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         Congenital Nephroblastoma:     more detail

21. BCcomm: Health & Fitness/Conditions & Diseases/Cancer/Kidney
SEE YOUR SITE HERE! CATEGORIES Support Groups. (1).Wilm's Tumor congenital nephroblastoma. (2).
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  • Support Groups Wilm's Tumor - Congenital Nephroblastoma

  • LINKS: My Links Reviews Details ... Kidney Cancer Directory of OnTumor.com A physician guided website for kidney cancer patients, their families, and caregivers. Your first stop for reliable cancer information on the web.
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    Recommend it Review It Rate It! ... What You Need to Know about Kidney Cancer An important booklet from the National Cancer Institute for kidney cancer patients, their caregivers, and healthcare professionals. URL: - http://cancernet.nci.nih.gov/wyntk_pubs/kidney.htm Report As Bad Recommend it Review It Rate It! ... Kidney Cancer Association Membership organization of patients, families, doctors, and health professionals in kidney cancer. URL: - http://www.nkca.org/

    22. Brusa-Torricelli Syndrome (www.whonamedit.com)
    A congenital syndrome in which aniridia (congenital absence of the iris) and nephroblastoma (Wilms' tumour) is
    http://www.whonamedit.com/synd.cfm/2404.html

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    Brusa-Torricelli syndrome Also known as:
    Aniridia-Wilms’ tumour syndrome
    Aniridia-Wilms' tumor association
    Miller’s syndrome (R. W. Miller)
    Synonyms: Aniridia-nephroblastoma syndrome, oculocerebrorenal syndrome. Associated persons: P. Brusa R. W. Miller C. Torricelli Max Wilms Description: A congenital syndrome in which aniridia (congenital absence of the iris) and nephroblastoma (Wilms' tumour) is associated with mental retardation, craniofacial defects (microcephaly), growth retardation and skeletal anomalies, deformed pinna, genitourinary anomalies, hamartomas, and umbilical and inguinal hernias. Other frequent features include cataract and glycoma, hypospadias, hemihypertrophy, and horseshoe kidney. The syndrome affects both sexes but is more frequent in males. Bibliography:
    • P. Brusa, C. Torricelli: Nefroblastoma di Wilms ed affezioni renali congenite nelle casistiche dell’ IIPAI di Milano. Minerva pediatrica, Torino, 1953, 5: 457-463.
    • R. W. Miller, J. F. Fraumeni, M. D. Manning:

    23. Nephroblastoma, [s8]uncommon
    Primary Surgery Volume One Nontrauma After Burkitt's lymphoma, nephroblastoma is the commonest solid tumour of childhood in Africa (in Caucasians it is the fourth commonest). congenital anomalies (eye defects, hemihypertrophy, and urinogenital anomalies), which are sometimes associated with a nephroblastoma.
    http://www.meb.uni-bonn.de/dtc/primsurg/docbook/html/x11710.html
    Primary Surgery: Volume One: Non-trauma Prev Chapter 18. Primary oncology Next
    Nephroblastoma, [s8]uncommon
    NEPHROBLASTOMA THE DIFFERENTIAL DIAGNOSIS includes hydronephrosis (often bilateral), polycystic disease of the kidneys (uncommon, haematuria is usual), or a neuroblastoma displacing the kidney downwards (rare in Africa). Prev Home Next Non-Hodgkin's lymphoma, [s8]uncommon Up Retinoblastoma, [s8]uncommon

    24. 1Up Health > Diseases & Conditions > N
    nephroblastoma, see Wilms tumor; Nephrocalcinosis; Nephrogenic diabetesinsipidus congenital, see congenital nephrogenic diabetes insipidus;
    http://www.1uphealth.com/health/disease_n.html
    1Up Health Home Contact Us Privacy Caring For Your Well Being Alternative Medicine Clinical Trials Health News Poisons ... Health Topics A-Z Search 1Up Health
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    25. Mesoblastic Nephroma
    This is a rare, usually congenital, neoplasm of the kidney. cystic nephroma, cystic partially differentiated nephroblastoma, cystic nephroblastoma, and cystic clear cell sarcoma of
    http://www.thedoctorsdoctor.com/diseases2/kidney_mesoblastic_nephroma.htm

