1. Eosinophilia When does eosinophilia occur? eosinophilia occurs in a wide range of conditions. http://www.netdoctor.co.uk/diseases/facts/eosinophilia.htm

The UK's leading independent health website Search NetDoctor NetDoctor.co.uk Home News and features News Newsletter Features Encyclopaedia Diseases Medicines Examinations Health centres Cancer Children's health Depression Erectile dysfunction ... All health centres Discussion and support Discussion forums Support groups Services Ask the doctor Find a hospital NetDoctor on call Search Medline ... Text message services Information About NetDoctor Commercial opportunities NetDoctor.com Eosinophilia Written by M Y Karim , lecturer in immunology What are eosinophils? An eosinophil is a type of white blood cell. Eosinophils are produced in the bone marrow and are normally found in the bloodstream and the gut lining. They contain proteins that help the body to fight infection from parasitic organisms, such as worms. But in certain diseases these proteins can damage the body. What is eosinophilia? The term eosinophilia refers to conditions in which abnormally high amounts of eosinophils are found in either the blood or in body tissues. When does eosinophilia occur?

2. National Eosinophilia Myalgia Syndrome Network A non-profit organization dedicated to helping EMS survivors and their families by offering educational Category Health Conditions and Diseases Blood Disorders eosinophilia......eosinophiliaMyalgia Syndrome was first recognized in 1989 in New Mexico.Three women sought medical help for a mysterious, undiagnosable http://www.nemsn.org/

Announcements Home Page Symptoms What Caused EMS? ... Physicians Eosinophilia-Myalgia Syndrome was first recognized in 1989 in New Mexico. Three women sought medical help for a mysterious, undiagnosable condition whose symptoms were marked by debilitating muscle pain and a high Eosinophilia count (a type of white blood cell that is usually found when a toxin or parasitic infection is present). It was eventually discovered that all of the women had one thing in common: they had been taking L-tryptophan, a health food supplement sold as a sleep aid. The tainted product was traced back to Showa Denko Inc, a Japanese company, that had been cutting corners in their purification procedure to reduce their manufacturing costs. Additionally, they were experimenting with genetically engineered bacteria in order to accelerate and increase the efficiency of their production process. As a result, contaminated batches of L-tryptophan were placed on the market. Within three months, 37 people died and over 1500 were permanently disabled from using this product. By early 1990, officers of the Food and Drug Administration (FDA) banned the sale of all over the counter L-tryptophan dietary supplements because it was found to be the common link in the EMS cases. Research was conducted to discover the cause of this illness. By using high performance liquid chromatography, an unidentified impurity, called "peak E" was found in batches of L-T as well as nearly 60 other contaminants. These batches were traced back to one manufacturer, Showa Denko KK (SDKK), one of Japan's largest petrochemical companies.

3. Definition For:Eosinophilia A brief definition of this disorder and eosinophils. http://www.kumc.edu/instruction/medicine/pathology/ed/keywords/kw_eosinoph2.html

Eosinophilia Chapter: 2 The condition of having an absolute (compared to a relative) increase in the number of eosinophil s in the circulating blood. The absolute number is obtained by multiplying the percentage of eosinophils times the white blood cell count. See Also Eosinophil (Chapter 2) Eosinophil cationic protein (Chapter 2) Eosinophilic Pneumonia: (Chapter 12)

4. Eosinophilia The shortened do.nu addy comes courtesy of these people. eosinophilia is a part of the Rain Collective http://eosinophilia.dot.nu/

5. The National Eosinophilia Myalgia Syndrome Network Page Has Moved Information and support site for people who ingested LTrytophan in the 1980's and are suffering from EMS. http://www.angelfire.com/ga3/ems2hope

The National Eosinophilia Myalgia Syndrome Network page has moved. Please click on the hyperlink below to find the new site. http://www.nemsn.org

