21. Glomerular Diseases glomerular diseases damage the glomeruli, letting protein and red blood cellsleak out of your body. WHAT YOU SHOULD KNOW ABOUT glomerular diseases. http://www.kidneyurology.org/Patient_Resources/PaR_Lib_Glomerular.htm

WHAT YOU SHOULD KNOW ABOUT GLOMERULAR DISEASES About Us Patient Resources Professional Resources Support Us ... Corporate Sponsors WHAT ARE THE GLOMERULI AND WHAT DO THEY DO? The glomeruli are clusters of blood vessels inside the kidney that help to clean waste and extra water from your body. The glomeruli are attached to small fluid-collecting tubes called tubules . Together, the glomeruli-and-tubules form nephrons. Each kidney has about 1 million nephrons. In healthy nephrons, the glomeruli filter out wastes and extra water, and keep blood cells and protein in the body. HOW DO GLOMERULAR DISEASES HURT YOUR KIDNEYS? Glomerular diseases damage the glomeruli, letting protein and red blood cells leak out of your body. Sometimes a glomerular disease makes it hard for your body to clean out wastes, so the wastes begin to build up in the blood. Also, the diseases make it hard for your body to get rid of extra water, meaning that fluids may begin to collect in the face, hands, feet, or ankles and cause swelling. WHAT ARE SIGNS OF GLOMERULAR DISEASE?

22. Glomerular Diseases Glomerular. Diseases. http://endeavor.med.nyu.edu/courses/systemicpathology/courseware/renalpath/r1/gl

Glomerular Diseases Educational Computing Curriculum General Pathology General Pathology Courseware Hippocrates Project, New York University School of Medicine

23. Renal Pathology Module Part I Introduction to glomerular diseases History of Renal Disease; NormalStructure and Function; glomerular diseases Morphologic Class, Function. http://endeavor.med.nyu.edu/courses/systemicpathology/courseware/renalpath/f1.ht

Renal Pathology Module Par t I - Introduction to Glomerular Diseases History of Renal Disease Normal Structure and Function Glomerular Diseases : Morphologic Class, Function. Immunopathology : Immunoflourescence Patterns ... Quiz Part II - Glomerular Diseases : Clinical Syndromes Introduction Acute Nephritic Syndrome Nephrotic Syndrome Rapidly Progressive Glomerulonephritis ... Final Exam Developed by The Hippocrates Project 1984-1998

24. Glomerular Diseases Glomerular Diseases IgA Nephropathy Hemolytic Uremic Syndrom glomerular diseases glomerular diseases IgA Nephropathy Hemolyticuremic syndrome Rapidly progessive glomerulonephritis. http://cnserver0.nkf.med.ualberta.ca/nephkids/glomdiseases.htm

Glomerular Diseases Glomerular diseases IgA Nephropathy Hemolytic uremic syndrome Rapidly progessive glomerulonephritis

25. Website OutlineWho We AreGlossaries    Medical Terms              glomerular diseases •glomerular diseases •IgA Nephropathy •Hemolyticuremic syndrome •Rapidly progessive glomerulonephritis. http://cnserver0.nkf.med.ualberta.ca/nephkids/menu.htm

Nephkids Who We Are General Information on the Kidney Your urinary system and how it works ... Valuable posts by parents of Nephkids Glossaries Medical Terms Kidney Drugs Kidney Diseases Discussion Topics ... Member listing Photos Map Renal Links

26. Understanding Glomerular Diseases Understanding glomerular diseases. Clinical Syndromes. Morphology. Pathogenesis. http://www.wramc.amedd.army.mil/departments/medicine/NEPHROLOGY/education/lectur

Understanding Glomerular Diseases Clinical Syndromes Morphology Pathogenesis Previous slide Next slide Back to first slide View graphic version

27. Understanding Glomerular Diseases First Previous Next Last Index Home Text. Slide 2 of 40. http://www.wramc.amedd.army.mil/departments/medicine/NEPHROLOGY/education/lectur

28. Clinical And Pathological Characteristics Of Patients With Glomerular Diseases A Clinical and pathological characteristics of patients with glomerular diseasesat a university teaching hospital 5year prospective review. http://www.hkmj.org.hk/hkmj/abstracts/v5n3/240.htm

