21. Duke News - Release dates, Genetic testing for charcotmarie-tooth disease. Back to List, http://dukemednews.duke.edu/news/article.php?id=5152

22. HONselect - Charcot-Marie-Tooth Disease English charcotmarie-tooth disease, - Atrophy, Muscular, Peroneal - HMSN Type I- HMSN Type II - Hereditary Motor and Sensory-Neuropathy Type II - Hereditary http://www.hon.ch/HONselect/RareDiseases/C10.500.300.200.html

List of rare diseases: English Deutsch Language: MeSH term: Accepted terms: English: Charcot-Marie-Tooth Disease - Atrophy, Muscular, Peroneal - HMSN Type I - HMSN Type II - Hereditary Motor and Sensory-Neuropathy Type II - Hereditary Motor, and Sensory Neuropathy Type I - Muscular Atrophy, Peroneal Français: AMYOTROPHIE CHARCOT-MARIE-TOOTH - CHARCOT-MARIE-TOOTH, MALADIE - AMYOTROPHIE PERONIERE - NEUROPATHIE HEREDITAIRE MOTRICE ET SENSORIELLE TYPE 1 Deutsch: Charcot-Marie-Tooth-Krankheit - Myelin-P0-Protein - Atrophie, muskuläre, peroneale - Erbliche Typ I motorische und sensorische Neuropathie - Erbliche Typ II motorische und sensorische Neuropathie - HMSN Typ I - HMSN Typ II Español: ENFERMEDAD DENTARIA DE CHARCOT-MARIE - ATROFIA MUSCULAR PERONEAL - NEUROPATIA MOTORA Y SENSORIAL HEREDITARIA TIPO I - NEUROPATIA MOTORA Y SENSORIAL HEREDITARIA TIPO II - NSMH TIPO I - HMSN TIPO II - ATROFIA PERONEAL MUSCULAR Português: DOENCA DE CHARCOT-MARIE-TOOTH - ATROFIA MUSCULAR PERONIAL - NEUROPATIA MOTORA E SENSORIAL HEREDITARIA TIPO I - NEUROPATIA HEREDITARIA MOTOR E SENSORIAL TIPO II - HMSN TIPO I - HMSN TIPO II - SINDROME DE ROUSSY-LEVY HONselect ressources Definition: Yes Articles: Yes Images: No News: No Conferences: No Clinical trials: No Web sites: English Yes Français No Deutsch No Español No Português No Home About us Site map Feedback ... HONewsletter http://www.hon.ch/HONselect/RareDiseases/C10.500.300.200.html

23. EMedicine - Charcot-Marie-Tooth Disease : Article By Divakara Kedlaya, MBBS charcotmarie-tooth disease. Last Updated December 26, 2001, Background Charcot-Marie-Toothdisease (CMT) is the most common inherited neurologic disorder. http://www.emedicine.com/pmr/topic29.htm

(advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Physical Medicine and Rehabilitation Peripheral Neuropathy Charcot-Marie-Tooth Disease Last Updated: December 26, 2001 Rate this Article Email to a Colleague Synonyms and related keywords: hereditary motor sensory neuropathy, HMSN, peroneal muscular atrophy, PMA, CMT AUTHOR INFORMATION Section 1 of 11 Author Information Introduction Clinical Differentials ... Bibliography Author: Divakara Kedlaya, MBBS , Assistant Professor, Department of Physical Medicine and Rehabilitation, Loma Linda University Medical Center Divakara Kedlaya, MBBS, is a member of the following medical societies: American Academy of Physical Medicine and Rehabilitation American Association of Electrodiagnostic Medicine American Pain Society American Paraplegia Society , and Association of Academic Physiatrists Editor(s): Milton J Klein, DO , Consulting Staff, Department of Physical Medicine and Rehabilitation, Sewickley Valley Hospital and Ohio Valley General Hospital; Francisco Talavera, PharmD, PhD

24. EMedicine - Charcot-Marie-Tooth Disease : Article By Divakara Kedlaya, MBBS charcotmarie-tooth disease. Last Updated May 21, 2002, Background Charcot-Marie-Toothdisease (CMT) is the most common inherited neurologic disorder. http://www.emedicine.com/orthoped/topic43.htm

(advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Orthopedic Surgery Foot And Ankle Charcot-Marie-Tooth Disease Last Updated: May 21, 2002 Rate this Article Email to a Colleague Synonyms and related keywords: CMT, hereditary motor and sensory neuropathy, HMSN, peroneal muscular atrophy, PMA AUTHOR INFORMATION Section 1 of 11 Author Information Introduction Clinical Differentials ... Bibliography Author: Divakara Kedlaya, MBBS , Assistant Professor, Department of Physical Medicine and Rehabilitation, Loma Linda University Medical Center Divakara Kedlaya, MBBS, is a member of the following medical societies: American Academy of Physical Medicine and Rehabilitation American Association of Electrodiagnostic Medicine American Pain Society American Paraplegia Society , and Association of Academic Physiatrists Editor(s): James K DeOrio, MD , Director of Foot and Ankle Fellowship Program, Medical Director, Outpatient Surgery Center, Mayo Clinic of Jacksonville; Assistant Professor, Department of Orthopedics, Mayo Medical School; Francisco Talavera, PharmD, PhD

25. The Physician And Sportsmedicine: Charcot-Marie-Tooth Disease In A High School T charcotmarie-tooth disease in a High School Tennis Player. 3. TABLE 1. DrugsThat May Be Toxic to Patients Who Have charcot-marie-tooth disease. http://www.physsportsmed.com/issues/2002/10_02/stadler.htm

Charcot-Marie-Tooth Disease in a High School Tennis Player Teresa S. Stadler, MD David Ross, MD THE PHYSICIAN AND SPORTSMEDICINE - VOL 30 - NO. 10 - OCTOBER 2002 For CME accreditation information, instructions and learning objectives, click here In Brief: A high school tennis player had recurrent ankle sprains that were initially attributed to incomplete rehabilitation. A closer look revealed subtle symptoms of Charcot-Marie-Tooth disease (CMT), a common, inherited neuromuscular disorder. This case underscores the importance of a wide differential diagnosis when encountering recurrent conditions. Early diagnosis of CMT is imperative so that appropriate injury-prevention measures can be taken. T he underlying cause of recurrent ankle sprains may be improper rehabilitation; however, other, less apparent, conditions may be the source. A comprehensive history and physical examination may lead to the diagnosis of Charcot-Marie-Tooth (CMT) disease, as in the following case. Awareness of this fairly common condition may lead to early diagnosis and prevent recurrent ankle injuries in an otherwise healthy patient. Case Report A 16-year-old male varsity tennis player came to our sports medicine clinic with persistent right ankle pain 2 days after he had an inversion injury while sidestepping in a tennis match. He was able to walk off the court but was not able to continue playing that day. The ankle did not swell.

26. CHARCOT-MARIE-TOOTH DISEASE charcotmarie-tooth disease. Cie Cie Glencross. charcot-marie-tooth diseasepresents in a variety of clinical forms and presents at different ages. http://www.curtin.edu.au/curtin/dept/physio/podiatry/encyclopedia/ciecle/

CHARCOT-MARIE-TOOTH DISEASE Cie Cie Glencross Figure 1: Charcot-Marie-Tooth typical cavus foot type and inverted champagne bottle leg Introduction Overview Specifics Summary ... References Back to Encyclopedia Index INTRODUCTION Scope of the Report Aims of the Report The report will cover the following areas: Mode of Inheritance Types of Charcot-Marie-Tooth disease Pathogenesis of Charcot-Marie-Tooth disease Pathology of Charcot-Marie-Tooth disease Clinical Features Diagnosis of Charcot-Marie-Tooth disease Conservative and Surgical Treatment of Charcot-Marie-Tooth disease. Back to Contents OVERVIEW: Prevalence Mode of Inheritance Types Back to Contents SPECIFICS: PATHOLOGENESIS Neural Pathogenesis Muscular Pathogenesis 1. The muscles supplied by the longest axon of the Sciatic nerve are affected first. 2. The muscles showing the least bulk are foremost in showing wasting. 3. Muscles above the knee are not affected. Downey et al (1992) and Mann and Missirian (1983; 1986) support this theory in explaining the pattern of muscle wasting and dysfunction. The intrinsic muscles of the foot are the first to atrophy as a result of their size and innervation by the medial and lateral plantar nerves. The anterior muscles of the leg are next to atrophy presumably as a result of their innervation be the smaller branch of the Sciatic nerve. As a result of the lack of muscle bulk, Peroneus Brevis and Peroneus Tertius atrophy before their counterpart Peroneus Longus. As Charcot-Marie-Tooth disease is progressive, the posterior leg muscle group and the triceps surae may be involved. However, because of the greatest muscle bulk, they are typically the last to atrophy (Downey, 1992).