    26. Samuel M. Mahaffey, M.D.
    of childhood; congenital diaphragmatic hernia; congenital and acquired anomalies stenosis; Gastroschisis; Omphalocele; Neuroblastoma; nephroblastoma (Wilm' tumor); Ovarian tumors
    http://surgery.duke.edu/people/mahaf001.html
    Samuel M. Mahaffey , M.D.
    Associate Professor of Surgery
    Medical Director of Perioperative Services
    Pediatric Surgery
    Contact Information
    DUMC Box 3815
    3446A Hospital North
    Duke University Medical Center
    Durham, NC 27710
    Phone (919) 681-5077
    Appointments (919) 681-5077
    Fax (919) 681-8353 Pager (919) 970-2720 Email mahaf001@mc.duke.edu Education Degrees 1979 M.D. West Virginia University, Morgantown, WV M.B.A. Duke University, Durham, NC (Fuqua Scholar) BA (Biology, BS (Chemistry) West Virginia University, Morgantown, WV Clinical Interests Pediatric trauma and critical care; solid tumors of childhood; Congenital diaphragmatic hernia; congenital and acquired anomalies of the lung, chest, neck, or abdomen; Intestinal atresia; Intestinal duplications; Hypertrophic pyloric stenosis; Gastroschisis; Omphalocele; Neuroblastoma; Nephroblastoma (Wilm' tumor); Ovarian tumors in children; Research Interests Information systems in Health Care; Operational improvements in the perioperative environment Clinical integration across expanding health care systems.

    27. Cancer Syndromes
    nephroblastoma. by OMIM. Rather numerous instances of multiple sibs with Wilms tumor have been described The syndrome of aniridia, hemihypertrophy and other congenital
    http://www.ibis-birthdefects.org/start/cancersy.htm
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    ... Etchings Please Explore: Support Groups Professional Associations Key Information Sources Topics include Title and Nephroblastoma Aniridia,Type II Wims Tumor-Aniridia-Genitourinary Anomalies-Mental Retardation Wilms Tumor 3 Wilms Tumor 2 Multiple Tumor Associated Chromosome Region 1 Special Resources Cancer Syndrome A Selection of Internet Sites [*] Outstanding [P] For Professionals [S] Support Groups Online Mendelian Inheritance in Man by OMIM ANIRIDIA ... ANIRIDIA, CEREBELLAR ATAXIA ... WAGR SYNDROME ... ANIRIDIA AND ABSENT PATELLA ... WILMS TUMOR 1 ... ECTOPIA PUPILLAE ... CAT EYE SYNDROME ... PETERS ANOMALY ... EXOSTOSES ... SPLIT-HAND/FOOT ... Wilms Tumor Nephroblastoma by OMIM Rather numerous instances of multiple sibs with Wilms tumor have been described ... The syndrome of aniridia, hemihypertrophy and other congenital anomalies with Wilms tumor, subsequently known as the WAGR syndrome, was first described by Miller et al. (1964) ... . Riccardi et al. (1978) observed a triad of aniridia, ambiguous genitalia and mental retardation (AGR triad) in 3 patients with an interstitial deletion of the short arm of chromosome 11 ... Marshall et al. (1982) studied 14 patients with aniridia .... 6 had interstitial deletion of 11p of various lengths. Band 11p13 was included in the deletion in all 6 cases ...

    28. Kidney
    Image URL congenital renal dysplasia, Image URL congenital renal dysplasia,Image URL Diabetes, Image URL nephroblastoma, Image URL nephroblastoma,
    http://www.brisbio.ac.uk/ROADS/subject-listing/kidney.html
    A collection of medical, dental and veterinary images for use in teaching. Home About the Archive FAQ Terms and Conditions ... Help
    Kidney
    Accelerated glomerulonephritis Acute diffuse proliferative glomerulonephritis Acute diffuse proliferative glomerulonephritis Acute diffuse proliferative glomerulonephritis Acute diffuse proliferative glomerulonephritis Acute interstitial nephritis Acute interstitial nephritis Acute interstitial nephritis Acute interstitial nephritis Acute proliferative glomerulonephritis Acute proliferative glomerulonephritis Acute pyelitis Acute pyelonephritis Acute pyelonephritis Acute pyelonephritis Acute pyelonephritis Acute pyelonephritis Acute pyelonephritis Acute pyelonephritis Acute pyelonephritis Acute pyelonephritis Acute pyelonephritis Acute pyelonephritis Acute pyelonephritis Acute pyelonephritis Acute pyelonephritis Acute pyelonephritis Acute pyelonephritis Acute pyelonephritis Acute renal failure Acute renal failure Acute renal failure Acute renal failure Acute renal failure Acute renal failure Acute renal failure Acute renal failure Acute renal failure Acute tubular necrosis Acute, exudative proliferative glomerulonephritis

