21. The Percept Of Pain: Where Does It Come From? movement to promote necessary healing processed (2). So essential is the painfulresponse that those individuals born with congenital pain insensitivity do not http://serendip.brynmawr.edu/bb/neuro/neuro02/web2/rdeering.html

This paper was written by a student in a course at Bryn Mawr College, and reflects that student's research and thoughts at the time the paper was written. Like other things on Serendip , the paper is not intended to be "authoritative" but is instead provided to encourage others to themselves learn about and think through subjects of interest, and, by providing relevant web links, to serve as a "window" to help them do so. Web links were active as of the time the paper was posted but are not updated. Biology 202 2002 Second Paper On Serendip The Percept of Pain: Where does it come from? Raquel Deering In class we have discussed the concept of pain, concluding that a conflict between what the brain anticipates occurring and what actually occurs has the potential to cause the perception of pain. Furthermore, it was suggested that genetics might have a role in the experience of pain, particularly when applied to the discussion of phantom limb pain. However, I found these inferences a bit unsatisfying and walked away with more questions than answers. Where does chronic pain come into the picture? Why is a stimulus that is painful for one person not for another? And the question that puzzled me the most: how, from a neurobiological perspective, can an individual experience pain in her arm if she was born without one? Pain, a component of the somatosensory system, is defined by the International Association for the Study of Pain as "an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage"

22. BI 2413 – Brain And Behaviour People who suffer congenital pain insensitivity (do not feel pain)rarely survive their teens! (suffer burns, lacterations, joint http://www.abu.nb.ca/FACULTY/MListon/BI 2413/Feb_26.htm

BI 2413 – Brain and Behaviour February 26, 2001 I. Somatosensory Cortex II. Pain and the Descending Analgesia Circuit III. Smell And Taste a. The olfactory system b. The gustatory system IV. Selective Attention V. Sensorimotor System a. Sensorimotor Function i. Hierarchical Organization ii. Sensory Input Guiding iii. Effects of Learning b. Posterior parietal Association Cortex c. Dorsolateral Prefrontal Association Cortex d. Secondary Motor Cortex i. Premotor cortex ii. Supplementary motor area iii. Cingulated motor areas e. Primary Motor Cortex f. Cerebellum and Basal Ganglia g. Basal Ganglia The Somatosensory System The two ascending pathways The dorsal-column medial-lemniscus system This system carries information about touch and proprioception to the cortex. The axons of receptors in the skin enter the spinal cord and ascend in the dorsal columns to the dorsal column nuclei The axons of the dorsal column nuclei cells decussate and ascend in the medial lemniscus to the ventral posterior nucleus (VPN) The axons of the VPN ascend to the Somatosensory cortex Axons from the toes that ascend in the dorsal columns are the longest in the body Anterolateral system This is the other Somatosensory pathway This system carries some crude information about touch, but really the primary function is to mediate the perception of pain and temperature

23. DINO - Language: Englisch - Health - Conditions And Diseases - C Dieser Link verweist auf eine HauptKategorie Congenital Nephroblastoma Dieser Linkverweist auf eine Haupt-Kategorie congenital pain insensitivity Dieser Link http://www.dino-online.de/dino_page_4d8b50989e03b07a158309b4ee7d1dc4.html