27. CHARCOT-MARIE-TOOTH DISEASE OSTEOCHONDROSIS OF THE NAVICULAR BONE KOHLER'S DISEASE. Daniel Wywiorski. SPECIFICS.What Causes Kohler's Disease? The exact cause http://www.curtin.edu.au/curtin/dept/physio/podiatry/encyclopedia/Kohler's Disea

OSTEOCHONDROSIS OF THE NAVICULAR BONE: KOHLER'S DISEASE Daniel Wywiorski Introduction Overview Specifics Summary ... Back to Encyclopedia Index INTRODUCTION An Osteochondrosis is “a disease of the growth ossification centres in children beginning as a degeneration or necrosis followed by regeneration or recalcification” (Dorland’s pocket medical dictionary, 1995, p.96). In the case of navicular osteochondoris, the navicular becomes sclerotic and fragmented, eventually becoming flattened into a ‘disc shape’ (visible on x-ray), with resultant re-shaping of the navicular into its original shape or a deformed one (Brower, 1983, p.103). Back to Contents OVERVIEW Age of Onset Speed (1927, p.179) reports a range of 2-10 years of age with an average of 3; Waugh (1958, p.765) reports an average of 5 years; Kidner and Muro (1924, p.1650) report a range of 5-8 years; while Tachdjian (1972, p.406) report a mean age of 5 years for boys and 4 years for girls. Karp (1937, p.84) suggests a ratio of boys:girls of 6:1 and an average age of 55 months (or approximately 4.5 years of age). Usually, only one foot is affected, with bilateral cases occurring approximately 15-20% of children studied (Williams and Cowell, 1981, p.53).

28. Orthoseek | Orthopedic Topics | Charcot-Marie-Tooth Disease charcotmarie-tooth disease or Peroneal Muscular Atrophy is the commonest diseasewithin a group of conditions called Hereditary Motor and Sensory Neuropathies http://www.orthoseek.com/articles/cmtdisease.html

Charcot-Marie-Tooth Disease What is it? Charcot-Marie-Tooth disease or Peroneal Muscular Atrophy is the commonest disease within a group of conditions called Hereditary Motor and Sensory Neuropathies (HMSN) . This group of diseases are caused by degeneration of the peripheral nerves, nerve roots, and even the spinal cord. Charcot-Marie-Tooth disease is also known as HMSN Type I, and is the most common disease in the group. The nerves that supply the small muscles of the feet are affected, causing weakness and deformity in the feet. There is also loss of position and vibration sense to the feet. Much later, the small muscles of the hands are also affected. What causes it? The disease is hereditary, and is inherited as an autosomal dominant trait. What are the symptoms? The affected child presents with high arches in his feet, as well clumsiness and pain in his feet and legs. Due to muscle imbalance in the feet, the child may develop a dropfoot , as well as a cavus foot , where the arch of the foot is very pronounced and fixed. Later, if the small muscles of the hands are also affected, he may develop clawing of the fingers. The affected child has normal intelligence, and a normal life span.

29. The Contact A Family Directory - CHARCOT-MARIE-TOOTH DISEASE printer friendly, charcotmarie-tooth disease, http://www.cafamily.org.uk/Direct/c27.html

printer friendly CHARCOT-MARIE-TOOTH DISEASE home more about us in your area conditions information ... how you can help search this site Charcot-Marie-Tooth: CMT: peroneal muscular atrophy: hereditary motor and sensory neuropathy This is a genetic disorder characterised by slowly progressive muscular weakness. Onset is in the lower limbs first causing weakness around the ankles and, often, an abnormality in the shape of the feet (high in-step.) After many years, weakness may develop in the hands and spread upwards in the lower limbs to affect the knees and thighs. Mild loss of sensation may be present in the feet and hands. The onset of the condition may be from childhood to late middle or old age. Inheritance patterns Autosomal dominant is the most common pattern of inheritance. Autosomal recessive (least common) X-linked passed to both sons and daughters. However, affected sons will usually display more severe symptoms. Pre-natal diagnosis In families who have Type 1a pre-natal diagnosis is now becoming available but is rarely requested.

