1. Degos Disease An in depth look at degos disease including prognosis and treatment. http://www.thedoctorsdoctor.com/diseases/degos_disease.htm

Background This rare disease is important because a skin biopsy may be the first clue to the diagnosis. Patients classically develop multiple skin papules that evolve to have a dimpled appearance with a porcelain white center. This is the clue to the underlying disease which can affect the gastrointestinal tract and central nervous system and may lead to death. The skin biopsy places the pathologist at the center of the diagnostic evaluation. SYNONYMS Malignant Atrophic Papulosis Köhlmeier-Degos' disease INCIDENCE Rare DISEASE ASSOCIATIONS CHARACTERIZATION Familial cases Rare PATHOGENESIS CHARACTERIZATION Unknown-has been considered a vasculitis, mucinosis, or thrombotic disorder No circulating immune complexes, anti-endothelial cell antibodies, or anticardiolipin antibodies identified Endovasculitis Some consider a primary endothelial cell defect with secondary thrombosis leading to infarctive changes LABORATORY/RADIOLOGIC/OTHER TESTS CHARACTERIZATION Impaired fibrinolytic activity Alterations in platelet function GROSS APPEARANCE/CLINICAL VARIANTS CHARACTERIZATION Classic Skin Lesions Crops of papules ranging from 0.5-1 cm which develop an umbilication with a porcelain white center with a telangiectatic ring

2. Degos Disease Judth Calder's support network for this rare vasculitis.Category Health Conditions and Diseases Rare Disorders Degos...... Zouboulis. How or why is he involved with degos disease? This is where I'll be postingall my news about degos disease. posted on Sunday, January 20, 2002 http://www.hodgers.com/degos/

PATIENT SUPPORT NETWORK AND INFORMATION RESOURCE Latest news... Tell me again about this Prof. Zouboulis. How or why is he involved with Degos Disease? I can't remember how you came into contact with him and why he would be interested in hosting a conference. Also...do you have any idea yet what this conference purpose would be? And what our (the Dego's Patient) involvement would be? OK - Professor Zouboulis is a dermatologist at the Benjamin Franklin Hospital in Berlin. The derm dept is a separate and newly refurbished department (it used to be the American Hospital!) - and it has a world renowned dermatologist heading it. His name is Professor Orfanos and he's Prof Z's boss. In August last year I got hold of the German "Dermatology" journal - it had only just been published. In it was an article which described the apparently successful treatment of a Degos patient. (Incidentally, it is named after Prof Robert Degos, a Frenchman....).The treatment was Trental - a vaso-dilator. My family doctor put me on it straight away . I rang the Berlin hospital which appeared under the names of the doctors, and asked if I could go and see them (cheeky bugger, aren't I?) They said OK, because they are always fascinated by such a rarity. So I went over with my husband and saw the doctors. They are lovely people and they speak excellent English - I think they've worked in America. They asked to see me again in December, by which time I had been taking the Trental for 4 months. They could see an improvement and asked me a million questions and showed me to a crowd of doctors from the hospital.

3. Degos Disease - 1 Dept. of Dermatology University of Iowa College of Medicine. Degos' Disease - Malignant Atrophic Papulosis http://tray.dermatology.uiowa.edu/Degos01.htm

Dept. of Dermatology - University of Iowa College of Medicine Degos' Disease - Malignant Atrophic Papulosis Return to Image Index page. Return to Image Index page. Return to Dermatology's Home page. September, 1995

4. Degos Disease - Information For Patients And Doctors degos disease information for patients and doctors. NZ DermNet is an online dermatology resource for patients, GPs and dermatologists conditions Patient Information - degos disease. degos disease. degos disease, also known as malignant atrophic http://www.dermnetnz.org/dna.degos/degos.html

Home Skin conditions Degos disease Degos disease, also known as malignant atrophic papulosis is a rare disorder. It generally occurs in young Caucasian adults. Degos disease affects the lining of the small blood vessels resulting in occlusion (blockage). The blood vessels affected include those supplying the skin, gastrointestinal tract and central nervous system. Degos scar Multiple lesions New lesions What is the cause of Degos disease? The underlying cause of the occlusion of the blood vessels in Degos disease is unknown. Three possible mechanisms are: Viral infection Disturbance in immunity Abnormality in the clotting system of blood What are its features? Skin lesions are the characteristic feature of Degos disease. The lesions are usually multiple and occur predominantly on the trunk and arms. They usually start as small red raised spots of 2-5mm in diameter. After a few days they enlarge and develop a central white spot that is depressed in comparison to the red skin around it. They heal leaving depressed porcelain-white scars. Gastrointestinal complications result from lack of blood supply to the lining of the gut and may lead to serious complications like perforation of the bowel. The usual symptoms are sudden onset of abdominal pain or gastrointestinal bleeding (vomiting blood or passing blood with the bowel motion).

