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         Duane Retraction Syndrome:     more detail
  1. Duane retraction syndrome: An entry from Thomson Gale's <i>Gale Encyclopedia of Genetic Disorders, 2nd ed.</i> by Margaret, PhD Alic, 2005

1. HONselect - Duane Retraction Syndrome
Translate this page English duane retraction syndrome, - Ocular Retraction Syndrome - Duane RetractionSyndrome, Type 1 - duane retraction syndrome, Type 2 - Duane Retraction
http://www.hon.ch/HONselect/RareDiseases/C10.292.562.250.html
List of rare diseases: English Deutsch
Language:
MeSH term:
Accepted terms:
English: Duane Retraction Syndrome - Ocular Retraction Syndrome
- Duane Retraction Syndrome, Type 1
- Duane Retraction Syndrome, Type 2
- Duane Retraction Syndrome, Type 3
- Duane Syndrome
- Duane's Syndrome
Français: DUANE RETRACTION, SYNDROME - RETRACTION GLOBE OCULAIRE, SYNDROME - STILLING-TURK-DUANE, SYNDROME - DUANE, SYNDROME - SYNDROME DE RETRACTION Deutsch: Duane-Retraktionssyndrom - Ophthalmoplegie - Okuläres Retraktionssyndrom - Retractio bulbi - Stilling-Türk-Duane-Syndrom Español: SINDROME DE RETRACCION DE DUANE - SINDROME DE RETRACCION OCULAR Português: SINDROME DA RETRACAO OCULAR - SINDROME DE RETRACAO OCULAR HONselect ressources Definition: Yes Articles: Yes Images: No News: No Conferences: No Clinical trials: No Web sites: English Yes Français No Deutsch No Español No Português No Home About us Site map Feedback ... HONewsletter http://www.hon.ch/HONselect/RareDiseases/C10.292.562.250.html Last modified: Thu Jul 25 2002

2. HOME: Internet Ophthalmology
A description of DRS, with clinical manifestations, pathogenesis and treatment. From University at Buffalo School of Medicine and Biomedical Sciences.
http://www.smbs.buffalo.edu/oph/ped/duanes.htm
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3. Duane Retraction Syndrome (DRS)
duane retraction syndrome (DRS) This condition was originally described at the end of the 19th century.
http://members.aol.com/scottolitsky/duanes.htm
Duane Retraction Syndrome (DRS)
This condition was originally described at the end of the 19th century. In 1905 Duane described 54 cases, summarized all the clinical findings, reviewed previous work, and offered theories on pathogenesis and treatment. DRS more frequently occurs in the left eye than in the right, and in females more than in males. Bilateral involvement is less frequent than unilateral occurrence. In several large series, the ratio of right eye to left eye involvement was 1:3, the prevalence of bilaterality was 20 per cent, and there was a slight preponderance of females over males (54 per cent versus 46 per cent). This condition is found in approximately 1 per cent of individuals with strabismus. Clinical Manifestations The most characteristic clinical findings in DRS include an absence of abduction of an eye with slight limitation of adduction, retraction of the globe in attempted adduction, and up- and downshooting, or both in adduction. Huber, with the support of electromyography, provided a useful classification of DRS into three types: Type I. Marked limitation or complete absence of abduction, normal or only slightly restrict adduction, narrowing of the palpebral fissure and retraction of the globe on adduction, and widening of the palpebral fissure on attempted abduction. Electromyography shows absence of electrical activity in the lateral rectus muscle on abduction, but paradoxic electrical activity on adduction.

