1. EMedicine - Central Pontine Myelinolysis : Article By Christopher C Luzzio, MD central pontine myelinolysis An introduction, clinical features, differencials, work up, treatment Category Health Conditions and Diseases......central pontine myelinolysis Adams et al described central pontine myelinolysis(CPM) as a unique clinical entity. central pontine myelinolysis. http://www.emedicine.com/neuro/topic50.htm

document.write(''); (advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Neurology Neurotoxicology Central Pontine Myelinolysis Last Updated: March 12, 2001 Rate this Article Email to a Colleague Synonyms and related keywords: osmotic myelinolysis AUTHOR INFORMATION Section 1 of 9 Author Information Introduction Clinical Differentials ... Bibliography Author: Christopher C Luzzio, MD , Clinical Assistant Professor, Department of Neurology, University of Wisconsin at Madison Christopher C Luzzio, MD, is a member of the following medical societies: American Academy of Neurology Editor(s): Howard A Crystal, MD , Professor, Departments of Neurology and Pathology, State University of New York Downstate Medical Center; Francisco Talavera, PharmD, PhD , Senior Pharmacy Editor, Pharmacy, eMedicine; Richard J Caselli, MD , Chairperson, Department of Neurology, Professor, Department of Neurology, Mayo Clinic of Scottsdale; Selim R Benbadis, MD

2. Metabolic Disorders: Central Pontine Myelinolysis, Marchiafava-Bignami Disease Neuropathology of MarchiafavaBignami Disease and central pontine myelinolysis central pontine myelinolysis. Case 1. Related Internet Resources http://www.neuropat.dote.hu/alcoh.htm

Metabolic Disorders Marchiafava-Bignami disease Case 1 Case 2 Related Internet Resources MRI Images - University of Florida, US Central pontine myelinolysis Case 1 Related Internet Resources Myelinolysis after Correction of Hyponatremia, Annals of Internal Medicine, 1997, 126:57-62 Other Resources Central Pontine Myelinolysis, eMedicine Demyelinating Diseases - Internet Handbook of Neurology Toxic Disorders - Internet Handbook of Neurology var site="sm5hegeduskdote" Last modified: February 17, 2001 If you have any comments, please, contact Neuroanatomy Structures Online Neuropathology Atlas Internet Handbook of Neurology

3. Pediatric Database central pontine myelinolysis. DEFINITION A neurodegenerative disorder characterized by degeneration of the CNS white http://www.icondata.com/health/pedbase/files/CENTRALP.HTM

Pediatric Database (PEDBASE) Discipline: CNS Last Updated: 5/21/94 CENTRAL PONTINE MYELINOLYSIS DEFINITION: A neurodegenerative disorder characterized by degeneration of the CNS white matter that primarily affects the pons. EPIDEMIOLOGY: incidence: ? age of onset: mostly in adults but has been seen in children as young as 3 years risk factors: 1. Major iatrogenic - rapid correction of hyponatremia other electrolyte disturbances, alcoholism, liver disease 2. Minor adrenal insufficiency, brain tumor, carcinoma, cerebral edema, chemotherapy, congestive heart failure, cranio-pharyngioma, Hodgkin's Disease, hyperglycemic coma, leukemia, malnutrition, renal disease, sepsis, sickle cell disease, Wilson's Disease PATHOGENESIS: 1. Background affected areas tend to be those with extensive grey-white matter apposition: base of pons, striatum, thalamus, geniculate bodies PATHOLOGY: 1. In Affected Areas destruction of myelin shealth, i.e., basis pontis (base of pons) absent or decreased oligodendroglia foamy macrophages CLINICAL FEATURES: 1. Neurological Manifestations

4. EMedicine - Central Pontine Myelinolysis : Article Excerpt By: Christopher C Luz central pontine myelinolysis Adams et al described central pontine myelinolysis(CPM) as a unique clinical entity. Excerpt from central pontine myelinolysis. http://www.emedicine.com/neuro/byname/central-pontine-myelinolysis.htm

