81. Advanced Search A Discussion of the antiphospholipid syndrome. The term antiphospholipidsyndrome originally described the clinical association http://www.aafp.org/afp/20020601/tips/11.html

Advanced Search Tips from Other Journals Previous Next A Discussion of the Antiphospholipid Syndrome The term "antiphospholipid syndrome" originally described the clinical association between antiphospholipid antibodies and a syndrome of hypercoagulability. The criteria for diagnosis of antiphospholipid syndrome and the terminology of the disease have evolved over the years as the relevant pathophysiology and immunology have become better understood. Levine and colleagues discuss antiphospholipid syndrome, an uncommon (but not rare) disease with serious risks of arterial and venous thrombosis as well as recurrent pregnancy loss. -glycoprotein I autoantibodies are another class of autoantibodies strongly associated with the syndrome, but they are not presently included in the consensus criteria. Antibody screening is typically performed in persons with early or recurrent thrombotic episodes. The authors note that the risk of clinical sequelae is most elevated in persons with laboratory evidence of antiphospholipid syndrome and additional risk factors that predispose to thrombosis (e.g., oral contraceptive use, immobility) or atherosclerotic damage to blood vessels (e.g., hyperlipidemia, smoking, diabetes). Both arterial and venous thromboses can be present in patients with antiphospholipid syndrome and can involve virtually any organ. Deep venous thrombosis of the leg is the most common venous occlusion, while stroke and transient ischemic attacks are the most frequently occurring arterial complications. Other signs in patients with antiphospholipid syndrome are concomitant thrombocytopenia and hemolytic anemia.

82. Anti-Neutrophil Antibody Clinical Significance The antiphospholipid syndrome (APS) is currently recognizedas a common risk factor for arterial or venous thromboembolic disease. http://www.aruplab.com/guides/clt/tests/clt_al58.htm

ARUP's Guide to Clinical Laboratory Testing (CLT) A B C D ... Search Note: Test code links throughout this Guide refer to the corresponding test in the User's Guide. Anti-Neutrophil Antibody Test Number: Methodology: Flow Cytometry Circulating antibodies in patient's serum are measured by flow cytometry after incubation with normal neutrophils. Values greater than 2 standard deviations of the control population are interpreted as "weakly positive" and those greater than 3 standard deviations are reported as "positive." Clinical Significance: Circulating antibodies to neutrophils can mediate neutropenia in a number of different disorders including systemic lupus erythematosus (SLE), Felty's syndrome, and drug-induced neutropenia. Isoimmune destruction of neutrophils also occurs in febrile transfusion reactions and in isoimmune neonatal neutropenia. In the latter circumstance, maternal isoimmunization is presumed to be responsible (analogous to fetal erythroblastosis). Anti-neutrophil antibodies may include anti-HLA antibodies. Reference Interval: Negative References: Boxer LA, et. al. Autoimmune neutropenia. N Engl J Med 1975; 293:748.

83. Information About Antiphospholipid Syndrome Information About the antiphospholipid syndrome. Information Aboutthe antiphospholipid syndrome The antiphospholipid syndrome is http://www.slrapls.org/InfoAS.html

Information About the Antiphospholipid Syndrome Information About the Antiphospholipid Syndrome The antiphospholipid syndrome is a blood clotting disorder that can sometimes lead to strokes, heart attacks, miscarriages, and other serious problems. This disorder is relatively common in patients with lupus (SLE), but it is also found in people who do not have lupus. The antiphospholipid syndrome is diagnosed when a person with a blood clotting problem is found to have one or more autoantibodies in their blood. Autoantibodies are proteins made by the immune system. Normally the purpose of immune antibodies is to attack foreign invaders such as bacteria and viruses. Instead of attacking foreign substances, however, autoantibody proteins can stick to parts of a person’s own body. This can interfere with important bodily functions or it can cause generalized inflammation. It is probably normal for transient autoantibodies to arise from time to time, especially during infections, but under most circumstances the immune system will rapidly compensate for the presence of these potentially harmful antibodies, either by covering them up with other antibodies or by quickly stopping their manufacture. In people with the antiphospholipid syndrome, as in people with other autoimmune diseases, the autoantibodies may persist for many years, eventually leading to harmful consequences. The particular autoantibodies that are found in the antiphospholipid syndrome seem to have a particular ability to bind to structures related to the fats (phospholipids) that make up cell membranes. Many of these autoantibodies have a specific interaction with one or more of the proteins that regulate blood clotting, which are often found on the surface of cell membranes. Taken together, these autoantibodies are collectively known as antiphospholipid antibodies (APL) and lupus anticoagulants (LA).

84. ANTIPHOSPHOLIPID SYNDROME This information can be found by going to www.heartcenteronline.com ANTIPHOSPHOLIPIDSYNDROME Back To Top. What is antiphospholipid syndrome? http://www.heartcenteronline.com/myheartdr/common/artprn_rev.cfm?filename=&ARTID

85. Health Library - Antiphospholipid Syndrome antiphospholipid syndrome. Synonyms Disorder Subdivisions General DiscussionResources Synonyms. Antiphospholipid Antibody Syndrome; APLS; APS. http://health_info.nmh.org/Library/HealthGuide/IllnessConditions/topic.asp?hwid=

86. Qango : Health: Diseases And Conditions: A: Antiphospholipid Syndrome (APS) category Options Help. Home Health Diseases and Conditions A antiphospholipid syndrome (APS), Suggest a Site. Health, etc. If you http://www.qango.com/dir/Health/Diseases_and_Conditions/A/Antiphospholipid_Syndr