Suche Profi-Suche Katalog Video ... Produkte Suchen: Web-Seiten Video Audio Bilder Produkte Schon gewusst? Hier suchen Sie in 2 Milliarden Webseiten. Live-Suche: Was suchen andere Dino-Besucher? You are here: DINO Language Englisch Health ... Conditions and Diseases C C Sprache/Language Categories Campylobacter Pylori Canavan Disease Cancer Candida Cardiomyopathy Carpal Tunnel Syndrome Cat-Scratch Disease Cataracts Causalgia Celiac Disease Central Pontine Myelinolysis Cerebellar Diseases Cerebellar Vermis Agenesis Cerebral Abscess Cerebral Edema Cerebral Gigantism Cerebral Palsy Cerebrocostomandibular Syndrome Cerebrohepatorenal Syndrome Cerebrotendinous Xanthomatosis Cervical Cancer Charcot-Marie-Tooth Disease Chicken Pox Childhood Depression Chlamydia Cholera Cholesteatoma Cholesterol and Other Fats Chondromalacia Chromosomal Disorders Chromosome 5p-Syndrome Chronic Fatigue Syndrome Chronic Obstructive Pulmonary Disease Chronic Progressive External Ophthalmoplegia Circulation Disorders Cleft Lip and Palate Cleidocranial Dysplasia Clubfoot Coccidioidomycosis Cockayne Syndrome Coffin Lowry Syndrome Cold Sores Colitis Common Cold Communication Disorders Complex Regional Pain Syndromes Compulsive Gambling Congenital Arthromyodysplasia Congenital Facial Diplegia Congenital Heart Disease Congenital Nephroblastoma Congenital Pain Insensitivity Conjunctivitis Constipation Continuous Muscle Fiber Activity Syndrome Contraception Conversion Disorder Cor Pulmonale Cornelia De Lange Syndrome Coronary Artery Disease

24. Genetic Disorders Information Sites Lowry Syndrome; congenital pain insensitivity@; Cornelia De Lange Syndrome@;Costello Syndrome; Cowden Syndrome; Craniofrontonasal Dysplasia; http://www.medicalorg.com/ConditionsandDiseases/GeneticDisorders/

MEDICALorg.com Search SPYorg.com (Not sure of spelling? Use first letters and * such as abc* or abcd* or abcde*) Match:.. All Any Format: Long Short Search Words: Top Health Conditions and Diseases : Genetic Disorders Aarskog Syndrome Aase Syndrome Ablepharon-Macrostomia Syndrome Acoustic Neuroma ... Zellweger Syndrome See Also: Health: Conditions and Diseases: Rare Disorders Science: Biology: Genetics: Eukaryotic: Animal: Mammal: Human Rare Genetic Diseases In Children - A layman's guide to genetic diseases, and a comprehensive resource for families on lysosomal storage diseases. Gene Clinics - Medical genetics knowledge base. NIH funded, expert-authored descriptions of inherited disorders. Covers genetic testing in diagnosis and management and genetic counseling of patients. Washington University in St Louis - Family resource for individuals with Papillon Lefevre, Haim-Munk Syndrome and Prepubertal Periodontis. Interested families may participate in a registry dedicated to learning about the natural history of these three conditions. Respiratory Syndromes Associated with Congenital Abnormalities of Mucociliary Clearance - A resource providing information for physicians and patients on laboratory analyses of Primary Ciliary Dyskinesia, Immotile Cilia Syndrome, and Kartagener's Syndrome.

25. Listings Of The World Health Conditions And Diseases Acrodynia (4) CharcotMarie-Tooth Disease (6) congenital pain insensitivity (4)Diabetic Neuropathies (5), Nerve Compression Syndromes (86) Neuralgias (18 http://listingsworld.com/Health/Conditions_and_Diseases/Neurological_Disorders/P

26. Congenital Insensitivity To Pain a CHORUS notecard document about congenital insensitivity to pain osteomyelitis (mandible, fingers, toes). DDx congenital insensitivity to pain with anhidrosis (aut. http://chorus.rad.mcw.edu/doc/00546.html

CHORUS Collaborative Hypertext of Radiology Musculoskeletal system Feedback Search congenital insensitivity to pain autosomal recessive neuropathic joints micro- and macrofractures epiphyseal separation osteomyelitis (mandible, fingers, toes) DDx: congenital insensitivity to pain with anhidrosis (aut. rec.) hereditary sensory radicular neuropathy (aut. rec.) congenital sensory neuropathy (aut. dom.) familial dysautonomia (aut. rec.) Lesch-Nyhan syndrome (X rec.) Charles E. Kahn, Jr., MD - 2 February 1995 Last updated 14 March 2001 Medical College of Wisconsin

27. NTRK1 gCAGTAG. Gln-Term. pain insensitivity, congenital. 1. CM990974. 85 http://www.uwcm.ac.uk/uwcm/mg/ns/1/127897.html