30. CJNS-Charcot-Marie-Tooth Disease And Related Inherited Peripheral Neuropathies Close Window Progress in Clinical Neurosciences charcotmarie-tooth disease andRelated Inherited Peripheral Neuropathies. Timothy J. Benstead and Ian A. Grant. http://www.canjneurolsci.org/28augtoc/charcot.html

Abstract Close Window Progress in Clinical Neurosciences: Charcot-Marie-Tooth Disease and Related Inherited Peripheral Neuropathies Timothy J. Benstead and Ian A. Grant Abstract: The classification of Charcot-Marie-Tooth disease and related hereditary motor and sensory neuropathies has evolved to incorporate clinical, electrophysiological and burgeoning molecular genetic information that characterize the many disorders. For several inherited neuropathies, the gene product abnormality is known and for others, candidate genes have been identified. Genetic testing can pinpoint a specific inherited neuropathy for many patients. However, clinical and electrophysiological assessments continue to be essential tools for diagnosis and management of this disease group. This article reviews clinical, electrophysiological, pathological and molecular aspects of hereditary motor and sensory neuropathies. Can. J. Neurol. Sci. 2001; 28: 199-214

31. Charcot-Marie-Tooth Disease_Figure_1 charcotmarie-tooth disease and Related Inherited Peripheral Neuropathies TimothyJ. Benstead and Ian A. Grant Can. J. Neurol. Sci. 2001; 28 199-214. http://www.canjneurolsci.org/28augtoc/28#3_figs/charcot-figure_1.htm

32. Charcot-Marie-Tooth Disease (www.whonamedit.com) charcotmarie-tooth disease Also known as Charcot-Marie syndrome Charcot-Marie-Tooth-Hoffmanndisease Charcot-Marie-Tooth-Hoffmann http://www.whonamedit.com/synd.cfm/30.html

33. Charcot-Marie-Tooth Disease - Diagnosis & Treatment - Podiatrychannel can reveal atrophy and can be used to establish a baseline from which disease progressioncan A DNA blood test identifies CharcotMarie-Tooth types 1A and 1X. http://www.podiatrychannel.com/charcot/treatment.shtml

Home Search SiteMap Ask the Dr. ... Medical Store advertisement CHARCOT-MARIE- TOOTH DISEASE Overview Cause Symptoms Diagnosis ... Treatment CONDITIONS Achilles Tendinitis Allergic Contact Dermatitis Ankle Injuries Athlete's Foot Brachymetatarsia Bunions ... Charcot-Marie-Tooth Disease Claw Toes Complex regional pain syndrome (CRPS) Corns Diabetes Fibromyalgia Gout ... Tarsal Tunnel Syndrome Toe Deformities Xerosis TREATMENT OPTIONS Orthotics RESOURCES Anatomy Clinical Trials HealthProfiler Links ... Free Podiatry Website ABOUT US Healthcommunities.com Pressroom Testimonials Diagnosis A physical examination may confirm a high arch, claw toes, and muscle weakness. The Achilles (above the heel) and patellar (knee) tendon reflexes are weak or absent. Muscle strength testing can reveal atrophy and can be used to establish a baseline from which disease progression can be tracked. Examining and testing several family members for signs of neuropathy can help establish a diagnosis. Tests Several tests are used to determine reduced muscle responses and nerve damage. A nerve conduction velocity (NCV) study measures the speed of nerve signal conduction. A patient with CMT1 has slower than normal NCV readings due to myelin deterioration.

