1. NINDS Corticobasal Degeneration Information Page Information sheet compiled by the National Institute of Neurological Disorders and Stroke.Category Health Conditions and Diseases corticobasal degeneration...... More about corticobasal degeneration, Studies with patients, Research literature, NINDScorticobasal degeneration Information Page Reviewed 0904-2001 http://www.ninds.nih.gov/health_and_medical/disorders/cortico_doc.htm

National Institute of Neurological Disorders and Stroke Accessible version Science for the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system Browse all disorders Browse all health organizations More about Corticobasal Degeneration Studies with patients Research literature Press releases Search NINDS... (help) Contact us My privacy NINDS is part of the National Institutes of Health NINDS Corticobasal Degeneration Information Page Reviewed 3-21-2003 Get Web page suited for printing Email this to a friend or colleague Table of Contents (click to jump to sections) What is Corticobasal Degeneration? Is there any treatment? What is the prognosis? What research is being done? ... Related NINDS Publications and Information What is Corticobasal Degeneration? Corticobasal degeneration is a progressive neurological disorder characterized by nerve cell loss and atrophy (shrinkage) of multiple areas of the brain including the cerebral cortex and the basal ganglia. Corticobasal degeneration progresses gradually. Initial symptoms, which typically begin at or around age 60, may first appear on one side of the body (unilateral), but eventually affect both sides as the disease progresses. Symptoms are similar to those found in Parkinson disease, such as poor coordination, akinesia (an absence of movements)

2. WE MOVE - Corticobasal Degeneration What is corticobasal degeneration? corticobasal degeneration (CBD) is a rare neurological disease in which parts of the http://www.wemove.org/cbd.html

What is corticobasal degeneration? Corticobasal degeneration (CBD) is a rare neurological disease in which parts of the brain deteriorate or degenerate. CBD is also known as corticobasal ganglionic degeneration, or CBGD. Several regions of the brain degenerate in CBD. The cortex, or outer layer of the brain, is severely affected, especially the fronto-parietal regions, located near the center-top of the head. Other, deeper brain regions are also affected, including parts of the basal ganglia, hence the name "corticobasal" degeneration. The combined loss of brain tissue in all these areas causes the symptoms and findings seen in people with CBD. What causes the degeneration of brain tissue in CBD? Unfortunately, the cause of CBD is entirely unknown. There is currently no strong evidence to suggest CBD is an inherited disease, and no other risk factors, such as toxins or infections, have been identified. Studies of brain tissue of individuals with CBD show certain characteristic cell changes. Similar, although not identical, changes are observed in two other neurodegenerative diseases, Pick's disease and progressive supranuclear palsy. These changes, involving a brain protein called tau, have provided researchers some initial clues in their search for the causes of CBD. What are the symptoms of CBD?

3. Cortico Basal Ganglionic Degeneration Article by Timothy C. Hain, MD from Northwestern University Medical School.Category Health Conditions and Diseases corticobasal degeneration......Corticobasal ganglionic degeneration (CBD). corticobasal degeneration sharesa common genetic background with progressive supranuclear palsy. http://www.neuro.nwu.edu/meded/MOVEMENT/corticobasal.html

Corticobasal ganglionic degeneration (CBD) Timothy C. Hain, MD Northwestern University Medical School, Most recent update: 7/2001 Please read our Corticobasal ganglionic degeneration (which we will call CBD) is a rare progressive neurological disorder characterized by a combination of Parkinsonism and cortical dysfunction. It is a rare sporadic progressive disorder first reported in 1968. CBD appears to be closely related to another, less rare, sporadic extrapyramidal degenerative disorder named Progresive Supranuclear Palsy (PSP) . In CBD, cognitive symptoms dominate, while in PSP, eye movement symptoms dominate the picture. The Parkinsonism is generally an asymetric akinetic rigid syndrome, unresponsive to levodopa, similar to that of multiple system atrophy and PSP . Eye movement abnormalities are common, as in PSP, and a supranuclear gaze palsy can be seen as in PSP. Given the genetic similarities between CBD and PSP, it seems possible that they are simply two "faces" of the same disease. Neuroradiological imaging studies in CBD demonstrate cortical atrophy, which may be symmetrical or asymmetrical. Other cortical signs include

4. NINDS - News And Events Sorry! There are no press releases for corticobasal degeneration. Useyour browser's Back button to return to your previous activity. http://www.ninds.nih.gov/health_and_medical/news.htm?url=/health_and_medical/dis

5. WE MOVE - Corticobasal Degeneration Chat Login Page corticobasal degeneration Chat Login. The corticobasal degeneration chat roomis always open. A login screen should appear in less than one minute. http://www.wemove.org/cbd_chat.html

