61. Headlines Index creutzfeldtjakob disease. 2002 Proteins may be culprit in Alzheimer's; Humantissue patches may cause CJD; WHO declares Britain free of foot-and-mouth 2001; http://www.canoe.ca/Health/index_c.html

Inside CANOE.CA SLAM! Sports Jam! Showbiz AllPop CNEWS Webfin Money C-Health Lifewise AUTONET.CA Newsstand Travel Search eBay.ca Get away today 411 online Free E-Mail Shop.canoe.ca CareerConnection Classified Extra Match Contact Obituaries Today Restaurants Hotels Weather Horoscopes Lotteries Crossword Scoreboard News Ticker Biz Ticker Sports Ticker TV Listings Movie Listings CLIVE Concerts Mutual Funds Stocks Feedback Index Home Top Stories Health Topics Health Assoc. ... Forums TOOLS: Disease Database Drug Database Alt. Health Dictionary ... Encyclopedia Headlines Index: C Health News Headlines Food Headlines Fitness Headlines TOPICS AT A GLANCE Cancer Breast Cancer Lung Cancer Prostate Cancer ... Cystic Fibrosis CANCER Breast Cancer Breast Cancer Special Report March 2002 Scientists developing blood test to back up mammograms February 2002 Panel reaffirms regular mammograms for women 40 and older Anti-depressants may double risk of breast cancer Long term hormone use may increase breast cancer risk Radioactive 'seed' treatment cuts radiation time ... Mammograms cut breast cancer deaths in half January 2002 Scientific dispute: Do mammograms really save lives?

62. Creutzfeldt-Jakob Disease Associated With Cadaveric Dura Mater Grafts -- Japan, creutzfeldtjakob disease Associated with Cadaveric Dura Mater Grafts Japan, January1979-May 1996. Number of cases of creutzfeldt-jakob disease Figure 2. http://wonder.cdc.gov/wonder/PrevGuid/m0049829/m0049829.asp

CDC WONDER CDC WONDER Home Utilities Help Contact Us Creutzfeldt-Jakob Disease Associated with Cadaveric Dura Mater Grafts Japan, January 1979-May 1996 MMWR 46(45);1066-1069 Publication date: 11/14/1997 Table of Contents Article Editorial Note References POINT OF CONTACT FOR THIS DOCUMENT: Figures Number of cases of Creutzfeldt-Jakob disease ... Year of neurosurgical or orthopedic procedure ... Article Summary Findings The 43 patients with CJD had onsets of illness from September 1985 to May 1996 ( Figure 1 Of the 43 CJD patients, 42 received their dura mater graft during 1979-1989 ( Figure 2 Figure 2 The most recent recipient of a dura mater graft among the 43 graft-associated CJD patients was a woman aged 65 years at the time of onset of CJD. She had two neurosurgical procedures in 1991 to repair a cerebral arterial aneurysm (one in September and one in October); dura mater grafts were used during both operations. In February 1994, 28 months after the second operation, she developed progressive dysphagia, dysarthria, and unsteady gait, followed within a few weeks by dementia. In April 1995, she developed generalized myoclonic jerks and akinetic mutism. An electroencephalograph showed a 6- to 10-Hz background rhythm with the periodic synchronized slow activity complexes typical of CJD. Examination of the cerebrospinal fluid revealed a normal protein level and cell count. A magnetic resonance imaging scan showed marked cerebral and cerebellar atrophy. The patient died in October 1995, and no autopsy was performed.

63. Creutzfeldt-Jakob Syndrome Medical Journal gathers together Government statements and BMJ extracts on BovineSpongiform Encephalopathy (BSE) and creutzfeldtjakob disease (CJD), brain http://omni.ac.uk/browse/mesh/detail/C0022336L0022336.html