    29. Gross Morbid Pathology Of Swine
    14. Cut section. nephroblastoma. nephroblastoma. Occassional metastasis to liverand lungs. 15. congenital / HEREDITARY. 16. Inguinal canal. Genetic, polygenic.
    http://www.afip.org/CLDavis/GrossCourse01/swine.htm
    Gross Morbid Pathology of Swine C. L. Davis Foundation’s “Gross Morbid Anatomy of Diseases of Animals” April 9-13, 2001, AFIP, Washington, DC. Dr. vet. Med. Matti Kiupel, MS, DACVP Animal Disease Diagnostic Laboratory and Department of Veterinary Pathobiology Purdue University, West Lafayette, IN tomcat@purdue.edu No. Tissue Etiology/Disease Gross Diagnosis Notes CAROUSEL 1 INTRODUCTION CL Davis Logo Picture ADDL/Logo Word slide
    Changes in Management Technologies Changes in Disease
    Traditional Technologies: Evolution in Management Technologies: Small farms; 50-100 sows Large farms; 1000-5000 sows Group farrowing; 2-4 gps/yr Reduced weaning age; 10-21 days-of-age Weaning age: 4-8 weeks-of-age Age-segregated rearing; AI/AO, SEW Continuous-flow rearing Site-segregated rearing; 2- or 3-site Word slide Ages/stages: Suckling 1-2 mo.; Grow/Fin. 3-6 mo.; Breeding/Adult Word slide Outline NEOPLASIA Kidney Lymphosarcoma Multifocal renal lymphoma All ages and sexes; multicentric or thymic Kidney, renal ln. Lymphosarcoma Multifocal to coelescing renal lymphoma Head, sagittal

    30. CYSTIC PARTIALLY DIFFERENTIATED NEPHROBLASTOMA (CPDN)
    INTRODUCTION Cystic Partially Differentiated nephroblastoma (CPDN), is a rare, circumscribed theyare congenital or acquired nonneoplastic abnormalities and;
    http://www.bhj.org/journal/1996/3804_oct/case_893.htm

    31. Congenital Malformations
    Causes of Malformations. Most congenital abnormalities do not have s ingle problembut are caused by Very low cure rate ( 5%). Wilm’s Tumor (nephroblastoma).
    http://rossmed.hypermart.net/notes/semesterthree/pedpath.htm

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    Congenital Malformations
    (From Dr. Tomlinson’s path lecture, 9 Nov 2000, by Brian Buschman Return to Semester Three Goodies Return to The Unofficial Ross Page
    Malformations
    Malformations are morphological problems that come along from the beginning. These include things like congenital heart disease. Deformations are defects arising later as problems from mechanical factors. These may be things like forces from leiomyomas or hydro- related factors. Disruptions are a destruction of a body part that began proper formation but something went wrong. This may include amniotic bands. Sequence refers to multiple congenital problems all secondary to a common cause. The most notable being oligohydraminos (Potter’s) sequence. Oligohydraminos causes fetal compression and problems with fancies, hands/feet and pulmonary hypoplasia.
    Causes of Malformations
    Most congenital abnormalities do not have s ingle problem but are caused by: Genetic causes Multifactoral causes The timing of the insult is most serious with the critical period being around the 4th or 5th week of pregnancy.

    32. Mesoblastic Nephroma
    The group of tumors with a better prognosis encompasses congenital mesoblasticnephroma (CMN), fetal rhabdomyomatous nephroblastoma and cystic, partially
    http://www.thedoctorsdoctor.com/diseases/kidney_mesoblastic_nephroma.htm
    Background This is a rare, usually congenital, neoplasm of the kidney. It was first identified in the kidneys sent in for Wilm's tumors and indeed the chief differential diagnosis is with this latter malignant tumor of the kidney. OUTLINE
    Epidemiology
    Disease Associations Pathogenesis Laboratory/Radiologic/Other Diagnostic Testing ... Internet Links
    EPIDEMIOLOGY CHARACTERIZATION INCIDENCE
    Rare AGE RANGE-MEDIAN Usually congenital DISEASE ASSOCIATIONS CHARACTERIZATION HYPERCALCEMIA
    Hypercalcemia in association with mesoblastic nephroma: report of a case and review of the literature. Ferraro EM, Klein SA, Fakhry J, Weingarten MJ, Rose JS.
    Pediatr Radiol 1986;16(6):516-7 Abstract quote Hypercalcemia, often associated with certain types of adult tumors, has also been described in pediatric neoplasms. In childhood, the more common associations include lymphoma, leukemia, rhabdomyosarcoma and rarely neuroblastoma. However, recently, several infants with hypercalcemia were described having renal tumors without bone metastases. The following is a case report of a 2-month-old infant who presented with severe hypercalcemia and a large right-sided abdominal mass, which at surgery was diagnosed as a cellular mesoblastic nephroma.

