81. Amyotrophic Lateral Sclerosis Or Lou Gehrig's Disease: Aging Begins At 30: Virtu Aging Begins at 30. amyotrophic lateral sclerosis or Lou Gehrig's Disease. See relatedPatient Topics amyotrophic lateral sclerosis or Brain and Nervous System. http://www.vh.org/adult/patient/internalmedicine/aba30/2001/lougehrigsdisease.ht

For Patients Aging Begins at 30 Amyotrophic Lateral Sclerosis or Lou Gehrig's Disease Ian Maclean Smith, M.D. Emeritus Professor Department of Internal Medicine University of Iowa Hospitals and Clinics Creation Date: June 2001 Last Revision Date: June 2001 Peer Review Status: Internally Peer Reviewed It's amyotrophic because the muscle supplied by the dead nerve cells wastes away; lateral because it affects the side of the spinal cord; and sclerosis because if you feel the cord in that region at autopsy the tissue feels very hard. It's Lou Gehrig's because the record-breaking first baseman and hitter died of it aged 38 in 1941. It is an adult-onset disease first described in France by Charcot in 1874. The disease affects men more than women and usually after age 40. Cells that are motor in function in the brain and spinal cord die and can no longer send messages to the muscles. There are signs of involvement of the brain to cord nerves (upper motor neurons) and of the cord to muscle nerves, (lower motor neurons). Most cases are sporadic, but about 5% occur in affected families. One unusual site for ALS is Guam where the disease is 50 times as prevalent as elsewhere. Viruses and prions have been looked for as a cause and not found. Initially the symptoms are difficulty in swallowing, slurred speech, and painless weakness in the hands or legs. The affected muscles show fasciculations that are rippling contractions seen through the skin or in the tongue. There is no curative treatment, although Rilutek (formerly Riluzole), an anti-glutamate medicine, adds months to patients' lifespan but does not relieve symptoms. At least 14 other drugs have been tested in controlled clinical trials and found to be ineffective. The disease progresses and patients usually die in three to five years, when the muscles controlling breathing fail. The brain, consciousness, eye movements and bladder muscles do not fail.

82. Riluzole For Amyotrophic Lateral Sclerosis (ALS)/motor Neuron Disease (MND) (Coc Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND)(Cochrane Review). Miller RG, Mitchell JD, Lyon M and Moore DH. ABSTRACT. http://www.update-software.com/abstracts/ab001447.htm

From The Cochrane Library, Issue 1, 2003 Abstract also available in Italian Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND) (Cochrane Review) Miller RG, Mitchell JD, Lyon M and Moore DH ABSTRACT Order full review View and/or submit comments What's new in this issue Search abstracts ... About The Cochrane Library A substantive amendment to this systematic review was last made on 20 February 2002. Cochrane reviews are regularly checked and updated if necessary. Background: Riluzole has been approved for treatment of patients with amyotrophic lateral sclerosis in many countries but not all. Questions persist about its clinical utility because of high cost, modest efficacy and concern over adverse effects. Objectives: To examine the efficacy of riluzole in prolonging survival, and in delaying the use of surrogates (tracheostomy and mechanical ventilation) to sustain survival. Search strategy: Search of the Cochrane Neuromuscular Disease Group Register for randomized trials and enquiry from authors of trials, Aventis (manufacturer of riluzole) and other experts in the field. The most recent search was May, 2001 Selection criteria: Types of studies: randomized trials Types of participants: adults with a diagnosis of amyotrophic lateral sclerosis Types of interventions: treatment with riluzole or placebo Types of outcome measures: Primary: pooled hazard ratio of tracheostomy-free survival over all time points with riluzole 100 mg.