Creutzfeldt-Jakob Syndrome [up] Creutzfeldt-Jakob Syndrome / etiology Creutzfeldt-Jakob Syndrome / transmission Related topics: broader Dementia Prion Diseases other AIDS Dementia Complex Alzheimer Disease Dementia, Vascular Encephalopathy, Bovine Spongiform ... BMJ BSE-CJD home page This homepage provided by the British Medical Journal gathers together Government statements and BMJ extracts on Bovine Spongiform Encephalopathy (BSE) and Creutzfeldt-Jakob Disease (CJD), brain diseases affecting cattle and humans respectively, covering the BSE debate since 1988. Creutzfeldt-Jakob Syndrome Encephalopathy, Bovine Spongiform BSE inquiry The BSE Inquiry was set up in December 1997 by the government, which aims to investigate the emergence and identification of Bovine Spongiform Encephalopathy (BSE) and the new variant CJD (Creutzfeldt-Jakob disease) in the UK. Their homepage here provides information from this inquiry, including the background to the story, draft full-text factual accounts (in HTML or PDF formats), press releases, witness statements and transcripts. Also provided is a glossary, timetables, and a list of people involved with the Inquiry. Creutzfeldt-Jakob Syndrome Encephalopathy, Bovine Spongiform

64. Creutzfeldt-Jakob Disease Links to information and resources for creutzfeldtjakob disease and the humanequivalent of mad cow disease. creutzfeldt-jakob disease page Guide picks. http://rarediseases.about.com/cs/creutzfeldtjakob/

zfp=-1 About Rare/Orphan Diseases Search in this topic on About on the Web in Products Web Hosting Rare/Orphan Diseases with Mary Kugler Your Guide to one of hundreds of sites Home Articles Forums ... Help zmhp('style="color:#fff"') Subjects BUYER'S GUIDE Before You Buy Top Picks Sites for Online Specialty Shopping ... All articles on this topic Stay up-to-date! Subscribe to our newsletter. Advertising Free Credit Report Free Psychics Advertisement Creutzfeldt-Jakob disease page Guide picks Links to information and resources for Creutzfeldt-Jakob disease (a rare, fatal brain disease) and the human equivalent of mad cow disease. Link to feature article Deaths from the human equivalent of mad cow disease, variant Creutzfeldt-Jakob disease, are on the rise in the UK. "Mad Cow Disease and Humans" explores the disease and its background. CDC: Questions and Answers on BSE and CJD Questions and Answers on bovine spongiform encephalopathy (BSE) and Creutzfeldt-Jakob disease, from the Centers for Disease Control and Prevention (U.S.). CJD Voice Support, information, chat, list of local contacts, and personal stories. NCID: Traveler's Health Bovine Spongiform Encephalopathy ("Mad Cow Disease") and New Variant Creutzfeldt-Jakob Disease (nvCJD) information, from the National Center for Infectious Diseases, at the Centers for Disease Control and Prevention (U.S.).

65. Creutzfeldt-Jakob Disease creutzfeldtjakob disease up. Related topics broader, prion diseases.Bovine spongiform encephalopathy (BSE), Written and published http://agrifor.ac.uk/browse/cabi/detail/74464a534f3e8d13eae3779b3153c0a9.html

Creutzfeldt-Jakob disease [up] Related topics: broader prion diseases Bovine spongiform encephalopathy (BSE) Written and published on the Web by the United States Department of Agriculture's (USDA's) Animal and Plant Health Inspection Service (APHIS), this site provides information on BSE and other Transmissible Spongiform Encephalopathies (TSE's), including Creutzfeldt-Jakob disease. Information is provided on a variety of BSE and TSE related topics, including BSE in the UK, BSE in the USA, Clinical Signs of BSE, Diagnosis of BSE, scrapie, and chronic wasting disease (CWD) of deer and elk. Some of these documents are in PDF format and can be viewed using Adobe Acrobat Reader. A bovine spongiform encephalopathy (BSE) response plan summary prepared by APHIS and the Food Safety and Inspection Service (FSIS) is available in PDF format. Creutzfeldt-Jakob disease bovine spongiform encephalopathy cattle diseases prion diseases ... Bovine Spongiform Encephalopathy - "mad cow disease" Published on the Web by Agriculture, Fisheries and Forestry - Australia (AFFA), this site provides access to a range of information on bovine spongiform encephalopathy (BSE). Information available includes a BSE factsheet, BSE FAQ, geographical risk of BSE country ratings, BSE glossary of terms, and details of variant Creutzfeld- Jakob Disease (vCJD). In addition, information is provided on Australia's beef industry, and a collection of links to related Web resources is provided.

