1. CMTA: Charcot-Marie-Tooth Association charcotmarie-tooth disease http://www.charcot-marie-tooth.org/

We are pleased to present your renovated CMTA website. This is truly your site as it is intended to provide you with current useful information about CMT. Click for more info. Swim for the Cure Support Steve O'Donnell Click Here Enter Click here to Sign-Up A Visit to the Wayne State CMT Clinic in Detroit, Michigan Issues Affecting Children Scoliosis... A Secondary Concern with CMT Nerve Conduction Velocity Test Vocational Rehabilitation... ... Help the Cause... Push Rare Disease Legislation Together, we can educate, fund research, and promote public awareness of CMT as the most common cause of hereditary motor sensory neuropathy. What if? ...up to 26% of each purchase you made went to a worthy cause close to home? Join the iGive.com community and it can. When you shop at GreaterGood.com up to 15% of every purchase automatically goes to Charcot-Marie-Tooth Association at no extra cost to you. Feeling the need to volunteer your time or donate to a good cause? Check out our list of

2. Charcot-Marie-Tooth Disease - Neurologychannel Incidence and Prevalence Approximately 125,000 people in the UnitedStates have charcotmarie-tooth disease. CMT occurs slightly http://www.neurologychannel.com/charcot/

Home Search SiteMap Ask the Dr. ... Medical Store advertisement advertisement CHARCOT-MARIE- TOOTH DISEASE Overview Cause Symptoms Diagnosis ... Treatment CONDITIONS ADHD ALS Alzheimer's Disease Autism ... Carpal Tunnel Syndrome Cephalic Disorders Cerebral Palsy Charcot-Marie-Tooth Disease Dementia Encephalitis Epilepsy Essential Tremor ... Guillain-Barre Syndrome Headache Huntington's Disease Hydrocephalus Lou Gehrig's Disease ... Traumatic Brain Injury Vertigo TREATMENT OPTIONS Botulinum Toxin Therapy Epidural Injection Trigger Point Injection Vagus Nerve Stimulation RESOURCES Clinical Trials Links Videos ABOUT US Healthcommunities.com Pressroom Testimonial Overview Charcot-Marie-Tooth (CMT) disease is an inherited, degenerative peripheral nerve disorder that causes muscle weakness and atrophy in the feet, legs, hands, and forearms. It is characterized by progressive loss of use and sensation in the limbs. Charcot, Marie, and Tooth are the names of the physicians who identified the disease and described its symptoms. It is not the same as Charcot's foot disease , a neuropathic joint disease that is a common complication of diabetes mellitus. In CMT, the

3. Charcot-Marie-Tooth Disease (CMT) (aka HMSN Or Peroneal Muscular Atrophy (PMA)) charcotmarie-tooth disease (CMT) (Also known as Hereditary Motor and Sensory Neuropathy(HMSN) or Peroneal Muscular Atrophy (PMA)) Click for Materials En http://www.mdausa.org/disease/cmt.html

Charcot-Marie-Tooth Disease (CMT) (Also known as Hereditary Motor and Sensory Neuropathy (HMSN) or Peroneal Muscular Atrophy (PMA)) Click for and MDAchats Bookmark this page! It's your source for information and news about CMT and will be updated regularly. Quick Definition: Childhood to young adulthood. Weakness and atrophy of muscles of hands and lower legs, with foot deformities and some loss of sensation in feet. Slow but variable progression among individuals. Normal life span. Autosomal dominant, autosomal recessive, X-linked recessive, X-linked dominant. Find Your Local MDA Do you need to find MDA in your city? Enter your Zip code here for where to turn for clinics and medical services; support groups; summer camp; local events and volunteer and fund-raising opportunities close to home. For more articles and references, please use the search feature Basic References Special CMT Materials FAQ's and Simply Stated Articles ... News Releases Basic References Facts About Charcot-Marie-Tooth Disease "Ask the Experts" Responses about CMT "Ask the Experts" Responses to General Neuromuscular Questions Genetics and Neuromuscular Diseases ... General Interest Publications Special CMT Materials CMT and DS: From Clear-Cut Endings to Complex Beginnings North American Database of People with CMT being Established FAQ's and Simply Stated... Articles

