1. Factor V Leiden University of Illinois Urbana/Champaign Carle Cancer Center Hematology Resource Page factor v leiden Over 95% of patients with APCR have factor v leiden. factor v leiden's overall impact on the coagulation cascade http://www-admin.med.uiuc.edu/hematology/PtFacV2.htm

University of Illinois - Urbana/Champaign Carle Cancer Center Hematology Resource Page Patient Resources Factor V Leiden Home Factor V Leiden Antiphospholipid Syndrome General Clotting Information ... Protein S deficiency Factor V Leiden is a genetically acquired trait that can result in a thrombophilic (hypercoaguable) state resulting in the phenomenon of activated protein C resistance (APCR) as described below. Associated with factor V Leiden, APCR was first described in 1993; factor V Leiden was subsequently discovered in 1994. Over 95% of patients with APCR have factor V Leiden. Factor V Leiden's overall impact on the coagulation cascade described below. Mechanism of Action of Factor V Leiden: Factor V Leiden is characterized by a phenomenon called APCR where a genetic mutation in the factor V gene causes a change in the factor V protein making it resistant to inactivation by protein C. Epidemiology of Factor V Leiden: Factor V Leiden is seen more commonly in the northern European populations. About 4-7% of the general population is heterozygous (see * below) for factor V Leiden. About 0.06 to 0.25% of the population is homozygous (see * below) for factor V Leiden. The factor V Leiden mutation is relatively uncommon in the native populations of Asia, Africa and North America. In contrast, in Greece and southern Sweden, rates above 10% have been reported.

2. Factor V Leiden Information, Living With Thrombophilia factor v leiden is the most common hereditary blood coagulation disorder in the United States. It Category Health Conditions and Diseases factor v leiden......This site contains information for those living with Thrombophilia orfactor v leiden. Your browser does not support script, Thrombophilia http://www.fvleiden.org/

Your browser does not support script Thrombophilia Support Page Factor V Leiden Prothrombin 20210 mutation Activated Protein C resistance Antithrombin Deficiency and other clotting disorders Factor V Leiden is the most common hereditary blood coagulation disorder in the United States. It is present in 5% of the Caucasian population and 1.2% of the Afro-American population. Factor V Leiden increases the risk of venous thrombosis 3-8 fold for heterozygous (one bad gene inherited) and substantially more, 30-140 fold, for homozygous individuals (two genes inherited are bad). The prothrombin 20210 mutation is the second most common inherited clotting abnormality; more common than protein S and C deficiency and Antithrombin deficiency combined. 2 % of the general population is heterozygous. It is only a mild risk factor for clots, but together with other risk factors (such as oral contraceptives, surgery, trauma, high blood pressure, obesity, smoking, etc.) or combined with other clotting disorders (like factor V Leiden), the risk of clotting increases dramatically. Factor V Leiden can be associated with the following complications: Venous thrombosis (blood clots in veins) such as - Deep vein thrombosis (DVT) (veins in legs and arms) - Superficial thrombophlebitis Pulmonary embolism (PE) (blood clot in lung)

3. GeneReviews: Factor V Leiden Thrombophilia Serwis Katalog w Wirtualna Polska S.A. pierwszy portal w Polsce. http://www.geneclinics.org/profiles/factor-v-leiden

Your browser does not support HTML frames so you must view Factor V Leiden Thrombophilia in a slightly less readable form. Please follow this link to do so.

4. Pregnancy, Clotting, And Factor V Leiden: An Overview Pregnancy, Clotting, and factor v leiden An Overview The past 10 years have brought new understanding of and explanations why some women clot on birth control pills and during pregnancy. The most common is factor v leiden, also known as http://www.naturalchildbirth.org/natural/resources/prebirth/prebirth35.htm

