41. Refs 82(4)23959. Feany MB, Dickson D. W. (1995) Widespread cytoskeletal pathologycharacterizes corticobasal degeneration. Am J Pathol 146 1388-1396. http://www.binderlab.northwestern.edu/refs.html

References Wilson, D. M., and Binder, L. I. (1997) Free fatty acids stimulate the polymerization of tau and amyloid beta peptides. In vitro evidence for a common effector of pathogenesis in Alzheimer's disease Am J Pathol 150, 2181-95. King, M. E., Ahuja, V., Binder, L. I., and Kuret, J. (1999) Ligand-Dependent Tau Filament Formation: Implications for Alzheimer's Disease Progression Biochemistry 38, 14851-14859 Gamblin, T. C., King, M. E., Dawson, H., Vitek, M. P., Kuret, J., Berry, R. W., and Binder, L. I. (2000) In Vitro Polymerization of Tau Protein Monitored by Laser Light Scattering: Method and Application to the Study of FTDP-17 Mutants Biochemistry 39, 6136-6144 King, M. E., Gamblin, T. C., Kuret, J., and Binder, L. I. (2000) Differential assembly of human tau isoforms in the presence of arachidonic acid J Neurochem 74, 1749-1757 Braak H., Braak E. (1989) Cortical and subcortical argyrophilic grains characterize a disease associated with adult onset dementia. Neuropath Appl Neurobiol 15: 13-26. Braak, H., and E. Braak. 1991. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. 82(4):239-59.

42. Corticobasal Degeneration corticobasal degeneration. This article submitted by Theresa Roberts on 10/10/95.My father too has CBD and has had it for approximately 5 years. http://neuro-www.mgh.harvard.edu/neurowebforum/MovementDisordersArticles/Cortico

Corticobasal Degeneration This article submitted by Theresa Roberts on 10/10/95. My father too has CBD and has had it for approximately 5 years. I am his primary caregiver as he can no longer perform any daily activities; eating, shaving, bathroom, shower, standing, etc. He recently has been declining mentally as well. He can no longer speak as coherently as he once had, and he drools constantly. He has currently been on several parkinson type meds that help. Through NORD (Nat'l Organization of Rare Disease) Network program, I was given a list of names of others who either have this disease or are caregivers of someone with CBD. In addition, I was put in tourch of a person who has created a CBD Network support group. If you are interested in any information, or would like to correspond, please let me know. My address is listed below or you can respond to this article with yours and I will get in touch with you. It really helps sharing information with others. I have learned a lot of things that help make my dad more comfortable. Sincerely

43. Alzheimer Toronto -- Related Dementias Internet Resources Binswanger's Disease corticobasal degeneration CreutzfeldtJakob Disease FrontotemporalDementia Lewy Body Disease Pick's Disease Vascular Dementia http://www.asmt.org/RD2.htm

Resources on the Internet Related Dementias This list has been prepared to act as a guide to some of the excellent sites on the Internet on Related Dementias Binswanger's Disease Corticobasal Degeneration Creutzfeldt-Jakob Disease Frontotemporal Dementia ... Wernicke-Korsakoff Syndrome Binswanger's Disease Binswanger's Disease fact sheet by the Cleveland Clinic Binswanger's Disease? fact sheet by CMRIS NINDS Binswanger's Disease Information Page produced by National Institute of Neurological Disorders and Stroke Senile Dementia of the Binswanger's Type American Family Physician December 1998 Corticobasal Degeneration Corticobasal Degeneration fact sheet and chat room provided by We Move NINDS Corticobasal Degeneration Information Page produced by National Institute of Neurological Disorders and Stroke Creutzfeldt-Jakob Disease Creutzfeldt-Jacob Disease General Health Encyclopedia CJD: a matter of life and death a photo essay by Gregg Williams documenting the last year of Donna Mellowship's struggle with CJD. produced by Time Europe CJD Directory by Marsha Penington, Coordinator of Alzheimer's Outreach

44. Feany 6. Feany MB, Dickson DW. Widespread cytoskeletal pathology characterizescorticobasal degeneration. Am J Pathol 1995;14613881396. http://neuro-oas.mgh.harvard.edu/alzheimers/research/Publications/feany.html