5. Eastern Mediterranean Health Journal, Vol. 6 No. 1, Degos Disease In A 24-year-o degos disease in a 24year-old Jordanian male R.M. Al-Smadi, F. Abu-Jamous and I. Omeish Volume 6, Issue 1, 2000, Page 194-196 Introduction degos disease (malignant atrophic papulosis) is a rare disease that affects skin and the gastrointestinal http://www.emro.who.int/Publications/EMHJ/0601/25.htm

Degos disease in a 24-year-old Jordanian male R.M. Al-Smadi, F. Abu-Jamous and I. Omeish Volume 6, Issue 1, 2000, Page 194-196 Introduction Degos disease (malignant atrophic papulosis) is a rare disease that affects skin and the gastrointestinal, ocular and central nervous systems. The disease is characterized by papules that develop porcelain-white centres and telangiectatic borders. The etiology of the disease is unknown; however, the immediate cause may lie in impaired endothelial function or abnormal coagulation (fibrinolytic activity). Viral causes have been implicated. Histopathological findings are wedge-shaped areas of dermal necrosis covered by markedly atrophic malpighian layers and collagen with a smudged appearance. Complications of the disease include peritonitis, intestinal perforation and, less frequently, cerebral infarction. There is no effective treatment; however, antiplatelet therapy may be beneficial for patients in whom platelet aggregation is impaired. Prognosis is poor when systemic involvement is found, but seems to be good in benign forms.

6. Degos Disease Message Board Susan 095332 02/24/02 (0) degos disease Mary Frances 20333102/10/02 (0) Congratulations! - Judith Calder 203212 02/10/02 http://www.hodgers.com/degos/message_board.shtml

PATIENT SUPPORT NETWORK AND INFORMATION RESOURCE Message Board Post Message FAQ add your art - related site to portal http://www.wooop.de Hair growth herbs Hanah Vision: what is life without it? Mahalo do you have free time? Mahalo My short history Steffi Degos world conference Judith Re: Degos world conference Pearl Fehily mother nature's wholesome art Mahalo free time business Mahalo Re: mother nature's wholesome art Mahalo Wanting to know more Katrina Dowling-Degos Mike Hofmann response to message caron Re: response to message Maureen Caroselli (Walsh) Degos related digestive system complications Bob Elsasser Loved your site. Maggie Re: Loved your site. Maggie hey Nadie mother nature's art Arnie Re: mother nature's art animichelle mother nature's art Arnie Touched by degos Deanna Dowling Degos Tim Re: Dowling Degos Judith Calder Re: Dowling Degos Flavia Risso People healed of Rare Incurable Disorders at: dave Consultation in Berlin Judith Re: Consultation in Berlin Bob Elsasser inadequacies hodgers (Critique of Pure Reason, B628) Chip Chipdinger To: Steff in Germany- Degos Mary Frances Thank you Judith Steffi Ehlers Hi susan Re: Thank you Judith susan reference for doctor Susan Degos Disease Mary Frances Congratulations!

7. NORD - Degos Disease Offers synonyms, a general discussion and further resources. http://www.stepstn.com/cgi-win/nord.exe?proc=GetDocument&rectype=0&recnu

8. Healthy Sexuality - Kohlmeier-Degos Disease - Webmd Welcome to the WebMD Healthy Sexuality Center, learn about symptoms, treatments and more for Kohlmeier-degos disease. http://redirect-west.inktomi.com/click?u=http://ads.247wsr.com/6103-5920539-1-8-

9. Dermatology Differential Diagnosis By Morphology Lichen sclerosis et atrophicus; Atrophic morphea; Lichen planus (atrophicvarient); degos disease Malignant atrophic papulosis. Acral Scleroatrophy. http://tray.dermatology.uiowa.edu/DDX/scar-atrophy.html

