1. Client Education Series: Cushings Syndrome A page designed to provide information about the causes, signs, diagnosis and treatment of canine Category Health Animal Pets Dogs Conditions and Diseases......Cushing’s syndrome. So your pet has been diagnosed with Cushing’s syndrome(also known as hyperadrenocorticism) What is Cushing’s syndrome? http://www.vetmed.auburn.edu/sac/mededu/cushings/home.html

Cushing’s syndrome So your pet has been diagnosed with Cushing’s syndrome (also known as hyperadrenocorticism)... What is Cushing’s syndrome? iatrogenic/induced pituitary-dependent adrenal tumor The normal pituitary-adrenal axis Clinical signs/symptoms Medical complications associated with Cushing’s disease Diagnosis Supportive findings ... Prognosis/survival What is Cushing’s syndrome? Cushing’s syndrome is a condition in which there is an excess of cortisol (cortisone). This can be caused by drugs (e.g. prednisone, depo-medrol, dexamethasone, betamethasone) often prescribed for the treatment of many diseases; this syndrome is known as iatrogenic Cushing’s syndrome. It can also be caused by an excess of the body’s own cortisol, caused by a pituitary tumor or adrenal tumor. Iatrogenic Cushing’s syndrome is caused by administration of drugs that suppress the body’s own cortisol production. Clinical signs and complications are similar to the naturally occuring disease. The dog can become dependent upon the drugs with chronic use, and abrupt withdrawal can lead to signs related to lack of cortisol, such as lethargy, depression, vomiting, and diarrhea. For these reasons, chronic steroid use is not recommended except in cases of life-threatening immune-mediated disease or chemotherapy protocols. The lowest possible dose of steroids should be used for therapy. Pituitary dependent Cushing’s disease is caused by a functional pituitary tumor that stimulates the adrenal glands to produce excess cortisol. The tumor is usually microscopic and benign (a microadenoma). Sometimes the tumor can be large enough to cause pressure on the nerves to the eyes and the part of the brain called the hypothalamus, causing behavior changes, lack of appetite, and blindness, in addition to the other signs of Cushing’s syndrome. These tumors are known as macroadenomas. Pituitary-dependent Cushing’s disease makes up about 85% of spontaneous Cushing’s disease cases.

2. Thepittsburghchannel.com - Health - Healthcast: Cushings Syndrome WTAETV Medical Editor Marilyn Brooks reports that cushings syndrome is a hormonal disorder that most commonly affects http://www.thepittsburghchannel.com/pit/health/stories/health-20001006-174452.ht

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3. Cushings Syndrome Reference Sites. The Diagnosis of cushings syndrome Atypical Presenations andLaboratory Shortcomings CSRF - Cushing's Support and Research Foundation. http://www.cushingssyndrome.org/links.asp

info@cushingssyndrome.org CUSHING'S SYNDROME RELATED LINKS Below you will find links relating to Cushing's Syndrome. Dedicated Drug / Treatment Sites Pregnancy Reference Sites ... Click here to submit a Cushing's Syndrome related site to our directory. Dedicated Life Experience with Cushings - cushings-help.com Drug / Treatment Sites Ketoconazole - Drug used to treat skin infections. Action of Ketoconazole Abstract from Iran - Brief description of Ketoconazole in Cushings. Comes from Iran Ketoconazole - Very brief abstract on Ketoconazole. Describes how it works to reduce the production of steroids. Pregnancy Worrisome striae in pregnancy - Shereen Ezzat Reference Sites The Diagnosis of Cushings Syndrome - Atypical Presenations and Laboratory Shortcomings CSRF - Cushing's Support and Research Foundation. Adrenal Gland Disorders - About Cushings Disease NADF - Cushing's Syndrome: the facts you need to know. Healthcyclopedia - Information and links related to Cushings Syndrome. Thyroid Disease - Overview, diagnosis, treatment and links. Discovery Health - Overview of Cushings Syndrome.