66. NJDHSS, Communicable Disease Service: Creutzfeldt-Jakob Disease . . creutzfeldtjakob disease. What is creutzfeldt-jakob disease? Who gets creutzfeldt-jakobdisease? creutzfeldt-jakob disease tends to strike the elderly. http://www.state.nj.us/health/cd/f_creutzfeldt.htm

Disease Index NJ InTouch What You Should Know About. . . Creutzfeldt-Jakob Disease What is Creutzfeldt-Jakob Disease? Creutzfeldt-Jakob Disease is a neurological illness believed to be caused by a prion, a newly identified type of disease-causing agent. It is different from a virus in that there is no immune response to infection, and that there is a very long time between infection and onset of symptoms. However, like viruses, it must invade living cells to cause damage and to multiply. Is this the same as "Mad Cow Disease"? No. "Mad Cow Disease" is similar but distinguishably different from Creutzfeldt-Jakob Disease. "Mad Cow Disease" tends to cause illness in individuals who are much younger, generally in their twenties and thirties. No cases of "Mad Cow Disease" have been identified in the United States. Who gets Creutzfeldt-Jakob Disease? Creutzfeldt-Jakob Disease tends to strike the elderly. Most individuals who have become ill with Creutzfeldt-Jakob Disease in the United States have been between 65 and 80 years of age. How is Creutzfeldt-Jakob Disease spread?

67. Welcome To BSEInfo.org creutzfeldtjakob disease (CJD). Discovery. creutzfeldt-jakob disease Deathsand Incidence in the United States, 1979-1998. Characteristics. Incidence l. http://www.bseinfo.org/dsp/dsp_locationContent.cfm?locationId=1260

68. CRUETZFEDLT-JAKOB DISEASE creutzfeldtjakob disease. What is creutzfeldt-jakob disease? creutzfeldt-jakobdisease (CJD) is a rare, fatal brain disorder caused by a prion. http://www.idph.state.il.us/public/hb/hbcjdhlb.htm

CREUTZFELDT-JAKOB DISEASE What is Creutzfeldt-Jakob disease? Creutzfeldt-Jakob disease (CJD) is a rare, fatal brain disorder caused by a prion. The disease causes mental deterioration and a variety of neurological symptoms, and usually leads to death within a year of onset. Threre are various forms of CVD; in about 85 percent of the cases, the cause is unknown. One form of CJD may be linked to consumption of beef in Great Britain. Another form is familial or genetic, that is, relatives of a CJD case with the form are more likely to develop the disease than other persons. Many Americans first heard of the disease in 1983 when they learned it had claimed the life of New York City Ballet choreographer George Balanchine. How does CJD affect the patient? In early stages of the disease, patients may experience failing memory, changes in behavior, lack of coordination or visual disturbances. As the illness progresses, mental deterioration becomes pronounced, involuntary movements (especially muscle jerks) appear, and the patient may become blind, develop weakness in the arms or legs, and ultimately lapse into a coma. Death is usually due to infections in the bedridden, unconscious patient. Symptoms of CJD can be similar to those seen in other progressive neurological disorders such as Alzheimer's disease and other dementias. However, CJD causes unique changes in brain tissue that, at this time, can be detected only by surgical biopsy or at autopsy.

69. MEL: Creutzfeldt-Jakob Disease Bovine Spongiform Encephalopathy (BSE) in the United Kingdom and CreutzfeldtJakob disease (CJD) Centers for disease Control and Prevention; http://mel.lib.mi.us/health/health-creutzfeldt.html

