61. MEDLINEplus Medical Encyclopedia: Epstein-Barr Virus Test epsteinbarr virus test. Definition Return to top This is a blood testused to detect antibodies to the epstein-barr virus (EBV) antigens. http://www.nlm.nih.gov/medlineplus/ency/article/003513.htm

Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Epstein-Barr virus test Contents of this page: Illustrations Alternative names Definition How the test is performed ... Special considerations Illustrations Blood test Alternative names Return to top EBV antibody test; Monospot; Heterophile agglutination test Definition Return to top This is a blood test used to detect antibodies to the Epstein-Barr virus ( EBV ) antigens. How the test is performed Return to top Adult or child: Blood is drawn from a vein ( venipuncture ), usually from the inside of the elbow or the back of the hand. The puncture site is cleaned with antiseptic, and a tourniquet (an elastic band) or blood pressure cuff is placed around the upper arm to apply pressure and restrict blood flow through the vein. This causes veins below the tourniquet to distend (fill with blood). A needle is inserted into the vein, and the blood is collected in an air-tight vial or a syringe. During the procedure, the tourniquet is removed to restore circulation. Once the blood has been collected, the needle is removed, and the puncture site is covered to stop any bleeding Infant or young child: The area is cleansed with antiseptic and punctured with a sharp needle or a lancet. The blood may be collected in a pipette (small glass tube), on a slide, onto a test strip, or into a small container. Cotton or a bandage may be applied to the puncture site if there is any continued bleeding.

62. BioMed Central Full Text High Incidence Of Epstein-Barr Virus High incidence of epsteinbarr virus, cytomegalovirus and human herpesvirus 6 infectionsin children with cancer Jaroslav Michálek 1 and Radek Horvath 2 1 http://www.biomedcentral.com/1471-2431/2/1

63. BioMed Central | Full Text | Epstein-Barr Virus Encoded Nuclear Protein EBNA-3 B epsteinbarr virus encoded nuclear protein EBNA-3 binds a novel human uridine kinase/uracilphosphoribosyltransferase Elena Kashuba 1 , Vladimir Kashuba 1 http://www.biomedcentral.com/1471-2121/3/23

Welcome guest user home journals A-Z journals by subject advanced search ... Volume 3 Viewing options Abstract Full text PDF Other links: E-mail to a friend Download references Post a comment PubMed record ... Related articles in PubMed Search PubMed For Kashuba E Kashuba V Sandalova T Klein G ... Szekely L Key E-mail Corresponding author Research article Epstein-Barr virus encoded nuclear protein EBNA-3 binds a novel human uridine kinase/uracil phosphoribosyltransferase Elena Kashuba Vladimir Kashuba Tatjana Sandalova George Klein and Laszlo Szekely Microbiology and Tumor Biology Centre (MTC), Karolinska Institute, S-171 77, Stockholm, Sweden Department of Medical Biochemistry and Biophysics (MBB), Karolinska Institute, S-171 77, Stockholm, Sweden BMC Cell Biology The electronic version of this article is the complete one and can be found online at: http://www.biomedcentral.com/1471-2121/3/23 Received Accepted Published Outline Abstract Abstract Background Results Discussion ... References Background Epstein-Barr virus (EBV) infects resting B-lymphocytes and transforms them into immortal proliferating lymphoblastoid cell lines (LCLs) in vitro . The transformed immunoblasts may grow up as immunoblastic lymphomas in immuno-suppressed hosts. Results Conclusion We suggest that EBNA-3 by direct protein-potein interaction induces the nuclear accumulation of a novel enzyme, that is part of the ribonucleotide salvage pathway. Increased intranuclear levels of UK/UPRT may contribute to the metabolic build-up that is needed for blast transformation and rapid proliferation.

64. Epstein Barr Virus Translate this page epstein-barr virus back to the roots. Das Epstein-Barr-Virus (EBV)-Genom hateine Länge von 172kb und codiert für etwa 100 verschiedene Genprodukte. http://www.vu-wien.ac.at/i123/SPEZVIR/EBV.HTML

Epstein-Barr Virus back to the roots Gammaherpesvirus Viraler Lebenszyklus des EBV Latenz Apoptose Lytischen Zustand Pfeiffersche Druesenfieber Inkubationszeit 8- 21 Tage. Therapie: Schnelle und hochdosierte Cortisonbehandlung kombiniert mit Chemotherapie. Dank an Herrn Oliver F. Strauch!