Nucleotide substitutions (missense / nonsense) Accession Number Codon Nucleotide Amino acid Phenotype Reference gCAG-TAG Gln-Term Pain insensitivity, congenital cCGT-AGT Arg-Ser Pain insensitivity, congenital CTG-CCG Leu-Pro Pain insensitivity, congenital gGAG-TAG Glu-Term Pain insensitivity, congenital gCAG-TAG Gln-Term Pain insensitivity, congenital CTG-CCG Leu-Pro Pain insensitivity, congenital TAC-TGC Tyr-Cys Sensory and autonomic neuropathy type V TACa-TAA Tyr-Term Pain insensitivity, congenital tGGG-CGG Gly-Arg Pain insensitivity, congenital cGGC-CGC Gly-Arg Pain insensitivity, congenital cATG-GTG Met-Val Pain insensitivity, congenital cCGA-TGA Arg-Term Pain insensitivity, congenital cCAT-TAT His-Tyr Pain insensitivity, congenital GGT-GTT Gly-Val Pain insensitivity, congenital GGG-GTG Gly-Val Pain insensitivity, congenital gGAG-TAG Glu-Term Pain insensitivity, congenital tGTG-TTG Val-Leu Pain insensitivity, congenital cCGG-TGG Arg-Trp Pain insensitivity, congenital aCGC-TGC Arg-Cys Pain insensitivity, congenital gGAT-TAT Asp-Tyr Pain insensitivity, congenital

28. 1957: Multisystem Involvement In Congenital Insensitivity To Pain With Anhidrosi congenital insensitivity to pain . see arthropathy neuropathic, insensitivity to pain congenital http://www.faseb.org/genetics/ashg99/f1957.htm

Program Nr: 1957 Multisystem involvement in congenital insensitivity to pain with anhidrosis (CIPA), a nerve growth factor receptor (TrkA) related disorder. E. Toscano , R. Della Casa , S. Mardy , G. Marzano , N. Varricchione , F. Sadile , C. Pignata , Y. Indo , G. Andria

29. Autonomic Dysfunction In Four Patients With Congenital Insensitivity Autonomic dysfunction in four patients with congenital insensitivity to pain Pages 591 600 Part of the OUP Brain WWW service Click here to register with OUP. Last updated 14 May 97 http://www3.oup.co.uk/jnls/supplements/braini/hdb/Volume_96/Issue_03/960591.sgm.

Volume 96: January - December 1973 Issue 3: September 1973 Abstract Autonomic dysfunction in four patients with congenital insensitivity to pain DC Thrush Pages: Part of the OUP Brain WWW service General Information Click here to register with OUP. This page is maintained by OUP admin Last updated 14 May 97 Part of the OUP Journals World Wide Web service Oxford University Press, 1997

30. AAOS On-Line Service - 1999 Annual Meeting Poster Exhibits Congenital Insensitiv An article about this disorder, explaining what it is and how it presents.Category Health Conditions and Diseases...... Exhibits. congenital insensitivity to pain. Poster Board Number 355. congenitalinsensitivity to pain is a challenging diagnosis. The http://www.aaos.org/wordhtml/anmeet99/poster/355.htm

American Academy of Orthopaedic Surgeons 1999 Annual Meeting Poster Exhibits Congenital Insensitivity to Pain Poster Board Number: John P Sheehan, MD , Wichita, KS Perry L Schoenecker, MD, Saint Louis, MO Category: Pediatrics Hall A of the Anaheim Convention Center Saturday February 6, 1999 10:00 AM-5:00 PM The principal exhibitor will be available from 12:00 Noon to 3:00 PM to discuss the exhibit and answer questions regarding the poster. Cameras may be used in the Poster Exhibit area. Home 1999 Meeting Poster Exhibits Last modified 08/January/1999 by IS

31. Congenital Insensitivity To Pain American Academy of Orthopaedic Surgeons 1999 Annual Meeting congenital insensitivity to pain Poster Board Number 355 John P Sheehan, MD, Wichita, KS Perry L Schoenecker, MD, Saint Louis, MO congenital insensitivity to pain is a rare disorder which is defined as the absence of normal subjective and objective http://chorus.rad.mcw.edu/to-go/00546.html

congenital insensitivity to pain autosomal recessive neuropathic joints micro- and macrofractures epiphyseal separation osteomyelitis (mandible, fingers, toes) DDx: congenital insensitivity to pain with anhidrosis (aut. rec.) hereditary sensory radicular neuropathy (aut. rec.) congenital sensory neuropathy (aut. dom.) familial dysautonomia (aut. rec.) Lesch-Nyhan syndrome (X rec.) Home Musculoskeletal system

