1. NINDS Soto's Syndrome Information Page Also known as cerebral gigantism, an information sheet compiled by NINDS.Category Health Conditions and Diseases Soto s Syndrome...... My privacy NINDS is part of the National Institutes of Health. NINDS Soto's SyndromeInformation Page Synonym(s) cerebral gigantism Reviewed 0701-2001 http://www.ninds.nih.gov/health_and_medical/disorders/sotos.htm

National Institute of Neurological Disorders and Stroke Accessible version Science for the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system Browse all disorders Browse all health organizations More about Soto's Syndrome Studies with patients Research literature Press releases Search NINDS... (help) Contact us My privacy NINDS is part of the National Institutes of Health NINDS Soto's Syndrome Information Page Synonym(s): Cerebral Gigantism Reviewed 07-01-2001 Get Web page suited for printing Email this to a friend or colleague Table of Contents (click to jump to sections) What is Soto's Syndrome? Is there any treatment? What is the prognosis? What research is being done? ... Organizations What is Soto's Syndrome? Soto's syndrome is a rare genetic disorder characterized by excessive physical growth during the first 2 to 3 years of life. The disorder may be accompanied by mild mental retardation, delayed motor, cognitive, and social development, hypotonia (low muscle tone), and speech impairments. Children with Soto's syndrome tend to be large at birth and are often taller, heavier, and have larger heads (macrocrania) than is normal for their age. Symptoms of the disorder, which vary among individuals, include a disportionately large and long head with a slightly protrusive forehead, large hands and feet, hypertelorism (an abnormally increased distance between the eyes), and downslanting eyes. Clumsiness, an awkward gait, and unusual aggressiveness or irritability may also occur. Although most cases of Soto's syndrome occur sporadically, familial cases have also been reported.

2. American Academy Of Family Physicians - Obese Children Sotos'. cerebral gigantism, physical overgrowth, hypotonia, delayed motor and cognitive development http://www.aafp.org/afp/990215ap/861.html

Advanced Search Evaluation and Treatment of Childhood Obesity REBECCA MORAN, M.D. Gilbert, Arizona A patient information handout on helping your child keep a healthy weight, written by the authors of this article, is provided on page 871. A patient information handout on helping your child lose weight, written by the authors of this article, is provided on page 873. A It is also directly related to all-cause mortality. Treatment of obesity in adults is notoriously frustrating for patients and physicians alike, and it rarely meets with long-term success. Thus, prevention is the best hope for decreasing the prevalence of this condition. In many obese people, the roots of their disorder can be traced back to childhood. Obesity tends to "track" throughout life, meaning that its presence at any age will increase the risk of persistence at subsequent ages. While most obese infants will not remain so, they are at increased risk of becoming obese children. These children are in turn more likely to become obese adolescents, who are then very likely to remain obese as adults. See editorial on page 758.

3. Tall Stature cerebral gigantism Page, Growth Index. http://www.fpnotebook.com/END42.htm

Home About Links Index ... Editor's Choice Paid Advertisement (click above). Please see the privacy statement Endocrinology Growth Assorted Pages Delayed Growth Calculation of Growth Delay Growth Delay Onset Determination Achondroplasia ... Risser Sign Tall Stature Book Home Page Cardiovascular Medicine Dental Dermatology Emergency Medicine Endocrinology Gastroenterology General Medicine Geriatric Medicine Gynecology Hematology and Oncology HIV Infectious Disease Jokes Laboratory Neonatology Nephrology Neurology Obstetrics Ophthalmology Orthopedics Otolaryngology Pediatrics Pharmacology Prevention Psychiatry Pulmonology Radiology Rheumatology Sports Medicine Surgery Urology Chapter Endocrinology Index Adrenal Disease General Cardiovascular Medicine Diabetes Mellitus Examination Ophthalmology Geriatric Medicine Growth Hematology and Oncology Hypoglycemia Laboratory Metabolism Neonatology Obesity Obstetrics Parathyroid Disease Pediatrics Pharmacology Pituitary Disease Prevention Radiology Nephrology Sex Sports Medicine Surgery Symptom Evaluation Thyroid Disease Page Growth Index Short Short Calculation Short Onset Short Achondroplasia Short Constitutional Short Familial Tall Tall Cerebral Gigantism Causes Constitutional or Familial Tall Stature Growth hormone secreting tumors ( Gigantism Thyrotoxicosis Homocystinuria Cerebral Gigantism ... Soto Syndrome Beckwith-Wiedemann Syndrome Omphalocele Macrosomia Macroglossia Hypoglycemia Congenital Adrenal Hyperplasia (Untreated, pubertal)