65. JAMA -- Page Not Found epsteinbarr virus Antibodies and Risk of Multiple Sclerosis A Prospective StudyAuthor Information Alberto Ascherio, MD, DrPH; Kassandra L. Munger, MSc http://jama.ama-assn.org/issues/v286n24/abs/joc11194.html

Select Journal or Resource JAMA Archives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology Surgery MSJAMA Science News Updates Meetings Peer Review Congress The page you requested was not found. The JAMA Archives Journals Web site has been redesigned to provide you with improved layout, features, and functionality. The location of the page you requested may have changed. To find the page you requested, click here HOME CURRENT ISSUE PAST ISSUES ... HELP Error 404 - "Not Found"

66. Member Sign In Miscellaneous Issues in Transplantation Ask The Expert epsteinbarr virusShedding? Epstein-Barr-virus shedding in saliva and the oropharynx. http://www.medscape.com/viewarticle/414311

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67. BestDoctors.com: Epstein Barr: What Is The Epstein-Barr Virus And Who Can Become September 27, 2000. What Is The epsteinbarr virus And Who Can Become Infected?The epstein-barr virus (EBV) is a member of the herpes virus family. http://www.bestdoctors.com/en/askadoctor/j/jones/jfjones_092700_q1.htm

Site Map Language English Spanish Select A Language Search Condition Summaries Doctor Is In™ James F. Jones, M.D. Questions for Dr. Jones What Is The Epstein-Barr Virus And Who Can Become Infected? How Is The Epstein Barr VirusAssociated Mononucleosis Diagnosed? Once You Have The Epstein-Barr Virus, Can It Go Away? Is There Any Treatment For Epstein-Barr Virus? ... What Research Efforts Are Under Way Involving Epstein-Barr Virus? September 27, 2000 What Is The Epstein-Barr Virus And Who Can Become Infected? The Epstein-Barr virus (EBV) is a member of the herpes virus family. Approximately 90 to 95 percent of individuals over age 30 have been exposed to the virus, often without knowing it, because it causes no overt or obvious infection in a large number of cases. EBV is most commonly transmitted from person-to-person with saliva. It has the widest range of illness associated with it of any infectious agent we deal with these days. The virus is most frequently associated with infectious mononucleosis in the minds of physicians and the public. Only about a third of people in the world who have antibodies to EBV or who have been infected with the virus, however, have ever had infectious mononucleosis. On the other hand, many different infectious agents can cause infectious mononucleosis.

68. BestDoctors.com: Epstein Barr: Is Epstein-Barr Virus Associated With Cancer? Is epsteinbarr virus Associated With Cancer? Yes, the virus has been associatedwith a number of cancers, but nobody is ready to say it causes them. http://www.bestdoctors.com/en/askadoctor/j/jones/jfjones_092700_q6.htm

Site Map Language English Spanish Select A Language Search Condition Summaries Doctor Is In™ James F. Jones, M.D. Questions for Dr. Jones What Is The Epstein-Barr Virus And Who Can Become Infected? How Is The Epstein Barr VirusAssociated Mononucleosis Diagnosed? Once You Have The Epstein-Barr Virus, Can It Go Away? Is There Any Treatment For Epstein-Barr Virus? ... What Research Efforts Are Under Way Involving Epstein-Barr Virus? September 27, 2000 Is Epstein-Barr Virus Associated With Cancer? Yes, the virus has been associated with a number of cancers, but nobody is ready to say it causes them. It was first found in a tumor called African Burkett's lymphoma, a cancer of the lymphoid cells of the head and neck found mostly in African males. The Epstein-Barr virus is present in about 95 percent of those tumor cells, but exactly how it got there and what role it plays is still unknown. The virus is also present in a smaller percentage of so-called American Burkett's lymphomas. Other B-cell tumors besides Burkett's lymphomas that contain EBV are Hodgkin's disease and non-Hodgkin's lymphomas. It is also present in T-cell lymphomas and nasopharyngeal carcinoma. They very recently identified it in breast cancer, but they don't know what it does. It could be that when the breast cells are undergoing replication they become altered, making it easier for the virus to get in.

69. Space Flight-Induced Reactivation Of Latent Epstein-Barr Virus Space FlightInduced Reactivation of Latent epstein-barr virus (E-Barr).Previous studies have demonstrated that cellular immunity http://www.utmb.edu/epstein-barr/ebvinfo/epstein.htm

Home Research Team Publications Our Studies ... Raymond P Stowe, Ph.D Space Flight-Induced Reactivation of Latent Epstein-Barr Virus ( E-Barr Previous studies have demonstrated that cellular immunity during and after spaceflight is significantly decreased. The mechanisms underlying this phenomenon are not well understood, but it has been proposed that physical and psychological stress (i.e., launch and landing stresses, microgravity, confinement, separation from family, sleep deprivation, etc.) may be major mediating factors in the impaired immune response of astronauts. Notably, stress can downregulate cellular immunity resulting in increased susceptibility to infections and delayed wound healing. Herpesviruses, in particular, are reactivated by stress.

