1. EFFORTS Signup Page Group promotes public awareness of this pulmonary disease and offers support to patients. Find treatment information and professional listings. 411 NE US HWY 69 * Claycomo, Mo. 64119 * FAX 816413-0176. emphysema, A Chronic Obstructive Pulmonary Disease (COPD) http://www.emphysema.net/

Claycomo Plaza * 411 NE US HWY 69 * Claycomo, Mo. 64119 * FAX 816-413-0176 Emphysema, A Chronic Obstructive Pulmonary Disease (COPD) Emphysema (COPD) takes your breath away Learn more about Emphysema (COPD) from folks who are living with it If you are looking for more information or support about Emphysema or other Chronic Obstructive Pulmonary Disease (COPD), you have found the most energetic and comprehensive organization on the web. Be an informed patient. Learn that living with COPD, while a change in lifestyle, is not a death sentence. As well as providing a very vital support mailing list and educational resource for its members, we are also working to educate and inform patients and care providers as well as promote deeper research for more effective treatment and hopefully a cure for Emphysema and other Chronic Obstructive Pulmonary Disease. Be an activist in managing your own disease and join our EFFORTS to help promote vital medical research and education. If we don't do this, who will? EFFORTS is a 501(c)(3), non-profit organization that was formed, funded and is operated by patients with the disease. Membership is free. All contributions are tax-deductible.

2. Emphysema A description of emphysema, followed by links, clinical trials, associations and technical papers emphysema. emphysema is a chronic disease of the lungs which is characterized by parenchymal destruction distal to the http://emphysema.allbio.org/

Emphysema Emphysema is a chronic disease of the lungs which is characterized by parenchymal destruction distal to the terminal bronchioles. Smoking, air pollution, environmental or occupational hazards, and genetic factors may play a role in this disease. Symptoms of emphysema usually begin with breathing difficulty especially during exhalation, shortness of breath, an enlarged chest, and bluish skin color. Acne Allergy Antibiotics Antioxidants ... Wedding General Information - Overview Emphysema - from Temple University Hospital. Symptoms of Emphysema - by Creighton University School of Medicine. Emphysema - from American Lung Association. Surgery Helps Emphysema Patients Breathe Easier - from Saint Louis University. Emphysema - from Catholic Healthcare West. Emphysema - by Canadian Lung Association. Chronic Bronchitis and Emphysema - from St. Joseph's Healthcare, Hamilton. Emphysema - from the Hutchinson Family Encyclopedia. Emphysema, Congenital Lobar - from Northwestern Memorial Hospital. Emphysema - from University of Texas Medical Branch.

3. Breathe Easy - Abnormal Lung Anatomy; Emphysema; What Happens With COPD. Guide offers illustrations of lungs with irritated bronchi due to emphysema. Download a video clip of the breathing process. http://www.lung.ca/copd/anatomy/emphysema.html

ABNORMAL LUNG ANATOMY What Happens With COPD Emphysema When you have emphysema, some of the air sacs deep in your lungs have been damaged. When the bronchi become irritated, the normal elasticity of the air sacs and the walls of the airways are destroyed. People with emphysema need to forcefully blow the air out in order to empty the lungs. Forcing the air out in this way puts pressure on the airways from the outside, compresses them and causes them to collapse. The walls of the tiny air sacs may even tear. Excessive coughing may cause the airways to collapse as well. MPG Clip (330K): A journey down the collapsing airway passages, and ending in the deteriorating alveoli. As the stretching and tearing of the walls of the air sacs continues, the lungs may become enlarged and less efficient at moving air into the lungs and contaminants out of the lungs. Because the walls of the air sacs are destroyed, there is less surface area available for gas exchange. Damage to the air sacs in the lungs not only results in difficulty breathing, but the heart also has to work harder to circulate blood through the lungs. All these changes make less oxygen available to the body. Emphysema is characterized by a large barrel-shaped chest, a poor air pumping system, and shortness of breath (SOB). In advanced stages, every breath is difficult. A cough may or may not be present with emphysema.