Pregnancy, Clotting, and Factor V Leiden: An Overview The past 10 years have brought new understanding of and explanations why some women clot on birth control pills and during pregnancy. Research into genetic origins of disease has uncovered many coagulopathies, some of them surprisingly common. The most common is Factor V Leiden, also known as Activated Protein C Resistance, which carries a 3-10 times greater risk of clot when someone has one copy of the gene and 30-140 times greater risk of clotting for someone with two copies. Between 3% and 10% of Caucasian people are heterozygous for Factor V Leiden, and a much smaller percentage are homozygous. In Sweden the rate of heterozygous mutation may be as high as 15% in some areas, while in other parts of the world and among other races only a fraction of a percent of the population may have it. It is thought that the original mutation occurred as much as 20,000-30,000 years ago in a single individual.(1) Women with Factor V Leiden (FVL) have a substantially increased risk of clotting in pregnancy (and on estrogen containing birth control pills or hormone replacement) in the form of DVT (deep vein thrombosis, sometimes

5. Factor V Leiden Mutation Test Department of Laboratory Medicine and Pathology The factor v leiden Mutation Test A New Test Offering from the UMHC Clinical Laboratory due to a single mutation of the factor V gene (factor v leiden). The factor v leiden mutation has a prevalence of 2% to http://www.borg.labmed.umn.edu/Outreach/FactorV.html

Department of Laboratory Medicine and Pathology The Factor V Leiden Mutation Test A New Test Offering from the UMHC Clinical Laboratory Evaluating the causes of thrombosis in young patients, and in patients with recurrent thrombosis has been a significant problem. A new inherited cause of thrombophilia (first described in 1993) is activated Protein C resistance (aPC-R). Up to 90% of aPC-R is due to a single mutation of the factor V gene (Factor V Leiden). The Factor V Leiden mutation has a prevalence of 2% to 7% in the general population; it is the most common inherited cause of a thrombotic tendency. The new test uses the power of the polymerase chain reaction (PCR) to amplify DNA from a patient's blood to detect the presence or absence of the Factor V Leiden mutation. Patients with the Factor V Leiden mutation have up to a 7 fold increase in risk of venous thrombosis over normals, which may rise to as high as a 30 fold increase in smokers, obese individuals, and women on oral contraceptives. The coagulation test aPC-R (done in UMHC Coagulation Laboratory) is useful for screening patients who have had venous thrombosis, but cannot be used when a patient is anticoagulated.

6. Kimball Genetics - Factor V Leiden DNA Test The factor v leiden mutation is the most common genetic risk factor for venous thrombosis, a serious health problem http://www.kimballgenetics.com/tests-factor_v.html

Factor V Leiden DNA Test The factor V Leiden mutation is the most common genetic risk factor for venous thrombosis, a serious health problem affecting approximately 1 in 1000 people and leading to 50,000 deaths annually in this country. This mutation is involved in 20-40% of venous thrombosis cases and is present in 5% of the general population. The Factor V Leiden DNA Test should be included in the evaluation of all patients with thrombosis or a family history of this condition. Venous thrombosis is multigenic, and up to a third of individuals affected with inherited thrombosis have two or more genetic defects. Kimball Genetics provides the Factor V Leiden DNA Test separately, in combination with the Prothrombin (Factor II) DNA Test, or as part of panels including coagulation tests for other inherited hypercoagulability disorders. Indications for Factor V Leiden DNA Testing Venous thrombosis Pulmonary embolism Transient ischemic attack or premature stroke Peripheral vascular disease, particularly lower extremity occlusive disease Cerebral vein thrombosis Multiple spontaneous abortions History of a thrombotic event Family history of venous thrombosis Relative known to have factor V Leiden Prior to major surgery, pregnancy, oral contraceptive use or estrogen therapy if there is a personal or family history of thrombosis

7. UPC Diagnosis Series - Disease Diagnosis -FACTOR V LEIDEN MUTATION - Controversy Increased risk for thrombosis in women with factor v leiden who are on oral contraceptives ref http://www.upcmd.com/dot/examples/00222/controversy.html

UPCMD Home Disease Diagnosis Home Authors-Editors Disease information ... Controversy Search Disease Diagnosis Factor V Leiden Mutation (FV) Synonyms Controversy 1. Factor V Leiden Mutation and Oral Contraceptive Use: Benefits of Screening 2. Effect of Factor V Leiden on Other Cardiovascular Disorders 1. Factor V Leiden Mutation and Oral Contraceptive Use: Benefits of Screening Benefits of Screening For Factor V Leiden Mutation Prior to Prescribing Oral Contraceptives Arguments for ref Increased risk for thrombosis in women with factor V Leiden who are on oral contraceptives [ ref Increased risk for thrombosis in control women on oral contraceptives is 2-4 fold while increased risk in women with factor V Leiden on oral contraceptives is up to 35 fold [ ref Resistance to activated protein C increases in control women as well as in women carrying factor V Leiden when on oral contraceptives [ ref Arguments against ref Cost to screen all women is not reasonable, therefore may be preferable to only test women with family or personal history of thrombosis [ ref Absolute risk of thrombosis is low.