4. Handbook Of Ocular Disease Management - Duane's Retraction Syndrome
Duane's Retraction Syndrome. Duane's retraction syndrome. Localizationof a gene for duane retraction syndrome to chromosome 2q31.
http://www.revoptom.com/handbook/oct02_sec6_1.htm
Duane's Retraction Syndrome Duane's retraction syndrome. Signs and symptoms: Duane's retraction syndrome (DRS) is a congenital disorder of ocular motility characterized by lim ited abduction, adduction or both. It is unilateral in 80% of cases. The hall mark clinical signs are the classic retraction of the globe and narrowing of the palpebral fissure on eye movement. Studies reveal a preponderance of cases (66%) involving the left eye. Other observations include exotropia in primary gaze (35%), crocodile-tearing phenomena (tearing while chewing, 12%), abduction deficit, globe retraction on attempted adduction, and compensatory face turn to maintain single simultaneous binocular vision. Undiagnosed or uncorrected DRS can lead to amblyopic vision loss. DRS has three presentations. Type 1 occurs in 85% of cases and predominantly in females (60%). It presents with an abduction palsy with globe retraction on attempted adduction. Type II DRS occurs in 14% of cases, and presents as an adduction palsy, globe retraction on attempted adduction and intact abduction. Type-III DRS comprises 1% of cases; both abduction and adduction limitations with any form of horizontal strabismus characterize this type. All cases may present with the "tether" phenomenon, with over-elevation or over-depression in adduction.

5. Duane Rétraction, Syndrome Sites Francophones
Le mot clé Duane rétraction, syndrome duane retraction syndrome est présent au sein de plusieurs arborescences du
http://www.chu-rouen.fr/ssf/pathol/stillingturkduanesyndrome.html

6. Duane Retraction Syndrome (DRS)
duane retraction syndrome (DRS). This condition was originally describedat the end of the 19th century. In 1905 Duane described
http://www.members.aol.com/scottolitsky/duanes.htm
Duane Retraction Syndrome (DRS)
This condition was originally described at the end of the 19th century. In 1905 Duane described 54 cases, summarized all the clinical findings, reviewed previous work, and offered theories on pathogenesis and treatment. DRS more frequently occurs in the left eye than in the right, and in females more than in males. Bilateral involvement is less frequent than unilateral occurrence. In several large series, the ratio of right eye to left eye involvement was 1:3, the prevalence of bilaterality was 20 per cent, and there was a slight preponderance of females over males (54 per cent versus 46 per cent). This condition is found in approximately 1 per cent of individuals with strabismus. Clinical Manifestations The most characteristic clinical findings in DRS include an absence of abduction of an eye with slight limitation of adduction, retraction of the globe in attempted adduction, and up- and downshooting, or both in adduction. Huber, with the support of electromyography, provided a useful classification of DRS into three types: Type I. Marked limitation or complete absence of abduction, normal or only slightly restrict adduction, narrowing of the palpebral fissure and retraction of the globe on adduction, and widening of the palpebral fissure on attempted abduction. Electromyography shows absence of electrical activity in the lateral rectus muscle on abduction, but paradoxic electrical activity on adduction.

7. The Contact A Family Directory - DUANE RETRACTION SYNDROME
printer friendly, duane retraction syndrome, duane retraction syndrome DuaneSyndrome DRS. There is no support group for duane retraction syndrome.
http://www.cafamily.org.uk/Direct/d35.html
printer friendly DUANE RETRACTION SYNDROME home more about us in your area conditions information ... how you can help search this site Duane Retraction Syndrome: Duane Syndrome: DRS Duane Retraction Syndrome is a congenital disorder of ocular movements which was first described in 1905. There are three types of DRS that share common features. The condition may affect one or both eyes. DRS more commonly affects the left eye and is more common in girls. The reasons for this are not yet known. In DRS there is an abnormality of horizontal eye movements resulting in restriction of the affected eye from turning outwards or inwards or in both directions. As the eye is turned in toward the nose (called adduction) the eyelids narrow as the eye is apparently drawn back (retracted). As the affected eye is turned outwards (abducted), the eye lids widen. There may be associated vertical eye movement changes causing an up shoot or down shoot. Individuals who are affected with DRS may also have a squint (strabismus) when they look straight ahead. It is possible to have good vision in each eye with stereo vision. However, in order to maintain stereo vision, individuals with DRS may adopt a face turn.