4. Every Breath You Take Government article covers the prevention, testing, and treatment of this disease. See links to related national organizations. http://www.fda.gov/fdac/features/1999/299_emph.html

Table of Contents FDA Consumer magazine March-April 1999 Every Breath You Take Preventing and Treating EMPHYSEMA by Carol Lewis We begin life with a breath, and the process continues automatically without a thought. It's only when we can't take a deep breath or, as in Shirley Gooden's case, can't catch our breath at all without effort, that we become aware of how precious easy breathing really is. Gooden, whose breathing is now supplemented with the help of an oxygen tank, was diagnosed with emphysema 14 years ago. Since then, the 68-year-old Bethesda, Md., resident has gradually felt the effects that the debilitating disease has had on her life as well as her lungs. "I'm held back from interacting with my grandchildren, " Gooden says, and like the healthy lungs she used to have, "that's something I can never get back." While it is true that the damage done to Gooden's lungs is not reversible, the disease is manageable, says John S. Saia, M.D., a pulmonary specialist with the Rockville Internal Medicine Group in Maryland, and Gooden's doctor. Saia adds that state-of-the-art medical advances can offer relief from many of the troubling symptoms of emphysema, and help patients breathe easier. What Is Emphysema?

5. NEF Home Frame Information about the organization that is dedicated to improving the quality of life for people with emphysema, asthma and related diseases. Included are featured articles and resources. http://emphysemafoundation.org/

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6. National Emphysema Treatment Trial Information about a research study, news room, glossary and resources. http://www.emphysemastudy.org

Emphysema Awareness Resources Contact Us The Study Glossary Newsroom Site Map Welcome to the National Emphysema Treatment Trial For patients with emphysema, a form of chronic obstructive pulmonary disease (COPD), inhaling can be as difficult as breathing through a pillow. There is no cure for emphysema, but treatment options are being investigated that may provide a breath of hope. The National Emphysema Treatment Trial (NETT) was established to determine if lung volume reduction surgery (LVRS) is effective in the treatment of emphysema. ABOUT NETT NETT is a clinical research study designed to determine if lung volume reduction surgery ( LVRS ) is effective in the treatment of emphysema . At 19 clinical sites across the United States, the study will enroll 2,500 patients who have been diagnosed with emphysema. All patients will receive medical treatment , with half also undergoing LVRS. NETT is funded and overseen by the National Heart, Lung, and Blood Institute (NHLBI), a component of the National Institutes of Health (NIH), in collaboration with the Health Care Financing Administration (HCFA), which manages Medicare. NAVIGATING THIS WEB SITE This Web site offers you information about emphysema and NETT, as well as an opportunity to have your eligibility determined for NETT. You may:

7. EFFORTS-Main Website nonprofit organization, formed, funded and operated by patients with the disease, working to promote research for emphysema and related lung diseases. vital support mailing list http://www.emphysema.net/bindex.html

Claycomo Plaza * 411 NE US HWY 69 * Claycomo, Mo. 64119 * FAX 816-413-0176 Emphysema (COPD) takes your breath away ABOUT EFFORTS LIVING WITH COPD ADVOCACY / AWARENESS Welcome About Us About EFFORTS The Origin of EFFORTS Our Official Position Our Official Goals ... World Members Contributions About Contributions EFFORTS List Join EFFORTS List List Conduct Guidelines How to send EMails How to manage Email ... View our Archives Other Member Lists Funday Caregivers Quitsters Walkers Complaints Complaint Department Search Search EFFORTS Website Everyday Support Living With COPD/Emphysema Exercise at Home - NIA Guide Coping Tips from Members Find a Pulmonary Rehab Facility ... Medicare, Medicaid and Soc. Sec Of Special Interest Lung Profiler © Treatment Decisions Oxygen Service- Member Surveys Spiriva Users - First Member Survey 2002 ... Quitsters-Stop Smoking Group Miscellaneous Links Important Related Links Private Spiritual Assistance Background The Goose Story Talking Points Latest Statistics - NHLBI Latest Statistics - CDC Guides Newsmedia Samples Contacts Supplies Business Cards Brochures Pins Bumper/Window Stickers ... Videotapes (Rally) Current Projects Medicare Prescription Bills Eloquium Journalism Award Previous projects Efforts goes to Congress 3rd Annual D.C. Rally

8. Emphysema emphysema is not curable, but it can be treated. Those who have it can be helped to live http://www.lung.ca/diseases/emphysema.html

Emphysema is not curable, but it can be treated. Those who have it can be helped to live with it. It is a destructive disease for thousands of Canadians and their families. Over 1100 people die of it as a major cause each year. Something can be done about emphysema today. Who gets Emphysema? Persons with emphysema are, for the most part, males between 50 and 70 years old. Women get emphysema, too, but so far, not as often as men. However these statistics are changing as women are starting to smoke more, and at an earlier age. A very high percentage of the people who have emphysema smoke cigarettes and have been heavy smokers for many years. Frequently, they live in areas where air pollution is a constant problem. Some people are born with a lack of a substance called alpha-1 antitrypsin. This makes them more likely than others to get emphysema and at an earlier age. How it Attacks A person with emphysema doesn’t develop the disease suddenly. It comes on gradually. He or she has probably had several very bad colds each winter for the past few years, each accompanied by a heavy cough, and often with chronic bronchitis. The cough often persists between colds and becomes chronic. The thing that usually brings the patient to the doctor is that he or she has begun to feel short of breath on exertion in morning or evening or both. The patient may think he or she has asthma or heart disease.