Dept. of Dermatology - University of Iowa College of Medicine D ermatology D ifferential D iagnosis by M orphology Scar / Sclerotic / Atrophy Lesions Atrophic White Spots Acral Scleroatrophy Epidermal Atrophy Dermal Atrophy ... Subcutaneous Atrophy Return to Dermatology's Home page. Return to Differential Diagnosis by Morphology Please read Under Construction Atrophic White Spots Lichen sclerosis et atrophicus Atrophic morphea Lichen planus (atrophic varient) Degos disease - Malignant atrophic papulosis Acral Scleroatrophy Acrodermatitis chronica atrophicans (Infection with Borrelia burgdorferi Acrogeria Scleroderma Epidermal Atrophy Steroid induced atrophy Senile atrophy Mycosis fungoides Poikilodermas Poikiloderma atrophicans vasculare ( +/- Reticulosis [ e.g. M.F. ] ) Poikiloderma of Civatte Poikiloderma congenitale Rothmund-Thomson syndrome Dermatomyositis Lupus erythematosus Lichen planus erythematosus Scleroderma (rare) Acrogeria / Progeria / Werner's syndrome Dermal Atrophy Anetoderma Jadassohn-Pellizari type (Inflammatory precursor) Schwenniger-Buzzi type (No precursor, arises

10. Reticular Melanotic Hypermelanoses Dowlingdegos disease, Arch Dermatol 1978;1141150. VARIANTS, Galli-Galli diseaseAn unrecognized entity or an acantholytic variant of Dowling-degos disease? http://www.thedoctorsdoctor.com/diseases/reticular_melanotic_hypermelanoses.htm

Background These rare pigmented diseases are all characterized by a peculiar reticulate pigmentation. They are divided into various disease based upon the distribution and associated conditions. OUTLINE Epidemiology Disease Associations Pathogenesis Gross Appearance and Clinical Variants ... Internet Links EPIDEMIOLOGY CHARACTERIZATION SYNONYMS Reticulate pigmentary disorders GEOGRAPHY More common in Asians DISEASE ASSOCIATIONS CHARACTERIZATION HIDRADENITIS SUPPURATIVA Hidradenitis suppurativa, Dowling Degos disease and perianal squamous cell carcinoma. Li M, Hunt MJ, Commens CA. Department of Dermatology, Westmead Hospital, Sydney, New South Wales, Australia. Australas J Dermatol 1997 Nov;38(4):209-11 Abstract quote A patient with hidradenitis suppurativa (HS) is described in association with Dowling Degos disease and perianal squamous cell carcinomas. As the initial treatment for HS failed to give any satisfactory relief he sought no further medical help for the subsequent 40 years. This patient illustrates the management difficulties in HS and the need for regular surveillance to exclude the development of anogenital squamous cell carcinoma. Previous reports of hidradenitis suppurativa in association with Dowling Degos disease are reviewed and the aetiology is discussed.

11. Degos Disease PATIENT SUPPORT NETWORK AND INFORMATION RESOURCE About Judith I am a 55 year old teacher who was diagnosed with this disease in January 1998. I was referred to Dr Peter Coburn, a Consultant Dermatologist in Chichester, UK who correctly diagnosed http://www.hodgers.com/degos/about_judith.shtml

PATIENT SUPPORT NETWORK AND INFORMATION RESOURCE About Judith... I am a 55 year old teacher who was diagnosed with this disease in January 1998. I was referred to Dr Peter Coburn, a Consultant Dermatologist in Chichester, UK who correctly diagnosed Degos Disease. He explained the nature of this extremely rare condition. It seems that the cells in the walls of the small and medium-sized arteries and veins multiply and close off blood-supply to the skin in the first stage. In some patients the disease does not progress beyond this stage. In others lesions internally may affect the small intestine and other major organs. I am now under the care of Dr Robin Russell-Jones at the Cromwell Hospital, London. He has prescribed 75mg Aspirin per day and 3mg per kilo bodyweight per day of Cyclosporin. This appears to be effective treatment although it is, of course, experimental. I appear to be the only patient in Europe with this diagnosis! Surely this cannot be true! If you - as a patient or physician - have any information or experience of this disease please contact me (see right) in order to be included on a database for the Degos Patients Network. Resources Contact JUDITH CALDER Phone: Fax: Email: judemymum@aol.com