4. Facts About Rare Muscular Dystrophies Describes the history and symptoms of CharcotMarie-Tooth, including inheritance patterns and efforts to find a cure for the disorder. http://www.mdausa.org/publications/fa-cmt.html

Facts About Charcot-Marie-Tooth Disease and Dejerine-Sottas Disease Charcot-Marie-Tooth Disease and Dejerine-Sottas Disease Dear Friends What Is Charcot-Marie-Tooth Disease? What Causes CMT? What Happens to Someone With CMT, and How Is It Treated? ... MDA Is Here to Help You George J. Donahue Dear Friends: I've lived with Charcot-Marie-Tooth disease This pamphlet has been prepared to give you the basic knowledge about CMT and Dejerine-Sottas disease that you'll need, in order to help you prepare for changes that may occur in your future. You'll learn that CMT is usually quite slow in progression and that, while it presents challenges in daily life, there are many techniques and devices to help you adapt to those challenges. You'll read that many different genetic causes of CMT have been found, and cases vary greatly. But CMT is almost never life-threatening, and it seldom affects the heart and breathing functions. Another important extended family in my life is the Muscular Dystrophy Association, which offers a great program of services, leads the world in CMT research and keeps us well informed about the disease. See " MDA Is Here to Help You ," for details of the Association's program.

5. Charcot-Marie-Tooth Disease of CM-T "How I AM" (hope this helps you understand) A Poem written about neuropathy (mine is CMT) by Janice De Vore-Robinson "Just The Way I Am" by Janice De Vore-Robinson......A http://www.geocities.com/parrotsville/C-M-T.html

Charcot-Marie-Tooth A Description of C-M-T "How I AM" (hope this helps you understand) A Poem written about neuropathy (mine is CMT) by Janice De Vore-Robinson "Just The Way I Am" by Janice De Vore-Robinson Doing time for no known crime Has been difficult for me It's hard to live with chronic pain That others cannot see The thief that robbed my body Stole my strength and left me pain I do my very best to cope I struggle to stay sane I miss our get-togethers I miss shopping at the mall It hurts me to be left behind It's not my choice at all I long for how it used to be When I could join right in To do the fun and simple things With family and friends You seldom call or visit You're tired of it, I guess Of always asking, "Come along" And never hearing, "Yes" I ache to be with all of you I wish I could explain How doing 'normal' things in life Can cause me so much pain I'm trapped inside this body With pain that has no end I grieve for all the things I've lost I'd like them back again When I decline to join you Please try to understand It's not that I don't want to It's just the way I am by Janice De Vore-Robinson Don't Call Me Disabled I have C-M-T 1 A Jazzy Power Chairs How Stella Got her Jazzy Back I got my Jazzy 1120 Power Chair 7/10/00 C-M-T Association MDA~Charcot-Marie-Tooth Disease (CMT) (Also known as Hereditary Motor and Sensory Neuropathy (HMSN) or Peroneal Muscular Atrophy (PMA)) ...A Guide to Related Materials on MDA's Web Site

6. CMTnet: Charcot-Marie-Tooth Disorders Information Exchange Information on research and treatment of CMT. Link to practitioner information and details of therapy and DNA testing. CMTnet is a repository of information for research and treatment of CharcotMarie-Tooth (CMT). http://www.ultranet.com/~smith/CMTnet.html

The purpose CMTnet is a repository of information for research and treatment of Charcot-Marie-Tooth (CMT). CMT is a hereditary progressive neuromuscular disorder that primarily effects the feet, legs and hands. CMTnet is intended to provide information for both the medical and non-medical communities. Last updated: 1/12/2000. Enter CMTnet

