21. Leslie of two cases. med8589 327 The spectrum of congenital facial diplegia(Moebius syndrome). med75-79 327 Moebius syndrome. med93-95 http://neuro-www.mgh.harvard.edu/neurowebforum/ChildNeurologyArticles/Leslie.htm

Leslie This response submitted by Dr. Shawn K. Centers on 12/19/96. Author's Email: Dear Leslie: Although previuosly it was thought that there was an agenesis ( failure to develop )of the control centers for the cranial nerves ( especially cranial nerve VI and VII) some of the recent research seems to call this into question. If there is complete agenesis this means that there is no possibility of the facial paralysis improving or worsening. One recent report describes muscle recruitment measured by EMG studies in two Moebius patients following treatment with simple physical therapy. In another report there is described improvement in facial paralysis using biofeedback techniques (the patients were both children). The Miami Project in FL seems to be the center that is doing the most research with biofeedback training in muscle paralysis. There is also a research center in England who claims to have gotten improvement in muscle hypotonia and facial paralysis using a type of tactile kinesthetic stimulation using "brushing technique" wirth a number of Moebius patients (mostly children). As of yet their research is unpublished. There are likewise reports of a Moebius patient's paralysis worsening and thought to be caused by a superimposed Bell's Palsy. When I was younger I recieved treatment at the Michigan State University We really have very little to offer them at this time in terms of treatment. With better information we may be able to offer some suggestions

22. Moebius Syndrome And Possible Causes Ziter et al. (1977) observed congenital facial diplegia and flexionfinger contractures in 7 members of 3 generations of a family. http://neuro-www.mgh.harvard.edu/forum/MoebiusSyndromeF/3.21.982.19AMMoebiussynd

Moebius syndrome and Possible Causes This article submitted by on 3/21/98. Email Address: The following is from "OMIM" - ONLINE MENDELIAN INHERITANCE IN MAN. This may lay to rest persistent remors re: the singular cause of Moebius being Herpes.... These are from various Moebius-related texts found at: http://www3.ncbi.nlm.nih.gov/htbin-post/Omim/getmim Harbord et al. (1989) described a child with Moebius syndrome associated with unilateral cerebellar hypoplasia. Journel et al. (1989) described Moebius syndrome in 2 brothers and a male first cousin who were sons of sisters, thus suggesting X-linked recessive inheritance. The 2 brothers also had hypoplasia of the thumbs and absence of the big toes. Kawai et al. (1990) described the fourth case of Moebius syndrome (which they referred to as Moebius sequence) associated with peripheral neuropathy and hypogonadotropic hypogonadism. Pulsatile administration of gonadotropin-releasing hormone for 3 months was effective therapy. Kumar (1990) provided a review, which was critiqued by Lipson et al. (1990). MacDermot et al. (1991) urged that the term Moebius syndrome be restricted to cases with congenital sixth and seventh nerve paralysis with skeletal defects; according to their analysis, the recurrence risk is low (about 2%) in these cases. In their review, no recurrence was noted in 31 cases with cranial nerve palsies associated with oral abnormalities and limb defects. The features in an index case that may indicate a higher risk of recurrence are the absence of skeletal defects, isolated facial palsy, deafness, ophthalmoplegia, and digital contractures. As an example of the latter category, MacDermot et al. (1991) described mother and son with fifth, sixth, seventh, and bulbar cranial nerve paralysis who had 2 similarly affected relatives: the mother's maternal aunt and her son.