Michigan.gov Home HAL Home MeL Internet MeL Magazines and eBooks Health Information Resources About the Health Collection Back to the Health Index Medline Evaluating Health Information ... Michigan Health and Hospitals Creutzfeldt-JakobDisease Blood Recall/Withdrawal - CJD support for recipeints of blood withdrawal notification due to the theoretical risk of Creutzfeldt-Jakob Disease. Bovine Spongiform Encephalopathy (BSE) in the United Kingdom and Creutzfeldt Jakob Disease (CJD) Centers for Disease Control and Prevention CJD Watch Creutzfeldt-Jakob Disease Foundation, Inc. CJD Voice Homepage An online discussion list "for families during and after CJD" National Institute of Neurological Disorders and Stroke Creutzfeldt-Jakob Disease Information Page National Organization for Rare Disorders (NORD) Creutzfeldt Jakob Disease Information The UK Creutzfeldt-Jakob Disease Surveillance Unit Go to the MEL BSE page Selector and Collection Librarian: Metta Lansdale ( lansdale@mel.org The Health Information Resources section of the Michigan Electronic Library (MEL) provides resources for informational purposes. Health information should always be carefully reviewed with your health care provider. This service is funded in part by the State of Michigan through the Library of Michigan.

70. Creutzfeldt-Jakob Disease creutzfeldtjakob disease (CJD). What is CJD? creutzfeldt-jakob disease (CJD)is a brain disorder that usually occurs in people over the age of 60. http://www.tdh.state.tx.us/ideas/factsht/cjd.htm

Creutzfeldt-Jakob Disease (CJD) What is CJD? Creutzfeldt-Jakob disease (CJD) is a brain disorder that usually occurs in people over the age of 60. Every year about one person out of every million is diagnosed with CJD. It is sometimes called a "spongiform" disease because the brain may develop holes in it like a sponge. There is no known treatment; most people with CJD die within 3 to 12 months of diagnosis. What Causes CJD? CJD is caused by small proteins called prions. Prions are smaller than bacteria or viruses. Scientists are still not sure how prions work; they seem to damage the brain by making cells swell until they burst. How Do You Get CJD? It is not known how most people get this rare disease, although we do know that you do not get it from being around someone with CJD. Approximately 10-15 percent of cases are inherited and a few cases have been related to transplants of tissues from the nervous system. In 1995 a new kind of CJD was recognized in Britain. Some scientists think that there may be a link between this new variation of CJD and foods made from British cattle with "mad cow disease." Public health officials in the U.S. are monitoring for this new type of CJD; to date, no cases have been reported. Furthermore, no cases of "mad cow disease" have been diagnosed in U.S. livestock. What Are CJD's Signs And Symptoms?

71. InteliHealth: format. creutzfeldtjakob disease. Health A to Z, Reviewed by the Facultyof Harvard Medical School creutzfeldt-jakob disease (CJD) http://www.intelihealth.com/IH/ihtIH/WSIHW000/9339/31162/210321.html?d=dmtHealth

72. Creutzfeldt-Jakob Disease Alzheimer's Outreach creutzfeldtjakob disease for healthcare workers and morticians. 67-75 (1990). Backto creutzfeldt-jakob disease Directory. Back to Other Dementia Directory. http://www.zarcrom.com/users/alzheimers/odem/cjd5.html

Creutzfeldt-Jakob Disease for healthcare workers and morticians DESCRIPTION: Creutzfeldt-Jakob disease (CJD) is a rare, fatal brain disorder caused by an unknown organism that can be experimentally transmitted from one animal to another, as well as from human patients to other animals. CJD affects both men and women, and most often appears in people ages 50 to 75. In the early stages of CJD, individuals may have failing memory, changes in behavior, lack of coordination, or visual disturbances. As the disease progresses, mental deterioration becomes pronounced, involuntary movements, especially muscle jerks, appear, and the patient may become blind, develop weakness in the arms or legs, and ultimately lapse into a coma. Symptoms of CJD may be similar to those of other progressive neurological disorders such as Alzheimer's disease. NINDS scientists have recently developed a diagnostic test for CJD that will allow doctors to distinguish CJD from other neurological disorders. The low random incidence of CJD indicates that person-to-person transmission probably does not occur. Spouses of patients and other household members appear to be at no higher risk of contracting the disorder than the general population. There is no effective treatment for CJD. The disease usually leads to death within a year of onset.