4. Cushings Syndrome Center by Mary Shannon Med Help Cushings Med Help International Fact Sheet - CSRFCushings Support and Research Foundation Cushing's Syndrome lvhealth.com http://www.cushingssyndrome.org/related.asp

info@cushingssyndrome.org CUSHING'S SYNDROME RELATED ARTICLES / CASE STUDIES Below you will find articles and case studies relating to Cushing's syndrome. Case Reports Dogs Medical References Overviews ... Click here to submit a Cushing's Syndrome related article to our directory. Case Reports Worrisome striae in pregnancy - 29 year old pregnant woman by Dr. Shereen Ezzat Cushing's syndrome (Right adrenal adenoma) by Department of Radiology, Nagasaki University. Cushing's Syndrome by Sanja Dacic, MD and Prabha B. Rajan, MD a 41-year-old Caucasian female who was admitted to the hospital for evaluation of high blood cortisol level. Cushing's Syndrome of the Adrenal: The Obesity Tumor by Endocrine Web. Dogs Canine Disease Information SuperVet information Cushings Disease in Dogs SuperVet information General Illnesses and Diseases The American Veterinary Medical Association Hyperadrenocorticsm - Merck Merck Veterinary Manual Medical References National Library of Medicine Current Bibliographies In Medicine Cushing's Syndrome induced by betaemethasone nose drops by Findarticles.com NIDDK Cushing's Syndrome Overviews Cushing's Syndrome Endocrine Resource Center by Mary Shannon Med Help - Cushings Med Help International Fact Sheet - CSRF Cushings Support and Research Foundation Cushing's Syndrome lvhealth.com

5. HealthlinkUSA Cushings Syndrome Links Wednesday February 5, 2003. The healthy way to search today's best sites.Links to websites which may include treatment, cures, diagnosis http://www.healthlinkusa.com/419ent.htm

6. Cushings Syndrome; Treatment, Prevention, Cure cushings syndromeSearch information from many of the best cushings syndrome healthsites. Quickly find information treatments, prevention, support and more. http://www.healthlinkusa.com/content/419.html

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7. About Cushings Syndrome A General Overview Cushing's Syndrome. WHAT IS IT? Hormones are special breaks down. Whentoo much Cortisol is produced, Cushings is the result. There http://www.webhealth.co.uk/WebHealth_A-Z_of_Health/About_Cushings_Syndrome_A_Gen

Cushing's Syndrome WHAT IS IT? Hormones are special chemicals which are produced then travel all over the body in the blood to do their work. The Adrenals (Latin for 'Near the Kidney') normally produce a hormone called Cortisol (also called Hydrocortisone). Cortisol is essential for life and health, but too much of it can be very harmful. When the adrenal glands become overactive, the normal healthy control of Cortisol breaks down. When too much Cortisol is produced, Cushings is the result. There are several forms of Cushings, each with it's own particular treatment. a) Pituitary Cushings. This is the most common and accounts for around 60% of all cases of Cushings. As its name suggests, the problem lays in the pituitary gland, a small gland below the brain, just behind the nose. This pea-sized chemical factory does many jobs for the body, one of which is the control of the amount of Cortisol the adrenal glands make. It does this by producing another hormone called ACTH

8. Cushings Self Help And Support Groups Cushing's Syndrome. The Association for Cushing's Treatment and Help. We area support group for people suffering from all forms of cushings syndrome. http://www.webhealth.co.uk/Self_Help_and_Support_Groups_R/Cushings_Self_Help_And

Cushing's Syndrome The Association for Cushing's Treatment and Help. We are a support group for people suffering from all forms of Cushings syndrome. The Association is patient-led and patient-run, sensitive to the needs of Cushings patients. OBJECTIVES: Patient-to-patient contact and support, and finding sources of counselling for individual sufferers Patient-led identification of the things that sufferers need from their carers, to inform the caring proffessionals Patient-guided production of written information for suffers, in co-operation with medical advice, for example: An information booklet for newly diagnosed patients Information sheet for the families of sufferers to help them manage the impact on family life. Individuals accounts of the illness Information sheets relating to post operative conditions and medications. A Newsletter THE SET UP The Association was started in October 1993 with the help of Dr. Chris Burke Endocrinologist. The Coordinator is progressively supported by a network of Regional Coordinators who will be beat placed to put individual people in touch with each other. Each coordinator keeps in touch with their area. They will meet or correspond as a forum for exchanging feedback on the needs of members, and coordinating the Association written information, with technical advice from a small medical advisory group. A small Management Committee will take the responsibility for fund-raising from the shoulders of the coordinators. The Association is self funded by an annual membership fee.