About the HKMJ Subscriptions Reprints Search past issues Clinical and pathological characteristics of patients with glomerular diseases at a university teaching hospital: 5-year prospective review KW Chan, TM Chan, IKP Cheng Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong OBJECTIVE: To examine the prevalence of glomerular disease in Hong Kong. DESIGN: Prospective review. SETTING: University teaching hospital, Hong Kong. PATIENTS: All patients who presented with suspected glomerular disease from 1993 through 1997. MAIN OUTCOME MEASURES: Histopathological diagnosis from biopsy examination and clinical features of presentation. RESULTS: A total of 1629 consecutive percutaneous renal biopsies of native kidneys showed glomerular disease in 1413 cases. The most common clinical indication for renal biopsy was persistent proteinuria (n=735; 52.0%), while the most frequently found glomerular lesion was immunoglobulin A nephropathy (n=338; 23.9%). Minimal-change nephrotic syndrome (n=125; 8.8%) and immunoglobulin M nephropathy (n=11; 0.8%), were the most common glomerular diseases that presented with nephrotic syndrome. The male to female ratio for lupus nephritis was 1:14 (n=290), whereas for minimal-change nephrotic syndrome, the ratio was 1.8:1 (n=125). Immunoglobulin A nephropathy and membranous glomerulonephritis (n=117) affected approximately equal numbers of male and female patients. Familial fibrillary glomerulonephritis, a disease hitherto unknown in Hong Kong, was diagnosed in two siblings.

29. Hereditary Glomerular Diseases Hereditary glomerular diseases. Dr. C. Stewart. Hereditary Nephritis (Alport’ssyndrome). Clinical Features. A genetic disease characterized http://www.uhmc.sunysb.edu/internalmed/nephro/webpages/Part_J.htm

Hereditary Glomerular Diseases Dr. C. Stewart Hereditary Nephritis (Alport’s syndrome) Clinical Features A genetic disease characterized by the onset of hematuria in early childhood and later progression to renal failure, predominantely in males, accompanied by the development of sensorineural (high frequency) hearing loss. A typical male patient presents with the onset of persistent gross or microscopic hematuria, sometimes exacerbated by upper respiratory illness, before the age of six. After years of recurrent or persistent hematuria, renal insufficiency is noted to occur, usually in the third or forth decade of life, occasionally before the age of twenty. Nephrotic syndrome may occurs in 30 – 40% of patients. Hearing loss is variable, ranging from complete deafness to (more frequently) a high-frequency loss detected by audiometric exam. Associated abnormalities may include megalocornea, lenticlonus, spherophakia, myopia, retinitis pigmentosa, and macrothrombocytopenia. In females, the disorder is usually mild, with only microscopic hematuria, and does not typically progress to renal failure. In one series, 74% of patients were less than six years of age at presentation.

30. Florida State University College Of Medicine Digital Library Patient/Family Resources by Topic Nephrology. glomerular diseasesPatient/Family Resources. glomerular diseases Clinical Resources. http://fsumed-dl.slis.ua.edu/patientinfo/nephrology/glomerulonephritis/

Patient/Family Resources by Topic: Nephrology Glomerular Diseases Patient/Family Resources See also: Autoimmune Disorders Patient/Family Resources General Nephrology Patient/Family Resources Glomerular Diseases Clinical Resources General Nephrology Patient/Family Resources Glomerular Diseases Patient/Family Resources by Sub-Topic: Acute Glomerulonephritis Chronic Glomerulonephritis Glomerulopathies Associated with Multisystem Diseases Nephrotic Syndrome ... Florida State University College of Medicine Service provided by the Clinical Digital Libraries Project of the UA and UNT Schools of Library and Information Studies Powered by UA Digital Libraries Navigation Lab technology

31. Florida State University College Of Medicine Digital Library glomerular diseases Clinical Resources. See also Nephrological ClinicalProcedure Resources; glomerular diseases Patient/Family Resources. http://fsumed-dl.slis.ua.edu/clinical/nephrology/glomerulonephritis/

Clinical Resources by Topic: Nephrology Glomerular Diseases Clinical Resources See also: Nephrological Clinical Procedure Resources Glomerular Diseases Patient/Family Resources General Nephrology Clinical Resources Glomerular Diseases Clinical Resources by Sub-Topic: Acute Glomerulonephritis Chronic Glomerulonephritis Glomerulopathies Associated with Multisystem Diseases Nephrotic Syndrome ... Rapidly Progressive Glomerulonephritis For other Glomerular Diseases Sub-Topics, go to General Nephrology Clinical Resources Medical Library Florida State University College of Medicine Service provided by the Clinical Digital Libraries Project of the UA and UNT Schools of Library and Information Studies Powered by UA Digital Libraries Navigation Lab technology

32. Study Questions - Proteinuria/Glomerular Diseases Study Questions Proteinuria/glomerular diseases. 1. Compare/contrast 2screening tests used for detection of proteinuria. Answer - Question 1. http://education.vetmed.vt.edu/Curriculum/VM8644/study/study5.htm

