis ... Resources Definition Adrenoleukodystrophy is a rare genetic disease characterized by a loss of myelin surrounding nerve cells in the brain and progressive adrenal gland dysfunction. Description Adrenoleukodystrophy (ALD) is a member of a group of diseases, leukodystrophies, that cause damage to the myelin sheath of nerve cells. Approximately one in 100,000 people is affected by ALD. There are three basic forms of ALD: childhood, adult-onset, and neonatal. The childhood form of the disease is the classical form and is the most severe. Childhood ALD is progressive and usually leads to total disability or death. It affects only boys because the genetic defect is sex-linked (carried on the X chromosome). Onset usually occurs between ages four and ten and can include many different symptoms, not all of which appear together. The most common symptoms are behavioral problems and poor memory. Other symptoms frequently seen are loss of vision, seizures, poorly articulated speech, difficulty swallowing, deafness, problems with gait and coordination, fatigue, increased skin pigmentation, and progressive dementia. The adult-onset form of the disease, also called adrenomyeloneuropathy, is milder, progresses slowly, is usually associated with a normal life span, and usually appears between ages 21-35. Symptoms may include progressive stiffness, weakness, or paralysis of the lower limbs and loss of coordination. Brain function deterioration may also been seen. Women who are carriers of the disease occasionally experience the same symptoms, as well as others, including ataxia, hypertonia (excessive muscle tone), mild peripheral neuropathy, and urinary problems. The neonatal form affects both male and female infants and may produce mental retardation, facial abnormalities, seizures, retinal degeneration, poor muscle tone, enlarged liver, and adrenal dysfunction. Neonatal ALD usually progresses rapidly.

80. Adrenoleukodystrophy adrenoleukodystrophy. adrenoleukodystrophy (ALD) is a member of a group of diseases,leukodystrophies, that cause damage to the myelin sheath of nerve cells. http://www.hendrickhealth.org/healthy/000033.htm

MAIN SEARCH INDEX Adrenoleukodystrophy Definition Description Causes and symptoms Diagnosis ... Resources Definition Adrenoleukodystrophy is a rare genetic disease characterized by a loss of myelin surrounding nerve cells in the brain and progressive adrenal gland dysfunction. Description Adrenoleukodystrophy (ALD) is a member of a group of diseases, leukodystrophies, that cause damage to the myelin sheath of nerve cells. Approximately one in 100,000 people is affected by ALD. There are three basic forms of ALD: childhood, adult-onset, and neonatal. The childhood form of the disease is the classical form and is the most severe. Childhood ALD is progressive and usually leads to total disability or death . It affects only boys because the genetic defect is sex-linked (carried on the X chromosome). Onset usually occurs between ages four and ten and can include many different symptoms, not all of which appear together. The most common symptoms are behavioral problems and poor memory. Other symptoms frequently seen are loss of vision, seizures, poorly articulated speech, difficulty swallowing, deafness, problems with gait and coordination, fatigue , increased skin pigmentation, and progressive dementia The adult-onset form of the disease, also called adrenomyeloneuropathy, is milder, progresses slowly, is usually associated with a normal life span, and usually appears between ages 21-35. Symptoms may include progressive stiffness, weakness, or

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