7. MEDLINEplus: Charcot-Marie-Tooth Disease Topics. charcotmarie-tooth disease. Contents Organizations. Search MEDLINEfor recent research articles on • charcot-marie-tooth disease. You http://www.nlm.nih.gov/medlineplus/charcotmarietoothdisease.html

Skip navigation Other health topics: A B C D ... List of All Topics Charcot-Marie-Tooth Disease Contents of this page: From the NIH General/Overviews Coping Diagnosis/Symptoms ... Organizations Search MEDLINE for recent research articles on Charcot-Marie-Tooth Disease You may also be interested in these MEDLINEplus related pages: Degenerative Nerve Diseases Muscle Disorders Brain and Nervous System Genetics/Birth Defects From the National Institutes of Health Charcot-Marie-Tooth Disease (National Institute of Neurological Disorders and Stroke) Charcot-Marie-Tooth Disorder (National Institute of Neurological Disorders and Stroke) General/Overviews Facts About Charcot-Marie-Tooth Disease (CMT) (Muscular Dystrophy Association) Also available in: Spanish Facts About Charcot-Marie-Tooth Disease (CMT): Questions and Answers (Muscular Dystrophy Association) Clinical Trials Clinical Trials: Identification of Gene Mutations in Families with Charcot-Marie-Tooth and Deafness (Muscular Dystrophy Association) Coping Bracing Experiences: Correct Braces Can Improve Mobility, Life (Muscular Dystrophy Association) Diagnosis/Symptoms Creatine Kinase Test (Muscular Dystrophy Association) Electromyography and Nerve Conduction Velocities (Muscular Dystrophy Association) Muscle Biopsies (Muscular Dystrophy Association) Research Facts About Charcot-Marie-Tooth Disease (CMT): MDA's Search For a Treatment or Cure (Muscular Dystrophy Association) From Clear-Cut Endings to Complex Beginnings: Researchers Probe the Origins of Charcot-Marie-Tooth Disease (Muscular Dystrophy Association)

8. MEDLINEplus Medical Encyclopedia: Charcot-Marie-Tooth Disease (hereditary) charcotmarie-tooth disease (hereditary). Treatment Return to top Thereis no known cure for charcot-marie-tooth disease. Treatment http://www.nlm.nih.gov/medlineplus/ency/article/000727.htm

Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Charcot-Marie-Tooth disease (hereditary) Contents of this page: Illustrations Alternative names Definition Causes, incidence, and risk factors ... Prevention Illustrations Central nervous system Alternative names Return to top Progressive neuropathic (peroneal) muscular atrophy; Hereditary peroneal nerve dysfunction; Neuropathy - peroneal (hereditary); Hereditary motor and sensory neuropathy Definition Return to top Charcot-Marie-Tooth disease defines a group of slowly progressive, inherited disorders that result from progressive damage to nerves. In addition to loss of sensation, there is wasting of muscle tissue in the feet and legs, then hands and arms. Causes, incidence, and risk factors Return to top Charcot-Marie-Tooth diseases involve damage to nerves (neuropathy), usually from demyelination or loss of the electrical insulation around nerve fibers. All nerves are affected, but motor nerves are disproportionately so. The nerves in the legs are affected first and most severely. Symptoms usually begin between mid-childhood and early adulthood. The disorder is inherited, with autosomal dominant and recessive as well as X-linked recessive inheritance patterns. At least four genes have been discovered to be the cause of this group of diseases.