Mel B. Feany, M.D., Ph.D. Original Articles: 1. Feany MB. Rescue of the learning defect in dunce, a Drosophila learning mutant, by an allele of rutabaga, a second learning mutant. Proc Natl Acad Sci (U.S.A.) 1990;87:2795-2799. 2. Feany MB, Lee S, Edwards RH, Buckley KM. The synaptic vesicle protein SV2 is a novel type of transmembrane transporter. Cell 1992;70:861-867. 3. Feany MB, Buckley KM. The synaptic vesicle protein synaptotagmin promotes formation of filopodia in fibroblasts. Nature 1993;364:537-540 (see also accompanying "News and Views" in same issue). 4. Feany MB, Yee AG, Delvy ML, Buckley KM. The synaptic vesicle proteins SV2, synaptotagmin and synaptophysin are sorted to separate cellular compartments in CHO fibroblasts. J Cell Biol 1993;123:575-584 (see also cover photograph). 5. Feany MB, Quinn WG. A neuropeptide gene defined by the Drosophila memory mutant amnesiac. Science 1995;268:869-873 (see also accompanying "Perspectives" in same issue). 6. Feany MB, Dickson DW. Widespread cytoskeletal pathology characterizes corticobasal degeneration. Am J Pathol 1995;146:1388-1396. 7. Feany MB, Ksiezak-Reding H, Liu W-K, Vincent I, Yen S-HC, Dickson DW. Epitope expression and hyperphosphorylation of tau protein in corticobasal degeneration: differentiation from progressive supranuclear palsy. Acta Neuropathol 1995;90:37-43.

45. Corticobasalganglionic Degeneration What is corticobasal degeneration? corticobasal degeneration (CBD) is a rare neurologicaldisease in which parts of the brain deteriorate or degenerate. http://www.angelfire.com/retro/michaelpoon168/corticobasalganglionic_degeneratio

Michael Poon's Shrine of Neurology HOME CONTENTS CONTACT US HOME ... CONTACT US Corticobasalganglionic Degeneration 04 September 2002 What is corticobasal degeneration? Corticobasal degeneration (CBD) is a rare neurological disease in which parts of the brain deteriorate or degenerate. CBD is also known as corticobasal ganglionic degeneration, or CBGD. Several regions of the brain degenerate in CBD. The cortex, or outer layer of the brain, is severely affected, especially the fronto-parietal regions, located near the center-top of the head. Other, deeper brain regions are also affected, including parts of the basal ganglia, hence the name "corticobasal" degeneration. The combined loss of brain tissue in all these areas causes the symptoms and findings seen in people with CBD. What causes the degeneration of brain tissue in CBD? Unfortunately, the cause of CBD is entirely unknown. There is currently no strong evidence to suggest CBD is an inherited disease, and no other risk factors, such as toxins or infections, have been identified. Studies of brain tissue of individuals with CBD show certain characteristic cell changes. Similar, although not identical, changes are observed in two other neurodegenerative diseases, Pick's disease and progressive supranuclear palsy. These changes, involving a brain protein called tau, have provided researchers some initial clues in their search for the causes of CBD.

46. Final Diagnosis -- Case 52 cortex is to be different from that found in the brain stem (6). Several other neurodegenerativediseases including corticobasal degeneration, Pick's disease http://path.upmc.edu/divisions/neuropath/bpath/cases/case52/dx.html