4. ELibrary.com - The Mosby Medical Encyclopedia 10-01-1996, 'cerebral eLibrary is the subscription based online library for fun or research. Find out more about securing your guaranteed Free 7day trial with your credit card and retrieve 'eLibrary.com - The Mosby Medical Encyclopedia 10-01-1996, 'cerebral gigantism'' http://redirect-west.inktomi.com/click?u=http://ask.elibrary.com/getdoc.asp%3Fpu

5. Health Library: All Topics: C: Cerebral Gigantism - Healthfinder® This minifact sheet provides basic consumer information about this genetic disorder,also known as cerebral gigantism because of the distinctive head shape http://www.healthfinder.gov/Scripts/SearchContext.asp?topic=146

6. Health Library: All Topics: C: Cerebral Gigantism - Healthfinder® home health library all topics C cerebral gigantism. categories and relatedtopics. find a specific kind of information on cerebral gigantism http://www.healthfinder.gov/Scripts/SearchContext.asp?topic=146&refine=1

7. ClinicalTrials.gov - Linking Patients To Medical Research Search Query Details. No studies were found for cerebral gigantism ALLFIELDS. ModifyYour Search. Individual Terms, Count. cerebral gigantism , None. Gigantism , None. http://www.clinicaltrials.gov/search/term=Cerebral Gigantism

8. What Is Sotos Syndrome? Sotos Syndrome, also known as cerebral gigantism because of the distinctive headshape and size, is a genetic condition causing physical overgrowth during the http://www.well.com/user/sssa/whatisit.htm

What is Sotos Syndrome? Translate this page with InterTran (tm) Deutsch Français Español Portuguese Japanese (Shift JIS) Finnish Italiano Svensk Russian/Ðóññêèé (CP 1251) Nederlands Brasileiro Danske Íslenska Norsk Croatian/hrvatski (CP 1250) Hungarian/Magyar (CP 1250) Polish/polski (CP 1250) Czech/ceski (CP 1250) Bulgarian (CP 1251) Romanian Serbian/srpski (Latin) Slovenian/slovenski (CP 1250) Greek/Åëëçíéêüò Welsh/'n Cymraeg Please MOVE AND HOLD your MOUSE CURSOR over the little DOWN ARROWS in the translated web page in order to see a pop-up window with ALTERNATIVE TRANSLATIONS. Excerpts from: "Sotos Syndrome: A Handbook for Families" by Rebecca Rae Anderson, M.S., J.D. Bruce A. Buehler, M.D. (This handbook is an exellent (really excellent!!!) resource for professionals and parents, alike. We encourage you to order copies not only for yourself, but also as an information source for your school, your library, your relatives, and even your doctor Sotos Syndrome, also known as cerebral gigantism because of the distinctive head shape and size, is a genetic condition causing physical overgrowth during the first years of life. Ironically, this rapid physical development is often accompanied by delayed motor, cognitive and social development. Muscle tone is low, and speech is markedly impaired.

9. NINDS - Neurological Disorder Information Neurological disorder information from NINDS, the National Institute of Neurological Disorders and Stroke. Cerebral Aneurysm. Cerebral Arteriosclerosis. Cerebral Atrophy. cerebral gigantism. Cerebral Palsy. CharcotMarie-Tooth http://www.ninds.nih.gov/health_and_medical/disorder_index.htm

National Institute of Neurological Disorders and Stroke Accessible version Science for the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system Browse all disorders Browse all health organizations More about a disorder Studies with patients Research literature Press releases Search NINDS... (help) Contact us My privacy NINDS is part of the National Institutes of Health Browse All Disorders (includes synonyms and research topics) Request mailed brochures Publicaciones en español Select a letter to jump to the disorder... or return to top of page A B C D ... Z A ADHD AIDS - Neurological Manifestations Acquired Epileptiform Aphasia Acute Disseminated Encephalomyelitis ... Autonomic Dysfunction Select a letter to jump to the disorder... or return to top of page A B C D ... Z B Back Pain Barth Syndrome Batten Disease Behcet's Disease ... Bulbospinal Muscular Atrophy Select a letter to jump to the disorder... or return to top of page A B C D ... Z C Canavan Disease Carpal Tunnel Syndrome Causalgia Cavernomas ... Cytomegalovirus Infection Select a letter to jump to the disorder... or return to top of page A B C D ... Z D Dancing Eyes-Dancing Feet Syndrome Dandy-Walker Syndrome Dawson Disease De Morsier's Syndrome ... Dystonias Select a letter to jump to the disorder... or return to