34. 1Up Health > Charcot-Marie-Tooth Disease (hereditary) > Causes, Incidence, And R 1Up Health Diseases Conditions charcotmarie-tooth disease(hereditary) Causes, Incidence, and Risk Factors. http://www.1uphealth.com/health/charcot_marie_tooth_disease_hereditary_info.html

1Up Health Charcot-Marie-Tooth disease (hereditary) Alternative Medicine Clinical Trials ... Health Topics A-Z Search 1Up Health Charcot-Marie-Tooth disease (hereditary) Information Charcot-Marie-Tooth disease (hereditary) Causes, Incidence, and Risk Factors Alternative names : Hereditary motor and sensory neuropathy, Hereditary peroneal nerve dysfunction, Neuropathy - peroneal (hereditary), Progressive neuropathic (peroneal) muscular atrophy Definition : Charcot-Marie-Tooth disease defines a group of slowly progressive, inherited disorders that result from progressive damage to nerves. In addition to loss of sensation, there is wasting of muscle tissue in the feet and legs, then hands and arms. Causes, Incidence, and Risk Factors Charcot-Marie-Tooth diseases involve damage to nerves (neuropathy), usually from demyelination or loss of the electrical insulation around nerve fibers. All nerves are affected, but motor nerves are disproportionately so. The nerves in the legs are affected first and most severely. Symptoms usually begin between mid-childhood and early adulthood. The disorder is inherited, with autosomal dominant and recessive as well as X-linked recessive inheritance patterns. At least four genes have been discovered to be the cause of this group of diseases. Charcot-Marie-Tooth disease causes destruction (degeneration) of the covering of the nerve cells ( myelin sheath) in some people. In other people, the

35. Charcot-Marie-Tooth Disease charcotmarie-tooth disease Guide picks. MDA Datos Sobre charcot-marie-tooth diseaseInformation in Spanish from the Muscular Dystrophy Association USA. http://rarediseases.about.com/cs/cmt/

zfp=-1 About Rare/Orphan Diseases Search in this topic on About on the Web in Products Web Hosting Rare/Orphan Diseases with Mary Kugler Your Guide to one of hundreds of sites Home Articles Forums ... Help zmhp('style="color:#fff"') Subjects BUYER'S GUIDE Before You Buy Top Picks Sites for Online Specialty Shopping ... All articles on this topic Stay up-to-date! Subscribe to our newsletter. Advertising Free Credit Report Free Psychics Advertisement Charcot-Marie-Tooth Disease Guide picks An inherited peripheral neuropathy characterized by a slowly progressive degeneration of the muscles. Feature article on Charcot-Marie-Tooth disease About.com Guide to Rare Diseases describes the disorder and its treatments. Charcot-Marie-Tooth Association (U.S.) Site offers information, publications, discussion forum, and resources. Charcot-Marie-Tooth International Site offers information, newsletter, pamphlets, and physician referrals in Canada and the U.S. Charcot-Marie-Tooth International UK Site offers information, support, and links. CMTnet Information for researchers, practitioners, and patients. Maladies de Charcot-Marie-Tooth Information, discussion, forum, newsletters, email list, all in French.

36. Charcot-Marie-Tooth Disease charcotmarie-tooth disease. Peripheral nerve disorders. What is it? Charcot-Marie-Toothdisease refers to a group of disorders with similar symptoms. http://rarediseases.about.com/library/weekly/aa032001a.htm

zfp=-1 About Rare/Orphan Diseases Search in this topic on About on the Web in Products Web Hosting Rare/Orphan Diseases with Mary Kugler Your Guide to one of hundreds of sites Home Articles Forums ... Help zmhp('style="color:#fff"') Subjects BUYER'S GUIDE Before You Buy Top Picks Sites for Online Specialty Shopping ... All articles on this topic Stay up-to-date! Subscribe to our newsletter. Advertising Free Credit Report Free Psychics Advertisement Charcot-Marie-Tooth Disease Peripheral nerve disorders Related Resources Internet links on Charcot-Marie-Tooth diseases Elsewhere on the Web NINDS: Charcot-Marie-Tooth diseases Mary Kugler, MSN, RN,BC Guide to Rare/Orphan Diseases Imagine that it's hard for you to lift up your feet, hold a pen, or keep your balance, and you'll have an idea of what life with Charcot-Marie-Tooth disease (CMT) is like. Although it is found worldwide, in people of all ethnic backgrounds, Charcot-Marie-Tooth is still considered rare. First described by researchers Jean-Marie Charcot, Pierre Marie, and Howard Henry Tooth in 1886, CMT is an inherited defect in the nerves that control the muscles of the hands, feet, and legs. CMT has at times been called peroneal muscular atrophy or hereditary motor and sensory neuropathies. What is it?