Corticobasal Degeneration Chat Login The corticobasal degeneration chat room is always open. A login screen should appear in less than one minute. Please enter a nickname to connect. DigiChat requires a Java Compatible Web browser to run. To our chat room and forum users: WE MOVE needs your help! As a small not-for-profit in New York City, our funding has been significantly affected by the 9/11 disaster. As you know, WE MOVE delivers all of its services free or at cost to the movement disorder community. Please click on the donation button now and give as generously as you can. Your contribution will help ensure that WE MOVE can continue to serve the millions of individuals, who, because their diseases are difficult to diagnose and manage, might suffer needlessly for years. Thank you so much! TECHNICAL NOTE: We have received comments about this chat service occasionally disconnecting users. This problem is related to the slow connection times between users and chat hosting machines or due to less stable Java support within client browsers. Use of a current Web browser such as Internet Explorer 5.x is strongly recommended. If technical problems persist, please report the error to WE MOVE.

6. ClinicalTrials.gov - Linking Patients To Medical Research: Results Search results for corticobasal degeneration ALLFIELDS are shown below. http://clinicaltrials.gov/search/term=Corticobasal+Degeneration

Home Search Browse Resources ... About Search results for Corticobasal Degeneration [ALL-FIELDS] are shown below. Show all trials, including those no longer recruiting patients. 1 study was found. Recruiting Study of Tongue Pressures Conditions: Deglutition Disorder; Healthy U.S. National Library of Medicine Contact NLM Customer Service National Institutes of Health Freedom of Information Act ... Accessibility

7. Corticobasal Degeneration corticobasal degeneration is characterized by loss and atrophy of multipleareas of the brain, including the cerebral cortex and the basal ganglia. http://healthlink.mcw.edu/article/921395030.html

Search Articles: search tips Please Take the HealthLink Survey Email this article Print this article Find related articles: By topic: Neurology By keywords: Receive Health Link via email! Subscribe now >> Corticobasal Degeneration Corticobasal degeneration is a progressive neurological disorder characterized by nerve cell loss and atrophy (shrinkage) of multiple areas of the brain including the cerebral cortex and the basal ganglia. Corticobasal degeneration progresses gradually. Initial symptoms, which typically begin at or around age 60, may first appear on one side of the body (unilateral), but eventually affect both sides as the disease progresses. Symptoms include signs of parkinsonism such as poor coordination, akinesia (an absence of movements), rigidity (a resistance to imposed movement), and disequilibrium (impaired balance); and limb dystonia (abnormal muscle postures). Other symptoms such as cognitive and visual-spatial impairments, apraxia (loss of the ability to make familiar, purposeful movements), hesitant and halting speech, myoclonus, and dysphagia (difficulty swallowing) may also occur. The patient is unable to walk. Symptoms vary among patients. Is there any treatment?

8. Cortico Basal Degeneration corticobasal degeneration. corticobasal degeneration (CBD) is a slowlyprogressive neurodegenerative disorder characterized by an http://www.lille.inserm.fr/u422/corticobasal.degeneration.html

Alzheimer Brain dis eases Research ... GD Bri C BD DS GSS F TD FTDP-17 H ... F H-S d IBM L BD MSA NPiD c PDG P D PiD P rion P SP PEP SSP ToD Corticobasal degeneration Corticobasal degeneration (CBD) is a slowly progressive neurodegenerative disorder characterized by an asymmetrical akinetic-rigid syndrome associated with cognitive (apraxia and aphasia) and extrapyramidal motor dysfunction (rigidity and dystonia). Moderate dementia emerges sometimes late in the course of the disease (Rinne et al., 1994). Key words: myoclonus, dystonia, alien limb, occulomotor apraxia Prevalence: 4.0 -7.3 /100.000 Incidence: 0.6-0.9 new cases per 100.000 person/year Neuropathology Neuropathological examination shows gliosis, neuronal loss, presence of achromatic ballooned neurons, neuritic changes and neurofibrillary tangles (Paulus et al., 1990 ; Ksiezak-Reding et al., 1994; Feany et al., 1994; Buée-Scherrer et al., 1996b) and astrocytic plaques. There is an overlap between progressive supranuclear palsy (PSP) and CBD (Feany et al., 1996), and it would be most helpful to distinguish these two pathologies on a neuropathological or immunochemical basis. By comparison, CBD is less prevalent, and usually dysplays a more severe cortical atrophy with fronto-parietal predominance partly sparing the central area.