9. Cushing's Syndrome Of The Adrenal: The Obesity Tumor. the ACTH was coming from the pituitary. Causes of cushings syndrome. Testingfor cushings syndrome. The most sensitive test to check for http://www.endocrineweb.com/obesity.html

~ Cushing's Syndrome ~ Note: this page contains information which assumes you have read our introduction to the adrenal gland page . If not, go there first. Remember, the adrenal gland has a center gland (medulla) which produces adrenaline , and an outer gland (the cortex) which produces several hormones such as cortisol an aldosterone. This page is about cortisol overproduction by the adrenal cortex. In 1932, a physician by the name of Harvey Cushing described eight patients with central body obesity, glucose intolerance, hypertension, excess hair growth, osteoporosis, kidney stones, menstrual irregularity, and emotional liability. It is now known that these symptoms are the result of excess production of cortisol by the adrenal glands. Cortisol is a powerful steroid hormone, and excess cortisol has detrimental effects on many cells throughout the body. Although some of these symptoms are common by themselves, the combination of these suggests that a workup for this disease may be in order. Keep in mind that Cushings syndrome is rare, occurring in only about 10 patients per one million population. On the other hand, simple obesity can be associated with some of these symptoms in the absence of an adrenal tumorthis is related to the slightly different mechanism by which normally produced steroids are metabolized by individuals who are obese. Note: The most common cause of excess steroids in the blood and its side effects, however, is long-term use of steroid medications for other disorders.

10. Cushings Syndrome Addison and Cushing International Federation Organization for individuals affectedby Addison's Disease, Cushing Syndrome, or related adrenal/pituitary http://www.foundhealth.com/Health/Conditions_and_Diseases/C/Cushings_Syndrome/

Advertisement Foundhealth.com Search All Terms Any Term Tips Browse foundhealth.com Health calculators Fast Food Database Speakers Bureau How to evaluate sites Submit a site Contact us Home - main directory Top Health Conditions and Diseases C : Cushings Syndrome See also: Health: Conditions and Diseases: P: Pituitary Disorders Health: Medicine: Medical Specialties: Endocrinology Addison and Cushing International Federation - Organization for individuals affected by Addison's Disease, Cushing Syndrome, or related adrenal/pituitary disorders, or support groups for affected individuals. Site contains information and articles about these disorders. Cushing Disease, Adrenal - A technical account of various case studies from Medline, complete with references. Cushing Syndrome - A brief description of the symptoms and diagnosis of Cushing Syndrome by Eric Daiter, MD. Cushing's Support and Research Foundation - Providing information and support for Cushing's Disease and Cushing's Syndrome patients and their families. Cushing's Syndrome - Detailed information about symptoms, diagnosis and treatment of Cushing's Syndrome from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).

11. Conditions And Diseases Cubital Tunnel Syndrome (5); cushings syndrome (8); Cyclic Vomiting Syndrome (13);Cystic Fibrosis (42); Cystic Hygroma (9); Cystitis@ (136); Cytomegalovirus (1). http://www.foundhealth.com/Health/Conditions_and_Diseases/C/

Advertisement Foundhealth.com Search All Terms Any Term Tips Browse foundhealth.com Health calculators Fast Food Database Speakers Bureau How to evaluate sites Submit a site Contact us Home - main directory Top Health Conditions and Diseases : C Canavan Disease Cancer Candida Canker Sores ... Cytomegalovirus Help build the largest human-edited directory on the web. Submit a Site Open Directory Project Become an Editor Parts of the Open Directory made available on foundhealth.com have been modified. Home Health Tools Fast Food Database Vitamins and Minerals ... foundhealth.com The content provided on this web site is for information purposes only. It is intended to provide educational material and is not designed to provide medical advice. Please consult your health care provider regarding any medical issues you have relating to symptoms, conditions, diseases, diagnosis, treatments and side- effects. Terms and conditions.