Brain Pathology Case of the Month - July 2000 FINAL DIAGNOSIS: PROGRESSIVE SUPRANUCLEAR PALSY, TYPICAL. DISCUSSION: REFERENCES: Litvan I, Mangone CA, McKee A et al. Natural history of progressive supranuclear aplsy (Steele-Richardson-Olszewski syndrome) and clinical predicators of survival: a clinicopathological study. J Neurol Neurosurg Psych 1996; 60:615-620. Ghika J, Bogousslavsky J. Presymptomatic hypertension is a major feature in the diagnosis of progressive supranuclear palsy. Archives of Neurol 1997; 54:1104-1108. Collins SJ, Ahlskog JE, Parisi JE, Maraganore DM. Progressive supranuclear palsy: neuropathologically based diagnostic clinical criteria. J Neurol Neurosurg Psych 1995; 58:167-173. Litvan I, Hauw JJ, Bartko JJ et al. Validity and reliability of the preliminary NINDS Neuropathologic criteria for progressive supranuclear palsy and related disorders. J Neuropathol Exp Neurol 1996; 55:97-105. Hauw JJ, Daniel SE, Dickson D et al. Preliminary NINDS neuropathologic criteria for Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy) Neurol 1994; 44:2015-2019. Schmidt ML. Huang R. Martin JA. et al. Neurofibrillary tangles in progressive supranuclear palsy contain the same tau epitopes identified in Alzheimer's disease PHFtau. Neuropathol Exp Neurol 1996; 55:534-9

47. CJNS - AbstractCJNS-Alien Hand Phenomena: A Review With The Addition Of Six Pers associated with two pathological processes 1) Infarction or hemorrhage in the territoryof the anterior cerebral arteries; and 2) corticobasal degeneration. http://www.canjneurolsci.org/27augtoc/alien.html

Abstract Close Window Alien Hand Phenomena: A Review with the Addition of Six Personal Cases C.M. Fisher Abstract: This is a comprehensive literature review of the motor abnormalities that have come to be included under the designation of Alien Hand Phenomena (AHP). Some of the disorders are dyspractic in nature - intermanual conflict, mirror movements, interference etc., while others - groping, grasping with inability to release, utilization etc. are frontal lobe reflexes. AHP are mainly associated with two pathological processes: 1) Infarction or hemorrhage in the territory of the anterior cerebral arteries; and 2) Corticobasal degeneration. Included in the review is a description of AHP in six personal cases of corticobasal degeneration. The summary includes a short discussion of the possible anatomy of 'free will' based on AHP. Can. J. Neurol. Sci. 2000; 27: 192-203

48. Parkinson's Disease Center And Movement Disorders Clinic Clinical presentation and pharmacological therapy in corticobasal degeneration. CorticobasalDegeneration Clinical and Research Aspects. http://www.bcm.tmc.edu/neurol/jankovic/educ_cbgd.htm

Parkinson's Disease Center and Movement Disorders Clinic Cortical-Basal Ganglionic Degeneration (CBGD) Joseph Jankovic, M.D. Previous What and How Next Download Summary ( Printer-Friendly) What is Cortical-Basal Ganglionic Degeneration? As with the other atypical parkinsonian syndromes, treatment with levodopa and related medications is only rarely, if ever, helpful. Sometimes muscle spasms and jerking can be reduced with tranquilizers, or with botulinum toxin injections into affected parts of the body. REFERENCES Jankovic J. Treatment of parkinsonian syndromes. In: Kurlan R, ed. The Treatment of Movement Disorders. J.B. Lippincott Company, Philadelphia, 1995:95-114. Kumar R, Bergeron C, Pollanen MS, Lang AE. Cortical-basal ganglionic degeneration. In: Jankovic J, Tolosa E, eds. Parkinson's Disease and Movement Disorders. Baltimore: Williams and Wilkins, 1998:297-316.

49. Mioti: Medical Condition Condition corticobasal degeneration. NINDS corticobasal degeneration InformationPage. Information NORD corticobasal degeneration. Information http://www.mioti.com/cat/condition/condition.asp?Cat=CorticobasalDeg

50. Directory :: Look.com corticobasal degeneration (3) See Also. corticobasal degeneration Information sheetcompiled by the National Institute of Neurological Disorders and Stroke. http://www.look.com/searchroute/directorysearch.asp?p=524639

51. NJ Neuroscience Institute At JFK Medical Center - Movement Disorders Corticalbasal ganglionic degeneration (or corticobasal degeneration) (CBGD)is an atypical parkinsonism (parkinsonism plus) syndrome of unknown cause. http://www.njneuro.org/movedis/cbgd.htm