(advertisement) Excerpt from Central Pontine Myelinolysis Synonyms, Key Words, and Related Terms: osmotic myelinolysis Please click here to view the full topic text: Central Pontine Myelinolysis Background: Adams et al described central pontine myelinolysis (CPM) as a unique clinical entity. They published their findings in 1958, observing that patients who suffered from alcoholism or malnutrition developed spastic quadriplegia, pseudobulbar palsy, and varying degrees of encephalopathy or coma from acute, noninflammatory demyelination that centered within the basis pontis. Contemporary physicians recognize that CPM occurs inconsistently as a complication of severe and prolonged hyponatremia, particularly when corrected too rapidly. Standard of care requires judicious treatment of electrolyte disturbances to reduce the incidence of osmotic myelinolysis. Pathophysiology: CPM is concentrated, frequently symmetric, noninflammatory demyelination within the central basis pontis. In at least 10% of patients with CPM, demyelination also occurs in extrapontine regions, including the mid brain, thalamus, basal nuclei, and cerebellum. The exact mechanism that strips the myelin sheath is unknown. One theory proposes that in regions of compact interdigitation of white and gray matter, cellular edema, which is caused by fluctuating osmotic forces, results in compression of fiber tracts and induces demyelination. Prolonged hyponatremia followed by rapid sodium correction results in edema. During the period of hyponatremia, the concentration of intracellular charged protein moieties is altered; reversal cannot parallel a rapid correction of electrolyte status. The term "osmotic myelinolysis" is more appropriate than "central pontine myelinolysis" for demyelination occurring in extrapontine regions after the correction of hyponatremia.

5. MEDLINEplus Medical Encyclopedia: Central Pontine Myelinolysis central pontine myelinolysis. The most common cause of central pontine myelinolysisis a rapid, drastic change in sodium levels in the body. http://www.nlm.nih.gov/medlineplus/ency/article/000775.htm

Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Central pontine myelinolysis Contents of this page: Illustrations Alternative names Definition Causes, incidence, and risk factors ... Prevention Illustrations Central nervous system Alternative names Return to top CPM Definition Return to top Central pontine myelinolysis is a condition characterized by nerve damage caused by the destruction of the covering layer ( myelin sheath) of nerve cells in the brainstem (pons). Causes, incidence, and risk factors Return to top The destruction of the myelin sheath that coats nerves inhibits impulse conduction within the cell and thus decreases its ability to communicate with other cells. The most common cause of central pontine myelinolysis is a rapid, drastic change in sodium levels in the body. Most commonly, this occurs when someone is being treated for low levels of sodium ( hyponatremia ) and the levels rise too fast, but it can occasionally occur when high levels of sodium in the body (hypernatremia) are corrected too quickly. This condition does not occur spontaneously; it is a complication of either treatment for other conditions or the other conditions themselves.

6. Central Pontine Myelinolysis Medical Encyclopdia article about central pontine myelinolysis A resource with information on over 4000 medical topics including central pontine myelinolysis http://www.marylandsids.com/medical-terms/02060.htm

Central pontine myelinolysis A Medical Encyclopedia Article provided by North Arundel Hospital A resource with information on over 4000 medical topics including: Central pontine myelinolysis Previous Next

7. Central Pontine Myelinolysis central pontine myelinolysis. toxic demyelination; rapid correctionof hyponatremia. low density in central pons variable size; may http://chorus.rad.mcw.edu/doc/00066.html

CHORUS Collaborative Hypertext of Radiology Nervous system Feedback Search central pontine myelinolysis toxic demyelination rapid correction of hyponatremia low density in central pons variable size may have paired, rounded lesions enhances in acute phase See also: demyelinating diseases white-matter diseases Charles E. Kahn, Jr., MD - 2 February 1995 Last updated 14 March 2001 Medical College of Wisconsin

8. Central Pontine Myelinolysis central pontine myelinolysis rapid correction of hyponatremia low density in central pons may have paired, rounded lesions enhances in acute phase © 2002, C.E. http://chorus.rad.mcw.edu/to-go/00066.html

central pontine myelinolysis toxic demyelination rapid correction of hyponatremia low density in central pons variable size may have paired, rounded lesions enhances in acute phase See also: demyelinating diseases white-matter diseases Home Nervous system

9. Nervous System - CHORUS artery anastomoses; cavernous sinus; central pontine myelinolysis; cephalohematoma;cerebellopontine angle (CPA) tumor; cerebellum; cerebrospinal http://chorus.rad.mcw.edu/index/1.html

CHORUS Collaborative Hypertext of Radiology Search by title Nervous system acoustic neuroma acute disseminated encephalomyelitis acute spinal cord compression adenoma sebaceum ... white-matter disease Charles E. Kahn, Jr., MD, Editor 1 January 2003 Medical College of Wisconsin