8. Factor V Leiden Information, Living With Thrombophilia This site contains information for those living with Thrombophiliaor factor v leiden. Your browser does not support script, Links http://www.fvleiden.org/links.htm

Your browser does not support script Links Relating to Thrombophilia Nine years ago when I searched the web for the first time, I only found one article on fvl. Now if you search, you'll find many articles. This list is not exhaustive or comprehensive. It is a sampling of what's out there. If you want to read up on APC, APS, FVL or any other clotting disorder go to one of the major search engines and put in a variety of spellings for the disorder. You will find many articles. Finding a doctor in your state that knows how to treat FVL-Just click on your state Links for FVL: Venous Thrombosis and the Factor V (Leiden) Mutation University of Illinois-Factor V Leiden Patient Information (excellent graphics and explanations) Coumadin information from CardioDoc.net Pregnancy, Clotting, and Factor V Leiden: An Overview ... Factor V Leiden Mutation Analysis APC and Protein S Deficiency articles: Resistance to activated protein C due to Factor V R506Q (Factor V Leiden) Protein S Deficiency and Thrombophilia web page from the UK EMedicine Protein S Deficiency Resistance to activated protein C due to Factor VR506Q(factor V Leiden) ... Resistance to activated protein C due to Factor V Leiden Prothrombin 20210A: Genotype Testing: Prothrombin G20210a references- this link leads to several others on the same subject General links regarding clotting and/or thrombosis information:

9. Factor V Leiden Informatie van ervaringsdeskundigen over erfelijke stollingsafwijkingen,zoals trombose en longembolie. http://www.leefwijzer.nl/factor-V-leiden

10. MSRGSNet/Genetic Drift/Venous Thrombosis And The Factor V (Leiden) Mutation Venous Thrombosis and the Factor V (Leiden) Mutation. The factor V mutation(factor v leiden) is the most common genetic cause of venous thrombosis. http://www.mostgene.org/gd/gdvol14b.htm

Previous Section This Issue- Table of Contents Next Section Vol. 14: Spring, 1997 Molecular Genetic Testing in Mainstream Medicine Venous Thrombosis and the Factor V (Leiden) Mutation Introduction Who should be tested? Deep vein thrombosis and pulmonary embolism Known genetic causes ... Illustrative case report Introduction Who should be tested? Indications include: Venous thrombosis or pulmonary embolism Transient ischemic attacks or premature stroke Peripheral vascular disease, particularly lower extremity occlusive disease History of a thrombotic event Family history of thrombosis or known factor V mutation in a relative Prior to major surgery, pregnancy, postpartum, oral contraceptive use or estrogen therapy if there is a personal or family history of thrombosis. Previous finding of activated protein C resistance by laboratory analysis Deep vein thrombosis and pulmonary embolism Venous thrombosis and pulmonary embolism pose a serious health problem. In this country half a million people are hospitalized each year and 50,000-100,000 deaths occur due to venous thrombosis which is also a leading cause of maternal death. The incidence of symptomatic venous thrombosis cases is approximately 1 in 1000 people per year. Venous thrombosis is a multifactorial condition caused by a combination of genetic, aquired or environmental influences. Natural anticoagulant systems (the protein C system and antithrombin III) are in place to keep coagulation in check. Excess clotting occurs when there is a disturbance in one of the coagulation inhibitor mechanisms or in natural lysis of clots.