9. Charcot-Marie-Tooth Syndrome charcotmarie-tooth disease (CMT) disease is named after its three discoverers,who first noted the disease around the turn of the century. http://www.ncbi.nlm.nih.gov/disease/Charcot.html

This Genes and Disease page has been moved to: Please update your bookmarks. If you are not automatically transported to the new page after 15 seconds, click on this link Genome View on chromosome 17 Databases PubMed the literature LocusLink collection of gene-related information OMIM catalog of human genes and disorders Information Charcot-Marie-Tooth Association patient support, education and research Charcot-Marie-Tooth International run by and for people who have CMT disease GeneClinics a medical genetics resource CHARCOT-MARIE-TOOTH disease (CMT) disease is named after its three discoverers, who first noted the disease around the turn of the century. It is the most common inherited peripheral neuropathy in the world, characterized by a slowly progressive degeneration of the muscles in the foot, lower leg, hand and forearm, and a mild loss of sensation in the limbs, fingers and toes. Full expression of CMT's clinical symptoms generally occurs by age 30. CMT is not a fatal disease, however, and the disorder does not affect normal life expectancy. CMT is a genetically heterogeneous disorder, in which mutations in different genes can produce the same clinical symptoms. In CMT, there are not only different genes but different patterns of inheritance. One of the most common forms of CMT is Type 1A. The gene for Type 1A CMT maps to chromosome 17 and is thought to code for a protein (PMP22) involved in coating peripheral nerves with myelin, a fatty sheath that is important for their conductance. Other types of CMT include Type 1B, autosomal-recessive and X-linked.

10. Welcome To CMT United Kingdom Support group for people with this disease and general information about it.Category Regional Europe charcot-marie-tooth disease...... Working to support those who are affected by charcotmarie-tooth disease, also knownas Hereditary Motor and Sensory Neuropathy or Peroneal Muscular Atrophy. http://www.cmt.org.uk/

CMT United Kingdom Working to support those who are affected by Charcot-Marie-Tooth Disease, also known as Hereditary Motor and Sensory Neuropathy or Peroneal Muscular Atrophy. Registered Charity No. 327971 Welcome to the website of the support group for people who are affected by Charcot-Marie-Tooth Disease, also known as Hereditary Motor and Sensory Neuropathy or Peroneal Muscular Atrophy. Coping with any medical condition for life is a daunting prospect, but is far more difficult if you can find little information about it or support. This is a problem faced by many people with CMT. Learning to cope with it often means a long search for answers and help. Our website, whilst it will not provide all of the answers, aims to perhaps give you a fresh insight into the condition as well as positive advice about how to live with it. There is also details of the CMT Book which contains a lot more information on CMT. Why not become a member of CMT United Kingdom and enjoy the benefits we are able to offer - ranging from the CMT book 'Charcot-Marie-Tooth Disease - A Practical Guide' through to local support groups, and of course CMT United Kingdom are always there to provide informed personal guidance if you need it.

11. NINDS Charcot-Marie-Tooth Disorder Information Page Information page compiled by National Institute of Neurological Disorders and Stroke.Category Health Conditions and Diseases charcot-marie-tooth disease...... charcotmarie-tooth disease Fact Sheet. charcot-marie-tooth disease fact sheet developedby the National Institute of Neurological Disorders and Stroke (NINDS). http://www.ninds.nih.gov/health_and_medical/disorders/charcot_doc.htm

National Institute of Neurological Disorders and Stroke Accessible version Science for the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system Browse all disorders Browse all health organizations More about Charcot-Marie-Tooth Disorder Studies with patients Research literature Press releases Search NINDS... (help) Contact us My privacy NINDS is part of the National Institutes of Health NINDS Charcot-Marie-Tooth Disorder Information Page Reviewed 07-08-2002 Get Web page suited for printing Email this to a friend or colleague Table of Contents (click to jump to sections) What is Charcot-Marie-Tooth Disorder? Is there any treatment? What is the prognosis? What research is being done? ... Additional resources from MEDLINEplus What is Charcot-Marie-Tooth Disorder? Is there any treatment? There is no cure or specific treatment for CMT. Proper foot care including custom-made shoes and leg braces may minimize discomfort and increase function. Physical therapy and moderate activity are often recommended to maintain muscle strength and endurance. For some patients, surgery may be beneficial. What is the prognosis?