12. What Is Cushings Syndrome Hyperadrenocorticism (Cushing’s Syndrome). What is Cushing’s syndrome? Cushing’ssyndrome is relatively common in dogs and rare in cats. http://www.gcvs.com/internists/cushings.htm

Search for: Search Tips Directions Hyperadrenocorticism (Cushing’s Syndrome) What is Cushing’s syndrome? What are the clinical signs of Cushing’s syndrome? There are many clinical signs that might be seen with Cushing’s syndrome. These include increased water consumption and urination, ravenous appetite, pot bellied appearance, thin skin, muscle wasting or weakness, ligament tears (commonly the cruciate ligaments of the knees), hair loss, panting, lethargy, recurrent urinary tract infections or neurological abnormalities. Many pets exhibit several of the listed clinical signs, but rarely does any one pet have all of the signs. Cats with Cushing’s syndrome are often diabetic and also have very thin skin that tears easily. How is Cushing’s syndrome diagnosed? How is Cushing’s Syndrome treated? Ketoconazole is an antifungal medication, which interferes with the production of cortisol. This medication is much more expensive than Mitotane and often less effective, but it is a viable alternative, especially in the short term if the pet requires surgery or if there is an adrenal tumor that is too large or invasive to be removed. L-Deprenyl (Anipryl) is another medication that might be recommended for some pets with pituitary dependent Cushing’s syndrome. This medication may help to alleviate some of the clinical signs by decreasing the amount of ACTH released from the pituitary gland. This medication hasn’t proven to be effective in all pets with pituitary disease and doesn’t suppress cortisol production like Lysodren does, but it has the benefit of being less toxic.

13. Cushings Syndrome, Adrenal Dysfunction - Hormonal Disorders CUSHING'S SYNDROME. What is cushings syndrome? Cushing's syndrome isa hormonal disorder caused by prolonged exposure of the body's http://www.medicalconsumerguide.com/primary_care/hormonal_disorders/cushings_dis

Primary Care Elective Care Dental Vision ... Pheochromocytoma CUSHING'S SYNDROME What is Cushings Syndrome? Cushing's syndrome is a hormonal disorder caused by prolonged exposure of the body's tissues to high levels of the hormone cortisol. Sometimes called "hypercortisolism," it is relatively rare and most commonly affects adults aged 20 to 50. An estimated 10 to 15 of every million people are affected each year. What are the Symptoms of Cushing's Syndrome? Symptoms vary, but most people have upper body obesity, rounded face, increased fat around the neck, and thinning arms and legs. Children tend to be obese with slowed growth rates. Other symptoms appear in the skin, which becomes fragile and thin. It bruises easily and heals poorly. Purplish pink stretch marks may appear on the abdomen, thighs, buttocks, arms and breasts. The bones are weakened, and routine activities such as bending, lifting or rising from a chair may lead to backaches, rib and spinal column fractures. Most people have severe fatigue, weak muscles, high blood pressure and high blood sugar. Irritability, anxiety and depression are common.

14. CUSHINGS SYNDROME cushings syndrome. PHYSICAL LEVEL. MEDICAL DEFINITION cushings syndromeis an endocrine imbalance due to hyperadrenalcorticocism. http://www.holisticvetpetcare.com/cushings-syndrome.htm

Search CUSHINGS SYNDROME What I have found: imbalances and energetic disturbances in the Pituitary-Adrenal Gland- Pancreas relationships on the physical and electromagnetic levels of the patient. PHYSICAL LEVEL MEDICAL DEFINITION:  Cushings Syndrome is an endocrine imbalance due to hyperadrenalcorticocism . This means it is caused by an abnormal increased secretion of hormones by the cortex of the Adrenal Gland. These hormones regulate water and electrolytes, blood sugar, sex hormones and natural cortisones. Generally the main defect is in the increased secretion of the glucocorticoid cortisol Hyperfunction of the adrenal cortex can be a result of abnormalities in the cortices, the pituitary or the hypothalamus of the brain. If one sided, the cause can be a tumor in the pituitary (adenomas or adenocarcinomas of the anterior lobe). Or it can be due to a defect in the negative feedback mechanism in the hypothalamus, whereby increasing levels of circulating cortisol (natural cortisone), does not result in physiologic inhibition of the