11. Predictive Genetics And DNA Diagnostics - Home Offers home collection kits for a range of tests including angiotensinogen, factor v leiden, hereditary hemochromatosis, periodontal disease and prothrombin. http://www.pgd2.com/

We provide genetic testing to promote a longer, healthier life. Genetic testing will allow those who are concerned about predisposition and family history to take preventative steps early. Testing is available nationwide. Our first priority is to our patients. In carrying out our day-to day business we: Treat our patients with respect and fairness. Provide quality testing with one of the fastest turn around times in the industry. Offer comprehensive follow-up to our patients and their families. Want to learn more about DNA? DNA Mutations Inheritance Why should I get tested? Home ... Contact Us

12. MoSt GeNe/Genetic Drift/Prenatal Diagnosis 20 Fall 2002. Heterozygote Counseling for the factor v leiden Mutation. FactorV Leiden is not known to be associated with arterial thrombosis. http://www.mostgene.org/gd/gdvol20g.htm

Previous Section This Issue- Table of Contents Genetic Considerations in Thrombotic Disorders Vol. 20: Fall 2002 Heterozygote Counseling for the Factor V Leiden Mutation Heterozygosity for the Leiden mutation in the factor V gene (FVL) is common and may present complex counseling issues. Heterozygosity refers to the situation when an individual has a single Leiden mutation in one of the factor V genes (see Adult Thrombotic Disorders in this issue of the Genetic Drift ). It is inherited in an autosomal dominant manner, and may be identified in individuals with thrombosis or their family members. Heterozygotes exhibit reduced penetrance, meaning some individuals will never exhibit symptoms. In this condition, at least 90% of heterozygotes are asymptomatic throughout their lives. The heterozygote frequency is 5% of the Caucasian US population, 2% of Hispanic Americans, about 1% of African Americans and Native Americans, and less than 1% of Asian Americans. In the general population, deep vein thrombosis occurs in 1 in 1,000 individuals. Heterozygosity for FVL confers a 4-8-fold increased lifetime risk for deep vein thrombosis, yet thrombosis occurs with other circumstantial factors in 50% of cases. Twenty to sixty percent of Caucasians with thrombosis have FVL, and most of these are heterozygotes. Homozygotes, or those with two copies of the faulty gene, have up to an 80-fold risk for thrombosis. For genetic counseling of heterozygotes, it is useful to divide the asymptomatic from the symptomatic, and adults from children.

13. Whoops Discusses the thrombotic risks of this inherited disorder, also known as factor v leiden. http://www.beckmancoulter.com/Coulter/Techpubs/coagulation/APC.asp

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14. Factor V Leiden Startpagina factor v leiden. Deze kennis willen wij graag met je delen, omdat we hetbelangrijk vinden dat er meer bekendheid komt over factor v leiden. http://www.factorvleiden.nl/

Lotgenotencontact Gastenboek E-mail Redactie Dit ad(d)ertje onder het gras, leid je direct naar de mailinglist Home Nieuws Trombose Longembolie ... Links Factor V Leiden Zoek je al lang naar begrijpelijke informatie over Factor V Leiden? Heb je vragen over Factor V Leiden waarop je arts geen antwoord weet? Zoek je informatie over Factor V Leiden of andere stollingsafwijkingen of ben je gewoon op zoek naar Je hebt het goede adres gevonden. Zelf zochten wij het internet af op zoek naar begrijpelijke informatie. Omdat wij niets konden vinden, hebben we zelf een site gebouwd. Wij zijn geen artsen, maar ervaringsdeskundigen. Wijs geworden door het uitwisselen van kennis en ervaringen op onze mailinglist . Wij actualiseren deze site maandelijks met informatie vanuit de mailinglist, informatie uit medische artikelen en informatie die wij van artsen krijgen. Deze kennis willen wij graag met je delen, omdat we het belangrijk vinden dat er meer bekendheid komt over Factor V Leiden. Daarnaast willen we op deze manier bijdragen aan een juiste behandeling van "dragers" van deze stollingsafwijkingen.