10. NINDS - News And Events Central Cord Syndrome Central Pain Syndrome Cephalic Disorders Cerebral AneurysmCerebral Arteriosclerosis Cerebral Atrophy cerebral gigantism Cerebral Palsy http://www.ninds.nih.gov/health_and_medical/news.htm

National Institute of Neurological Disorders and Stroke Accessible version Science for the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system Browse all disorders Browse all health organizations More about a disorder Studies with patients Research literature Press releases Search NINDS... (help) Contact us My privacy NINDS is part of the National Institutes of Health Please Select a Disorder (includes synonyms and research topics) Select a letter to jump to the disorder... or return to top of page A B C D ... Z A ADHD AIDS - Neurological Manifestations Acquired Epileptiform Aphasia Acute Disseminated Encephalomyelitis ... Autonomic Dysfunction Select a letter to jump to the disorder... or return to top of page A B C D ... Z B Back Pain Barth Syndrome Batten Disease Behcet's Disease ... Bulbospinal Muscular Atrophy Select a letter to jump to the disorder... or return to top of page A B C D ... Z C Canavan Disease Carpal Tunnel Syndrome Causalgia Cavernomas ... Cytomegalovirus Infection Select a letter to jump to the disorder... or return to top of page A B C D ... Z D Dancing Eyes-Dancing Feet Syndrome Dandy-Walker Syndrome Dawson Disease De Morsier's Syndrome ... Dystonias Select a letter to jump to the disorder... or return to

11. SOTOS SYNDROME (CEREBRAL GIGANTISM) Features Listed For SOTOS SYNDROME (cerebral gigantism). McKusick117550. Advanced bone age/large epiphyses; Advanced tooth eruption http://www.hgmp.mrc.ac.uk/dhmhd-bin/hum-look-up?1613

12. Result Of Search SOTOS SYNDROME (cerebral gigantism) 3;p;2114 GM1 (GENERALISED GANGLIOSIDOSIS TYPE1) 11;p;15 3;p;21-14 7;q;35-36 ROMANO-WARD SYNDROME. Cytogenetic Aberrations. http://www.hgmp.mrc.ac.uk/dhmhd-bin/hum-id-look2.pl?3 p 21

13. SOTOS SYNDROME growthstimulating material; also called cerebral gigantism Syndrome.CLINICAL FEATURES 1. Infancy/Childhood. birth weight and length http://www.icondata.com/health/pedbase/files/SOTOSYND.HTM

Pediatric Database (PEDBASE) Discipline: END Last Updated: 5/19/94 SOTOS SYNDROME DEFINITION: An endocrine disorder of unknown etiology characterized by gigantism, peculiar facies, and mental retardation. EPIDEMIOLOGY: incidence: rare (about 150 cases worldwide) age of onset: large at birth but diagnosis by 2-3 years risk factors: mostly sporadic but some autosomal dominant and autosomal recessive forms M = F PATHOGENESIS: 1. Background unknown but abnormal dermatographics and large size at birth suggest a prenatal abnormality; there may be a role for some as yet unidentified growth-stimulating material also called Cerebral Gigantism Syndrome CLINICAL FEATURES: 1. Infancy/Childhood birth weight and length usually greater than the 90th% mean weight and height are 3.9 kg and 55.2 cm, respectively may be respiratory and feeding problems in the neonatal period during the first 4-5 years, there may be a rapid increase in height but then the height remains parallel to the normal growth curve along or greater than the 95th% 2. Characteristic Features

14. Sotos' Syndrome (www.whonamedit.com) Sotos' syndrome A syndrome of excessive growth during the first 4 to 5 years oflife, cerebral gigantism, acromegalic features, and mild mental retardation http://www.whonamedit.com/synd.cfm/2464.html