15. Disease Medicine. Homeopathy For Animals. Alternative Health. cushings syndrome (new); Addisons Disease and Treatment (new); Allergiesand Skin Problems in Cats; Allergies and Skin Problems in Dogs. http://www.holisticvetpetcare.com/disease_medicine_cat.htm

Search Disease and Natural Medicine Please select a link below for complete detailed information. Categories not highlighted are currently being compiled and researched. Obesity, Cause, Prevention and Natural Therapy (new) Cushings Syndrome Feline Urethral Obstruction Addisons Disease and Treatment Allergies and Skin Problems in Cats ... Homeopathy Remedies With first order of $100 or more receive Detox-Blue-Green-Papers and Newsletter #7 Price Reduction on Trail and First Aid Kits P. O. Box 1242 Gualala, CA 95445 24 hour Telephone and Fax (707) 785-9171 Email everglo@mcn.org

16. Capital Health - Cushings Syndrome cushings syndrome, Audio File. Cushing's syndrome occurs when thereis an excess of steroid hormones in the blood. It may result from http://www.cha.ab.ca/Health Services/Health Topics/Body Location Systems/Endocri

Hospitals Capital Health Link Site Map Media Desk ... Quick Links Endocrine System (Hormones) Capital Health Home Your Health Health Topics Body Location Systems ... Endocrine System (Hormones) Cushings Syndrome Audio File Cushing's syndrome occurs when there is an excess of steroid hormones in the blood. It may result from overproduction of the hormones by the adrenal glands or from prolonged use of steroid drugs taken for another illness, such as rheumatoid arthritis or asthma. It can also be caused by tumors in the adrenal glands, pituitary glands or lungs. Cushing's syndrome most commonly affects adults aged 20 to 50. In Cushing's syndrome, the face becomes puffy, round and red. The neck and torso develop fat. A hump of fat may develop between the shoulder blades. Muscle begins to waste, and the arms and legs become thin. Purplish stretch marks may appear on the abdomen, breasts, buttocks and thighs. Fatigue and weakness set in. Skin becomes thin, fragile and easily bruised. The bones become thin and fracture easily. Women usually have excess hair on their faces, necks, chests, abdomen and thighs. Their menstrual periods may become irregular or stop. Men have decreased fertility and diminished or absent sex drive. A diagnosis may be made based upon symptoms and by measuring the hormones in blood and urine. CT or MRI scanning of the pituitary and adrenal glands and x-rays of the lungs may also be done.

17. [MOL] ABout Cushings Syndrome [01148] MOL ABout cushings syndrome. To Medical On Line Forum molcancer@lists.meds.com ;Subject MOL ABout cushings syndrome; From Martin http://www.meds.com/archive/mol-cancer/2000/02/msg01148.html

Date Prev Date Next Thread Prev Thread Next ... Thread Index [MOL] ABout Cushings Syndrome To mol-cancer@lists.meds.com Subject : [MOL] ABout Cushings Syndrome From fitecancer@earthlink.net Date : Sun, 27 Feb 2000 07:24:05 -0800 Organization : Cancer Support Reply-To mol-cancer@lists.meds.com Sender owner-mol-cancer@lists.meds.com Good Day All, HOpe the following information is beneficial to those with the Condition of Cushings Disease. Leuprolide Acetate Therapy Reverses Cushing's Syndrome WESTPORT, Nov 22 (Reuters Health) - A 63-year-old woman with Cushing's syndrome had a complete reversal of symptoms after treatment with leuprolide acetate, Canadian researchers report in the November 18th issue of The New England Journal of Medicine. Dr. Andre Lacroix and colleagues of Hotel-Dieu du Centre Hospitalier de l'Universite de Montreal, in Canada, present the case report of a woman with corticotropin-independent Cushing's syndrome caused by bilateral adrenal hyperplasia. Her symptoms became apparent transiently during pregnancy and permanently after menopause. http://ipn.intelihealth.com/ipn/ihtIPN?c=253417