83. Rinat Disease Areas - Amyotrophic Lateral Sclerosis amyotrophic lateral sclerosis amyotrophic lateral sclerosis (ALS), also calledLou Gehrig's disease, is a terminal degenerative neurological disorder http://www.rinatneuro.com/m_s_d_amyotrophic.htm

Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis (ALS), also called Lou Gehrig's disease, is a terminal degenerative neurological disorder characterized by a gradual deterioration in motor function as a result of the progressive degeneration of motorneurons. The disease follows a relentless course, often starting with muscle weakness in the limbs and culminating in respiratory paralysis and death, usually within two to five years after diagnosis. ALS affects 30,000 people in the U.S. and 70,000 worldwide with over 10,000 new cases diagnosed each year. Patients suffering from ALS require 24-hour intensive care at a cost exceeding $200,000 per patient per year. Additionally, ALS is responsible for one out of every 100,000 deaths in people over age 20. There is no known cure for the disease. Currently available treatment options focus on relieving symptoms and helping patients cope. Rinat is developing a protein-based therapeutic

84. Amyotrophic Lateral Sclerosis amyotrophic lateral sclerosis (ALS). Key Words Nacetylaspartate; magneticresonance spectroscopy; amyotrophic lateral sclerosis; riluzole. http://thor.bic.mni.mcgill.ca/als.html

85. Amyotrophic Lateral Sclerosis: A Guide For Patients And Families, 2nd Edition - Sclerosis. amyotrophic lateral sclerosis A Guide For Patients and Families,2nd Edition Hiroshi Mitsumoto, MD Theodore L, Munstat, MD http://www.demosmedpub.com/book111.html

April 2001 470 pages Soft Cover Regular Price: Discount Price: For related titles see: Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis: A Guide For Patients and Families, 2nd Edition Hiroshi Mitsumoto, M.D. Theodore L, Munstat, M.D. "A somewhat clinical, but very comprehensive guide to medical treatment, rehabilitation, day-to-day living, end-of-life issues, and supportive resources." Disability Resources Monthly "...well written and avoids jargon and highly technical language. It would serve as a useful introduction to clinicians who are dealing with ALS for the first time as well as a guide to patients and families." Physical Therapy, Elizabeth H. Littell, PT, PhD, January 2002 ALS, also known as "Lou Gehrig's disease", cannot be cured but it can be treated. A great deal can be done by physicians and other health care professionals to treat the symptoms of ALS, to improve the patient’s quality of life, and to help caregivers and families to cope with the disease. This extensively revised and rewritten new edition is specifically addressed to the needs of patients and families living with the reality of ALS. Since publication of the first edition of this book, the understanding and treatment of ALS have changed dramatically. The many puzzles of this disease are being steadily solved. One cause of familial ALS has been identified, and the mechanisms of motor neuron cell death are much better understood. The FDA has approved riluzole, the first drug available for the treatment of ALS. Additional drugs are being tested and others are on the horizon.

86. Disease Category Listing (160): Amyotrophic Lateral Sclerosis (ALS) CenterWatch Listing of Clinical Research Trials for amyotrophic lateral sclerosis(ALS). Clinical Trials amyotrophic lateral sclerosis (ALS). Massachusetts. http://www.centerwatch.com/patient/studies/cat160.html

Clinical Trials: Amyotrophic Lateral Sclerosis (ALS) Massachusetts Boston; Massachusetts General Hospital ALS Gene Study Boston; Massachusetts General Hospital Celebrex in Subjects with Amyotrophic Lateral Sclerosis (ALS) Back to Clinical Trials by Medical Areas Research centers specializing in this illness area Additional resources ... in this illness area This site is run by CenterWatch, a publishing company that focuses on the clinical trials industry. The information provided in this service is designed to help patients find clinical trials that may be of interest to them, and to help patients contact the centers conducting the research. CenterWatch is neither promoting this research nor involved in conducting any of these trials. Trial listing updated: March 25, 2003 at 12:16:21 PM Patient Resources: [ Trial Listing Notification Services Drug Directories About Clinical Research ... Patient Bookstore Professional Resources: [ Research Center Profiles Industry Provider Profiles Industry News Professional Resources ... Professional Bookstore General: [ Search Site Map Your Privacy CW World ... Home This site was developed in association with Illumina Interactive of Boston, MA