73. Creutzfeldt-Jakob Disease Alzheimer's Outreach The CJD Directory. Below you will find a listing of informationaldocuments I hope will be useful if your loved one has CJD. I http://www.zarcrom.com/users/alzheimers/odem/cjd-d.html

The "CJD " Directory Below you will find a listing of informational documents I hope will be useful if your loved one has CJD. I know there is not much in here now, but it will be growing steadily! Please feel free to take anything you feel might be helpful to you. Simply print it out, or copy it to your hard drive or disk. Creutzfeldt-Jakob Disease Fact Sheet What is CJD? Creutzfeldt-Jakob Disease Guide Answers to Common Questions About CJD ... Creutzfeldt-Jakob Disease for Healthcare Workers and Morticians (for healthcare workers ONLY!) Back to Other Dementia Directory

74. Apr_Subject Frequently Asked Questions about creutzfeldtjakob disease (CJD) What is creutzfeldt-jakobdisease (CJD)? What is variant creutzfeldt-jakob disease (vCJD)? http://www.moh.govt.nz/moh.nsf/wpg_Index/About-CJD

ABOUT Frequently Asked Questions about Creutzfeldt-Jakob Disease (CJD) What is Creutzfeldt-Jakob Disease (CJD)? What is variant Creutzfeldt-Jakob Disease (vCJD)? What are the unique differences between CJD and vCJD? Have there been any cases of CJD in New Zealand? ... Do other countries use leucodepletion? What is Creutzfeldt-Jakob Disease (CJD)? Creutzfeldt-Jakob Disease is a rare fatal brain disorder which was first recognised more than 70 years ago. There is no effective treatment and no reliable test to predict the disease. Approximately 85 percent of Creutzfeldt-Jakob Disease illnesses occur spontaneously without any known cause. Other causes include certain medical treatments that are no longer used such as human growth hormone injections, dural grafts (brain membrane). The symptoms may take 30 years to develop. Since the disease was identified by Dr. Alfons Maria Jakob in the 1920's, over 3,000 cases have been reported world-wide. What is variant Creutzfeldt-Jakob Disease (vCJD)? A new and more aggressive strain of the disease which was identified in the United Kingdom in 1996. It produces similar symptoms to classical CJD though the disease develops more rapidly. Variant CJD is thought to be contracted by eating meat infected with bovine spongiform encephalitis (BSE) which has been described as "mad cow disease". It historically has affected people in the 16 to 52 year age group. The mean age is 28 years. What are the unique differences between CJD and vCJD?

75. NIH: Health Information creutzfeldtjakob disease. Resources. NINDS. NIEHS. Clinical Trials. NINDS logoNINDS. creutzfeldt-jakob disease. La Enfermedad de creutzfeldt-jakob Spanish. http://health.nih.gov/result.asp?disease_id=172

76. Creutzfeldt-Jakob Disease - Wikipedia creutzfeldtjakob disease. From Wikipedia, the free encyclopedia.creutzfeldt-jakob disease is a brain disorder characterized by http://www.wikipedia.org/wiki/Creutzfeldt-Jakob_Disease

Main Page Recent changes Edit this page Older versions Special pages Set my user preferences My watchlist Recently updated pages Upload image files Image list Registered users Site statistics Random article Orphaned articles Orphaned images Popular articles Most wanted articles Short articles Long articles Newly created articles Interlanguage links All pages by title Blocked IP addresses Maintenance page External book sources Printable version Talk Log in Help Creutzfeldt-Jakob Disease From Wikipedia, the free encyclopedia. Creutzfeldt-Jakob Disease is a brain disorder characterized by memory loss, jerky movements, gait disorder, rigid posture , and seizures due to a rapid loss of cerebral cells caused by transmissible proteins called prions . The incidence of the disease is about 2 per 1,000,000 and it usually appears in mid-life with an average disease onset age of 50. The prion that is believed to cause Creutzfeldt-Jakob exhibits an amino acid sequence and configuration which makes it in soluble in water , while the normal protein is highly soluble. So, as the numbers of defective prion proteins propagate and increase exponentially , the process leads to a huge load of insoluble prions in affected cells . This load of proteins disrupts cell function and causes cell death. Once the prion is transmitted, the defective proteins invade the brain like a

77. Medicine Online Medical Reference, Cosmetic Plastic Surgery, Bid For Rx, Medicat diseases and Conditions Infectious diseases - creutzfeldt-jakobdisease. It also talks briefly about creutzfeldt-jakob disease. http://www.medicineonline.com/Default.asp?SubSubCatID=194&Main=1