70. BUMC: Epstein-Barr Virus (EBV) Protocol Information Protocol Title A Phase I/II Trial of Butyrate and Ganciclovir inepsteinbarr virus (EBV)-Associated Malignancies. Investigators http://www.bumc.bu.edu/Departments/PageMain.asp?Page=3503&DepartmentID=109

71. Herpesviruses: HHV-4 epsteinbarr virus (EBV/HHV-4). HHV-4 has a dual cell tropism for humanB-lymphocytes (generally non-productive infection) and epithelial http://www-micro.msb.le.ac.uk/335/HHV4.html

: HHV-4 Search Epstein-Barr Virus (EBV/HHV-4) HHV-4 has a dual cell tropism for human B-lymphocytes (generally non-productive infection) and epithelial cells (productive infection). There is no suitable animal host, but replication/latency has been studied extensively in transformed human cell lines. HHV-4 is widespread worldwide, with ~75% of UK adults infected (lifelong!): The usual outcome of infection is polyclonal B-cell activation and benign proliferation, which may be sub-clinical or produce infectious mononucleosis (glandular fever): Disease: Comments: Infectious mononucleosis ("glandular fever") Primary infection, self limiting. Occurs in ~50% of primary infections of adolescents and young adults. Burkitt's lymphoma Hodgkin's disease Sporadic lymphoma; latent HHV-4 found in ~50% of cases. B-lymphoproliferative disease Lymphoproliferative disease/lymphomas, almost exclusively in the immunocompromised host, especially post-transplant (as a result of immunosuppressive drug therapy) and in AIDS. Might occur in primary infection or persistent infection. X-linked lymphoproliferative syndrome Rare genetic immune dysfunction results in fatal primary infection (see below).

72. Epstein-Barr Virus member of the herpesvirus family ds DNA enveloped virus nucleocapsid 100 nm indiameter, with 162 capsomers membrane is derived by budding of immature http://virology-online.com/viruses/EBV.htm

Herpesviruses Slide Set EPSTEIN-BARR_VIRUS PROPERTIES member of the herpesvirus family ds DNA enveloped virus nucleocapsid 100 nm in diameter, with 162 capsomers membrane is derived by budding of immature particles through cell membrane and is required for infectivity. genome is a linear ds DNA molecule with 172 kbp the viral genome does not normally integrate into the cellular DNA but forms circular episomes which reside in the nucleus. the genome is large enough to code for 100 - 200 proteins but only a few have been identified. The proteins characterized thus far fall into the following groups : A._Latent_proteins 1. EB viral nuclear antigen complex (EBNA) - EBNA is now known to be a complex of at least 6 proteins ie. EBNA 1-6. Their functions have yet to be understood but EBNA 1 is thought to be essential for the maintenance of the episomal state of EBV in infected cells and binds to the origin of replication. EBNA 1 is expressed in all known virus carrying cells, but its expression may be lost when a lytic cycle ensues. EBNA 2 has two phenotypes, A and B, strain A, which is found mainly in Caucasians, is more efficient in immortalizing B lymphocytes than strain B, which is mainly found in Africa. However, neither strains have any specific disease association. 2. Latent membrane protein (LMP)

73. Entrez-PubMed Human p32 a coactivator for epsteinbarr virus nuclear antigen-1-mediated transcriptionalactivation and possible role in viral latent cycle DNA replication. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1

74. Entrez-PubMed Interaction of epsteinbarr virus nuclear antigen 1 with the virallatent origin of replication. Hearing J, Mulhaupt Y, Harper S http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1

75. JAMA Women's Health Information Center - Epstein-Barr Virus JAMA Vol. 286, pp 30833088, December 26, 2001 epstein-barr virus Antibodiesand Risk of Multiple Sclerosis A Prospective Study ABSTRACT. http://www.ama-assn.org/special/womh/library/scan/vol_8/no_1/ascherio.htm

76. AMNews: Jan. 28, 2002. Epstein-Barr Virus Is Implicated In MS ... American Medic HEALTH SCIENCE. epsteinbarr virus is implicated in MS. Most recently, the Epstein-Barrvirus has been linked to MS. According to a study published in the Dec. http://www.ama-assn.org/sci-pubs/amnews/pick_02/hlsa0128.htm