6. MEDLINEplus Medical Encyclopedia: Simple Pulmonary Eosinophilia (Loeffler's Synd Adam.com defines this disorder, its causes, incidence and risk factors. http://www.nlm.nih.gov/medlineplus/ency/article/000105.htm

Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Simple pulmonary eosinophilia (Loeffler's syndrome) Contents of this page: Illustrations Alternative names Definition Causes, incidence, and risk factors ... Prevention Illustrations Lungs Respiratory system Alternative names Return to top Pulmonary infiltrates with eosinophilia; Eosinophilic pneumonia; Loeffler's syndrome Definition Return to top Simple pulmonary eosinophilia is characterized by abnormal chest X-ray findings. These vary the abnormality may appear in one part of the lung at one time, but the next X-ray may show no pathology or a problem in a different part of the lung. The abnormal X-rays are accompanied by a rise in the number of eosinophils (a type of white blood cell which is probably involved in allergies) in the blood. The disease is usually self-limited so it often resolves itself without treatment. Causes, incidence, and risk factors Return to top Loeffler's syndrome appears to be caused by an allergic reaction. A common cause is the migration of the parasitic worm Ascaris lumbricoides through the respiratory tract. Proteins on the surface of the worm probably incite this allergic reaction. Other parasites of the Ascaris family may also cause the syndrome. Additional possible causes include allergies to medications, for example, sulfonamide antibiotics. Symptoms Return to top general ill feeling malaise fever dry cough chest pain shortness of breath wheezing rapid respiratory rate rash Note: Symptoms range from none at all to mild to severe. They will usually resolve without treatment.

7. THE MERCK MANUAL, Sec. 11, Ch. 136, Eosinophilic Disorders The development of eosinophilia has features of an immune response a primary challenge with an agent such as http://www.merck.com/pubs/mmanual/section11/chapter136/136b.htm

This Publication Is Searchable The Merck Manual of Diagnosis and Therapy Section 11. Hematology And Oncology Chapter 136. Eosinophilic Disorders Topics [General] Eosinophilia Idiopathic Hypereosinophilic Syndrome Eosinophilia The development of eosinophilia has features of an immune response: a primary challenge with an agent such as Trichinella spiralis invokes a primary response with relatively low levels of eosinophils, whereas repeated challenges result in an augmented or secondary eosinophilic response. Factors that decrease the eosinophil count include -blockers, corticosteroids, stress, and (sometimes) bacterial and viral infections. Several compounds released by mast cells and basophils as a consequence of antigenic coupling of IgE molecules on their surface are chemotactic for eosinophils: eg, eosinophil chemotactic factor of anaphylaxis, leukotriene B4, complement complex (C567), and histamine (over a narrow range of concentration). Etiology Eosinophilia may be primary or secondary to an underlying disorder (see Table 136-1 ). In the USA

8. NATIONAL EOSINOPHILIA It has been almost a decade since the eosinophiliamyalgia syndrome (EMS)epidemic. Clauw GJ Animal models of eosinophilia-myalgia syndrome. http://www.nemsn.org/Articles/Gleich summary 98.htm

Announcements Home Page Symptoms What Caused EMS? ... Physicians National EMS Network Newsletter, February 1998 Current Status of Research on EMS: Gerald J. Gleich, M.D. By Gerald J. Gleich, M.D. REFERENCES Clauw DJ, Pincus T: Eosinophilia-myalgia syndrome: review and reappraisal of clinical, epidemilogic and animal studies symposium. J Rheumatol 1996; 23 (Suppl 46): 1-110. Daniels SR, Hudson KI, Horwitz RI: Epidemiology of potential association between L-tryptophan ingestion and eosinophilia-myalgia syndrome. J Clin Epidemiol 1995; 48:1413-27. Kilbourne EM, Philen RM, Kamb ML, Falk H: Tryptophan produced by Showa Denko and epidemic eosinophilia-myalgia syndrome. J Rheumatol 1996; 23(Suppl 46): 81-8. Belongia EA, Gleich GJ: The eosinophia-myalgia syndrome revisited. J Rheumatol 1996; 23:1682-85 (Editorial). Kita H, Mayeno AN, Weyand CM, Goronzy JJ, Weiler DA, Lundy SK, Abrams JS, Gleich GJ: Eosinophil-active cytokine from mononuclear cells cultured with L-tryptophan products: An unexpected consequence of endotoxin contamination. J Allergy Clin Immunol 1995; 95:1261-67. Tagaki H, Ochoa MS, Zhou L, Helfman T, Murata H, Falanga V: Enhanced collagen synthesis and transcription by peak E, a contaminant of L-tryptophan preparations associated with the eosinophilia-myalgia syndrome. J Clin Invest 1995;96:2120-2125.