9. Corticobasal Degeneration http://www.lille.inserm.fr/u422/DCB.html

Accueil Le laboratoire Maladie d'Alzheimer Autres maladies ... Associations de famille Nouveau La Recherche Base de données Dégénérescence corticobasale English version: Corticobasal degeneration Aspects cliniques: Il s'agit d'une maladie neurodégénérative relativement rare qui touche essentiellement les régions cérébrales sous-corticales, puis corticales. Les éléments les plus caractéristiques sont un dysfonctionnement moteur asymétrique (apraxie de la main gauche), une perte sensorielle corticale, et une apraxie sans détérioration intellectuelle à ce stade. Mais le tableau clinique est souvent voisin de la Paralysie supranucléaire Progressive (PSP ou Maladie de Steele -Richardson-Olszewski): résistance à la L-dopa, tremblement d'attitude, syndrome pseudo-bulbaire avec dysarthrie, dysphagie, troubles oculomoteurs ainsi qu'une démence peuvent être associées. Neuropathologie: On peut observer une dégénérescence neurofibrillaire dans les noyaux sous corticaux ainsi que dans le cortex, et préférentiellement dans les régions frontales. Il y a également une perte neuronale et une gliose. Il y a également des cellules chromatolytiques (ou cellules de Pick, à ne pas confondre avec les corps de Pick). Les régions les plus touchées sont frontales et pariétales. La DNF affecte également les astrocytes pour former les "glial tangles" et les plaques astrocytaires. La technique de Gallyas (imprégnation argentique optimale pour la DNF) revèle des plaques astrocytaires en étoile pour la PSP (tufted plaques), alors que pour la CBD, le marquage est plutôt en couronne (astroyctic plaques).

10. Corticobasal Degeneration The first book to focus exclusively on corticobasal degeneration (CBD),this volume offers invaluable assistance in diagnosing this disease. http://www.lww.com/eproduct/0,0,521566637,00.html

Home Shopping Cart My Account Contact LWW ... Login . Not a member? Register Product Search Keyword Author ISBN/ISSN Title Advanced Help Please submit your email for LWW.com Updates and LWW.com Insider Corticobasal Degeneration , Hardbound Associated Specialties: Neurology Author(s): Irene Litvan MD Christopher G. Goetz MD Anthony E. Lang MD Availability: In Stock The first book to focus exclusively on corticobasal degeneration (CBD), this volume offers invaluable assistance in diagnosing this disease. The book reviews current knowledge of the pathology of CBD and thoroughly examines its clinical manifestations, including apraxia, parkinsonism, dystonia, myoclonus, alien limb syndrome, aphasia, eye movement disorders, and dementia. Noted experts define criteria for diagnosing CBD and differentiating CBD from other movement disorders or dementia disorders, including Parkinson's disease, progressive supranuclear palsy, Alzheimer's disease, and Pick's disease. Full consideration is given to diagnostic controversies, such as the relationship of CBD to Pick's disease. A chapter on therapy is also included. May we also recommend: Tourette Syndrome , Book Neocortical Epilepsies , Book Functional Imaging in the Epilepsies , Book Jasper's Basic Mechanisms of the Epilepsies , Book , Book Price: ISBN: Pub Date: November 1999 Pages: Illustrations: More Information: Table of Contents Search on Irene Litvan Review LWW Products Send Page to a Friend ... Linking Policy

11. Corticobasal Degeneration corticobasal degeneration. What is corticobasal degeneration? Corticobasal ganglia.corticobasal degeneration progresses gradually. http://www.clevelandclinic.org/health/health-info/docs/1200/1266.asp?index=5999

12. Show-documents.asp The Cleveland Clinic, corticobasal degeneration Written Information.Care Treatment. corticobasal degeneration. New Search1. http://www.clevelandclinic.org/health/search/do-query.asp?TopicId=1290

13. NINDS Corticobasal Degeneration Information Page More about NINDS corticobasal degeneration Information Page. Content for thispage. NINDS corticobasal degeneration Information Page. Reviewed 0904-2001. http://accessible.ninds.nih.gov/health_and_medical/disorders/cortico_doc.htm