87. ThirdAge - Adam - Amyotrophic Lateral Sclerosis amyotrophic lateral sclerosis. Definition amyotrophic lateral sclerosisis a disorder involving loss of the use and control of muscles. http://www.thirdage.com/health/adam/ency/article/000688.htm

document.write(''); document.write(''); document.write('<'); document.write('/SCRIPT>'); document.write(''); document.write(''); document.write('<'); document.write('/A>'); document.write('<'); document.write('/NOSCRIPT>'); document.write('<'); document.write('/IFRAME>'); Activities Computers Family Tree Health ... Prevention Amyotrophic lateral sclerosis Definition: A disorder causing progressive loss of control of voluntary muscles due to destruction of nerve cells in the brain and spinal cord. Alternative Names: Lou Gehrig's disease; ALS Causes, incidence, and risk factors: Amyotrophic Lateral Sclerosis is a disorder involving loss of the use and control of muscles. The nerves controlling these muscles are destroyed, which results in loss of muscle tissue due to the lack of nervous stimulation. Muscle strength and coordination decreases, beginning with the voluntary muscles (those under conscious control, such as the muscles of the arms and legs). The extent of loss of muscle control continues to progress, and more and more muscle groups become involved. There may be a loss of nervous stimulation to semi-voluntary muscles, such as the muscles that control breathing and swallowing. There is no effect on ability to think or reason. 5- 10% of cases are thought to be due to a genetic mutation. The rest of the cases are sporadic. Though it is still not known what precisely is the cause of the nerve cell destruction, it is thought to be due to free radical injury associated with toxicity of glutamate, a neurotransmitter.

88. Cogprints - Language Impairments In ALS/MND (Amyotrophic Lateral Sclerosis/Motor Language impairments in ALS/MND (amyotrophic lateral sclerosis/Motor NeuronDisease). Corpus callosum atrophy in amyotrophic lateral sclerosis. http://cogprints.ecs.soton.ac.uk/archive/00002438/

Cogprints Home About Browse Search ... Help Language impairments in ALS/MND (Amyotrophic Lateral Sclerosis/Motor Neuron Disease) Bongioanni, Dr. Paolo and Buoiano, Dr. Giancarlo and Magoni, Dr. Marzia (2002) Language impairments in ALS/MND (Amyotrophic Lateral Sclerosis/Motor Neuron Disease). In Proceedings European Society for Philosophy and Psychology Meeting 2002 , pages 20-21, Lyon, France. Full text available as: PDF - Requires Adobe Acrobat Reader or other PDF viewer. Abstract c Corresponding author: Giancarlo Buoiano Via del Morello 8 Bargecchia I-55040 Corsanico (LU) email: giancarlo@neurolinguistics.0catch.com Language impairments in Amyotrophic Lateral Sclerosis/Motor Neuron Disease (ALS/MND) Abstract We review 6 papers on Motor Neuron Disease (MND) and language impairments. ALS/MND (Amyotrophic Lateral Sclerosis/MND) is an wide-ranging term used to cover several derangements of the motor neurons. ALS/MND brings to progressive degeneration of the motor neurons. The motor neurons control the muscles that consent us to move and act. Until some years ago, ALS/MND was thought not to affect language and higher-order cognitive functions, but at present it is acknowledged that about 3-5% of patients affected by ALS/MND show cognitive impairments. Up to date, it is not possible to establish whether this subgroup is affected by ALS/MND and Fronto-Temporal Dementia (FTD) or FTD/Aphasia syndrome or whether FTD/aphasia syndrome can be, in some cases, a consequence of ALS/MND. Furthermore, it is not clear whether MND/FTD syndrome brings to language breakdown or whether MND/Aphasia can be considered a self-standing syndrome. Lexical category-specific impairments affect more often than not verbs, while nouns appear to be by some means preserved. The verbs deficit is remarkable because it can place a new light on the link between actions, verbal and cognitive imagery, and ideomotor praxis. Language impairments detected in ALS/MND point largely to frontal and frontostriatal damages.