9. Alpha-1 Related Emphysema Information about A1AD related emphysema which is caused by an inherited lack of a protective protein Category Health Conditions and Diseases emphysema...... Alpha1 Related emphysema. March 18, 2003. WHAT IS ALPHA-1 RELATEDemphysema? Alpha-1 related emphysema or Alpha-1 deficiency, is http://www.lungusa.org/diseases/luna1ad.html

Home Diseases A to Z Article Search Site Local Search Enter Your ZIP Alpha-1 Related Emphysema March 30, 2003 March 2002 What is Alpha-1 Related Emphysema? How Is AAT Deficiency Inherited? Who Is Most At Risk? How Does Emphysema Develop? ... Additional Information WHAT IS ALPHA-1 RELATED EMPHYSEMA? Alpha-1 related emphysema or Alpha-1 deficiency, is caused by an inherited lack of a protective protein called alpha-1 antitrypsin (AAT). In normal and healthy individuals, AAT protects the lungs from a natural enzyme (called neutrophil elastase) that helps fight bacteria and clean up dead lung tissue. However, this enzyme can also eventually damage lung tissue if not neutralized by AAT. If allowed to progress, this form of emphysema becomes chronic and lung tissue continues to be destroyed; eventually it is fatal if the progress is not slowed down or halted. HOW IS AAT DEFICIENCY INHERITED? Every person inherits two AAT genes, one from each parent. A person has AAT Deficiency (Alpha-1) only if he or she inherits two abnormal genes. People who have only one abnormal gene and one normal AAT gene are "carriers.” Their AAT levels may be lower than normal, but not as low as the deficiency state, and their risk of significant health problems is much lower than those with the severe deficiency.

10. Respiratory Physiology Menu Tutorials Labs Quizzes Encyclopedia Dictionary About this program http://omie.med.jhmi.edu/res_phys/Encyclopedia/Emphysema/Emphysema.HTML

Tutorials Labs Encyclopedia Dictionary Tutorials Labs Encyclopedia Dictionary ... About this program

11. NATIONAL EMPHYSEMA TREATMENT TRIAL The first multi-center clinical trial designed to determine the role, safety, and effectiveness Category Health Conditions and Diseases emphysema...... multicenter clinical trial designed to determine the role, safety, and effectivenessof bilateral lung volume reduction surgery in the treatment of emphysema. http://www.nhlbi.nih.gov/health/prof/lung/nett/lvrsweb.htm

NATIONAL EMPHYSEMA TREATMENT TRIAL (NETT): EVALUATION OF LUNG VOLUME REDUCTION SURGERY FOR EMPHYSEMA What is NETT? Why is NETT Necessary? Background and Rationale NETT Protocol ... List of Participating Centers What is NETT? The National Emphysema Treatment Trial (NETT), supported by the National Heart, Lung, and Blood Institute (NHLBI), the Health Care Financing Administration (HCFA), and the Agency for Health Care Policy and Research (AHCPR), is the first multi-center clinical trial designed to determine the role, safety, and effectiveness of bilateral lung volume reduction surgery (LVRS) in the treatment of emphysema. Emphysema is a chronic lung condition that is a major cause of death and disability in the U.S. If LVRS is found to be beneficial, then a secondary objective will be to develop criteria for identifying patients who are likely to benefit from the procedure. Why is NETT necessary? Return to Top In patients with emphysema, the walls between the tiny air sacs in the lungs are damaged. While healthy lungs expand with each inhalation and collapse with each exhalation, helping to move air in and out lungs damaged by emphysema gradually lose their elasticity, becoming floppy and over-expanded like a spent rubber band. The airways, normally held open by the elastic pull of the lungs, also become floppy and collapse on exhalation. As a result, patients with emphysema have increasing difficulty moving air in and out of their lungs. In Lung Volume Reduction Surgery (LVRS), the size of the lungs is reduced. The theory underlying the surgery is that reducing the lung size will pull open the airways and allow the breathing muscles to return to a more normal and comfortable position, making breathing easier.