23. WebMD - Synonyms congenital facial diplegia Syndrome; Congenital Oculofacial Paralysis;Mobius Syndrome; Moebieus Sequence. Disorder Subdivisions None. General Discussion. http://my.webmd.com/NR/internal.asp?GUID={E7A1B26A-1D20-4DA5-93CB-EB1CF75ACE09}

24. MEDLINEplus: Facial Injuries And Disorders and Stroke); Mobius Syndrome (congenital facial diplegia) (NationalInstitute of Neurological Disorders and Stroke); Orbital Trauma http://www.nlm.nih.gov/medlineplus/facialinjuriesanddisorders.html

Skip navigation Other health topics: A B C D ... List of All Topics Facial Injuries and Disorders Contents of this page: General/Overviews Coping Pictures/Diagrams Treatment ... Children Search MEDLINE for recent research articles on Facial Injuries and Disorders You may also be interested in these MEDLINEplus related pages: Bell's Palsy Cleft Lip and Palate Trigeminal Neuralgia Brain and Nervous System ... Injuries and Wounds General/Overviews Facial Injuries (American Association of Oral and Maxillofacial Surgeons) Clinical Trials ClinicalTrials.gov: Craniofacial Abnormalities (National Institutes of Health) Coping Common Questions About Craniofacial Conditions (Children's Craniofacial Association) Pictures/Diagrams Atlas of the Body: The Skull (American Medical Association) Specific Conditions/Aspects Coffin Lowry Syndrome (National Institute of Neurological Disorders and Stroke) Craniofacial Syndrome Descriptions (Children's Craniofacial Association) Craniosynostosis and Craniofacial Disorders (American Association of Neurological Surgeons) Crouzon Syndrome (Craniofacial Dysostosis) (Cleft Palate Foundation) Hemifacial Spasm (National Institute of Neurological Disorders and Stroke) Holoprosencephaly (National Institute of Neurological Disorders and Stroke) Information About Pierre Robin Sequence/Complex (Cleft Palate Foundation) Know the Score on Facial Sports Injuries (American Academy of Otolaryngology-Head and Neck Surgery, Inc.)

25. MEDLINEplus: Birth Defects Drug Information); Mobius Syndrome (congenital facial diplegia) (NationalInstitute of Neurological Disorders and Stroke); Pregnancy http://www.nlm.nih.gov/medlineplus/birthdefects.html

Skip navigation Other health topics: A B C D ... List of All Topics Birth Defects Contents of this page: News From the NIH General/Overviews Anatomy/Physiology ... Statistics Search MEDLINE for recent research articles on Birth Defects You may also be interested in these MEDLINEplus related pages: Cleft Lip and Palate Congenital Heart Disease Down Syndrome Facial Injuries and Disorders ... Genetics/Birth Defects Latest News Birth Defects Linked to Mega-Progesterone (03/21/2003, United Press International) Popular Supplement Causes Mutations (03/18/2003, United Press International) From the National Institutes of Health Jablonski's Multiple Congenital Anomaly/Mental Retardation Syndromes Database (National Library of Medicine) General/Overviews Birth Defects (March of Dimes Birth Defects Foundation) Also available in: Spanish Birth Defects (Nemours Foundation) Birth Defects (American College of Obstetricians and Gynecologists) Descriptions of Leading Categories of Birth Defects (March of Dimes Birth Defects Foundation) Anatomy/Physiology Genes and Birth Defects: Common Forms of Inheritance (March of Dimes Birth Defects Foundation) Late-Appearing Defects (March of Dimes Birth Defects Foundation) Multifactorial Inheritance (March of Dimes Birth Defects Foundation) Clinical Trials ClinicalTrials.gov: Abnormalities

26. NORD - National Organization For Rare Disorders, Inc. View Cart/Checkout. Copyright 1987, 1990, 1995, 1998, 1999, 2000 Synonymsof Moebius Syndrome congenital facial diplegia Syndrome; http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Moebius Syndr

27. YOUNG ONSET NEUROLOGICAL DISEASE ASSOCIATION Br YONDA For Short Coffin Lowry Syndrome, Coma, including Persistent Vegetative State, Complex RegionalPain Syndrome, congenital facial diplegia, Congenital Vascular Cavernous http://www.geocities.com/yondaohio/01.html

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28. Mestrado Translate this page Summary. Moebius syndrome, also known as congenital facial diplegia, comprisesan heterogeeneous group of conditions, caused by vascular disruption. http://www.unb.br/fs/dd_cesm.htm