Disorders - National Institute of Neurological Disorders and Stroke (NINDS) Skip menus Main sections of the NINDS web site Home About NINDS Disorders-you are in this section ... Find People Disorders section pages and search Image Description Science For the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system. Select Topic Disorder Quick Links Alzheimer's Autism Cerebral Palsy Chronic Pain Epilepsy Headache Multiple Sclerosis Parkinson's Stroke Traumatic Brain Injury More about NINDS Corticobasal Degeneration Information Page Studies with patients Research literature Press release NINDS Search (search help) Contact us My privacy NINDS is part of the National Institutes of Health Contact us Content for this page NINDS Corticobasal Degeneration Information Page Reviewed 3-21-2003 Get Web page suited for printing Email this to a friend or colleague Table of Contents (click to jump to sections) What is Corticobasal Degeneration? Is there any treatment? What is the prognosis? What research is being done? ... Related NINDS Publications and Information What is Corticobasal Degeneration? Corticobasal degeneration is a progressive neurological disorder characterized by nerve cell loss and atrophy (shrinkage) of multiple areas of the brain including the cerebral cortex and the basal ganglia. Corticobasal degeneration progresses gradually. Initial symptoms, which typically begin at or around age 60, may first appear on one side of the body (unilateral), but eventually affect both sides as the disease progresses. Symptoms are similar to those found in Parkinson disease, such as poor coordination

14. Neuropathologic Diagnosis Of Corticobasal Degeneration (CB)and Development Of Cr Neuropathologic Diagnosis of corticobasal degeneration (CB) and Developmentof Criteria cosponsored by the Office of Rare Diseases at NIH. http://rarediseases.info.nih.gov/news-reports/workshops/corticobasal000708.html

National Institute on Aging (NIA) and the Office of Rare Diseases Neuropathologic Diagnosis of Corticobasal Degeneration (CB) and Development of Criteria Table of Contents Agenda Consensus Criteria Neuropathologic Diagnosis of Corticobasal Degeneration (CB) and Development of Criteria Agenda Saturday, July 8, 2000 5th floor Conference Room, Gateway Building Program Chair: Dennis Dickson, M.D. 8:00-8:15 AM I. Litvan, M.D. 8:15-9:15 AM Discussion of typical cases of CBD. J.J. Hauw 9:15-10:15 AM Discussion of atypical neuropathological cases of CBD. C. Bergeron, M.D. 10:15-10:30 AM Coffee 10:45-12:45 AM Decide upon sampling areas and techniques. D. Houroupian, M.D. 12:45-1:45 PM Lunch 1:45-3:45 PM Discussion of specific neuropathological inclusion/exclusion criteria. 3:45-4:00 PM Coffee 4:00-5:00 PM Summary and Recomendations. Dennis Dickson, M.D. 5:00-6:00 PM I. Litvan, M.D. 6:00-6:15 PM Discussion of provocative questions. Peter Lantos, M.D. 6:15-6:30 PM Concluding Remarks. J. J. Hauw, M.D. CONSENSUS CRITERIA Participants European neuropathologists S. Daniel, Parkinson Brain Bank, London

15. Corticobasal Degeneration Articles, Support Groups, And Resources corticobasal degeneration articles, support groups, and resources for patientsfrom Med Help International (www.medhelp.org). corticobasal degeneration. http://www.medhelp.org/HealthTopics/Corticobasal_Degeneration.html

[Health Topics A-Z] A B C D ... Z Corticobasal Degeneration [Med Help Home] [Library Search] [Medical Forums] [Patient Network] Revised: 3/30/2003

16. The Parkinson's Institute Movement Disorders corticobasal degeneration (CBD) is a rare neurological disease of unknowncause that, in the early stages, can mimic Parkinson's disease. http://www.parkinsonsinstitute.org/movement_disorders/corticobasal.html

Treatment Center PD Dystonia ET Treatment Center PD Dystonia ET ... TS Corticobasal degeneration (CBD) is a rare neurological disease of unknown cause that, in the early stages, can mimic Parkinson's disease. The symptoms of CBD generally begin after the age of 60 with a clumsiness and slowness of a limb. Like typical Parkinson's disease, the symptoms of CBD generally begin on one side of the body, however, unlike Parkinson's disease, there is no response to levodopa. As the disease progresses, jerkiness of a limb (myoclonus), dysphasia (difficulty with speech generation), dysarthria (difficulty with articulation), facial dystonia (difficulty controlling the muscles of the face and mouth) and gait disturbance may begin to emerge and then spread to the other side of the body. Cognitive problems also worsen as the disease progresses. The cortex, or outer layer of the brain, is severely affected, especially the fronto-parietal regions, resulting in behavioral problems, sensory loss and the "alien hand/limb" phenomenon (difficulty controlling the movements of a limb, so that the limb seems to move on its own, and may seem to the patient to be not his or her own limb). Unfortunately, this disease is invariably progressive with little benefit from pharmacological treatment, although some patients may derive some mild improvement with antiparkinsonian drugs. Physical and speech therapy can also provide some benefit; however, as the disease progresses, dysphagia (swallowing difficulty), dysarthria (speech difficulty) and marked immobility result in considerable disability. [return to top]