8. The Contact A Family Directory - Index D
DiGeorge Syndrome DHPA see Purine Pyrimidine Metabolic Diseases DHPD see Purine Pyrimidine Metabolic Diseases DRS see duane retraction syndrome Dancing Eye
http://www.cafamily.org.uk/Idx/d.html
printer friendly home more about us in your area ... how you can help search this site Please use the Index below to access the condition on which you require information. If you do not find what you want in the Index then try our search facility in the navigator on the left. Contact a Family also has information on many other specific conditions and rare disorders. If you cannot find the information you require in The Contact a Family Directory Online , you may wish to use our Contact a Family Helpline service. D+HUS see Haemolytic Uraemic Syndrome
DAF Syndrome see Niemann-Pick Disease
DAMP see Dyspraxia
DDH see Congenital Dislocation and Developmental Dysplasia of the Hip
DGS see DiGeorge Syndrome
DHPA see
DHPD see
DRS see Duane Retraction Syndrome
Dancing Eye Syndrome

Dandy-Walker Cysts see Dandy-Walker Syndrome
Dandy-Walker Syndrome
De Morsiers syndrome see Septo-Optic Dysplasia Deaf/Blind/Rubella Damaged Deafness Deficiency of HLA Expression see Primary Immunodeficiencies Dejerine-Sottas Disease see Muscular Dystrophy and neuromuscular disorders Dementia, Hereditary Multi-infarct Type see CADASIL Dementia with Lewy bodies see Dementias Dementias Dermatitis Herpetiformis see Coeliac Disease Dermatomyositis and Polymyositis Dermatosparaxis Type Ehlers-Danlos Syndrome see Ehlers-Danlos Syndrome Developmental Dysplasia of the Hip see Congenital Dislocation and Developmental Dysplasia of the Hip Diabetes Insipidus see Pituitary Disorders Diabetes Mellitus Diabetic neuropathy see Peripheral Neuropathy Diamond Blackfan Syndrome Diaphragmatic Hernia Diaphyseal Aclasis see

9. AOJ 43:18-26 "Surgery For Duane Syndrome"
duane retraction syndrome is a spectrum of eye motility disorders whosecommon feature is retraction of the affected eye on adduction.
http://www.aoj.org/abstracts/43/43_18.html
Am Orthopt J 43:18-26 (1993) Surgery for Duane Syndrome Stephen P. Kraft, M.D., F.R.C.S.C. Duane retraction syndrome is a spectrum of eye motility disorders whose common feature is retraction of the affected eye on adduction. The presumed cause is aberrant innervation of the third cranial nerve to the lateral rectus muscle, which co-contracts with the medial rectus on adduction. This article reviews my surgical approach for treating Duane syndrome. It involves the analysis of five aspects of the patient's clinical presentation: laterality, primary position alignment, compensatory head posture, severity of retraction, and presence of upshoots or downshoots on adduction. This analysis allows me to devise an individualized surgical plan for each patient to treat all of the anomalies in one operation.

10. Duane Rétraction, Syndrome : Sites Et Documents Francophones
Translate this page Voir aussi ophtalmoplégie . Arborescence(s) du thesaurus MeSH contenantle mot-clé Duane rétraction, syndrome duane retraction syndrome
http://www.chu-rouen.fr/ssf/pathol/duaneretractionsyndrome.html
Duane Rétraction, Syndrome Menu général CISMeF Synonyme(s) duane, syndrome ; retraction globe oculaire, syndrome ; stilling-turk-duane, syndrome ; syndrome de retraction
Voir aussi ophtalmoplégie
Arborescence(s) Duane rétraction, syndrome Duane retraction syndrome
maladies et malformations congénitales, héréditaires et néonatales
oeil, maladies système nerveux, maladies Position du mot-clé dans l' (les) arborescence(s) : Vous pouvez consulter 28 janvier 2003
courriel
Menu général CISMeF Haut de page © CHU de Rouen . Toute utilisation partielle ou totale de ce document doit mentionner la source.