CORTICAL - BASAL GANGLIONIC DEGENERATION (CBGD) Philip A. Hanna, MD Parkinson's Disease and Movement Disorders Center New Jersey Neuroscience Institute Edison, New Jersey What is Cortical-Basal Ganglionic Degeneration? Similar to other atypical parkinsonian syndromes, treatment with levodopa and related medications is rarely, if ever, helpful. Muscle spasms and myoclonus may be reduced with tranquilizers, or with botulinum toxin injections. Articles For Further Reading: Hanna PA, Doody RS. Alien Limb Syndrome. In: Goetz CG, Lang AE, Litvan I, eds. Corticobasal Degeneration: Clinical and Research Aspects. Advances in Neurology Series. Lippincott-Raven Publishers, 1999. (In press). Kumar R, Bergeron C, Pollanen MS, Lang AE. Cortical-basal ganglionic degeneration. In: Jankovic J, Tolosa E, eds. Parkinson's Disease and Movement Disorders. Baltimore:Williams and Wilkins, 1998:297-316. Kompoliti K, Goetz CG, Boeve BF, et al. Clinical presentation and pharmacological therapy in corticobasal degeneration. Arch Neurol 1998;55:957-961.

52. Cleveland Clinic Health System - Health Information Search Results The following information is available for the topic CorticobasalDegeneration. Please select one. , corticobasal degeneration. New Search. http://www.cchs.net/health/getcontents.asp?DocID=do-query&TopicId=1290

53. Societat Catalana De Neurologia Translate this page Accuracy of the clinical diagnosis of corticobasal degeneration a clinicopathologicstudy. The nature of apraxia in corticobasal degeneration. http://www.scn.es/cursos/demencias/corticob/cortba.htm

Buscar en la web DEGENERACION CORTICOBASAL Alfredo Robles. Figura 1 apraxia ideomotora e Tc-HMPAO o tabla 1 tabla 2 forma parietal de la enfermedad de Pick tabla 3 tabla 4 ). A diferencia de la DCB, la enfermedad de Alzheimer tabla 4 enfermedad de Parkinson es la falta de respuesta a la l-dopa en la primera de ellas. El parkinsonismo vascular Demencia con cuerpos de Lewy 2.- Leiguarda R, Lees AJ, Merello M, Starkstein S, Marsden CD. The nature of apraxia in corticobasal degeneration. J Neurol Neurosurg Psychiatry 1994; 57: 455-459. 3.-Doody RS, Jankovic J. The alien hand and related signs. J Neurol Neurosurg Psychiatry 1992; 55: 806-810. 4.-Ohkawa S, Yamasaki H, Yoshida T et al. "Forced mouth opening reaction" associated with corticobasal degeneration. Rinsho Shinkeigaku 1997; 37: 275-282 (tomado del resumen de MEDLINE). 6.-Lippa CF, Cohen R, Smith TW et al. Primary progressive aphasia with focal neuronal achromasia. Neurology 1991; 41: 882-886. 7.-Lang AE. Cortical basal ganglionic degeneration presenting with "progressive loss of speech output and orofacial dyspraxia". J Neurol Neurosurg Psychiatry 1992; 55: 1101.

54. Curso De Neurología De La Conducta Y Demencias A clinical profile of corticobasal degeneration presenting as primary progressiveaphasia . European Neurology, 36 134137. corticobasal degeneration . http://oaid.uab.es/nnc/html/entidades/web/22cap/c22_11.html

[1] PICK, A. (1892). "Über die Beziehungen der senilen Hirnatrophie zur Aphasie". Prag. Med. Wchnschr. [2] ONARI, K.; SPATZ, H. (1926). "Anatomische Beitrage zur Lehre von der Pickschen umschreibenen Grosshirnrinden-Atrophie ("Picksche Krankheit")". [3] CONSTANTINIDIS, J.; RICHARD, J.; TISSOT, R. (1974). "Pick’s disease - histological and clinical correlations". European Neurology, [4] BRUN, A. (1987). "Frontal lobe degeneration of non-Alzheimer type. I. Neuropathology". Arch. Gerontol. Geriatr., [5] GUSTAFSON, L. (1987). "Frontal lobe generation of non-Alzheimer type. II. Clinical picture and differential diagnosis". Arch. Gerontol. Geriatr. [6] NEARY, D.; SNOWDEN, J. S.; NORTEEN, B.; GOULDING, P. (1988). "Dementia of frontal lobe type". Journal of Neurology, Neurosurgery, and Psychiatry