12. Charcot-Marie-Tooth Disease Fact Sheet What is charcotmarie-tooth disease? What are the symptoms of Charcot-Marie-Toothdisease? The neuropathy of CMT affects both motor and sensory nerves. http://www.ninds.nih.gov/health_and_medical/pubs/CMT.htm

National Institute of Neurological Disorders and Stroke Accessible version Science for the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system Browse all disorders Browse all health organizations More about a disorder Studies with patients Research literature Press releases Search NINDS... (help) Contact us My privacy NINDS is part of the National Institutes of Health Charcot-Marie-Tooth Disease Fact Sheet Get Web page suited for printing Email this to a friend or colleague Request free mailed brochure Table of Contents What is Charcot-Marie-Tooth disease? What are the symptoms of Charcot-Marie-Tooth disease? What are the types of Charcot-Marie-Tooth disease? What causes Charcot-Marie-Tooth disease? ... Where can I get more information? What is Charcot-Marie-Tooth disease? Charcot-Marie-Tooth disease (CMT) is one of the most common inherited neurological disorders, affecting approximately 1 in 2,500 people in the United States. The disease is named for the three physicians who first identified it in 1886 - Jean-Marie-Charcot and Pierre Marie in Paris, France, and Howard Henry Tooth in Cambridge, England. CMT, also known as hereditary motor and sensory neuropathy (HMSN) or peroneal muscular atrophy, comprises a group of disorders that affect peripheral nerves. The peripheral nerves lie outside the brain and spinal cord and supply the muscles and sensory organs in the limbs. Disorders that affect the peripheral nerves are called peripheral neuropathies.

13. Charcot-Marie-Tooth Disease charcotmarie-tooth disease. Synonym Peroneal Muscular Atrophy, Hereditary Motorand Sensory Neuropathy. charcot-marie-tooth disease on-line discussion groups. http://www.familyvillage.wisc.edu/lib_cmtd.htm

Charcot-Marie-Tooth Disease Synonym: Peroneal Muscular Atrophy, Hereditary Motor and Sensory Neuropathy Who to Contact Where to Go to Chat with Others Learn More About It Web Sites ... Search AltaVista for "Charcot-Marie-Tooth Disease" Who to Contact CMT International 1 Springbank Drive St. Catharines, Ontario, Canada L2S 2K1 Fax: [905] 687-8753 E-mail: CMTINT@VAXXINE.COM CMT International provides support and information to persons who have Charcot-Marie-Tooth disease, their families, caregivers and professionals. They work with medical and research advisors, who constantly update research news and views as well as explore new treatment possibilities. CMT International publishes a bi-monthly newsletter which includes tips for parents of children with Charcot-Marie-Tooth disease, student scholarship applications and sharing information for seniors. There is also a continual update of a list of drugs that can make CMT worse. They also publish pamphlets and booklets on various aspects of CMT. Charcot-Marie-Tooth Association (CMTA) Crozer Mills Enterprise Center 601 Upland Avenue Upland, PA 19015 USA

14. Charcot-Marie-Tooth Disease charcotmarie-tooth disease On-Line Discussion Groups. Mailing Lists. ChatRooms. Chat Room at MGH Scroll down to charcot-marie-tooth disease. http://www.familyvillage.wisc.edu/lists/charcot.htm

Charcot-Marie-Tooth Disease On-Line Discussion Groups Mailing Lists MD-LIST Created as a forum for exchanging information about muscular dystrophy among patients, family, and friends. People interested in CMT are welcome. To subscribe, send a message to: MD-List-Request@Basix.COM In the body of your message type: SUBSCRIBE MD-List Web Boards Charcot-Marie-Tooth (CMT), HNPP and other Hereditary Motor Sensory Neuropathies at MGH Chat Rooms Chat Room at MGH Scroll down to Charcot-Marie-Tooth Disease If you know of an on-line discussion group that should be added to the list, please send a note to Linda Rowley at: rowley@waisman.wisc.edu Last updated 19-August-1997 by rowley@waisman.wisc.edu.