@import url(http://www.ama-assn.org/sci-pubs/amnews/site/amnbasic.css); @import url(http://www.ama-assn.org/sci-pubs/amnews/site/amnprint.css) print; American Medical News LISTINGS '02 By date '02 By region Map '02 By health plan ... Search SERVICES Mobile edition E-mail alert Subscribe! Staff directory ... Send feedback ADVERTISEMENT Epstein-Barr virus is implicated in MS Recent study points to an association, but few believe it is the only culprit. By Victoria Stagg Elliott AMNews staff. Jan. 28, 2002. There was a time when the measles was fingered as a cause of multiple sclerosis. That connection, though, was ruled out so long ago that the virus doesn't even make the list of likely suspects anymore. Then, during the mid-1990s, human herpesvirus 6 became a likely culprit. This virus's wayward cousin, herpes simplex 1, was also listed among the possible guilty parties, as were certain bacteria, such as Chlamydia pneumoniae frequently found on the scene. Some disease detectives also have questioned whether these suspects could have been working together or with some of the other 40 infectious agents implicated thus far in causing multiple sclerosis. Or maybe it was none of them at all. With this article Unraveling multiple sclerosis Links To date, despite evidence linking these agents and MS, there continues to be difficulty making a case for a specific causal relationship beyond a shadow of a doubt.

77. Epstein-Barr Virus Report HOME. Aims and Scope Editorial Board Subscriptions Contents IncludeClick Journal Cover for a Larger View. Published by Maney on behalf http://www.maney.co.uk/epstein.html

HOME Aims and Scope Editorial Board Subscriptions Contents Include Click Journal Cover for a Larger View Published by Maney on behalf of Leeds Medical Information , University of Leeds, UK

78. The Scientist - Epstein-Barr Virus: Implicated In Cancer Etiology In China, Impe The Scientist 1361, Mar. 15, 1999, '); //. News. epsteinbarr virus Implicatedin Cancer Etiology in China, Impetus for a Vaccine. By Myrna E. Watanabe. http://www.the-scientist.com/yr1999/mar/watanabe_p1_990315.html

The Scientist 13[6]:1, Mar. 15, 1999 News Epstein-Barr Virus: Implicated in Cancer Etiology in China, Impetus for a Vaccine By Myrna E. Watanabe Virologist Hans Wolf of the University of Regensburg in Germany has been working on the etiology of nasopharyngeal carcinoma (NPC) in areas of China since 1979. Researchers from the U.S. National Cancer Institute (NCI), too, have been working with their Chinese colleagues on cancer epidemiology and etiology. The reasons for this cooperative research vary, but as Federico Welsch , associate director for international affairs at NCI, points out, "They have some cancers that are rare in the developed world." Among these are nasopharyngeal cancer, certain liver cancers, and esophageal cancer. Environmental factors have been implicated. Research by Wolf and Chinese colleagues Yi Zeng , chief of the department of tumor viruses at the Institute of Virology, Chinese Academy of Preventive Medicine (CAPM) and former president of CAPM, Shu-Yan Gu , now deputy director of the National Center for AIDS Prevention and Control, and others, is leading to development of a vaccine. But in some areas of the world, especially parts of Asia and Africa, "the people develop nasopharyngeal carcinoma," states Wolf. And in areas of Africa where there is a high prevalence of malaria, people infected with EBV may later develop Burkitt's lymphoma. The Chinese develop NPC. Only a small percentage of those infected ever develop this cancer, but it seems that infection with EBV is one of the essential risk factors. Zeng and his colleagues found evidence of an EBV gene and EBV proteins in in vitro cell lines developed from nasopharyngeal carcinomas and in cell lines developed from NPC cells transplanted into nude mice.

79. Nature Publishing Group 3 pp 350 355 epstein-barr virus nuclear protein EBNA-3C interacts with the humanmetastatic suppressor Nm23-H1 A molecular link to cancer metastasis Chitra http://www.nature.com/cgi-taf/DynaPage.taf?file=/nm/journal/v7/n3/full/nm0301_35

80. Rubella Vaccine Linked To Epstein Barr Virus Rubella vaccine linked to epsteinbarr virus—Dr Mendelsohn MD (1987).Many people now know about the dangers of DPT shots in babies. http://www.whale.to/v/ebv.html

Rubella vaccine linked to Epstein-Barr Virus Many people now know about the dangers of DPT shots in babies. and they are rejecting those particular shots. Yet, they still accept other vaccines for their children. So for those trusting souls, here is the latest evidence on the dangers of the German measles vaccine. A study of 200 patients with Epstein-Barr Virus (often called Yuppie disease) is scheduled for publication this spring in the journal Medical Hypothesis. In an advance report in the San Diego Tribune Biomedical researcher Allen D. Allen of Algorithms. Inc. of Northridge. California, blames EBV syndrome on Merck Sharp and Dohme’s Biavax and Meruvax vaccines which were introduced in the late 1970’s. Allen says. ‘I can say all this attention to the (Epstein-Barr) syndrome. the public awareness. started in the early 1980’s. right after these vaccines came out. Young adults. the ones most likely to be in contact with young children, are the primary targets. It’s too much of a coincidence to ignore." In a similar study. Dr. Hugh Fudenberg

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