55. CLINICAL RESEARCH Keywords brain atrophy, PET, MRI, corticobasal degeneration. This method was evaluatedin the normal subjects and in patients with corticobasal degeneration. http://www.nirs.go.jp/report/nene/h12/1004/1004-7.htm

43. Quantitative Estimation of Brain Atrophy and Function with PET and MRI Two-dimensional Projection Images Hinako Toyama, Reiko Saito, Koji Uemura, Kenji Ishii, Michio Senda and Akihiko Uchiyama Keywords brain atrophy, PET, MRI, corticobasal degeneration The purpose of this paper is to estimate the brain atrophy and the decline in brain function objectively and quantitatively. Two-dimensional projection images of PET and MRI were made from the 3D transaxial images by using the mollweide method which keeps the area of the brain surface. The sulcus is extracted automatically by means of K-means clustering the correlation image between MRI and CBF (FDG) PET images. the rate of atrophy is calculated from the ratio of the extracted sulcus to the area of 2D-brain-surface of MRI. the cerebral function (such as blood flow or glucose metabolic rate), is calculated from the cerebral cortex area except the sulcus in the PET image, and then the relationship between atrophy and function is evaluated. This method is applied to two groups, the young and the aged normal subjects, then the relationship between the age and the rate of atrophy or the cerebral blood flow is investigated. This method is also applied to two groups of the normal control and the corticobasal degeneration patients, the relationship between the disease and the rate of atrophy or the functional disorder is investigated.

56. Staff Frattali, C, Grafman, JG, Patronas, N, Makhlouf, F, Litvan, I. (2000).Languagedisturbances in corticobasal degeneration. Neurology, 54, 990992. http://www.cc.nih.gov/rmd/slp/staff.shtml

Contact Us Site Map Search Tips Rehabilitation Medicine at the NIH Clinical Center ... Clinical Research Staff Carol Frattali, Ph.D. Carol M. Frattali, Ph.D. is the Research Coordinator in the Speech Language Pathology Section. She received her doctorate in speech-language pathology at the University of Pittsburgh, her M.A. in Speech-Language Pathology at the San Francisco State University and her B.S. in Speech-Language Pathology and Audiology at Ithaca College. Dr. Frattali's clinical/research expertise lies in the areas of neurologic communication disorders in adults, and development and validation of communication disability measures.Dr. Frattali is the author of numerous peer-reviewed articles and book chapters, and editor of three textbooks in the field: Professional Issues in Speech-Language Pathology and Audiology [co-edited], Measuring Outcomes in Speech-Language Pathology and Neurogenic Communication Disorders: A Functional Approach (co-edited). Among her recent publications are: Journal articles: Frattali, C, Liow, K, Craig, G, Korenman, L, Makhlouf, F, Sato, S, Biesecker, L, Theodore, WH. (2001).Cognitive deficits in children with gelastic seizures and hypothalamic hamartoma. Neurology, 57, 43-46.

57. Corticobasal Degeneration corticobasal degeneration. Re corticobasal degeneration Lorrie Koehler 16043710/19/00 (0) Re corticobasal degeneration Bruce 210408 9/19/00 (0) http://www.healthboards.com/brain-and-nervous-system-disorders/1470.html

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58. Re: Corticobasal Degeneration Re corticobasal degeneration. In Reply to corticobasal degeneration postedby Lorrie on July 27, 2000 at 114538 I am 36 and have CBGD. http://www.healthboards.com/brain-and-nervous-system-disorders/1684.html