12. Health Library - Degos Disease degos disease. degos disease is a rare systemic disorder that affects small and mediumsized arteries, causing them to become blocked (occlusive arteriopathy). http://health_info.nmh.org/Library/HealthGuide/IllnessConditions/topic.asp?hwid=

13. Health Library Deep Vein Leg ThrombosisDeep Leg Vein Thrombosis. Deep Vein Thrombosis-Deep LegVein Thrombosis. degos disease. Dehydration. Dejerine Sottas Disease. Dengue Fever. http://health_info.nmh.org/Library/HealthGuide/IllnessConditions/_SearchResults.

14. Kohlmeier – Degos Disease Expand your medical search to other sites by only one click . For MedicalProfessionals only. Kohlmeier – degos disease,, Print this article, http://www.amershamhealth.com/medcyclopaedia/Volume IV 1/KOHLMEIER DEGOS DISEAS

Medcyclopaedia About Medcyclopaedia Amersham Health Search for: Type a word or a phrase. All forms of the word are searchable. Advanced search Browse entry words starting with: A B C D ... Other characters Try our Medcyclopaedia Premium Edition with added tools and functionality tailored to make your working day easier. The following tools are presently available: Expanded search *For Medical Professionals only, registration required Kohlmeier – degos disease, rare vasculitis characterized by skin lesions as well as malabsorption, bowel ischaemia and perforation. ALB The Encyclopaedia of Medical Imaging Volume IV:1 Welcome to Medcyclopaedia. This site is open to a public audience, still we want to know a little more about our visitors. Please tick off the boxes that match your profile. Do you live in Europe? Yes No Are you a medical professional? Yes No This frame will disappear when submitted Legal Contact us Making Waves

15. Degos' Disease only one click For Medical Professionals only. Degos' disease,,Print this article, (Robert Degos, born 1904, French dermatologist http://www.amershamhealth.com/medcyclopaedia/Volume IV 1/DEGOS DISEASE.asp

Medcyclopaedia About Medcyclopaedia Amersham Health Search for: Type a word or a phrase. All forms of the word are searchable. Advanced search Browse entry words starting with: A B C D ... Other characters Try our Medcyclopaedia Premium Edition with added tools and functionality tailored to make your working day easier. The following tools are presently available: Expanded search *For Medical Professionals only, registration required Degos' disease, (Robert Degos, born 1904, French dermatologist) (also called atrophic papulosis), obliterating angitis of unknown origin characterized by cutaneous papules associated with signs of bowel ischaemia, haemorrhage, perforation and obstruction. ALB The Encyclopaedia of Medical Imaging Volume IV:1 Welcome to Medcyclopaedia. This site is open to a public audience, still we want to know a little more about our visitors. Please tick off the boxes that match your profile. Do you live in Europe? Yes No Are you a medical professional? Yes No This frame will disappear when submitted Legal Contact us Making Waves

16. NORD - National Organization For Rare Disorders, Inc. degos disease. To purchase fulltext report ($7.50) Copyright 1994, 1999,2000 Synonyms of degos disease Degos Syndrome; Degos-Kohlmeier Disease; http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Degos Disease

17. Degos Disease In A Patient With Acquired Immunodeficiency Click here to return to AIDSLINE main menu degos disease in a patientwith acquired immunodeficiency syndrome. J Am Acad Dermatol. http://www.aegis.com/pubs/aidsline/1998/aug/M9881102.html

Important note: Information in this article was accurate in 1998. The state of the art may have changed since the publication date. Degos disease in a patient with acquired immunodeficiency syndrome. J Am Acad Dermatol. 1998 May;38(5 Pt 2):852-6. Unique Identifier : AIDSLINE MED/98252499 Requena L; Farina C; Barat A; Department of Dermatology, Fundacion Jimenez Diaz, Universidad; Autonoma, Madrid, Spain. Abstract: Malignant atrophic papulosis is a rare disorder characterized by pathognomonic cutaneous lesions that consist of infarctive thrombosis. Visceral involvement often occurs; the gastrointestinal tract and the central nervous system are most frequently involved. Malignant atrophic papulosis has not been previously described in an AIDS patient. We describe a 58-year-old homosexual man with AIDS who developed typical cutaneous lesions of malignant atrophic papulosis. No visceral involvement has been detected in 2 years. Keywords: *Acquired Immunodeficiency Syndrome/COMPLICATIONS *Skin Diseases, Papulosquamous/COMPLICATIONS *Skin Diseases, Vascular/COMPLICATIONS National Library of Medicine . Reproduced under license with the National Library of Medicine, Bethesda, MD.