CARLOS EDUARDO SPECK MARTINS Nome do Autor: Carlos Eduardo Speck Martins Data da defesa: 04/01/2000. Nome do orientador: Riccardo Pratesi Summary Moebius syndrome, also known as congenital facial diplegia, comprises an heterogeeneous group of conditions, caused by vascular disruption. Its origin is probably environmental in the vast majority of the cases. There are some works on families with a mendelian pattern of inheritance. Some factors have been implicated in the genesis of the disorder: drugs acting as inductors of uterine contratility, maternal hypotension, maternal trauma and hyperthermia. In the present work we analyze 105 patients with Moebius syndrome seen in the ambulatorys of pediatrics and genetics at the Sarah Network of Hospitals. We studied the association between Moebius and vaginal bleeding. We also analyzed the following parameters: maternal hyperthermia and trauma in the first trimester and polyhydramnius. Our data confirm the statistical significance between Moebius syndrome and vaginal bleeding. We were not able to establish a causal relationship. It was also confirmed the relationship between the disease and ingestion of misoprostol in the first trimester of pregnancy.

29. MSN Health - Synonyms congenital facial diplegia Syndrome; Congenital Oculofacial Paralysis;Mobius Syndrome; Moebieus Sequence. Disorder Subdivisions None. General Discussion http://content.health.msn.com/NR/internal.asp?GUID={E7A1B26A-1D20-4DA5-93CB-EB1C

30. NINDS - Neurological Disorder Information Pain 23 Coffin Lowry Syndrome 24 Coma, including Persistent Vegetative State 25Complex Regional Pain Syndrome 26 congenital facial diplegia 27 Congenital http://accessible.ninds.nih.gov/health_and_medical/disorder_index.htm

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31. Mobius Syndrome Mobius Syndrome. Synonym(s) congenital facial diplegia What is MobiusSyndrome? Mobius syndrome, a rare genetic disorder characterized http://www.clevelandclinic.org/health/health-info/docs/1300/1307.asp?index=6064

32. C Website Results :: Linkspider UK Arthromyodysplasia@ (96); congenital facial diplegia@ (5); CongenitalHeart Disease@ (53); Congenital Nephroblastoma@ (5); Congenital http://www.linkspider.co.uk/Health/ConditionsandDiseases/C/

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33. Directory :: Look.com treatment options. Mobius Syndrome Also known as congenital facial diplegia,an information sheet compiled by NINDS. Moebius Syndrome http://www.look.com/searchroute/directorysearch.asp?p=522991

34. Searchalot Directory For C Pain Syndromes (9); Compulsive Gambling (61); Congenital Arthromyodysplasia(96); congenital facial diplegia (5); Congenital Heart Disease http://www.searchalot.com/Top/Health/ConditionsandDiseases/C/

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35. Genetic Approaches To Ocular Motility Disorders The three most commonly used minimal criteria are 1) congenital facial diplegia2) congenital facial diplegia and unilateral or bilateral loss of abduction 3 http://mediswww.meds.cwru.edu/dept/neurology/ocular/full020.html