10. Health Ency.: Disease: Central Pontine Myelinolysis There is no known cure for central pontine myelinolysis and treatment is focused on relieving symptoms. http://www.gopbi.com/shared/health/adam/ency/article/000775trt.html

SEARCH: The Web Yellow Pages HOME Illustrated Health Encyclopedia Important notice Ency. home Disease C Central pontine myelinolysis Overview Symptoms Treatment Prevention Treatment This is an emergency disorder that requires hospitalization for initial diagnosis and treatment. There is no known cure for central pontine myelinolysis and treatment is focused on relieving symptoms. Double vision may be reduced with the use of an eye patch. Physical therapy, may help maintain muscle strength, mobility, and function in weakened arms and legs. Prognosis The neurologic damage caused by central pontine myelinolysis is usually persistent. The disorder can cause serious chronic disability. Complications Permanent neurologic losses Decreased ability to work or care for self Decreased ability to interact with others Call Your Health Care Provider If: Go to the emergency room or call the local emergency number (such as 911) if seizures muscle weakness , or other symptoms of central pontine myelinolysis occur. Ency. home Disease C Please read this Important notice Also Check Out Home Autos Classifieds Events ... Advertise here By using GoPBI.com you accept the terms of our

11. 1Up Health > Central Pontine Myelinolysis > Causes, Incidence, And Risk Factors Comprehesive information on central pontine myelinolysis (CPM ). Central pontinemyelinolysis Causes, Incidence, and Risk Factors. Alternative names CPM. http://www.1uphealth.com/health/central_pontine_myelinolysis_info.html

1Up Health Central pontine myelinolysis Alternative Medicine Clinical Trials ... Health Topics A-Z Search 1Up Health Central pontine myelinolysis Information Central pontine myelinolysis Causes, Incidence, and Risk Factors Alternative names : CPM Definition : Central pontine myelinolysis is a condition characterized by nerve damage caused by the destruction of the covering layer ( myelin sheath) of nerve cells in the brainstem (pons). Causes, Incidence, and Risk Factors The destruction of the myelin sheath that coats nerves inhibits impulse conduction within the cell and thus decreases its ability to communicate with other cells. The most common cause of central pontine myelinolysis is a rapid, drastic change in sodium levels in the body. Most commonly, this occurs when someone is being treated for low levels of sodium ( hyponatremia ) and the levels rise too fast, but it can occasionally occur when high levels of sodium in the body (hypernatremia) are corrected too quickly. This condition does not occur spontaneously; it is a complication of either treatment for other conditions or the other conditions themselves. Risks include hyponatremia from any cause.

12. 1Up Health > Central Pontine Myelinolysis (CPM ) Information Comprehesive information on central pontine myelinolysis (CPM ). 1UpHealth Diseases Conditions central pontine myelinolysis. http://www.1uphealth.com/health/central_pontine_myelinolysis.html

1Up Health Alternative Medicine Clinical Trials Health News ... Health Topics A-Z Search 1Up Health Central pontine myelinolysis Information Guide Alternative names : CPM Definition : Central pontine myelinolysis is a condition characterized by nerve damage caused by the destruction of the covering layer ( myelin sheath) of nerve cells in the brainstem (pons). Jump to a Section of this Guide Definition Causes, Incidence, and Risk Factors Symptoms Prevention ... Calling your Health Care Provider Related Tools and Utilities Search Books on Amazon: Read Articles on eLibrary: Health Products on drugstore.com: Alcoholism Cranial mononeuropathy VI Delirium Dilutional hyponatremia (SIADH) ... More More Topics Chronic Confusion Consciousness - decreased Constipation ... More Search 1Up Health A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org). URAC's accreditation program is the first of its kind, requiring compliance with 53 standards of quality and accountability, verified by independent audit. A.D.A.M. is among the first to achieve this important distinction for online health information and services. Learn more about A.D.A.M.'s editorial reviewers . A.D.A.M. is also a founding member of Hi-Ethics (www.hiethics.com) and subscribes to the principles of the Health on the Net Foundation (www.hon.ch). Home Contact Us Privacy Links Directory