12. Facts About Emphysema Information from the American Lung Association of Georgia.Category Health Conditions and Diseases emphysema...... Facts about emphysema. What Is emphysema? emphysema is a condition in which thereis overinflation of structures in the lungs known as alveoli or air sacs. http://abrannen.home.mindspring.com/alag/emphysma.htm

Facts about Emphysema What Is Emphysema? Emphysema is a condition in which there is over-inflation of structures in the lungs known as alveoli or air sacs. This over-inflation results from a breakdown of the walls of the alveoli, which causes a decrease in respiratory function (the way the lungs work) and often, breathlessness. Early symptoms of emphysema include shortness of breath and cough. How Serious Is Emphysema? Emphysema is a widespread disease of the lungs. In 1987, 2.0 million people in the U.S. had emphysema. It is estimated that 70,000 to 100,000 Americans living today were born with a deficiency of a protein known as alpha I-antitrypsin (AAT) which can lead to an inherited form of emphysema. Emphysema ranks ninth among chronic conditions that contribute to lack of activity: Over 42% of individuals with emphysema report that their daily activities have been limited by the disease. Many of the people with emphysema are older men, but the condition is increasing among women. Males with emphysema outnumber females by 64%.. Causes of Emphysema It is known from scientific research that the normal lung has a remarkable balance between two classes of chemicals with opposing action. The lung also has a system of elastic fibers. The fibers allow the lungs to expand and contract. When the chemical balance is altered, the lungs lose the ability to protect themselves against the destruction of these elastic fibers. This is what happens in emphysema.

13. Emphysema And Lung Cancer Treatment And Surgery, COPD, Breathing Disorders And B Surgical procedures for lung cancer and emphysema. http://www.cmclungctr.com/

Emphysema, Lung Cancer, Chronic Obstructive Pulmonary Disease [COPD] and other breathing disorders. Emphysema, Lung Cancer, Chronic Obstructive Pulmonary Disease [COPD] and other breathing disorders and difficulties are what we treat in a caring atmosphere here at the Chapman Lung Center. We are your specialists in treating lung cancer and emphysema. Featuring new surgical procedures that may improve the quality of life for many patients with severe emphysema and a minimally invasive surgery for lung cancer, the Chapman Lung Center continues to strive to be at the forefront of the medical community. Video Assisted Thoracoscopic Surgery (VATS) for Lung Volume Reduction Surgery Lung Volume Reduction Surgery (LVRS) is an effective new treatment in properly selected patients with moderate to severe symptoms from emphysema. Over the past several years, numerous papers have demonstrated the benefits of LVRS in thousands of patients. For most patients, LVRS improved pulmonary function tests, relieved oxygen and steriod dependence, relieved symptoms of dyspnea and improved quality of life, with reasonable morbidity and mortality. In contrast, medical management, including pulmonary rehabilitation, has failed to improve pulmonary function tests despite decreasing oxygen requirements and increasing exercise tolerance.

14. Emphysema Center Information about therapy for emphysema and lung volume reduction and pulmonary rehabilitation program.Category Health Conditions and Diseases......COPDemphysema Center. Division of reduction surgery. Therapy for emphysema/LungVolume Reduction. The Pulmonary Rehabilitation Program. http://www.chestsurg.org/emphsema.htm

COPD-Emphysema Center Division of Thoracic Surgery Brigham and Women's Hospital 75 Francis Street Boston, MA 02115 In response to the recent developments in the fields of volume reduction surgery and lung transplantation, a Multidisciplinary Clinic has been established for the evaluation and care of patients with surgically treatable emphysema and chronic obstructive pulmonary disease. In addition, an Emphysema Cooperative Study Group has been established consisting of community and academic pulmonologists and thoracic surgeons throughout New England. Activities are centered around a prospective randomized trial seeking to compare the efficacy of pulmonary rehabilitation alone in emphysema patients eligible for volume reduction surgery versus rehabilitation of these patients followed by volume reduction surgery. Therapy for Emphysema/Lung Volume Reduction The Pulmonary Rehabilitation Program var MenuLinkedBy='AllWebMenus [2]', awmBN='460'; awmAltUrl=''; var MenuLinkedBy='AllWebMenus [2]', awmBN='460'; awmAltUrl=''; var MenuLinkedBy='AllWebMenus [2]', awmBN='460'; awmAltUrl='';

15. Emphysema emphysema. March 18, 2003. of emphysema called alpha 1antitrypsin(AAT) deficiency-related emphysema. HOW DOES emphysema DEVELOP? http://www.lungusa.org/diseases/lungemphysem.html