GENETIC APPROACHES TO OCULAR MOTILITY DISORDERS Elizabeth C. Engle, M.D. Department of Anatomy and Neurobiology Children's Hospital Boston, MA, USA GENETICS OF CONCOMITANT STRABISMUS GENETICS OF INCOMITANT STRABISMUS Incomitant strabismus occurs when the misalignment or the angle of deviation of the eyes varies with gaze direction. This results from mechanical dysfunction in the orbit or neuromuscular dysfunction at the level of the muscle, nerve, or brainstem. Restricted neuromuscular disorders in this group include Duane syndrome, CFEOM, strabismus fixus, Möbius syndrome, and isolated cranial nerve palsies. Of these, the neuropathology of Duane and CFEOM have been described and have interesting parallels to one another. In addition, CFEOM, strabismus fixus, and some rare forms of Duane syndrome show clear patterns of inheritance, making them accessible to molecular genetic studies. 1. "CLASSIC" CFEOM CFEOM has been a major focus of our laboratory investigations. Individuals with CFEOM have ptosis, infraductive strabismus, and severely restricted eye movements. The ophthalmoplegia is virtually complete with the eyes fixed at 20 to 40 degrees below the horizontal. Residual eye movements are typically in the horizontal plane and are often notable for aberrant and jerky convergent or divergent movements on attempted vertical gaze as well as retraction of the globe into the orbit. Affected individuals lack binocular vision, and frequently have significant refractive errors and amblyopia. We have noted hypotonia and mild gross motor delay in young affected children, and mild facial weakness in all affected individuals.

36. Member Sign In when combined with methotrexate, may not induce abortion when taken alone; however,it can cause such anomalies as congenital facial diplegia (Möbius' syndrome http://www.medscape.com/viewarticle/420944

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37. Tables MelkerssonRosenthal syndrome, Congenitally fissured tongue, orofacial edema, facialpalsy 5, Möbius' syndrome, congenital facial diplegia, ophthalmoplegia 6, http://www.medscape.com/content/2002/00/43/11/431188/431188_tab.html

Tables for: Man With Facial Weakness Table 1. Differential Diagnosis for Bell's Palsy Disease Symptoms Diagnostic tools Melkersson-Rosenthal syndrome Congenitally fissured tongue, orofacial edema, facial palsy Congenital facial diplegia, ophthalmoplegia Ascending motor weakness, usually beginning in legs and possibly leading to respiratory muscle paralysis Nerve conduction velocity; electromyography Facioscapulohumeral muscular dystrophy Progressive weakness in the face, neck, upper torso, and upper arms Serum creatine kinase; electromyography Myasthenia gravis Weakness and fatigue, particularly of the extraocular, pharyngeal, facial, cervical, and respiratory musculature Computed tomography; electrodiagnostic studies Sarcoidosis Shortness of breath, cough, skin and ocular lesions; weakness, fatigue, fever, malaise Imaging studies; bronchoscopy; lymph node biopsy

38. AnsMe Directory - Health > Conditions And Diseases > C Compulsive Gambling. Congenital Arthromyodysplasia. congenital facial diplegia.Congenital Heart Disease. Congenital Nephroblastoma. Congenital Pain Insensitivity. http://dir.ansme.com/health/43345.html

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39. Browsing Health Conditions And Diseases C Category Cold Communication Disorders Complex Regional Pain Syndromes Compulsive GamblingCongenital Arthromyodysplasia congenital facial diplegia Congenital Heart http://www.uksprite.com/search/search/Health/Conditions_and_Diseases/C/

40. Please Click The Current Issue Button Above To Return To The Bilateral Bell's phenomenon is found in myasthenia gravis, sarcoidosis, bilateralBell's palsies, congenital facial diplegia, some rare forms of muscular http://www.studentbmj.com/back_issues/0801/education/275.html

Please click the Current Issue button above to return to the contents page Improving your blood taking skills Dermatology clinic Managing a suspected adverse drug reaction Snippets Picture Quiz Epidemiological research Radiology Quiz Write a response to this article Snippets A 69 year old patient presented for arthroscopic knee surgery. Her husband, a doctor with severe Parkinson's disease, had been mistakenly resuscitated against his wishes and died three weeks later in the intensive care unit. After this event the patient had written a living will to ensure that no such confusion would occur in her case. A living will should be sufficient in making clear a patient's wishes, but in order to further clarify her instructions, she had also had the words "Do Not Resuscitate" tattooed on her left chest wall. The arthroscopy was completed without adverse event under regional anaesthesia. C McCartney assistant professor Glen McGuire assistant professor, department of anesthesia and pain management, Toronto Western Hospital, Toronto, Canada J Smith

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