17. Entrez-PubMed Click here to read corticobasal degeneration and progressive supranuclearpalsy share a common tau haplotype. Houlden H, Baker M http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1

18. Cbd corticobasal degeneration (CBD). ACTA NEUROPATHOLOGICA 103 469474. Stover, NP,Watts, RL (2001) corticobasal degeneration. SEMINARS IN NEUROLOGY 21 49-58. http://www.biols.susx.ac.uk/home/Julian_Thorpe/ad_cbd.htm

Alzheimer's Disease and the Tauopathies: a review with particular reference to Pin1 protein Home About this Site Pin1 protein Alzheimer's Disease ... Tauopathies Literature: A-K L-Z subject area Search site by subject area ... Feedback Compiled by: Julian Thorpe Corticobasal Degeneration (CBD) N.B. This page is in the initial phases of construction, so I suggest you follow the external link below for more on this disease. (external site links in italics See: NINDS CBD Information Page and the 'We Move' site ('the Internet's most comprehensive resource for movement disorder information ') Type: CBD is a sporadic, adult-onset neurodegenerative disease and belonging to the frontotemporal dementia (FTD) group. It is a movement disorder but there is also mild-to-moderate cognitive impairment. Regions affected: Cerebral cortex deep cerebellar nuclei and substantia nigra Tau pathology: Neuronal: intracytoplasmic PHF-like filaments and straight tubules.

19. PiD PL (2001) Distinct isoforms of tau aggregated in neurons and glial cells in brainsof patients with Pick's disease, corticobasal degeneration and progressive http://www.biols.susx.ac.uk/home/Julian_Thorpe/ad_PiD.htm

Alzheimer's Disease and the Tauopathies: a review with particular reference to Pin1 protein Home About this Site Pin1 protein Alzheimer's Disease ... Tauopathies Literature: A-K L-Z subject area Search site by subject area ... Feedback Compiled by: Julian Thorpe Pick's Disease (PiD) N.B. This page is in the initial phases of construction, so I suggest you follow the external link below for more on this disease. (external site links in italics See: NINDS Pick's disease Information Page Type: PiD is a sporadic tauopathy belonging to the frontotemporal dementia (FTD) group of neurodegenerative diseases. Regions affected: neocortex and hippocampus. Tau pathology: Neuronal: Pick bodies of straight and twisted filaments of tau in the neocortex (most numerous in layers 2 and 6) and in the dentate granule neurons of the hippocampus. Glial Other Pathology : frontotemporal lobar and limbic atrophy, spongiosis and gliosis. Some Related References Arai, T, Ikeda, K, Akiyama, H, Shikamoto, Y, Tsuchiya, K, Yagishita, S, Beach, T, Rogers, J, Schwab, C, McGeer, PL (2001)

20. Corpus Callosum Atrophy & Cognitive Impairment In CorticoBasal Degeneration Atrophy of the Corpus Callosum, Cortical Hypometabolism, and Cognitive Impairmentin corticobasal degeneration. Corpus Callosum Atrophy And Cognitive Impairment. http://www.albany.net/~tjc/corpus-callosum.html

Corpus Callosum Atrophy And Cognitive Impairment Hiroshi Yamauchi, MD, PhD; Hidenao Fukuyama, MD, PhD; Yasuhiro Nagahama, MD, PhD; Yukinori Katsumi, MD; Yun Dong, MD; Takuya Hayashi, MD; Junji Konishi, MD, PhD; Jun Kimura, MD Arch Neurol 1998 May;55(5):609-14 "Atrophy of the Corpus Callosum, Cortical Hypometabolism, and Cognitive Impairment in Corticobasal Degeneration" PMID# 9605717; UI# 98266754 Abstract Objective To investigate whether atrophy of the Corpus Callosum is associated with Cognitive Impairment and Cerebral Cortical HypoMetabolism in CorticoBasal Degeneration. Prospective ClinicoRadiological correlation with Magnetic Resonance Imaging and Positron Emission Tomography (PET) in a university hospital. Eight right-handed patients with clinically diagnosed Corticobasal Degeneration (mean±SD age, 64±8 years). Main Outcome Measures Midsagittal Corpus Callosum area-skull area ratio on T -weighted Magnetic Resonance Images. The sum of the scaled scores of the 6 subtests on the Wechsler Adult Intelligence Scale-Revised (Digit Span, Arithmetic, Picture Arrangement, Object Assembly, Block Design, and Digit Symbol). And, Cerebral metabolic rate of Glucose (measured with PET by using FludeoxyGlucose F 18 as a tracer).

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