9. Non Allergic Rhinitis Information about nonallergic types of rhinitis, including infectious rhinitis, hormonal rhinitis, non-allergic rhinitis with eosinophilia syndrome (NARES), certain types of occupational rhinitis, gustatory and drug-induced rhinitis. http://www.jcaai.org/Param/Rhinitis/Complete/non_allergic_rhinitis.htm

13. Nonallergic rhinitis is characterized by sporadic or persistent perennial symptoms of rhinitis that do not result from IgE-mediated immunopathologic events. Examples of nonallergic rhinitis are infectious rhinitis, hormonal rhinitis, vasomotor rhinitis, nonallergic rhinitis with eosinophilia syndrome (NARES), certain types of occupational rhinitis, and gustatory and drug-induced rhinitis. The differential diagnosis of nonallergic rhinitis is extensive. The mechanisms in each are poorly understood. Nonallergic rhinitis with inflammatory cells present in the mucosa can be classified by inflammatory cell type. Nonallergic rhinitis with eosinophilia syndrome (NARES) is characterized by nasal congestion and prominent nasal eosinophilia. (see summary statement #15) The mechanism of the eosinophil infiltration is not known. Eosinophilia is also prominent when nasal polyps are present, but again the mechanism of eosinophil recruitment is not known. Subjects with aspirin sensitivity have nasal eosinophilia. Aspirin and other nonsteroidal antiin-flammatory drugs (NSAIDs) block cyclooxygenase activity, and shunt arachidonic acid to the 5-lipoxygenase pathway that increases production of the potent proinflammatory cysteinyl leukotrienes (LTC , LTD , and LTE Neutrophilic infiltrates usually indicate the presence of bacterial rhinosinusitis, especially when humoral immunodeficiency or ciliary dysmotility are present. LTB

10. Eosinophilia-Myalgia: Advocacy, Information, Support Offers Advocacy, information, and support for EMS.Category Health Conditions and Diseases Blood Disorders eosinophilia......eosinophiliaMYALGIA SYNDROME. eosinophilia-Myalgia Syndrome (EMS)is a rare, multi-systemic, chronic, autoimmune disease caused http://www.eosinophilia-myalgia.net/

EOSINOPHILIA-MYALGIA SYNDROME Eosinophilia-Myalgia Syndrome (EMS) is a rare, multi-systemic, chronic, autoimmune disease caused by ingestion of impure L-tryptophan, an amino acid dietary supplement. Many Americans used this supplement during the 1980s, often upon the advice of a physician, for medical problems such as trouble sleeping, chronic pain, and depression; however, an Epidemic of a novel illness, which came to be called Eosinophilia-Myalgia Syndrome, occurred in 1989 into early 1990. The overwhelming majority of persons who got sick with EMS had ingested contaminated L-Tryptophan eventually traced to one large petrochemical company, Showa Denko K.K., of Japan. Bottle labeling did not indicate the raw product originated overseas, and nobody in this country or elsewhere, it seems, was told that genetic engineering had been used to make the L-Tryptophan. Although five to ten thousand Americans (and many scores in various other nations) were probably affected, approximately 2,000 Americans were seriously injured, many of whom continue to suffer with a variety of symptoms: chronic pain, cognitive dysfunction, muscle weakness and spasms, and many others. Since about 1996, research has slowed to a near standstill. Fewer studies at any time involve EMS, a toxin-induced disease. EMS is on the verge of becoming a mere footnote in medical history: Therefore, I call EMS "The Forgotten Disease" just as the Korean War is often called "The Forgotten War."