Home List categories Eponyms A-Z Biographies by country ... Contact Sotos' syndrome Also known as: Nevo's syndrome Sotos' sequence Synonyms: Cerebral gigantism, cerebral gigantism in childhood, constitutional gigantism, gigantismus cerebralis, gigantismus constitutionalis, gigantismus idiopathicus, hypothalamic gigantism, macrostomia-mental retardation syndrome, mental retardation-overgrowth sequence, pituitary gigantism, prenatal gigantism with macrocephaly. Associated persons: S. Nevo Juan Fernandez Sotos Description: A syndrome of excessive growth during the first 4 to 5 years of life, with cerebral gigantism and generalised large muscles in childhood, acromegalic features, and a nonprogressive cerebral disorder with nonprogressive mild mental retardation and defective coordination. After early childhood growth seems to approach normal, remaining, however, two standard deviations above means for chronological age. Birth weight and length greater than normal. Other principal features are dolicocephaly, macrocrania, hypertelorism, antimongoloid palpebral slant, high-arched palate, frontal bossing, mandibular prognathism, and precocious dentition. Occasionally, obesity, convulsions, abnormal dermatoglyphic pattern. Both sexes. Most cases are sporadic but some are transmitted as an autosomal dominant trait. Sotos and collaborators in 1964 first defined this syndrome, which was already well known to paediatricians.

15. S. Nevo (www.whonamedit.com) geneticist Associated eponyms Sotos' syndrome A syndrome of excessive growth duringthe first 4 to 5 years of life, cerebral gigantism, acromegalic features http://www.whonamedit.com/doctor.cfm/2154.html

Home List categories Eponyms A-Z Biographies by country ... Contact S. Nevo Israeli human geneticist Associated eponyms: Sotos' syndrome A syndrome of excessive growth during the first 4 to 5 years of life, cerebral gigantism, acromegalic features, and mild mental retardation and defective coordination. Biography: Ole Daniel Enersen

16. 1Up Health > Soto's Syndrome [Cerebral Gigantism] - Birth Defects & Genetic Diso Soto's Syndrome cerebral gigantism . Read detailed informationabout Soto's Syndrome cerebral gigantism . Includes a set of http://www.1uphealth.com/medical/disease/birth-defects-genetic-disease/soto's-sy

Home Contact Us Privacy Caring For Your Well Being Alternative Medicine Clinical Trials Health News Poisons ... Health Topics A-Z Search 1Up Health 1Up Health Diseases and Conditions A B C D ... Z Soto's Syndrome [Cerebral Gigantism] Main Article What is Soto's Syndrome? Is there any treatment? What is the prognosis? What research is being done? ... Organizations Search: The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only they do not constitute endorsements of those other sites. Home Contact Us Privacy Links Directory

17. 1Up Health > Diseases, Conditions, Illnesses, And Disorders Information Alpha1 Antitrypsin Deficiency Angiomatosis cerebral gigantism Coffin Lowry SyndromeCongenital Facial Diplegia Cystic Fibrosis (CF) Encephalotrigeminal http://www.1uphealth.com/medical/disease/by-type.html

1Up Health Home Contact Us Privacy Caring For Your Well Being Alternative Medicine Clinical Trials Health News Poisons ... Health Topics A-Z Search 1Up Health Browse through this A-Z index of more than 1600 diseases, conditions, illnesses, and disorders with comprehensive information such as the causes, incidence, risk factors, symptoms, diagnosis, tests, signs, treatment, prognosis, expectations, complications, support groups, and tips on when to contact your health care provider. A B C D ... Z Frequently Requested Topics Arrhythmias Arthritis Asthma Back Pain ... Urinary tract Infection A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org). URAC's accreditation program is the first of its kind, requiring compliance with 53 standards of quality and accountability, verified by independent audit. A.D.A.M. is among the first to achieve this important distinction for online health information and services. Learn more about A.D.A.M.'s editorial reviewers . A.D.A.M. is also a founding member of Hi-Ethics (www.hiethics.com) and subscribes to the principles of the Health on the Net Foundation (www.hon.ch). Home Contact Us Privacy Links Directory

18. Database Search Results Database Search Results. Searched keywords for cerebral gigantism.Sotos Syndrome Support Association. NHIC Home Page http://www.health.gov/nhic/NHICScripts/Hitlist.cfm?Keyword=Cerebral Gigantism

19. Health Information Resource Database: Sotos Syndrome Support Association Sotos syndrome, also known as cerebral gigantism, is a neurological brainbaseddisorder resulting in physical and mental developmental delays in children. http://www.health.gov/NHIC/NHICScripts/Entry.cfm?HRCode=HR2419

20. Service Page - Pathologie Information DISEASE Nevo syndrome, Synonym(s) cerebral gigantism nevo type,MIM 601451, Sign(s) of the disease (21), Outpatient clinic(s). http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=GB&Expert=2691

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