15. Hospital Practice: Charcot-Marie-Tooth Disease charcotmarie-tooth disease A Gene-Dosage Effect Lupski JR et al DNA duplicationassociated with charcot-marie-tooth disease type 1A. Cell 66219, 1991. http://www.hosppract.com/genetics/9705gen.htm

Molecular Genetics in Clinical Practice Charcot-Marie-Tooth Disease: A Gene-Dosage Effect JAMES R. LUPSKI Baylor College of Medicine A broad spectrum of inherited neuropathy has been traced to three myelin genes, yet in the two most common disorders, there is no mutated gene. Instead, a gene has an extra or missing copy, as part of a 1.5-megabase DNA duplication or deletion. Eventually, duplications may emerge as a large fraction of all mutations. The discoveries have implications even for acquired disordersincluding carpal tunnel syndrome. Dr. Lupski is Cullen Professor of Molecular and Human Genetics, Professor of Pediatrics, and Director, Medical Scientist Training Program, Baylor College of Medicine, Houston. In 1886, the French physicians Jean Martin Charcot and Pierre Marie, and independently the English physician Howard Henry Tooth, described an insidious, slowly progressive atrophy of distal limb muscles that would eventually be recognized as the most common inherited disorder of the peripheral nervous system. It is also among the most common of all genetic disorders, affecting one person in 2,500. Characteristically, the illness becomes evident during the first two decades of life. Often, patients are liable to trip and sprain their ankles, and footdrop forces them to lift the knee, resulting in an equine gait. Eventually, pes cavus appears, and distal muscle atrophy may cause a stork-leg appearance. Weakness of hand muscles usually begins later; in severe cases, claw-like deformity develops.

16. MEL: Charcot-Marie-Tooth charcotmarie-tooth disease. Charcot-Marie-Tooth Association; CMT News (Charcot-Marie-ToothDisease); Family Village on charcot-marie-tooth disease; Tooth Disease; http://mel.lib.mi.us/health/health-charcot.html

Michigan.gov Home HAL Home MeL Internet MeL Magazines and eBooks Health Information Resources About the Health Collection Back to the Health Index Medline Evaluating Health Information ... Michigan Health and Hospitals Charcot-Marie-Tooth Disease Charcot-Marie-Tooth Association CMT News (Charcot-Marie-Tooth Disease) Family Village on Charcot-Marie-Tooth Disease Muscular Dystrophy Association Facts About Charcot-Marie-Tooth Disease Charcot-Marie-Tooth Disease - Also known as Hereditary Motor and Sensory Neuropathy (HMSN) or Peroneal Muscular Atrophy Facts About Charcot-Marie-Tooth Disease National Alliance OF The DisAbled (NAOTD) CMT - Charcot Marie Tooth Disease National Institute of Neurological Disorders and Stroke Charcot-Marie-Tooth Disorder National Organization for Rare Disorders (NORD) Charcot Marie Tooth Disease Summary NeurologyChannel Charcot-Marie-Tooth Disease See also the MEL Muscular Dystrophy Page Back to the Neurological Disorders index page Selector and Collection Librarian: Metta Lansdale ( lansdale@mel.org

17. HealthlinkUSA Charcot-marie-tooth Disease Links AhHa. Click here for page 1 of charcot-marie-tooth disease informationfrom the HealthlinkUSA directory. Save on Drugs Here. Accutane; http://www.healthlinkusa.com/67ent.htm

18. Charcot-marie-tooth Disease; Treatment, Prevention, Cure charcotmarie-tooth disease Search here for information which may include treatment,diagnosis, prevention, support groups, email lists, messageboards http://www.healthlinkusa.com/content/67.html