89. NIH Guide: AMYOTROPHIC LATERAL SCLEROSIS amyotrophic lateral sclerosis NIH GUIDE, Volume 22, Number 7, February 19, 1993PA NUMBER PA93-54 PT 34 Keywords Neuromuscular Disorders Biology, Cellular http://grants.nih.gov/grants/guide/pa-files/PA-93-054.html

Return to 1993 Index Return to NIH Guide Main Index Department of Health and Human Services National Institutes of Health (NIH) 9000 Rockville Pike Bethesda, Maryland 20892

90. SUPPLEMENTARY THERAPEUTIC MEASURES IN AMYOTROPHIC LATERAL SCLEROSIS SUPPLEMENTARY THERAPEUTIC MEASURES IN amyotrophic lateral sclerosis/MOTORNEURO DISEASE Author David Atkinson BACKGROUND More http://www.baar.com/atk_rept.htm

SUPPLEMENTARY THERAPEUTIC MEASURES IN AMYOTROPHIC LATERAL SCLEROSIS/MOTOR NEURO DISEASE Author: David Atkinson BACKGROUND: More than 120 years of symptomatic treatment has produced little more then frustration and despair for patient and physician alike. Most likely there will not be a single drug or therapy which will overcome ALS. REVIEW SUMMARY: This recent and on-going study, involving Supplementary Therapeutic Measures in ALS, has produced relevant strategies which have impacted ALS patients significantly, by (1) producing improved quality of life, (2) stabilization and reversal of symptoms, (3) as well as extended life survival. The Combination of Supplementary Therapeutic Measures include: Deprogramming the negative emotional mind-set that occurs when one receives a terminal diagnosis, and replacing the debilitating negative effect with a positive self-empowering thought process -Meditation - Visualization - Guided imagery - Improved family environment - Biofeedback - Spirituality - Massage - Healthy nutrition - Antioxidants. Additionally, a large segment of the ALS population, involved in this study, has used an Electrical application, the The Baar* Battery.

91. Amyotrophic Lateral Sclerosis - Cambridge University Press Home Catalogue amyotrophic lateral sclerosis. Related Areas AmyotrophicLateral Sclerosis. A Synthesis of Research and Clinical Practice. http://books.cambridge.org/0521581036.htm

Home Catalogue Related Areas: Medicine New titles Email For updates on new titles in: Medicine Amyotrophic Lateral Sclerosis A Synthesis of Research and Clinical Practice Andrew Eisen, Charles Krieger In stock Amyotrophic lateral sclerosis otherwise known as Lou Gehrig’s or motor neuron disease is one of several degenerative diseases of the aging nervous system. This text neatly synthesises the recent explosion of research into this particular condition to construct a detailed and comprehensive overview. From its epidemiology, molecular biology and pathophysiology right through to clinical assessment and care, Drs Eisen and Krieger bring their research expertise and extensive clinical experience to provide this practical and thought-provoking account. Reviews ‘ this volumes strengths - its clarity, brevity, and breadth of vision - are to be applauded. Where else would one find tidy one paragraph descriptions of the basis of magnetic resonance spectroscopy, or the difference between an odds ratio and a relative risk? I have already lent out my copy of this handy little one volume summation and recommend it as a launchpad for readers’ further investigations into ALS/MND.’Matthew Parton, Journal of Neurology, Neurosurgery and Psychiatry ‘This excellent review of ASL is well-written in a languabge easily understood even by medical students and residents. Thus it appeals to health professionals involved in the care of patients with the disease and makes it different from other books written on this subject.’Cristina Y. Go, Doody's Journal

92. HealthlinkUSA Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease AhHa. Click here for page 1 of amyotrophic lateral sclerosis (Lou Gehrig'sDisease) information from the HealthlinkUSA directory. Save on Drugs Here. http://www.healthlinkusa.com/14ent.htm

93. Rocky Mountain Amyotrophic Lateral Sclerosis Association (ALS) Chapter information and support for people with amyotrophic lateral sclerosis (ALS or LouGehrig's Disease) based in Denver, Colorado and serving the Rocky Mountain http://www.alsaco.org/