18. Re [MOL] ABout Cushings Syndrome/Marty [01172] Re MOL ABout cushings syndrome/Marty. To molcancer@lists.meds.com ;Subject Re MOL ABout cushings syndrome/Marty; From Lillian http://www.meds.com/archive/mol-cancer/2000/02/msg01172.html

Date Prev Date Next Thread Prev Thread Next ... Thread Index Re: [MOL] ABout Cushings Syndrome/Marty To mol-cancer@lists.meds.com Subject : Re: [MOL] ABout Cushings Syndrome/Marty From firefly@islc.net Date : Sun, 27 Feb 2000 12:38:29 -0800 References 38B94195.BCFBD31E@earthlink.net Reply-To mol-cancer@lists.meds.com Sender owner-mol-cancer@lists.meds.com http://ipn.intelihealth.com/ipn/ihtIPN?c=253417 http://www.meds.com/con_faq.html http://www.meds.com/con_faq.html Follow-Ups Re: [MOL] ABout Cushings Syndrome/Marty From: References [MOL] ABout Cushings Syndrome From: Prev by Date: Re: [MOL] From Chris - Chris Next by Date: No Subject Prev by thread: [MOL] ABout Cushings Syndrome Next by thread: Re: [MOL] ABout Cushings Syndrome/Marty Index(es): Date Thread

19. Sophie's Anipryl Treatment For Cushings Syndrome Next Progress. Cushings Disease Definition Cushing's Pet Forum You arevisitor, Author Vern Tallman, Santa Clara, CA Revised October 29, 2000. http://members.aol.com/vtallman/Treatment.htm

RESCUED!! The Story of Sophie Home Meet Sophie Rescue Story Medical Check ... Read Guestbook TREATMENT March 20, 1998 The vet prescribed Anipryl to treat the disease, partly at our request after reading various accounts of animal response to the alternative medications. This is a relatively new drug (available for about a year in the US), has had promising results and is reported to have fewer side-effects. The dosage is one 30 mg tablet per day. We wrap the pill in a small piece of chicken luncheon meat as a "treat" in the morning. Following the first month of treatment, blood tests will be performed to assess the effectiveness of the treatment. March 22, 1998 While on the medication, the vet is depending on us to monitor Sophie's condition, and note any improvements in Cushing's-related symptoms. Several of the typical symptoms can only be subjectively evaluated. The information pamphlet that accompanies the Anipryl notes that in test cases, many of the animals showed "improved activity", however, monitoring should be based on history and physical examination findings. Of the "classic" symptoms of Cushing's, Sophie exhibits the following:

20. CUSHING'S SYNDROME IN HORSES - Equiworld - Equestrian Information - Horses And P be published. Please visit Phil Val's website for more informationand the story of Flame, a pony with cushings syndrome If you http://www.equiworld.net/uk/horsecare/veterinary/cushings.htm

CUSHING'S SYNDROME IN HORSES Cushing's Syndrome is well known in humans, cats and especially in dogs. It is also becoming more prevalent in horses, and yet there is little written about identifying it, and caring for horses who suffer from it. It is regarded as incurable in horses, though it is possible that horses can live reasonably happily for a long time whilst suffering from it. CUSHING'S DISEASE IS HYPERADRENOCORTICISM "Cushing's disease" is a term used in human medicine that refers to pituitary dependent hyperadrenocorticism. According to veterinary and human medical experts the disease is characterised by excessively high levels of steroids in the body. Steroids are compounds that circulate naturally in our bodies and our pets' bodies. Two major centres in the body regulate the levels of these steroids. The main centre is a gland in the brain called the pituitary. This gland controls most of the hormones in the body. This disease is called hyperadrenocorticism.; (hyper = too much; adreno = adrenal gland; cort = cortex, the outer layer of the adrenal gland; ism = process). Blood tests often help the diagnosis of Cushing's Syndrome, and they indicate high levels of blood glucose. This would be similar to diabetes, which is very rare in horses, but is sometimes found in horses with Cushing's. SYMPTOMS In dogs and cats There are times when the steroid control in the body becomes deregulated and excess steroids are present. Clinical signs, in dogs, include

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