78. NIH Guide: DEVELOPMENT OF RAPID ASSAY FOR CREUTZFELDT-JAKOB DISEASE (NINDS-99-RF DEVELOPMENT OF RAPID ASSAY FOR creutzfeldtjakob disease Release Date May 19,1999 REQUEST FOR INFORMATION NINDS-99-RFI-01 PT NATIONAL INSTITUE OF http://grants.nih.gov/grants/guide/notice-files/not99-090.html

kd17c@nih.gov , will also be accepted. Return to Volume Index Return to NIH Guide Main Index Department of Health and Human Services National Institutes of Health (NIH) 9000 Rockville Pike Bethesda, Maryland 20892

79. Bovine Spongiform Encephalopathy And Creutzfeldt-Jakob Disease BSECJD pages. Bovine spongiform encephalopathy and creutzfeldt-jakob disease. Bovinecreutzfeldt-jakob disease? Failures of epidemiology must be remedied. http://bmj.com/collections/bse/30-3-ed.htm

BSE-CJD pages Bovine spongiform encephalopathy and Creutzfeldt-Jakob disease The link is unproved, but no better explanation is presently forthcoming The identification of 10 cases of a highly stereotyped clinicopathological variant of Creutzfeldt-Jakob disease (CJD) in adolescents and young adults occurring in Britain within the past 24 months (R G Will, J Ironside, et al , personal communication) is cause for serious rethinking about the possibility of human infection from bovine spongiform encephalopathy (BSE). Typically, "sporadic" (idiopathic) cases of Creutzfeldt-Jakob disease begin in the sixth or seventh decade of life with a loss of memory or, less commonly, with behavioural changes or higher cortical function deficits such as dysphasia or dyslexia. Over several weeks the mental deterioration progresses to frank dementia in association with abnormalities of vision or coordination, rigidity, and involuntary movements (especially myoclonic jerks), which often occur in synchrony with periodic spike waves on electroencephalography.[ii] Death usually occurs within six months, and at necropsy the brain shows a pathognomonic spongiosis with neuronal loss and gliosis in the cortex, deep nuclei, and cerebellum. Amyloid plaques are found in only about 5% of cases.[iii] Creutzfeldt-Jakob disease contracted from infected growth hormone also begins in a stereotyped way but with ataxia or other abnormalities of coordination. By contrast, the newly reported variant syndrome is characterised clinically by onset with psychiatric symptoms and progressive neurological deficits with an unusual neuropathological profile (R G Will, I Ironside

80. Diagnosing Creutzfeldt-Jakob Disease Editorial. Diagnosing creutzfeldtjakob disease. National creutzfeldt-jakob diseaseSurveillance Unit, Western General Hospital, Edinburgh ER4 2XU. REFERENCES. http://bmj.com/collections/bse/05-10-e.htm

BSE-CJD pages BMJ Volume 313 No 7061 Saturday 5 October 1996 Editorial Diagnosing Creutzfeldt-Jakob disease Case identification depends on neurological and neuropathological assessment Central to the identification and classification of patients with Creutzfeldt-Jakob disease (CJD) is the application of standardised diagnostic criteria based on accumulated data on the clinical and pathological features of the disease. Typically, patients present clinically with rapidly progressive dementia and myoclonus associated with various focal neurological signs. The diagnosis is confirmed by identifying characteristic neuropathological features, which include spongiform change, astrocytic gliosis, and neuronal loss. Diagnostic criteria originally proposed in 1979(1) have been validated by the "gold standard" of experimental transmissibility in primates.(2) This indicates that the clinical diagnosis is highly accurate, particularly if there is a characteristic appearance on an electroencephalogram. However, not all cases are straightforward: about 10% of patients have a protracted clinical course, which makes the distinction from Alzheimer's disease difficult(3); 20-40% of patients do not exhibit a typical electroencephalogram(4); and unusual clinical phenotypes occur in patients with genetic and iatrogenic forms of the disease.(4) Updated diagnostic criteria have been published, including new definitions for "familial" and iatrogenic Creutzfeldt-Jakob disease,(5) but case ascertainment in the small proportion of atypical cases depends on review of a wide spectrum of suspect cases and a high necropsy rate.

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