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94. Amyotrophic Lateral Sclerosis Last updated June, 2002. Electrical Stimulation In Amyotrophic LateralSclerosis. Adobe Reader Version. Because amyotrophic lateral http://www.ifess.org/Services/Consumer_Ed/ALS.htm

Last updated: June, 2002 Electrical Stimulation In Amyotrophic Lateral Sclerosis Adobe Reader Version Because amyotrophic lateral sclerosis [ALS] is a chronic disorder in which there may be periods of spasticity and muscle weakness and then a long term period of mower motor neuron degeneration and "flaccid paralysis," the indications for and the application of electrical stimulation [ES] will vary with the symptoms and functional limitations. ES may be helpful in the management of spasticity, with resulting improvement in muscle performance, urinary incontinence, breathing and a reduction in pain. Applications that involve the use of skin electrodes may be accomplished with a variety of commercially available electrical stimulation devices that are small, battery powered and inexpensive. Implantable electrical stimulation technology would be selected by the surgeon. Management Of Spasticity: As a result of ES, spasticity has been reduced, pain was less, bowel and bladder function improved and voluntary use of the hand increased as a result of reduction in interfering spasticity. Maintaining Or Improving Joint Range Of Motion: For the ALS individual who has sufficient nerve supply to the muscles, ES can be used to move the joint to the end of the available range or it can be combined with the patient's exercise to be sure the patient is going to the end of the range and stretching just a bit. Electrical stimulation for this purpose has advantages over vigorous manual range of motion including the use of the individual’s muscles to gain the range in a gentle manner without traumatizing the tissues and it can be done several times during the day as part of a home program.

95. Amyotrophic Lateral Sclerosis Links amyotrophic lateral sclerosis (ALS, Lou Gehrig’s Disease) Amyotrophic LateralSclerosis (MedicineNet, Inc.) amyotrophic lateral sclerosis (ALS) (National http://phg.mc.vanderbilt.edu/Disease Links/amyotrophic_lateral_sclerosis_links.h

Amyotrophic Lateral Sclerosis (ALS, Lou Gehrig’s Disease) Amyotrophic Lateral Sclerosis (MedicineNet, Inc.) Amyotrophic Lateral Sclerosis (ALS) (National Institute of Neurological Disorders and Stroke) Amyotrophic Lateral Sclerosis: Lou Gehrig's Disease (American Academy of Family Physicians) Facts About Amyotrophic Lateral Sclerosis (ALS) (Muscular Dystrophy Association) Glimmer of Hope for People with ALS (Food and Drug Administration) Last Updated by Brian Scruggs

96. Departmental Directory: Amyotrophic Lateral Sclerosis Clinic the 27710 ZIP code. amyotrophic lateral sclerosis Clinic. 6813386 SeeNeurology Division. Departmental Directory Alphabetical Listings http://www.duke.edu/deptdir/Amyotrophic_Lateral_Sclerosis_Clinic.html

Resources Admissions Medical Center Administration Unless otherwise indicated: All telephone numbers are area code All addresses are Durham, NC. All box numbers are in the ZIP code except Medical Center box numbers, which are in the ZIP code. Amyotrophic Lateral Sclerosis Clinic See Neurology Division Departmental Directory Alphabetical Listings A B C D ... A Search the Departmental Directory People Pages Duke Welcome Page Libraries Student Services ... Updates and corrections to this listing can be submitted online Other questions or problems with this service should be sent to webmaster@www.duke.edu Last updated March 30, 2003

97. Amyotrophic Lateral Sclerosis amyotrophic lateral sclerosis. Definition. amyotrophic lateral sclerosis.New York, Oxford University Press, 1997. Periodicals Ansevin CF. http://www.healthatoz.com/healthatoz/Atoz/ency/amyotrophic_lateral_sclerosis.htm