11. Duane Syndrome, Engle Lab - Children's Hospital Boston
A description, photograph and review of the genetics of Duane syndrome.Category Health Conditions and Diseases duane retraction syndrome...... 1. DeRespinis, PA, Caputo, AR, Wagner, RS Guo, S. Duane's retraction syndrome. Localizationof a gene for duane retraction syndrome to chromosome 2q31.
http://web1.tch.harvard.edu/research/engle/duane.html
Research: Duane syndrome
Clinical classification and description
Radial ray anomalies Clinical evaluation Genetics ...
Congenital Ptosis

Duane syndrome
Eye Muscle Anatomy
How linkage analysis is done

Participation in research
Our laboratory is studying the genetic basis of Duane syndrome, but we have not yet identified any Duane syndrome gene loci. Duane syndrome (DS) is an eye movement disorder present at birth (congenital) characterized by a limited ability to move an eye inward towards the nose (adduction), outward towards the ear (abduction), or in both directions. In addition, when the affected eye(s) move inward towards the nose, the eyeball retracts (pulls in) and the eye opening (palpebral fissure) narrows. In some cases when the eye attempts to look inward, it moves upwards (upshoot) or downwards (downshoot). Similar to CFEOM, Duane syndrome falls under the larger heading of strabismus (misalignment of the eyes) under the subclassification of incomitant strabimsus (misalignment of the eyes which varies with gaze directions) and subheading of extraocular muscle fibrosis syndromes (conditions associated with restriction of both active and passive movement of the eyeball). Although "muscle fibrosis" suggests that syndromes under this heading are primary disorders of muscle, evidence suggests that DS (and other syndromes under this heading, including CFEOM) may actually be primary disorders of nerve innervation. A review of fibrosis syndromes can be found in Engle 1998.

12. EMedicine - Duane Syndrome : Article Excerpt By: Arun Verma, MD
Duane Syndrome duane retraction syndrome (DRS) was first described in the laterpart of the 19th century by Sinclair (1895), Bahr (1896), Stilling (1887
http://www.emedicine.com/oph/byname/duane-syndrome.htm
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Excerpt from Duane Syndrome
Synonyms, Key Words, and Related Terms: Duane’s syndrome, Duane retraction syndrome, congenital retraction syndrome, DRS, Stilling-Turk-Duane retraction syndrome
Please click here to view the full topic text: Duane Syndrome
Background: Duane retraction syndrome (DRS) was first described in the later part of the 19th century by Sinclair (1895), Bahr (1896), Stilling (1887), Turk (1899), and Wolff (1900). However, in 1905 when Duane described 54 cases, summarized all the clinical findings, reviewed previous work, and offered theories on pathogenesis and treatment. In 1974, Huber, with the support of electromyography and following the suggestions of Lyle and Malbran, classified DRS into the following 3 types: Duane 1, Duane 2, and Duane 3. Duane syndrome is a congenital ocular motility disorder characterized by limited abduction and/or limited adduction. The palpebral fissure narrows (the globe retracts) on attempted adduction. Upward or downward deviation may occur with attempted adduction due to a leash effect. Often associated with this condition is a “tether” phenomenon consisting of overelevation, overdepression, or both, in adduction as the retracted globe escapes from its horizontal rectus restrictions. It is a condition of aberrant innervation that results in co-contraction of the medial and lateral recti in the affected eye. Thus, Duane syndrome can be considered to be a congenital miswiring of the medial and the lateral rectus muscles such that globe retraction occurs on adduction.