Home Diseases A to Z Emphysema Search Site Local Search Enter Your ZIP Emphysema March 30, 2003 March 2002 How Serious Is Emphysema? Causes Of Emphysema How Does Emphysema Develop? Treatment For Emphysema ... Prevention of Emphysema WHAT IS EMPHYSEMA? Emphysema is a condition in which there is over-inflation of structures in the lungs known as alveoli or air sacs. This over-inflation results from a breakdown of the walls of the alveoli, which causes a decrease in respiratory function (the way the lungs work) and often, breathlessness. Early symptoms include shortness of breath and cough. Early symptoms of emphysema include shortness of breath and cough. Emphysema and chronic bronchitis together comprise chronic obstructive pulmonary disease (COPD). HOW SERIOUS IS EMPHYSEMA? Emphysema is a widespread disease of the lungs. Close to 2.8 million Americans have been diagnosed with emphysema. Emphysema ranks 15th among chronic conditions that contribute to activity limitations: almost 44 percent of individuals with emphysema report that their daily activities have been limited by the disease. Men tend to have higher rates of emphysema. In 1999, the emphysema prevalence rate was 53% higher in males compared to females.

16. NEF Home Frame Early symptoms of emphysema include shortness of breath and cough. emphysema and chronic bronchitis together comprise http://www.emphysemafoundation.org/

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17. American Lung Association -- Diseases A To Z Information on lung cancer, tuberculosis, emphysema and A1AD related emphysema, pneumonia, sarcoidosis, HIV/AIDS and lung disease, and influenza. http://www.lungusa.org/diseases/

Home Diseases A to Z Search Site Local Search Enter Your ZIP A B C D ... T Lung disease is the number three killer in America, responsible for one in seven deaths. Lung disease and other breathing problems are the number one killer of babies younger than one year old. Today, more than 30 million Americans are living with chronic lung disease such as asthma, emphysema and chronic bronchitis. This section includes information on lung cancer, tuberculosis, emphysema and A1AD related emphysema, pneumonia, sarcoidosis, HIV/AIDS and lung disease, and influenza. View research projects funded by the American Lung Association on 'Lung Cancer' for 2002-2003. Give us your feedback on the content in this index! A Alpha-1 Related Emphysema Acute Respiratory Distress Syndrome (ARDS) Fact Sheet African Americans and Lung Disease Fact Sheet African Americans and Tobacco Fact Sheet ... AIDS Related Lung Disease, Minority Lung Disease Data 2000 Allergies American Indians/Native Alaskans and Lung Disease Fact Sheet American Indians/Native Alaskans and Tobacco Fact Sheet Statement on Anthrax and How it Relates to Lung Disease ... Asthma, Minority Lung Disease Data 2000 B Bronchitis, Chronic

18. Alpha1-Antitrypsin Deficiency Of Inherited Emphysema-Medfacts-National Jewish Me Definition, diagnosis, and treatment for inherited emphysema.Category Health Conditions and Diseases emphysema......Alpha1Antitrypsin Deficiency of Inherited emphysema and Management MedFact fromNational Jewish Medical and Research Center 1 Respiratory Hospital in America. http://www.nationaljewish.org/medfacts/alpha1.html

Alpha1-Antitrypsin Deficiency of Inherited Emphysema Chronic obstructive pulmonary disease or COPD for short, is a lung disease that affects millions of people each year. COPD is a general term used to describe diseases such as emphysema and chronic bronchitis. In emphysema there is damage to the walls of the air sacs (alveoli) in the lungs. What is Inherited Emphysema? Most cases of emphysema are caused by smoking or other environmental factors. However, in a small number of cases of emphysema, there is a hereditary basis for the disease. The earliest symptom of emphysema is shortness of breath during activity. Later the shortness of breath occurs with rest also. The inherited form of emphysema is called alpha1 antitrypsin deficiency or "alpha - one" for short. People with this disease don't have enough of a major protein in the blood. This protein is alpha1 antitrypsin. Although there are many different genetic variations of this protein, only some will cause lung disease. It is more often seen in people of northern European descent, especially Scandinavians. What Does the Alpha1 Protein do in the Body?

19. WebMD/Lycos - Health Guide Causes, diagnosis, and treatment. http://webmd.lycos.com/content/dmk/dmk_article_40023

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20. Women & Smoking American Legacy Foundation tobacco education campaign features real women battling very real tobaccorelated illnesses light emphysema, lung cancer, and throat cancer, and highlights their real parting letters to their family and loved ones. http://women.americanlegacy.org/

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