15. Factor V factor v leiden / APC resistentie 1 op de 5 mensen is drager van FactorV Leiden. Hiervan Wat is factor v leiden / APC resistentie? Factor http://www.factorvleiden.nl/factor5.htm

Lotgenotencontact Gastenboek E-mail Redactie Dit ad(d)ertje onder het gras, leid je direct naar de mailinglist Home Nieuws Trombose Longembolie ... Factor III / thromoplastine [ factor v ] factor viii APC Antitrombine III deficiëntie Lupus Anticoagulant ... (Hyper)homocysteïne Factor V Leiden / APC resistentie 1 op de 5 mensen is drager van Factor V Leiden. Hiervan krijgt een groot gedeelte nooit klachten. Wat is Factor V Leiden / APC resistentie? Factor V Leiden / APC resistentie (ongevoeligheid) is de meest voorkomende stollingsafwijking . Deze twee termen lijken verwarrend maar eigenlijk zijn het twee termen voor één afwijking. Kort samengevat: Door een defect op het vijfde gen (factor V) krijgt APC niet de kans zijn werk te doen. Met APC is niets mis, het gaat fout in Factor V. Acht procent van de Nederlandse bevolking heeft een APC resistentie en heeft hierdoor een zes keer zo groot risico op trombose In combinatie met anticonceptie is dit risico zelfs veertig keer zo groot.

16. Factor V Leiden Syndrome factor v leiden Syndrome Spanish *Pfactor v leiden ThrombophiliaGeneClinics Medical Genetics Knowledge Base, April 1999. http://ibis-birthdefects.org/start/f5fact.htm

Factor V Leiden Syndrome About I.B.I.S. Home Search Topics Search all contents ... "In the News" Messages... Questions/comments Report Dead Links S.O.S. - Exchange Join I.B.I.S. ... Etchings A Selection of Internet Sites [*] Outstanding [P] For Professionals [Spanish] [*][P] Factor V Leiden Thrombophilia GeneClinics: Medical Genetics Knowledge Base, April 1999. A superb presentation by J. Kujovich and S. Goodnight. [*][P] Factor V. Leiden APC Resistance Omim comprehensive clinical and genetic review - 1998. [P] Mutation in blood coagulation factor V Extracts from the Seminole paper by R. M. Bertina et al, Nature, 369: 64, 1994. "... single point mutation in the gene for the blood coagulation protein factor V ... 20 percent of all patients with venous thrombosis as well as 4 percent of the general population are carriers of this mutations ..." This site offers information mostly for educational purposes. This site is not intended to alter health care protocols nor to serve as a sole source of medical information. Please read full Always seek the advice of your local health care provider.

17. Nanogen: Products: ASRs/Protocols: Factor V Leiden Nanogen » Products » ASRs/Applications » factor v leiden factor v leiden ASRNanogen's Factor V (Leiden) Analyte Specific Reagents (ASR) determines if the http://www.nanogen.com/products/factor_v.htm

ASRs/Applications CFTR Factor V HFE Factor V/Prothrombin Consumables Nanogen ... ASRs/Applications Factor V Leiden ASR Nanogen's Factor V (Leiden) Analyte Specific Reagents (ASR) determines if the Factor V (Leiden) mutation is present in a sample by detecting the presence of a certain characteristic gene polymorphism. The Factor V (Leiden) ASR consists of active reagents that CLIA-certified high complexity laboratories can use in their tests to detect this mutation. Factor V (Leiden) Reagents Factor V (Leiden) Primer Mix and Factor V (Leiden) Heterozygous Control Primers for amplification of Factor V (Leiden) mutation locus (100 samples) and genomic heterozygous control DNA - 5 reactions Factor V (Leiden) Reporter/Stabilizer Mix and Factor V (Leiden) Ratio Reference Sample Reporters for genotyping of Factor V (Leiden) (480 samples) and ratio reference DNA for normalization - 5 reactions [ back to top ] Home Products Corporate Profile ... Contact Us