Latest Health News Find Drug Information Health Calculators All Words Any Words A B C D ... Z Sunday, March 30, 2003 Alternative therapy struggles to bridge East-West divide Click here to read more Doctors are not following guidelines recommending flu and pneumonia vaccinations for hospitalized adults, leaving millions of elderly patients vulnerable to potentially deadly ailment Click here to read more A helping hand for uninsured; Agencies find ways to provide health care for area children Click here to read more The government has approved the first generic version of the acne drug, Accutane Click here to read more Gates to give India $100m for AIDS; Microsoft CEO begins controversy-laced trip to fight virus Click here to read more Allergies and Asthma Alternative Medicine Arthritis and Your Health ... Women's Health Sunday March 30, 2003 Spina Bifida: Spina Bifida is a rare birth disorder, affecting approximately 1 in 12-1400 live births. Click here to learn more Craniosynostosis: Sagittal Synostosis...males are affected about three times as often as females. Click here to learn more Spinal Cord Injury: Acts of violence have now overtaken falls as the second most common source of spinal cord injury.

19. Charcot-Marie-Tooth Disease Survey And Information Charcot Marie Tooth DiseaseDiagnosis,Rehabilitation,Survey Information. CMT DrugAlerts, CMT Journal Articles,. ****PLEASE READ DISCLAIMER*****. http://www.geocities.com/dgosling_rn/

We subscribe to the HONcode principles of the Health On the Net Foundation and the Medinex Code Of Online Excellence Check Your Drugs for interactions with other drugs. CMT - What is it? CMT Internet Links CMT Rehabilitation + Exercise CMT Survey * Unavailable at this time* CMT Survey Preliminary Results Diagnosis of CMT Discount Medical Books ... MDA Support for CMTers Medical Books and Medical Supplies "Numb Toes & Aching Soles": Book Review" "Problem With AFOs In CMT" Research Projects in CMT ... Website Awards "Charcot-Marie-Tooth Disease - Survey and Information" This Site was created and is maintained and funded by Dorothy B. Gosling Reg.N. and Others have donated their time, money and expertise for the benefit of all CMTers. Some Web Page Design features supplied by Webmaster Email: D. B. Gosling This page has been viewed times. Changes last made on: Monday, November 26, 2001 6:08:11 PM

20. CMT - Charcot Marie Tooth Disease CMT Charcot Marie Tooth Disease In Memory of Barbara Coupe/CMT - 12/30/98. TheInternet helps folk with charcot-marie-tooth disease face it head on. http://www.naotd.org/cmt.htm

CMT - Charcot Marie Tooth Disease In Memory of Barbara Coupe/CMT - 12/30/98 Charcot-Marie-Tooth disease (CMT) is named after the three doctors who first described it in 1886, Professor Jean-Martin Charcot (pronounced sharko)(1825-1893), his student, Pierre Marie (1853-1940), who both worked in Paris at the Hospital de Salpetriere named after the former gunpowder factory site where it still stands, and Dr. Howard Tooth (1926-1956) of London. CMT is primarily a disease of the nerves, whereby the myelin or insulating sheath of myelin on the nerves does not stay intact and the messages from the brain to the muscles through the nerves are not carried properly. It differs from muscular dystrophy in that people who have CMT are born with normal muscles. The muscles atrophy because the CMT affected nerves that serve them cannot properly send the message from the brain for them to move. Therefore, muscles can atrophy even though they are being used. It is also called peroneal muscular atrophy (PMA) because the peroneal muscle down the front of the shin that enables you to pull your foot up, is usually the first muscle to be affected. CMT also has a third and more recent name, hereditary motor and sensory neuropathy(HMSN). This name more accurately describes the syndrome because it is hereditary, can affect both or either the ability to move (motor) or the ability to feel (sensory). CMT can be inherited three ways but most cases are inherited autosomal dominate pattern meaning it comes directly down a line from parent to child. In this form of inheritance there is a 50/50 chance at each conception that the child will have CMT. There is also 'spontaneous mutation', where there has never been any sign of the disease in family history, but one, or both parents have carried the gene recessively.

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