13. EMedicine - Globe Retraction : Article Excerpt By: Michael T Yen, MD
It may occur from active cocontraction of the horizontal rectus musclessuch as in duane retraction syndrome. Patients with Duane
http://www.emedicine.com/oph/byname/globe-retraction.htm
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Excerpt from Globe Retraction
Synonyms, Key Words, and Related Terms: enophthalmos
Please click here to view the full topic text: Globe Retraction
Background: Globe retraction occurs when globe is displaced deeper within the orbit from its normal position. It may occur from active co-contraction of the horizontal rectus muscles such as in Duane retraction syndrome. Patients with Duane syndrome have strabismus, upshooting or downshooting eye movements, and narrowing of palpebral fissure and retraction of globe on adduction. Enlargement of orbital cavity after blowout fractures also may cause the globe to be retracted. It may be due to prolapse of orbital contents into adjacent sinus, atrophy of orbital fat, or contracture of necrotic extraocular muscles entrapped within the fracture. Globe retraction also can be seen in metastatic scirrhous breast carcinoma from cicatrization of orbital tissue. Although less common, some cases of sclerosing orbital pseudotumor have been reported to cause globe retraction. A thorough history and examination are required to determine appropriate management for patients with globe retraction. Pathophysiology: Mechanism for globe retraction in Duane retraction syndrome is believed to be anomalous innervation of lateral rectus muscles from branches of oculomotor nerve (cranial nerve III). Both electromyographic and autopsy studies in Duane syndrome patients have demonstrated this anomalous innervation. In attempted adduction, simultaneous contractions of lateral and medial rectus muscles cause the globe to retract. Anomalous innervation between medial rectus and vertical rectus or oblique muscles also may explain upshoots and downshoots seen in adduction.

14. Duane Syndrome
duane retraction syndrome. Ophthalmol Clin.of North America. 1440717 (8)GurwoodsAS, Terrigno CA (2000) Duane's retraction syndrome literature review.
http://orphanet.infobiogen.fr/data/patho/GB/uk-duane.html
Duane syndrome Authors: Doctors Elena Piozzi and Cristina Patrosso
Scientific Editor: Doctor Maria Teresa Marsili Creation date: December 2002 Disease name and synonyms
  • Duane syndrome Stilling-Turk-Duane Congenital retraction syndrome
The syndrome was first described in the last part of the 19th century by Hueck (1879), Stilling (1887) and Turk (1896). It was defined as a clinical entity by Duane in 1905 and Duane syndrome is the most commonly used name for the disorder. Diagnosis criteria/Definition
Duane syndrome is a congenital disorder of ocular motility characterized by horizontal eye movement limitation, globe retraction with palpebral fissure narrowing in attempted adduction (1,2,3,4,5).
As suggested by Huber (6), Duane syndrome can be divided into three different types, depending on the distribution or development of aberrant innervation (2,7).
- Type I: Defective abduction , normal or minimal defective adduction.
- Type II: Defective adduction, normal abduction, there is exotropia of the affected eye.
- Type III: Defective abduction and adduction.

15. Searchalot Directory For Duane Retraction Syndrome
Duane syndrome. duane retraction syndrome A description of DRS,with clinical manifestations, pathogenesis and treatment. From
http://www.searchalot.com/Top/Health/ConditionsandDiseases/NeurologicalDisorders
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16. Searchalot Directory For D
Dry Eye (5); duane retraction syndrome (4); Dubowitz Syndrome (5);Dwarfism (10); Dysencephalia Splanchnocystica (5); Dysmenorrhea (12
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17. 1Up Health > Health Links Directory > Conditions And Diseases: Neurological Diso
Conditions and Diseases Neurological Disorders Ocular Motility Disordersduane retraction syndrome . Uncover resources and links
http://www.1uphealth.com/links/ocular-motility-disorders-duane-retraction-syndro
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... Ocular Motility Disorders : Duane Retraction Syndrome
Sites Children's Hospital Boston
A description, photograph and review of the genetics of Duane syndrome.
Duane Retraction Syndrome
A discussion and support network for those affected by the syndrome. Duane Retraction Syndrome A description of DRS, with clinical manifestations, pathogenesis and treatment. From University at Buffalo School of Medicine and Biomedical Sciences. NORD - Duane Syndrome Offers the synonyms, a general discussion and further resources. Help build the largest human-edited directory on the web. Submit a Site Open Directory Project Become an Editor Parts of the directory made available on 1UpHealth have been modified. External Web site links provided on this site are meant for convenience and for informational purposes only; they do not constitute an endorsement. Search: The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only they do not constitute endorsements of those other sites.