18. Factor V Leiden: Should All Pregnant Women Be Tested For Clotting Disorders? factor v leiden Should all pregnant women be tested for clottingdisorders? One of my friends experienced a stillbirth. It was http://www.parentsplace.com/pregnancy/trimester1/qas/0,10338,166389_433344,00.ht

var cimsCid = ''; var cimsUid = '433344'; main COMMUNITY Message Boards Chats ... Community Challenges find on iVillage on astrology on babies on beauty on books on food on health on lamaze.com on money on parenting on pets on relationships on women.com on work MAGAZINES on Cosmopolitan on Country Living on Good Housekeeping on House Beautiful on Marie Claire on Redbook on Victoria you are here: iVillage parentsplace pregnancy first trimester ... Talent Test more centers iMaternity Shop Amazon RECOMMENDED Baby-Making Basics Are You Pregnant? Chinese Gender Chart Top Baby Names by State ... Postpartum Depression: Are You at Risk? WHAT'S NEW Best Advice for Life after Baby Twin Pregnancy Symptoms Week-by-Week Pregnancy Guide TOPICS Trying to conceive Infertility Adoption Pregnancy ... Pregnancy and babies A-Z FEATURES Boards Chats Experts Quizzes ... Tools FREE NEWSLETTERS ParentsPlace more newsletters Factor V Leiden: Should all pregnant women be tested for clotting disorders? One of my friends experienced a stillbirth. It was later discovered, through a simple blood test, that she has a blood clotting disorder (Factor V Leiden and protein C deficiency). If she, or more importantly, her doctors had known of this inherited clotting disorder, she believes her baby would be alive today. Shouldn't there be testing of all pregnant women to prevent tragedies like this from occurring? Peg Plumbo Peg Plumbo has been a Certified Nurse Midwife (CNM) since 1976 and has assisted at over 1,000 births.

19. Factor V Leiden factor v leiden is not a disease, it is the presence of a particular genethat is passed on from your parents. The factor v leiden. Reviewed http://www.netdoctor.co.uk/diseases/facts/factorv.htm

The UK's leading independent health website Search NetDoctor NetDoctor.co.uk Home News and features News Newsletter Features Encyclopaedia Diseases Medicines Examinations Health centres Cancer Children's health Depression Erectile dysfunction ... All health centres Discussion and support Discussion forums Support groups Services Ask the doctor Find a hospital NetDoctor on call Search Medline ... Text message services Information About NetDoctor Commercial opportunities NetDoctor.com Factor V Leiden Reviewed by Dr Patrick Davey , cardiologist and Dr Rachel Green , consultant haematologist What is Factor V Leiden? The role of Factor V Leiden is still uncertain. Factor V Leiden is not a disease, it is the presence of a particular gene that is passed on from your parents. Factor V Leiden is a variant of the protein Factor V (5) which is needed for blood clotting. People who have a Factor V deficiency are more likely to bleed badly while people with Factor V Leiden have blood that has an increased tendency to clot. People carrying the Factor V Leiden gene have a five times greater risk of developing a blood clot (thrombosis) than the rest of the population. However, many people with the gene will never suffer from blood clots. In Britain, five per cent of the population carry one or more genes for Factor V Leiden, which is far more than the number of people who will actually suffer from thrombosis.

20. Factor V Leiden Mutation And The Risks..., Annals 15 Nov 97 factor v leiden Mutation and the Risks for Thromboembolic Disease A ClinicalPerspective. factor v leiden Mutation and Risk for Venous Thromboembolism. http://www.acponline.org/journals/annals/15nov97/factorvl.htm

Annals of Internal Medicine Current Issue Past Issues Library for Internists Subscriptions ... Email this page Annals of Internal Medicine REVIEW Factor V Leiden Mutation and the Risks for Thromboembolic Disease: A Clinical Perspective Annals of Internal Medicine 15 November 1997. 127:895-903. Daniel T. Price, MD, and Paul M. Ridker, MD Background: A single point mutation in the gene coding for coagulation factor V results in a form of factor Va that is resistant to degradation by activated protein C and leads to a relative hypercoagulable state. This mutation, factor V Leiden, is found in 4% to 6% of the U.S. population. Purpose: To review clinical data on factor V Leiden mutation, with emphasis on prevalence of and risks for thromboembolism and implications for screening and management. Data Sources: A MEDLINE search of the English-language literature published between 1993 and April 1997 and an extensive bibliography review. Study Selection: Case-control and prospective cohort studies were reviewed if clinical features of thromboembolic disease associated with factor V Leiden mutation or resistance to activated protein C were presented. Original research articles were reviewed if they addressed the identification of the laboratory abnormality of activated protein C or factor V Leiden mutation. Case reports and case series were reviewed when no analytic data were available. Data Extraction: Review of the identified articles.

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