    33. Www.whonamedit.com
    syndrome). A congenital syndrome in which aniridia and nephroblastoma(Wilms' tumour) is associated with multiple abnormalities. Aniridia
    http://www.whonamedit.com/syndlist.cfm/193

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    Eponyms in category: Multiple congenital anomalies 188 main and alternative entries found.
    Aase-Smith syndrome
    A familial deformity syndrome. Aase’s syndrome (Aase-Smith syndrome) A familial deformity syndrome. Alè-Calò syndrome (Langer-Giedion syndrome) Syndrome characterized by a combination of mental retardation and a long list of physical abnormalities, including multiple extoses, peculiar facies, and loose redundant skin. Alfi's syndrome A very rare chromosome anomaly also known as monosomy 9P. Aniridia-Wilms' tumor association (Brusa-Torricelli syndrome) A congenital syndrome in which aniridia and nephroblastoma (Wilms' tumour) is associated with multiple abnormalities. Aniridia-Wilms’ tumour syndrome (Brusa-Torricelli syndrome) A congenital syndrome in which aniridia and nephroblastoma (Wilms' tumour) is associated with multiple abnormalities. Appelt-Gerken-Lenz syndrome (Roberts' pseudothalidomide syndrome) A syndrome of multiple congenital abnormalities. Audry’s syndrome I (Hallermann-Streiff-François syndrome) A syndrome of multiple congenital abnormalities comprising an abnormally shaped skull, proportionate dwarfism, birdlike facies, atrophy of the skin, bilateral microphtalmia, mental retardation and congenital cataracts.

    34. Cancer Syndromes
    WAGR) syndrome; Wilms tumor associated with congenital absence of Additional featuresWilms tumor (nephroblastoma), gonadoblastoma, hemangioma, and pigmented
    http://ibis-birthdefects.org/start/cancersy.htm
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    ... Etchings Please Explore: Support Groups Professional Associations Key Information Sources Topics include Title and Nephroblastoma Aniridia,Type II Wims Tumor-Aniridia-Genitourinary Anomalies-Mental Retardation Wilms Tumor 3 Wilms Tumor 2 Multiple Tumor Associated Chromosome Region 1 Special Resources Cancer Syndrome A Selection of Internet Sites [*] Outstanding [P] For Professionals [S] Support Groups Online Mendelian Inheritance in Man by OMIM ANIRIDIA ... ANIRIDIA, CEREBELLAR ATAXIA ... WAGR SYNDROME ... ANIRIDIA AND ABSENT PATELLA ... WILMS TUMOR 1 ... ECTOPIA PUPILLAE ... CAT EYE SYNDROME ... PETERS ANOMALY ... EXOSTOSES ... SPLIT-HAND/FOOT ... Wilms Tumor Nephroblastoma by OMIM Rather numerous instances of multiple sibs with Wilms tumor have been described ... The syndrome of aniridia, hemihypertrophy and other congenital anomalies with Wilms tumor, subsequently known as the WAGR syndrome, was first described by Miller et al. (1964) ... . Riccardi et al. (1978) observed a triad of aniridia, ambiguous genitalia and mental retardation (AGR triad) in 3 patients with an interstitial deletion of the short arm of chromosome 11 ... Marshall et al. (1982) studied 14 patients with aniridia .... 6 had interstitial deletion of 11p of various lengths. Band 11p13 was included in the deletion in all 6 cases ...

    35. Uhrad.com - Pediatric Imaging Teaching Files
    Peds Case Forty Seven Small Bowel Rupture. Peds Case Forty Eight - Wilm's Tumor(nephroblastoma). Peds Case Sixty - congenital Adenomatoid Malformation.
    http://www.uhrad.com/pedsarc.htm
    uhrad.com - Pediatric Imaging Teaching Files
    Peds Case One - Posterior Epidural Abscess Peds Case Two - Rickets Peds Case Three - Proximal Tracheal Esophageal Fistula Peds Case Four - Juvenile Ankylosing Spondylitis ... Return to Home Page