18. 1Up Health > Health Links Directory > Conditions And Diseases: Neurological Diso
Categories. Adie Syndrome (5) duane retraction syndrome (4) Miller FisherSyndrome (3). Ophthalmoplegia (2) Pathologic Nystagmus (7) Strabismus (9).
http://www.1uphealth.com/links/neurological-disorders-ocular-motility-disorders.
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Duane Retraction Syndrome
Miller Fisher Syndrome Ophthalmoplegia ... Strabismus See Related Categories Health: Conditions and Diseases: Eye Disorders Sites NORD - Tolosa Hunt Syndrome A general discussion, the synonyms and further resources are offered. Tolosa Hunt Syndrome A description of this disorder, its symptoms and diagnosing. Help build the largest human-edited directory on the web. Submit a Site Open Directory Project Become an Editor Parts of the directory made available on 1UpHealth have been modified. External Web site links provided on this site are meant for convenience and for informational purposes only; they do not constitute an endorsement. Search: The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only they do not constitute endorsements of those other sites.

19. 15p
A New Way to Enhance Abduction in Selected Patients with Duane RetractionSyndrome. Surgery on the normal eye in duane retraction syndrome.
http://med-aapos.bu.edu/AAPOS2002/15p.htm
Thursday, 10:15 Ð 11:15 am
A New Way to Enhance Abduction in Selected Patients with Duane Retraction Syndrome
James L. Mims, III, M.D. University of Texas Health Science Center - San Antonio San Antonio, Texas Introduction: Patients with Duane Retraction Syndrome (DRS) may be designated as eso DRS, ortho DRS, or exo DRS according to their primary position deviation. A recent publication suggested using very small (3 mm) lateral rectus (LR) resections and moderate (4-5 mm) medial rectus (MR) recessions for eso DRS patients who have few signs of co-contraction. Saunders et al have published descriptions of 3 patients with DRS with exotropia in the primary position (exo DRS) whose face turns were eliminated with large recessions (8 to 12 mm) of the other (non-Duane's) lateral rectus. The purpose of this paper is to describe the results of treating 5 patients with unilateral ortho DRS, for whom the parents' primary concern was the severe limitation of abduction of the Duane's eye. For these 5 patients, we performed recess-resect for the Duane's eye, intentionally creating an exo DRS, and curing the induced exotropia at the same surgery with a large recession of the LR of the non-Duane's eye. Methods: Five cases with little or no signs of co-contraction were selected, because the recess-resect (2 mm resection, 4 mm recession) of the Duane's eye would make any co-contraction worse. All 5 cases also received Posterior Fixation Sutures on the medial rectus of the non-Duane's eye.

20. Eidactics Visual Biosimulation/ Orbit Movies
Observation vs Theory Von Noorden (1990) characterized 3 types ofduane retraction syndrome on the basis of clinical signs. It
http://www.eidactics.com/Orbit_Movies/Top_Orbit_Movies.html
Orbit movies are If you are unfamiliar with Quicktime movies, read these instructions for installation and play (PDF). Muscle Colors: total force : pure red, pink, and grey represent, high, intermediate, and zero forces, respectively (color variations within a muscle are variations in lightness, to give the muscles a 3-dimensional appearance).
Normal Eyes
Normal
Eyes (MacOS) Normal
Eyes (Wintel) Click the appropriate movie icon to download a self-extracting archive containing 7 movie files (2.5MB). It will appear on your disk in the folder you have chosen for browser downloades. Double-click the archive or to unpack a folder containing:
  • Normal_Common_Video.mov is the video track common to all Normal Eyes movies. The file can also be played independently as a silent movie. Each of the remaining files in this group contains a soundtrack that represents the innervation level of the named muscle, and a reference to the common video. If your computer complains that the video cannot not be found, you may need to help it by navigating to the file Normal_Common_Video.mov.

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