37. Arch Neurol -- Page Not Found The Many Faces of charcotmarie-tooth disease Author Information JefferyM. Vance, MD, PhD charcot-marie-tooth disease an intermediate form. http://archneur.ama-assn.org/issues/v57n5/ffull/ned8531.html

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38. Health Information Resource Database: CMT International (Charcot-Marie-Tooth Dis CMT International (charcotmarie-tooth disease/Peroneal Muscular Atrophy InternationalAssociation, Inc.). Contact Information. 1 Springback Drive St. http://www.health.gov/NHIC/NHICScripts/Entry.cfm?HRCode=HR2300

39. SupportPath.com: Charcot-Marie-Tooth Disease SupportPath.com, charcotmarie-tooth disease. Also called CMT, Charcot-Marie Disease. ClinicalTrials Research on charcot-marie-tooth disease None Listed. http://www.supportpath.com/sl_c/charcot_marie_tooth_disease.htm

Charcot-Marie-Tooth Disease Also called: CMT, Charcot-Marie Disease Other topics of interest on SupportPath.com: disABILITIES About Us Add-A-Link Email ... here Online Communities / Message Boards... Braintalk Communities: Charcot Marie Tooth Website: Description: A part of the BrainTalk Communities website. Registration is required to post to this message board. Date Added: 06/06/2002 Online Chats... Note: Regularly scheduled chats are listed on our NEW Online Events Calendar Links in this section are primarily to chat rooms open 24/7 which may or may not be moderated. None Listed Usenet Groups... Note: Your browser must be properly configured to access Usenet groups from this site. None Listed Mailing Lists... None Listed National / International Organizations... Charcot-Marie-Tooth Association (CMTA) Note: Groups are listed alphabetically by U.S. state and then country. None Listed None Listed Professional Organizations of Interest... None Listed None Listed Miscellaneous Links... None Listed Books about Charcot-Marie-Tooth Disease and Related Topics... None Listed (The following search link is offered in association with Amazon.com

40. Charcot-Marie-Tooth Disease Fact Sheet Health Contact us . Content for this page. charcotmarie-tooth diseaseFact Sheet. What is charcot-marie-tooth disease? Charcot-Marie-Tooth http://accessible.ninds.nih.gov/health_and_medical/pubs/CMT.htm

Disorders - National Institute of Neurological Disorders and Stroke (NINDS) Skip menus Main sections of the NINDS web site Home About NINDS Disorders-you are in this section ... Find People Disorders section pages and search Image Description Science For the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system. Select Topic Disorder Quick Links Alzheimer's Autism Cerebral Palsy Chronic Pain Epilepsy Headache Multiple Sclerosis Parkinson's Stroke Traumatic Brain Injury More about a disorder Studies with patients Research literature Press release NINDS Search (search help) Contact us My privacy NINDS is part of the National Institutes of Health Contact us Content for this page Charcot-Marie-Tooth Disease Fact Sheet Get Web page suited for printing Email this to a friend or colleague Request free mailed brochure Table of Contents What is Charcot-Marie-Tooth disease? What are the symptoms of Charcot-Marie-Tooth disease? What are the types of Charcot-Marie-Tooth disease? What causes Charcot-Marie-Tooth disease? ... Where can I get more information? What is Charcot-Marie-Tooth disease? Charcot-Marie-Tooth disease (CMT) is one of the most common inherited neurological disorders, affecting approximately 1 in 2,500 people in the United States. The disease is named for the three physicians who first identified it in 1886 - Jean-Marie-Charcot and Pierre Marie in Paris, France, and Howard Henry Tooth in Cambridge, England. CMT, also known as hereditary motor and sensory neuropathy (HMSN) or peroneal muscular atrophy, comprises a group of disorders that affect peripheral nerves. The peripheral nerves lie outside the brain and spinal cord and supply the muscles and sensory organs in the limbs. Disorders that affect the peripheral nerves are called peripheral neuropathies.

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