    36. Uhrad.com - Pediatric Imaging Teaching Files
    Discussion Wilm's tumor (nephroblastoma) is the most common Associated conditionsinclude congenital genitourinary malformations, hemihypertrophy, sporadic
    http://www.uhrad.com/pedsarc/peds048.htm
    uhrad.com - Pediatric Imaging Teaching Files
    Case Forty Eight - Wilm's Tumor (Nephroblastoma)
    Click on Images for Enlarged View Clinical History: 18-month-old female with palpable abdominal mass. Findings: Ultrasound: Large inhomogeneous mass arising from the upper right kidney. Multiple areas of decreased echogenicity are present compatible with necrosis. MRI: The mass demonstrates heterogeneous low T1 and high T2 signal characteristics with areas of high T1 signal corresponding with hemorrhage. A pseudocapsule is evident on T2 imaging. There is no involvement of the renal vein or IVC. Diagnosis: Wilm's tumor (nephroblastoma). Discussion: Wilm's tumor (nephroblastoma) is the most common abdominal malignancy, and the most common solid renal mass in childhood. The incidence is 1 in 10,000 with a bimodal peak at ages 2.5 and 3.5 years (1). There are both hereditary and sporadic forms, and approximately 6% are bilateral(1). Most are unicentric and arise from the kidney. Extra-renal Wilm's tumor is rare. Associated conditions include congenital genitourinary malformations, hemihypertrophy, sporadic aniridia, as well as Beckwith-Weidemann and Drash syndromes. nephroblastomatosis (residual metanephrogenic blastema beyond 36 weeks gestation) is also associated with Wilm's tumor and is considered by many its precursor.

    37. Publikationen
    problems and complicationsevaluation of the nephroblastoma Study SIOP 9 D. SchmidtSuccessful therapy of local recurrence of congenital mesoblastic nephroma
    http://www.med-rz.uni-sb.de/med_fak/kinderklinik/Publikationen/body_publikatione

    38. Congenital Mesoblastic Nephroma From Pediatrics / Oncology
    to a nonrenal lowgrade congenital infantile fibrosarcoma Fetal rhabdomyomatous nephroblastoma(monophasic Wilms tumor) nephroblastomatosis (nephrogenic rests
    http://author.emedicine.com/PED/topic3007.htm
    eMedicine Journal Pediatrics Oncology
    Congenital Mesoblastic Nephroma
    Synonyms, Key Words, and Related Terms: Mesoblastic nephroma, leiomyomatous hamartoma, congenital mesoblastic nephroma of infancy, fetal renal hamartoma, CMN Author Information Introduction Clinical Differentials ... Bibliography
    AUTHOR INFORMATION Section 1 of 12 Authored by Helen SL Chan, MBBS, FRCP(C), FAAP , Senior Scientist, Research Institute; Professor, Division of Hematology/Oncology, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Canada Helen SL Chan, MBBS, FRCP(C), FAAP, is a member of the following medical societies: American Academy of Pediatrics American Association for Cancer Research American Society of Clinical Oncology American Society of Hematology , and Royal College of Physicians and Surgeons of Canada Edited by Stephan A Grupp, MD, PhD , Director, Stem Cell Biology Program, Children's Hospital of Philadelphia; Assistant Professor, Department of Pediatrics, Division of Oncology, University of Pennsylvania; Mary L Windle, PharmD

    39. Nephroblastoma: Some Details
    nephroblastoma Also known as Wilms tumour; Usually presents as a palpable abdominalmass in a otherwise well child; Associated with other congenital anomalies
    http://www.mds.qmw.ac.uk/biomed/kb/humandevelopment/stage2/learning landscapes/w
    Nephroblastoma
    • Also known as Wilms tumour Usually presents as a palpable abdominal mass in a otherwise well child Associated with other congenital anomalies such as hemihypertrophy, aniridia and ambiguous genitalia Occasional findings are haematuria and hypertension Diagnosis is usually made on ultrasound
    Left sided abdominal mass Nephroblastoma: some pictures
    • CT scan Resected kidney Typical “triphasic” wilms tumour with dense clusters of blastemal cells and pale staining stroma and epithelial (tubular) tissue

    40. Nephroblastoma
    nephroblastoma. Three associated congenital malformations 3. BeckwithWiedmannsyndrome - Hemihypertrophy, enlarged organs (omphalocele
    http://pathophysiology.uams.edu/Spring01/peds/lect40-s01/tsld046.htm
    Nephroblastoma
      Three associated congenital malformations:
      3. Beckwith-Wiedmann syndrome - Hemihypertrophy, enlarged organs (omphalocele) renal cysts and adrenal cytomegally. The genetic locus for these patients is on 11p15.5 (WT-2)
      Wilms (10%) be bilateral or multifocal, but usually are solitary and well circumscribed.
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