32. Musculoskeletal System - CHORUS Kleeblatschaedel); cold bone lesions; Colles fracture; congenital infectionToRCHS syndrome; congenital insensitivity to pain; congenital http://chorus.rad.mcw.edu/index/6.html

CHORUS Collaborative Hypertext of Radiology Search by title Musculoskeletal system absent distal clavicle absent nasal septum achondroplasia acro-osteolysis ... wrist fractures Charles E. Kahn, Jr., MD, Editor 1 January 2003 Medical College of Wisconsin

33. Genetics Of Congenital Insensitivity To Pain With Anhidrosis (CIPA) Patient medical question and doctor answer from The Neurology and Neurosurgery Forum at Med Help. Health topic area and articles about neurology. recessive disorder characterized by congenital insensitivity to pain, anhidrosis, defective temperature control, and http://www.medhelp.org/perl6/neuro/messages/30436a.html

Advertisement Welcome to Med Help International A not-for-profit organization Questions in The Neurology Forum are being answered by doctors from The Cleveland Clinic , consistently ranked one of the best hospitals in America. Subject: Genetics of Congenital Insensitivity to Pain with Anhidrosis (CIPA) Topic Area: Neurology Forum: The Neurology and Neurosurgery Forum Question Posted By: Clark on Sunday, March 05, 2000 My first child has a disease very close to CIPA. While waiting for further diagnosis, I am now expecting my second child. I would apprecaite it very much if anyone could help me by answering the following questions: 1/How much is the chance of my second child getting the same disease? 2/ Is it possible to have a test to find out the condition of my second baby? Answer Posted By: CCF Neuro[P] MD, RPS on Sunday, March 05, 2000 Dear Clark: I am sorry to hear about your child. Hereditary sensory and autonomic neuropathy type IV is a rare autosomal recessive disorder characterized by congenital insensitivity to pain, anhidrosis, defective temperature control, and mild mental retardation. There is a selective loss of unmyelinated axons and small myelinated fibers. The gene locus for this entity maps to chromosome 1q21-22. Mutations in the trkA gene encoding the tyrosine kinase receptor for nerve growth factor have been described in some patients. I know you know this already, but I thought I'd put it in for others. As an autosomal recessive gene, the chances of your next child having the disease is 25%. As much as I know, there is no prenatal test for this entity. Because the gene is not known for sure, we can't test for what we do not know.

34. NTRK1 CD991822, 66, GGCGCA^GAGAaCCTGACTGAG, pain insensitivity, congenital,1. CD000267, 129, CTGGAG^TCTCtcTCCTGGAAAA, pain insensitivity, congenital,2. http://www.uwcm.ac.uk/uwcm/mg/ns/4/127897.html

Small deletions Accession Number Location/ codon Deletion Phenotype Reference GGCGCA^GAGAaCCTGACTGAG Pain insensitivity, congenital CTGGAG^TCTCtcTCCTGGAAAA Pain insensitivity, congenital TGGAT^GGGCAgccggcaCCGTCTCTGC Pain insensitivity, congenital CATCAAG^CGCcgGGACATCGTG Pain insensitivity, congenital CGAGAGT^GCTcGGCAGGACTT Pain insensitivity, congenital GGCCGC^CCCCtGCTCATGGTC Pain insensitivity, congenital References 1 - Mardy (1999) Am J Hum Genet 2 - Miura (2000) Hum Genet ... Nat Genet HGMD

35. Handbook Of Congenital Insensitivity To Pain With Anhidrosis Handbook of congenital insensitivity to pain With Anhidrosis March, 19971. What is congenital insensitivity to pain with Anhidrosis (CIPA)? http://www02.so-net.ne.jp/~tomorrow/en2/hand_e.htm