11. Eosinophilia-Myalgia Advocacy, Information, Support eosinophiliaMyalgia Advocacy, Information, Support http://redirect-west.inktomi.com/click?u=http://www.eosinophilia-myalgia.net/&y=

12. Eosinophilia-Myalgia Syndrome Symptoms Symptoms of eosinophiliaMyalgia Syndrome (EMS). Symptoms of EMS in its VariousStages from Acute to Chronic. Please see Bibliography at end of List. http://www.eosinophilia-myalgia.net/symptoms.htm

Symptoms of Eosinophilia-Myalgia Syndrome (EMS) Symptoms of EMS in its Various Stages from Acute to Chronic Please see Bibliography at end of List Symptoms Often Found in the Acute Phase of EMS (early months; onset) Please remember that this list is not meant to be absolutely representative of all cases at this stage. EMS is a diverse disease which manifested in different ways in people. However, certain symptoms tended to appear frequently in the acute stage, though not in all persons. Also, it's possible other symptoms appeared in some persons at this point in the disease not listed here. I am not an expert. Please see references at end. Eosinophilia (elevated levels of eosinophils , a type of white blood cell; sometimes was not tested, so was missed; may be possible that some persons got EMS but did not have eosinophilia) Myalgia (muscle pain) Swelling (edema) of the face or extremities or other areas of the body, such as the arms Weight changes (gain followed by loss; or just loss; or perhaps just gain) Hair loss (scalp and body hair; tended to grow back later though not always a complete return to normal)

13. Eosinophilia-Myalgia: Advocacy, Information, Support Advocacy, information, and support for those with eosinophiliaMyalgia (EMS). http://www.swiftsite.com/eosinophilia-myalgia/

EOSINOPHILIA-MYALGIA SYNDROME Eosinophilia-Myalgia Syndrome (EMS) is a rare, multi-systemic, chronic, autoimmune disease caused by ingestion of impure L-tryptophan, an amino acid dietary supplement. Many Americans used this supplement during the 1980s, often upon the advice of a physician, for medical problems such as trouble sleeping, chronic pain, and depression; however, an Epidemic of a novel illness, which came to be called Eosinophilia-Myalgia Syndrome, occurred in 1989 into early 1990. The overwhelming majority of persons who got sick with EMS had ingested contaminated L-Tryptophan eventually traced to one large petrochemical company, Showa Denko K.K., of Japan. Bottle labeling did not indicate the raw product originated overseas, and nobody in this country or elsewhere, it seems, was told that genetic engineering had been used to make the L-Tryptophan. Although five to ten thousand Americans (and many scores in various other nations) were probably affected, approximately 2,000 Americans were seriously injured, many of whom continue to suffer with a variety of symptoms: chronic pain, cognitive dysfunction, muscle weakness and spasms, and many others. Since about 1996, research has slowed to a near standstill. Fewer studies at any time involve EMS, a toxin-induced disease. EMS is on the verge of becoming a mere footnote in medical history: Therefore, I call EMS "The Forgotten Disease" just as the Korean War is often called "The Forgotten War."