Chat Forums Free Email Personals Classifieds ... Help Qango Directory Antiphospholipid Syndrome (APS) all of Qango only this category Options Help Home Health ... A > Antiphospholipid Syndrome (APS) Suggest a Site Health, etc If you would like to suggest a site for this category please click here Home Health Diseases and Conditions ... A > Antiphospholipid Syndrome (APS) Suggest a Site Home Suggest a Site Search ... Login

87. P030106a - Catastrophic Antiphospholipid Syndrome - Plasmapheresis Catastrophic antiphospholipid syndrome Plasmapheresis. Question Is plasmapheresisan effective therapy for the catastrophic antiphospholipid syndrome? http://www.emory.edu/WHSCL/grady/amreport/litsrch02/p030106a.html

Catastrophic Antiphospholipid Syndrome - Plasmapheresis 1/06/03 (Arellano) Question: Is plasmapheresis an effective therapy for the catastrophic antiphospholipid syndrome? Link Directly to Fulltext article in Ovid Unique Identifier:11882732 Authors: Levine JS. Branch DW. Rauch J. Institution: Department of Medicine, Section of Nephrology, University of Chicago, USA. Title: The antiphospholipid syndrome.[comment]. [Review] [96 refs] Source: New England Journal of Medicine. 346(10):752-63, 2002 Mar 7. Link Directly to Fulltext article in Ovid Unique Identifier:10961585 Authors: Asherson RA. Cervera R. Institution: Department of Medicine, The Groote School Hospital, University of Cape Town School of Medicine, South Africa. ashspot@icon.co.za Title: Catastrophic antiphospholipid syndrome. [Review] [13 refs] Source: Current Opinion in Hematology. 7(5):325-9, 2000 Sep. Link Directly to Fulltext article in Ovid Unique Identifier:9653431 Authors: Asherson RA. Cervera R. Piette JC. Font J. Lie JT. Burcoglu A. Lim K. Munoz-Rodriguez FJ. Levy RA. Boue F. Rossert J. Ingelmo M. Institution: Rheumatic Diseases Unit, University of Cape Town School of Medicine, South Africa.

88. TCL - Reference - Antiphospholipid Syndrome Search TCL. antiphospholipid syndrome Douglas C. Aziz MD, Ph.D. ClinicalFeatures. 30 Diagnosis of Antiphospholipid Antibody Syndrome. http://www.tclonline.com/referance/antiphospho.htm

Click here to print this page Search TCL Antiphospholipid Syndrome Douglas C. Aziz M.D., Ph.D. Clinical Features Four clinical features are common in patients with antiphospholipid syndrome (APS): venous thrombosis, arterial thrombosis, pregnancy loss and thrombocytopenia. Approximately half of the patients present with primary APS (no associated systemic disease); the remainder have secondary APS associated with other diseases such as systemic lupus erythematosus (SLE), other connective tissue diseases, HIV or other infections, malignancy and drug-induced APS. APS is now recognized as one of the most important causes of hypercoagulability and thrombosis. Thrombosis is the most common presentation of APS, and the site of thrombosis (arterial or venous) can define two syndromes with different clinical and laboratory features: anticardiolipin (ACA)-positive APS and lupus anticoagulant (LA)-positive APS. The prevalence, etiology and management of these to distinct but related syndromes are different. ACA-APS is more common than LA-APS; the relative prevalence is 5 to 1. Both are associated with thrombosis, fetal wastage and thrombocytopenia. ACA-APS is associated with both arterial and venous thrombosis including deep vein thrombosis and pulmonary embolus, premature coronary artery disease and premature cerbrovascular disease. In contrast, LA-APS is more commonly associated with venous thrombosis involving (in addition to peripheral venous thrombosis) mesenteric, renal, hepatic and portal veins and vena cava.

89. Hotdog Express Version 1.0 Document Features background information, message board, chat room, and related links. http://www.mindspring.com/~waxman/

Antiphospholipid Antibody Syndrome (APS) On The Net This Page Was Created On 3/22/98, Last Modified On 12/18/99 Our MESSAGE Board on Delphi is up and running. Its a YEAR old, and there are Thousands of messages for you to look at! Lots of people like YOU who also have APS who want to talk. Come Join US!! See Below For Link!! Information and Links concerning Antiphospholipid Antibody Syndrome, Antiphospholipid Syndrome, APLS, APS This Site Was Created By Mark Waxman Keywords: Antiphospholipid Antibody Syndrome, Antibodies, APLS, APS, Blood, Clot, Clotting, Disorder, Heart, Lupus The information presented here is for informational and educational purposes only and should not be used for diagnostic or treatment purposes, in other words, they are not a substitute for medical care or treatment by a qualified professional. If you believe that you have Antiphospholipid Antibody Syndrome, see your Doctor or Healthcare Professional immediately. The author of this web page is NOT a Doctor or Healthcare Professional but IS an individual who has been diagnosed with Antiphospholipid Antibody Syndrome. What Is Antiphospholipid Antibody Syndrome, (APS)?

90. Health And Medical Information: Diseases And Conditions, Medical Dictionary, Pro A look at antiphospholipid antibody syndrome, what laboratory tests can support the diagnosis of this syndrome, what are the causes and how is it treated. http://www.medicinenet.com/Script/Main/Art.asp?li=MNI&d=255&cu=16583&

91. Delphi Forum Registration page for the antiphospholipid antibody syndrome group. http://login.prospero.com/dir-login/index.asp?webtag=APSANTIBODY&lgnDST=http

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