Handbook of Congenital Insensitivity to Pain With Anhidrosis - For Teachers In Charge of Children With Congenital Insensitivity to Pain With Anhidrosis "Tomorrow" - The Association of Congenital Insensitivity to Pain With Anhidrosis Index Handbook of Congenital Insensitivity to Pain With Anhidrosis Introduction 1. What is Congenital Insensitivity To Pain With Anhidrosis? 2. The Growth Process of and Disorders affecting Children With Congenital Insensitivity To Pain With Anhidrosis 3. Notes on Everyday Life Situations And How To Cope With Them 4. Medical Tests Afterword Illustration / Layout Hiroaki Watanabe Introduction Are you familiar with "Congenital Insensitivity to Pain With Anhidrosis (CIPA)"? Most probably, this is the first experience for most teachers. I presume you must be feeling apprehensive and somewhat at a loss at the news that a child with a disease you have never heard of is going to be a member of your class. This disease, as it literally means, is a disease in which patients do not have a sense of pain or perspiration from birth. It is almost impossible for you to imagine what kind of problems will result from this disease.

36. Academic Activities sensory and autonomic neuropathy (HSAN)is usually divided into six types(Liberfarb,1993).Type4 of HSAN shows congenital insensitivity to pain with anhidrosis http://www02.so-net.ne.jp/~tomorrow/en3/act.htm

Academic Activities Clinical Studies of Hereditary Sensory and Autonomic Neuropathy Type 4 5th Asian and Oceanian Congress of Child Neurology, Istanbul Turkey, 1996, October Kenji Nihei, Yutaka Awaya, and Syouta Miyake 1) Department of Pediatric Neurology, National Children's Hospital. 2) Department of Pediatrics, Seibo Hospital. 3) Yokohama Ryouiku-en, Tokyo, Japan. Hereditary sensory and autonomic neuropathy (HSAN)is usually divided into six types(Liberfarb,1993).Type 4 of HSAN shows congenital insensitivity to pain with anhidrosis and autosomal recessive trait. Serious complications were Charcot joints, repeated severe burns, osteomyclitis, bone fracture, traumas of tongue and mucous and hyperthermia or heat stroke due to anhidorosis. In some cases these complications were the cause of death. It is very important to prevent these complications. Further study is needed. Seizures in Congenital Insensitivity to Pain with Anhidrosis (CIPA) 8th International Child Neurology Congress, Ljubljana, Slovenia,1998, September

37. Genetics Of Congenital Insensitivity To Pain With Anhidrosis (CIPA) Subject Genetics of congenital insensitivity to pain with Anhidrosis (CIPA) TopicArea Neurology Forum The Neurology and Neurosurgery Forum Question Posted http://www.medhelp.org/forums/neuro/messages/30436a.html

Advertisement Welcome to Med Help International A not-for-profit organization Questions in The Neurology Forum are being answered by doctors from The Cleveland Clinic , consistently ranked one of the best hospitals in America. Subject: Genetics of Congenital Insensitivity to Pain with Anhidrosis (CIPA) Topic Area: Neurology Forum: The Neurology and Neurosurgery Forum Question Posted By: Clark on Sunday, March 05, 2000 My first child has a disease very close to CIPA. While waiting for further diagnosis, I am now expecting my second child. I would apprecaite it very much if anyone could help me by answering the following questions: 1/How much is the chance of my second child getting the same disease? 2/ Is it possible to have a test to find out the condition of my second baby? Answer Posted By: CCF Neuro[P] MD, RPS on Sunday, March 05, 2000 Dear Clark: I am sorry to hear about your child. Hereditary sensory and autonomic neuropathy type IV is a rare autosomal recessive disorder characterized by congenital insensitivity to pain, anhidrosis, defective temperature control, and mild mental retardation. There is a selective loss of unmyelinated axons and small myelinated fibers. The gene locus for this entity maps to chromosome 1q21-22. Mutations in the trkA gene encoding the tyrosine kinase receptor for nerve growth factor have been described in some patients. I know you know this already, but I thought I'd put it in for others. As an autosomal recessive gene, the chances of your next child having the disease is 25%. As much as I know, there is no prenatal test for this entity. Because the gene is not known for sure, we can't test for what we do not know.