14. Eosinophilia-Myalgia: Advocacy, Information, Support Offers Advocacy, information, and support for EMS. http://www.Eosinophilia-Myalgia.net

EOSINOPHILIA-MYALGIA SYNDROME Eosinophilia-Myalgia Syndrome (EMS) is a rare, multi-systemic, chronic, autoimmune disease caused by ingestion of impure L-tryptophan, an amino acid dietary supplement. Many Americans used this supplement during the 1980s, often upon the advice of a physician, for medical problems such as trouble sleeping, chronic pain, and depression; however, an Epidemic of a novel illness, which came to be called Eosinophilia-Myalgia Syndrome, occurred in 1989 into early 1990. The overwhelming majority of persons who got sick with EMS had ingested contaminated L-Tryptophan eventually traced to one large petrochemical company, Showa Denko K.K., of Japan. Bottle labeling did not indicate the raw product originated overseas, and nobody in this country or elsewhere, it seems, was told that genetic engineering had been used to make the L-Tryptophan. Although five to ten thousand Americans (and many scores in various other nations) were probably affected, approximately 2,000 Americans were seriously injured, many of whom continue to suffer with a variety of symptoms: chronic pain, cognitive dysfunction, muscle weakness and spasms, and many others. Since about 1996, research has slowed to a near standstill. Fewer studies at any time involve EMS, a toxin-induced disease. EMS is on the verge of becoming a mere footnote in medical history: Therefore, I call EMS "The Forgotten Disease" just as the Korean War is often called "The Forgotten War."

15. Www.nlm.nih.gov/cgi/mesh/2K/MB_cgi?term=Eosinophilia Similar pages More results from www.nlm.nih.gov The National eosinophilia Myalgia Syndrome Network page has movedThe National eosinophilia Myalgia Syndrome Network page has moved. Pleaseclick on the hyperlink below to find the new site. http//www.nemsn.org. http://www.nlm.nih.gov/cgi/mesh/2K/MB_cgi?term=Eosinophilia

16. Eosinophilia eosinophilia up. Related topics other, Infectious Mononucleosis. narrower, HypereosinophilicSyndrome. American Partnership For Eosinophilic Disorders APFED, http://omni.ac.uk/browse/mesh/detail/C0014457L0014457.html

Eosinophilia [up] Related topics: other Infectious Mononucleosis narrower Hypereosinophilic Syndrome American Partnership For Eosinophilic Disorders : APFED The American Partnership For Eosinophilic Disorders (APFED) is a non-profit organisation that is dedicated to helping patients and their families cope with eosinophilic gastrointestinal disorders. The site provides information about eosinophilic enteropathy (EE), a digestive system disorder, up-to-date news, and a glossary of terms. There is a list of related links. The information provided here is reviewed and verified by the APFED Medical Advisory Board. Charities Eosinophilia Organizations, Nonprofit United States Last modified 28/Mar/2003 [Low Graphics]

17. Postgraduate Medicine: A Practical Workup For Eosinophilia A practical workup for eosinophilia. You can investigate the most likely causesright in your office. Malcolm L. Brigden, MD. eosinophilia in children. http://www.postgradmed.com/issues/1999/03_99/brigden.htm

A practical workup for eosinophilia You can investigate the most likely causes right in your office Malcolm L. Brigden, MD VOL 105 / NO 3 / MARCH 1999 / POSTGRADUATE MEDICINE CME learning objectives To summarize effective history taking and physical examination to disclose the cause of eosinophilia To tabulate the likelihood of causes of eosinophilia on the basis of severity To present a practical and cost-effective approach to management of patients with an increased eosinophil count This page is best viewed with a browser that supports tables Preview : Underlying disorders that can cause increased eosinophil count range from simple hay fever to a malignant tumor. In this article, Dr Brigden summarizes where to start in evaluating a patient with this finding and how to proceed cost-effectively. He discusses risks that can be ascertained through history taking (eg, travel, occupational exposure to allergens) and provides lists of likely causes based on the degree of eosinophilia. He also tabulates commonly used drugs capable of precipitating allergic reactions with eosinophilia, characteristics of pulmonary eosinophilic syndromes, and common parasitic infections that might be the culprit. T oday's sophisticated hematologic instruments, which provide automated five-part white blood cell differential counts, are identifying many new, often unanticipated, cases of eosinophilia (1). It is preferable to record the eosinophil count as an absolute count rather than a percentage, because the numbers depend on the total cell count. The upper range of the absolute eosinophil count probably extends to 0.65 X 10