Encyclopedia Index A Home Encyclopedia Encyclopedia Index A Amyotrophic lateral sclerosis Definition Amyotrophic lateral sclerosis (ALS) is a disease that breaks down tissues in the nervous system (a neurodegenerative disease) of unknown cause that affects the nerves responsible for movement. It is also known as motor neuron disease and Lou Gehrig's disease, after the baseball player whose career it ended. Description ALS is a disease of the motor neurons, those nerve cells reaching from the brain to the spinal cord (upper motor neurons) and the spinal cord to the peripheral nerves (lower motor neurons) that control muscle movement. In ALS, for unknown reasons, these neurons die, leading to a progressive loss of the ability to move virtually any of the muscles in the body. ALS affects "voluntary" muscles, those controlled by conscious thought, such as the arm, leg, and trunk muscles. ALS, in and of itself, does not affect sensation, thought processes, the heart muscle, or the "smooth" muscle of the digestive system, bladder, and other internal organs. Most people with ALS retain function of their eye muscles as well. However, various forms of ALS may be associated with a loss of intellectual function ( dementia ) or sensory symptoms.

98. Multiple Sclerosis, Amyotrophic Lateral Sclerosis, Lou Gehrig's Disease Support amyotrophic lateral sclerosis (ALS, Lou Gehrig's Disease) Websites. AmyotrophicLateral Sclerosis Advocacy Existing for patients and families affected by ALS. http://www.supportpilot.com/neuro.html

Diseases and Conditions Relating to Neurology Amyotrophic Lateral Sclerosis (ALS, Lou Gehrig's Disease) Websites Amyotrophic Lateral Sclerosis Advocacy Existing for patients and families affected by ALS. ALS Amyotrophic Lateral Sclerosis Discussion Board at Support-group.com ALS Association Dedicated to Public Awareness and Research of Lou Gehrig's Disease. Mailing List (Bob Broedel) Sign up for Email mailing list (not a list-serv) Travel Society for Advancement of Travel for the Handicapped 347 Fifth Avenue, Ste. 610 New York, NY 10016 (212) 447-SATH Multiple Sclerosis (MS) Websites National Organization for Multiple Sclerosis A national organization dedicated to promoting research and education about MS. Medsupport FSF International MedSupport is a non-profit Internet site that provides support and information for Multiple Sclerosis patients and their families. MS Foundation Multiple Sclerosis Foundation offers services free of charge. Support for Those Affected by Multiple Sclerosis Multiple Sclerosis Support HOME

99. University Of Miami School Of Medicine - Glossary - Amyotrophic Lateral Sclerosi Diseases and Conditions. amyotrophic lateral sclerosis. amyotrophic lateral sclerosis(ALS or Lou Gehrig's Disease ). What is amyotrophic lateral sclerosis? http://www.med.miami.edu/patients/glossary/art.asp?articlekey=265

100. Adult Health Advisor 2002.1: Amyotrophic Lateral Sclerosis (ALS) amyotrophic lateral sclerosis (ALS). What is amyotrophic lateral sclerosis (ALS)?ALS is a disease that causes gradual loss of control and weakness of muscles. http://www.med.umich.edu/1libr/aha/aha_als_sha.htm

Adult Health Topics All Health Topics Find a UMHS Doctor Search Adult Topics Search All Topics T his information is not a tool for self-diagnosis or a substitute for medical treatment. You should speak to your physician or make an appointment to be seen if you have questions or concerns about this information or your medical condition. McKesson Clinical Reference Systems: Adult Health Advisor 2002.1 Amyotrophic Lateral Sclerosis (ALS) What is amyotrophic lateral sclerosis (ALS)? ALS is a disease that causes gradual loss of control and weakness of muscles. The mind is usually not affected, despite worsening weakness of the body. ALS is also called Lou Gehrig's disease, after a well-known baseball player who died of ALS. It is rare. About 1 new case per 100,000 people is diagnosed each year. Symptoms most often appear in people who are between 40 and 70 years old. The symptoms worsen more rapidly in some people than in others, eventually leading to death. How does it occur?

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