38. Congenital Autonomic Dysfunction With Universal Pain Loss (Riga-Fede Disease) from congenital autonomic dysfunction with universal pain loss, which is a form ofhereditary sensory autonomic neuropathy. The patient's insensitivity to pain http://dermatology.cdlib.org/DOJvol7num2/nyu2/7/7.html

refs = new Array("References:","Burgess G, et al. Eosinophilic ulcer of the tongue: report of two cases. Arch Dermatol 113:644, 1977 ", "Elzay R. Traumatic ulcerative granuloma with stromal eosinophilia (Riga-Fede's disease and traumatic eosinophilic granuloma). Oral Surg Oral Med Oral Pathol 55:497, 1983 ", "Rongioletti F, et al. Traumatic eosinophilic ulcer of the oral mucosa. Cutis 43:357, 1989 ", "Eichenfeld L, et al. Traumatic granoloma of the tongue (Riga-Fede disease): association with familial dysautonomia. J Pediatr 116:742, 1990 ", "Mezei M, et al. Eosinophilic ulcer of the oral mucosa. J Am Acad Dermatol 33:734, 1995 "); DOJ Contents English Congenital autonomic dysfunction with universal pain loss (Riga-Fede disease) Brian R. Toy Dermatology Online Journal 7(2): 17 New York University Department of Dermatology History This 20-month-old boy presented to the Bellevue Hospital Medical Center at age ten months for evaluation of oral plaques of three-months duration. The lesions appeared shortly after teething and were exacerbated by repetitive tongue thrusting and lip biting. Past medical history includes developmental delay and poor feeding since birth. Family history is negative for skin and developmental disorders and congenital syndromes.

39. Insensitivity To Pain, Congenital click For Medical Professionals only. insensitivity to pain, congenital,,Print this article, absent or markedly reduced sensitivity http://www.amershamhealth.com/medcyclopaedia/Volume VII/INSENSITIVITY TO PAIN CO

Medcyclopaedia About Medcyclopaedia Amersham Health Search for: Type a word or a phrase. All forms of the word are searchable. Advanced search Browse entry words starting with: A B C D ... Other characters Try our Medcyclopaedia Premium Edition with added tools and functionality tailored to make your working day easier. The following tools are presently available: Expanded search *For Medical Professionals only, registration required Insensitivity to pain, congenital, absent or markedly reduced sensitivity to pain which means that children repeatedly injure themselves but do not present clinically as they do not feel pain in relation to the injury. They may also have multiple ulcerations of the lips and tongue due to biting. Inheritance is autosomal recessive. Clinically, children can present with palpable healing fractures, deformity, ulceration or evidence of osteomyelitis. Radiologically, the appearances are those of multiple fractures which heal without osteoporosis. There may also be evidence of osteomyelitis. HC The Encyclopaedia of Medical Imaging Volume VII Welcome to Medcyclopaedia.

40. Pain, Congenital Indifference To All of the syndromes of congenital insensitivity to pain, such as familial dysautonomia(Riley Day syndrome), show virtually identical skeletal abnormalities. http://www.amershamhealth.com/medcyclopaedia/Volume III 1/pain congenital indiff

Medcyclopaedia About Medcyclopaedia Amersham Health Search for: Type a word or a phrase. All forms of the word are searchable. Advanced search Browse entry words starting with: A B C D ... Other characters Try our Medcyclopaedia Premium Edition with added tools and functionality tailored to make your working day easier. The following tools are presently available: Expanded search *For Medical Professionals only, registration required Pain, congenital indifference to, an insensitivity to pain, occurring as a component of several hereditary sensory neuropathies. Among the symptoms that may be recognized in infancy or childhood are a decreased or absent reaction to pain, scars on the tongue or finger due to burns or infections, corneal opacities resulting from unnoticed foreign bodies, and self-mutilation with amputation of fingers and toes. On radiographs patients may have fractures of the metaphysis and diaphysis of long bones, epiphyseal separations, neuropathic osteoarthropathy and soft tissue ulcerations ( Fig.1

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