18. HON Allergy Glossary Eosinophilia More on this topic. Relevant sites from HON's MedHunt eosinophilia Multimediafrom HONselect eosinophilia. eosinophilia Blood eosinophilia http://www.hon.ch/Library/Theme/Allergy/Glossary/eosinophilia.html

Allergy : A B C ... W X Y Z Pollen Calendar More on this topic Relevant sites from HON's MedHunt: Eosinophilia Multimedia from HONselect: Eosinophilia External survey "Questionnaire on mood" conducted by the "IMSP- Faculty of Medicine - University of Geneva" Eosinophilia Blood eosinophilia An abnormally high number of eosinophils in the blood. Not a disease in itself but usually a response to a disease. An elevated number of eosinophils usually indicates a response to abnormal cells, parasites or allergens . See also Eosinophils and IgE Home About us Site map ... HONewsletter http://www.hon.ch/Library/Theme/Allergy/Glossary/eosinophilia.html Last modified: Fri Jun 28 2002

19. HONselect - Angiolymphoid Hyperplasia With Eosinophilia English Angiolymphoid Hyperplasia with eosinophilia, Granuloma, Pseudopyogenic- Kimura Disease - Pseudopyogenic Granuloma - Disease, Kimura - Granulomas http://www.hon.ch/HONselect/RareDiseases/C15.378.553.231.085.html

List of rare diseases: English Deutsch Language: MeSH term: Accepted terms: English: Angiolymphoid Hyperplasia with Eosinophilia - Granuloma, Pseudopyogenic - Kimura Disease - Pseudopyogenic Granuloma - Disease, Kimura - Granulomas, Pseudopyogenic - Pseudopyogenic Granulomas Français: HYPERPLASIE ANGIOLYMPHOIDE AVEC EOSINOPHILIE Deutsch: Angiolymphoide Hyperplasie mit Eosinophilie - Granulom, pseudopyogenes - Kimura-Krankheit Español: HIPERPLASIA ANGIOLINFOIDE CON EOSINOFILIA - GRANULOMA SEUDOPIOGENICO - ENFERMEDAD DE KIMURA Português: HIPERPLASIA ANGIOLINFOIDE COM EOSINOFILIA - GRANULOMA PSEUDOPIOGENICO - DOENCA DE KIMURA HONselect ressources Definition: Yes Articles: Yes Images: No News: No Conferences: No Clinical trials: No Web sites: English Yes Français No Deutsch No Español No Português No Home About us Site map Feedback ... HONewsletter http://www.hon.ch/HONselect/RareDiseases/C15.378.553.231.085.html Last modified: Thu Jul 25 2002

20. Eosinophilia Lawsuit News Find Trial Lawyers And Attorneys For InjuryBoard News eosinophilia Find trial lawyers and attorneys with experiencein lawsuits involving eosinophilia. eosinophilia. Need More? , Ask an Attorney. http://www.injuryboard.com/lvltwoinjury.cfm/hurl/fstli=2/secli=79

Airbags Airlines Avandia Baycol / Cerivastatin ... Blood Disorders Eosinophilia If you or a family member has been injured, Contact an Attorney today. Just fill out InjuryBoard.com's On-line Questionnaire and have an attorney evaluate your case - free of charge. Ask an Attorney Eosinophilia is a blood disorder characterized by an abnormally high number of eosinophils in the blood. Eosinophils are manufactured in the bone marrow. When a foreign substance is detected within the body, eosinophil production is increased. While Eosinophilia is not a disease in and of itself, a high number of eosinophils indicates the presence abnormal cells, parasites, or allergens. What do I do Now? As with many personal injury claims, time is critical. Contact an attorney today to protect your rights. An Injuryboard sponsor will: Help you with the merits of your case.

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