13. ThirdAge - Adam - Central Pontine Myelinolysis Activities Beauty Style Computers Family Tree Health Horoscopes Love Money Travel Overview Symptoms Treatment Prevention central pontine myelinolysis Alternative Names CPM Treatment This is an emergency disorder that requires http://www.thirdage.com/health/adam/ency/article/000775trt.htm

document.write(''); document.write(''); document.write('<'); document.write('/SCRIPT>'); document.write(''); document.write(''); document.write('<'); document.write('/A>'); document.write('<'); document.write('/NOSCRIPT>'); document.write('<'); document.write('/IFRAME>'); Activities Computers Family Tree Health ... Prevention Central pontine myelinolysis Alternative Names: CPM Treatment: This is an emergency disorder that requires hospitalization for initial diagnosis and treatment. There is no known cure for central pontine myelinolysis and treatment is focused on relieving symptoms. Double vision may be reduced with the use of an eye patch. Physical therapy may help maintain muscle strength, mobility and function in weakened arms and legs. Expectations (prognosis): The neurologic damage caused by central pontine myelinolysis is usually persistent. The disorder can cause serious chronic disability. Complications: Permanent neurologic losses Decreased ability to work or care for self Decreased ability to interact with others Calling your health care provider: Go to the emergency room or call the local emergency number (such as 911) if seizures muscle weakness , or other symptoms of central pontine myelinolysis occur.

14. Central Pontine Myelinolysis The symptoms of central pontine myelinolysis are quadriparesis, pseudobulbar palsy and changing levels of consciousness, http://www.amersham-health.com/medcyclopaedia/Volume%20VI%201/CENTRAL%20PONTINE%

Medcyclopaedia About Medcyclopaedia Amersham Health Search for: Type a word or a phrase. All forms of the word are searchable. Advanced search Browse entry words starting with: A B C D ... Other characters Try our Medcyclopaedia Premium Edition with added tools and functionality tailored to make your working day easier. The following tools are presently available: Expanded search *For Medical Professionals only, registration required Central pontine myelinolysis, (also called osmotic demyelination), demyelinating disorder found in alcoholics or in association with many systemic disorders with electrolyte abnormalities. Because of the common association with rapidly corrected hyponatraemia, the term "osmotic demyelination syndrome" has been proposed. The symptoms of central pontine myelinolysis are quadriparesis, pseudobulbar palsy and changing levels of consciousness, including coma and death. Histologically, the area of myelin breakdown is sharply demarcated and displays extensive loss of oligodendrocytes, infiltration with foamy macrophages and reactive astrocytosis. At MR the lesion is characterized by T2 hyperintensity in a central pontine location ( Fig.1

15. Central Pontine Myelinolysis Subject central pontine myelinolysis Topic Area Myelin Forum The Neurology andNeurosurgery Forum Question Posted By Ottilie on Saturday, March 04, 2000 http://www.medhelp.org/forums/neuro/messages/30435a.html

Advertisement Welcome to Med Help International A not-for-profit organization Questions in The Neurology Forum are being answered by doctors from The Cleveland Clinic , consistently ranked one of the best hospitals in America. Subject: central pontine myelinolysis Topic Area: Myelin Forum: The Neurology and Neurosurgery Forum Question Posted By: Ottilie on Saturday, March 04, 2000 Would like to know if any research is being done on this disease on the brain stem (pons). I have it plus it has caused down beat nystagmus which prevents me from driving. The psychological impact is terrible. I also would like to find someone with this disease. So far I have not. Answer Posted By: CCF Neuro[P] MD, RPS on Saturday, March 04, 2000 Dear Ottilie: Central pontine myelinosis is usually results from changes in the osmolarity (electrolyte and protein concentration) in the brain versus the blood stream. The abnormal difference between the two causes the myelin surrounding the nerve processes to become unraveled. This inturn causes dysfunction of the nerves in this area. This is not a disease, but the result from an abnormality. Pontine problems can also arise from stroke in the pons. This will give similar symptoms (although much more focal, such as only downbeat mystagmus). If the stroke is large enough, it can cause complete loss of most movement below the eyes.