**** Menu **** Home Acne ADD Addiction Addison's Disease Aging Issues AIDS Allergies ALS Alternative Medicine Alzheimer's Anemia Arthritis Asthma Autism Back Problems Bowel Disorders Cancer Caregivers Carpal Tunnel Syndrome Cerebral Palsy Children's Health Chronic Fatigue Common Cold Cosmetic Surgery Cystic Fibrosis Dental Problems Depression Diabetes Digestive Disorders Disabilities Down Syndrome Eating Disorders Epilepsy Fibromyalgia Foot Problems General Health Gulf War Syndrome Headaches Hearing Disorders Heart Disorders Hepatitis Herpes High Blood Pressure High Cholesterol HIV/AIDS Immune Disorders Infectious Diseases Infertility Inner Ear Disorders Irritable Bowel Kidney Disorders Leukemia Lupus Lyme Disease Menopause Men's Health Mental Health Multiple Sclerosis Muscular Dystrophy Myositis Neuromuscular Diseases Neuropathy Osteoporosis Pain Management Parkinson's Polio Pregnancy Rare Disorders Reflex Sympathetic Dystrophy Restless Leg Syndrome Sexual Health Sexually Transmitted Diseaases SIDS Sleep Disorders Smoking Cessation Spinal Cord Disorders Stroke Thyroid Disorders TMJ Disorder Tuberculosis Viagra Weight Loss Women's Health Message Boards on Health Related Topics brain and nervous system disorders message board Re: Corticobasal Degeneration Click Here to Visit our Sponsor FREE HealthBoards.com info from vendors! Select:

59. CORTICOBASAL DEGENERATION BASIC SIGNS AND SYMPTOMS FOR DIAGNOSIS OF corticobasal degeneration AND THEIR IMPORTANCE(Litvan I. et al, Neurology 1997;4811925). Diagnostic importance. http://www.centroalzheimer.it/crcorben.htm

BASIC SIGNS AND SYMPTOMS FOR DIAGNOSIS OF CORTICOBASAL DEGENERATION AND THEIR IMPORTANCE (Litvan I. et al, Neurology 1997;48:119-25) Diagnostic importance Dystonia of a limb Absence of balance and gait disturbances Focal myoclonus Neuroimaging asymmetrical and hemispherical severe atrophy, contralateral to symptoms

60. KCL: Institute Of Psychiatry - Department Of Neuropathology NJ and Lantos, PL (2000) A quantitative study of the pathological lesions in theneocortex and hippocampus of twelve patients with corticobasal degeneration. http://www.iop.kcl.ac.uk/iop/Departments/NeurPath/Publications.shtml

Institute of Psychiatry Department of Neuropathology Search the IoP Welcome Contents Recent Publications Nigel J. Cairns BA BSc PhD MRCPath (Senior Lecturer in Neuropathology) Armstrong, R.A., Lantos, P.L. and Cairns, N.J. (2001) The spatial patterns of prion protein deposits in Creutzfeldt-Jakob disease: comparison with beta-amyloid deposits in Alzheimer's disease. Neuroscience Letters 298:53-56. Gulesserian, T., Seidl, R., Hardmeier, R., Cairns, N. and Lubec, G. (2001) Superoxide dismutase SOD1, encoded on chromosome 21, but not SOD2 is overexpressed in brains of patients with Down syndrome. Journal of Investigative Medicine 49:41-46. Ishii, K., Lippa, C., Tomiyama, T., Miyatake, F., Ozawa, K., Tamaoka, A., Hasegawa, T., Fraser, P.E., Sholi, S., Nee, L.E., Pollen, D.A., St. George-Hyslop, P.H., Ii, K., Ohtake, T., Kalaria, R.N., Rossor, M.N., Lantos, P.L., Cairns, N.J., Farrer, L.A. and Mori, H. (2001) Distinguishable effects of presenilin-1 and APP mutations on amyloid plaque deposition. Neurobiology of Aging 22:367-376. Mann, D.M.A., Takeuchi, A., Sato, S., Cairns, N.J., Lantos, P.L., Rossor, M.N., Haltia, M., Kalimo, H. and Iwatsubo, T. (2001) Cases of Alzheimer's disease due to deletion of exon 9 of the presenilin-1 gene show an unusual but characteristic b-amyloid pathology known as 'cotton wool' plaques. Neuropathology and Apllied Neurobiology 27:189-196.

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