18. Dowling-Degos Disease (reticulate Pigmented Anomaly Of The Flexures) - European Dowlingdegos disease (reticulate pigmented anomaly of the flexures). 3.Reticulate pigmented anomaly of the flexures (Dowling-degos disease). http://www.john-libbey-eurotext.fr/articles/ejd/7/6/465-6/

European Journal of Dermatology European Journal of Dermatology. Vol. 7, Issue 6, September 1997: 465-6, Guess what ! GUESS WHAT! B. Amichai1 M.H. Grunwald2 R. Bergman3 1, Department of Dermatology, Tel-Nordoy Clinic, 1. Dov Hoz St., Tel-Aviv, Israel. 2, Department of Dermatology, Soroka Medical Center, Beer-Sheva, Israel. Fax: (+972) 7.64.31.770. 3, Department of Dermatology, Rambam Medical Center, Haifa, Israel. Reprints M.H. Grunwald. RESUME SUMMARY ARTICLE, Part. 1 ... FIGURES RESUME / SUMMARY Haut de page Key-words ARTICLE Haut de page A 34-year-old woman presented with macular hyperpigmentation which had appeared progressively over the previous eight years. Her medical and family history was unremarkable. On examination, grouped, small, brownish macules were found in the axillary, inguinal and submammary folds as well as on the arms and the neck ( Figs. 1 and ). The mucous membranes were not affected. The histopathological findings are seen in Figure 3 Dowling-Degos disease (reticulate pigmented anomaly of the flexures) Histological examination of a lesion showed elongation, tufting, and deep pigmentation of the rete ridges. PAS stain was negative

19. Dowling-Degos Disease (reticulate Pigmented Anomaly Of The Flexures) - European European Journal of Dermatology. European Journal of Dermatology.Vol. 7, Issue 6, September 1997 4656, Guess what ! GUESS WHAT! http://www.john-libbey-eurotext.fr/articles/ejd/7/6/465-6/images.htm

European Journal of Dermatology European Journal of Dermatology. Vol. 7, Issue 6, September 1997: 465-6, Guess what ! GUESS WHAT! Auteur(s) B. Amichai, M.H. Grunwald, R. Bergman Figure 1. Grouped brown macules on the axilla. Figure 2. Small brown macules on the neck. Figure 3. Elongation, tufting, and deep pigmentation of the rete ridges (hematoxylin-eosin, x 40). © John Libbey Eurotext. Tous droits réservés. Retour accueil

20. 1Up Health > Health Links Directory > Conditions And Diseases: Rare Disorders: D degos disease Judth Calder's support network for this rare vasculitis. DoctorsDoctor An in depth look at degos disease including prognosis and treatment. http://www.1uphealth.com/links/rare-disorders-degos.html

Home Contact Us Privacy Caring For Your Well Being Alternative Medicine Clinical Trials Health News Poisons ... Health Topics A-Z Search 1Up Health Health Directory Addictions Alternative Animal ... Weight Loss By Demography Child Health Teen Health Men's Health Women's Health ... Rare Disorders : Degos Description See Related Categories Health: Conditions and Diseases: Cardiovascular Disorders: Vascular Disorders Sites Degos Disease Judth Calder's support network for this rare vasculitis. Doctors Doctor An in depth look at degos disease including prognosis and treatment. NORD - Degos Disease Offers synonyms, a general discussion and further resources. Yahoo! Groups : Degos Disease An email group offering description of what to expect upon joining, joining instructions, post and read mail. Help build the largest human-edited directory on the web. Submit a Site Open Directory Project Become an Editor Parts of the directory made available on 1UpHealth have been modified. External Web site links provided on this site are meant for convenience and for informational purposes only; they do not constitute an endorsement. Search: The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only they do not constitute endorsements of those other sites.

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