16. Central Pontine Myelinolysis Subject central pontine myelinolysis Topic Area Traumatic Brain Injury ForumThe Neurology and Neurosurgery Forum Question Posted By gsoh on Monday http://www.medhelp.org/forums/neuro/messages/30819a.html

Advertisement Welcome to Med Help International A not-for-profit organization Questions in The Neurology Forum are being answered by doctors from The Cleveland Clinic , consistently ranked one of the best hospitals in America. Subject: Central Pontine Myelinolysis Topic Area: Traumatic Brain Injury Forum: The Neurology and Neurosurgery Forum Question Posted By: gsoh on Monday, September 25, 2000 Her cognitive abilities were not affected albeit minor behavioral change. She has improved from assisted standing to self-gait walking (500 meters) over 6 weeks. Able to stand up on her own from a few limited sitting positions. Her right hand is able to hold a small cup of water. Taking a deep breath to hold on is still a difficulty. Rollover on bed is still very difficult. The strongest part of the four limbs at right leg is still having difficulty for coordinated movement. She was discharged on 23/8/00 and being 24 hours attended in the home. I am obviously more interested to know any chances of speeding up the process of re-myelination before it is too late. I started reading about the myelin reformation. Unfortunately, I cannot find any resources that confirm positively the process in adult brain cells. Nor is there any authority to rule out the process or point to the timing of a brain damage like CPM or other brain disorders. I started giving her Omega-3 oil, colloidal form minerals, Vitamin B6, B12. I read about IgG that may act with adult Oligodendroglia for the re-myelination process. So I give her chewable tablets of colostrums which contained high concentration of Immunoglobulin G. All these, being health food supplements, in my mind, should have minimal side effects.

17. Central Pontine Myelinolysis After Alcohol Withdrawal central pontine myelinolysis after Alcohol Withdrawal Click here for article writtenby Isabelle KornLubetzki, MD, Yelena Virozub, MD and Hedi Orbach, MD. http://212.199.79.240/imaj/aug02-21.htm

18. Central Pontine Myelinolysis CPM central pontine myelinolysis, central pontine myelinolysis in an alcoholicpatient with an admitting serum sodium of 160 (normal up to 145). http://uscneurosurgery.com/glossary/c/cpm.htm

Central pontine myelinolysis Injury to the pons (brainstem) usually due to excessively rapid correction of hypernatremia (excessive sodium in the blood). Hypernatremia is not uncommon in alcoholic patients who are relatively dehydrated. Cross section of the pons with evidence of central tissue death. Gregory Pinsky MD USC Neuropathology Central pontine myelinolysis in an alcoholic patient with an admitting serum sodium of 160 (normal up to 145). During correction of his hypernatremia with infusion of a dilute (low sodium) intravenous water solution the patient became progressively sleepier until her lapsed into a coma and died. The pons is swollen with abnormal white areas where myelinolysis (death of the myelin cells that normally surround neurons) has occured. Gregory Pinsky MD USC Neuropathology Return to uscneurosurgery.com Homepage

19. Neurosurgical Terms C CP (Cerebellopontine) angle. CPM (central pontine myelinolysis). CPP (Cerebralperfusion pressure). central pontine myelinolysis (CPM). Cephalohematoma. http://uscneurosurgery.com/glossary/terms plain english c.htm

A B C D ... Z C -cephaly C fibers peripheral nerves C waves of intracranial pressure (ICP) CMRO ... Cysticercosis C Return to uscneurosurgery.com Homepage

20. Health Ency.: Disease: Central Pontine Myelinolysis Ency. home Disease C central pontine myelinolysis. Central pontinemyelinolysis. Ency. home Disease C central pontine myelinolysis. http://www.accessatlanta.com/shared/health/adam/ency/article/000775.html

SEARCH: The Web Yellow Pages HOME AJC.COM Illustrated Health Encyclopedia Important notice Ency. home Disease C Central pontine myelinolysis Overview Symptoms Treatment Prevention Definition: Central pontine myelinolysis is a condition characterized by neurologic damage caused by the destruction of the covering layer ( myelin sheath) of nerve cells in the brainstem (pons). Causes and Risks The destruction of the myelin sheath inhibits impulse conduction along the nerve cell. The most common cause of this condition is rapid correction of low sodium levels in the body (hyponatremia). Less commonly, this also occurs from rapid correction of high levels of sodium in the body (hypernatremia). Risks include hyponatremia from any cause. Alcoholism Wernicke-Korsakoff syndrome , and general ill health and malnutrition associated with serious illnesses (cachexia) increase the risk of central pontine myelinolysis. This condition does not occur spontaneously, but it results from other conditions that cause the damage. Ency. home Disease C Please read this Important notice Also Check Out Subscribe to The Atlanta Journal-Constitution Home Autos Classifieds ... Our Sponsors By using AccessAtlanta.com you accept the terms of our

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