Study Questions - Proteinuria/Glomerular Diseases 1. Compare/contrast 2 screening tests used for detection of proteinuria. Answer - Question 1 2. List pre-renal, renal, and post-renal causes of proteinuria. Answer - Question 2 3. Discuss the diagnostic evaluation of a patient with proteinuria. Answer - Question 3 4. What is the primary indication for performing urine protein electrophoresis? Answer - Question 4 5. List common diseases that may predispose to development of glomerulonephritis or amyloidosis. Answer - Question 5 6. What is the difference between amyloidosis in dogs and cats? Answer - Question 6 7. Recommend treatment for a patient with glomerulonephritis. What is the prognosis? Answer - Question 7 8. Recommend treatment for a patient with amyloidosis. What is the prognosis? Answer - Question 8 Answers 1. Screening tests used to detect proteinuria Urine dipstick colorimetric - see color change to indicate presence of protein mostly detects albumin and not globulin or Bence Jones proteins Sulfosalicylic acid (SSA) turbidimetric test - add reagent to urine and look for white color (values from 1+ to 4+) detects albumin, globulin, and Bence Jones proteins

33. Glomerular Diseases: Part A & B II. glomerular diseases A. Etiologic types 1. Immunologic glomerulardiseases. 2. Metabolic diseases (Diabetic Mellitus, Amyloidosis). http://www.umdnj.edu/pathnweb/syspath/lec_1/gd_ab/gd_ab.htm

Home G.D.: C II. Glomerular Diseases: A. Etiologic types: 1. Immunologic glomerular diseases 2. Metabolic diseases (Diabetic Mellitus, Amyloidosis) 3. Coagulopathic disorders (DIC, Hemolytic-uremic syndrome, and Thrombotic-thrombocytopenic Purpura) (See General Path Syllabus : Thrombosis Lecture 4. Hypertension (benign and malignant) 5. Congenital/Hereditary Diseases 6. Idiopathic B. Pathogenic mechanisms of immunologic glomerular diseases: 1.Immune-complex mediated: characterized by granular capillary wall and mesangial immunofluorescent pattern of immune reactants (Ig, complement) and electron dense deposits in EM. (Fig: 3A, 3B) Fig 3A Fig 3b a.Deposition of circulating immune complexes: (Fig: 4A, 4B, 4C) Fig 4A Fig 4B Fig 4C i.Antigen exogenous (e.g., infections, drugs, foreign proteins) ii.Antigen endogenous (e.g., DNA, Ig, tumor antigens) b.In-situ immune complex formation: (Fig: 5A) Fig 5A i.Visceral epithelial cell GP330 antigen (Exp. Model: Heyman nephritis) (Fig 5B) Fig 5B ii.Planted (trapped) antigens: (Fig:5C)

34. Glomerular Diseases: Part D,E & F 3. End stage disease. E. Classification of glomerular diseases 1.Primary glomerular diseases, eg, Postinfectious, Drugs, etc. 2 http://www.umdnj.edu/pathnweb/syspath/lec_1/gd_def/gd_def.htm

Home G.D.: C D. Pattern of injury: 1. Acute and Chronic 2. Diffuse, Focal, Segmental and Global glomerular injury 3. End stage disease E. Classification of glomerular diseases: 1. Primary glomerular diseases, e.g., Postinfectious, Drugs, etc. 2. Glomerular diseases associated with systemic diseases, e.g. SLE, Systemic Vasculitis, Coagulopathic Disorders, Neoplasia, Amyloidosis, and Diabetes Mellitus 3. Hereditary F. Clinical Syndromes: 1. Asymptomatic hematuria/proteinuria 2. Nephritic Syndrome 3. Nephrotic Syndrome 4. Hypertension 5. Acute and Chronic Renal Failure Back to Page 4 Home G.D.: C Pathology Course Menu ... UMDNJ Please direct questions and coments to Alexander G. Izaguirre izaguial@umdnj.edu

35. Glomerular Diseases First Previous Next Last Index Text. Slide 21 of 43. http://pathophysiology.uams.edu/Spring01/renal/lec16s01/sld021.htm

First Previous Next Last ... Text Slide 21 of 43

36. Glomerular Diseases II glomerular diseases II. 1/12/01. Click here to start. Table of Contents. GlomerularDiseases II. Renal Disease associated with Diabetes Mellitus (p569). http://pathophysiology.uams.edu/Spring01/renal/lec19s01/

Glomerular Diseases II Click here to start Table of Contents Glomerular Diseases II Renal Disease associated with Diabetes Mellitus (p569) Diabetic Nephropathy Diabetic Nephropathy ... Hyperacute Transplant Rejection Author: Patrick D. Walker, M.D. Home Page: http://pathophysiology.uams.edu

37. Glomerulonephritis Basics Classification of Proteinuria glomerular diseases. Classification of Proteinuria glomerular diseases Isolated Proteinuria. Classification http://www.curriculum.som.vcu.edu/m2/renal/ppt/GlomerulonephritisBasics/

38. Classification Of Proteinuria Glomerular Diseases First Previous Next Last Index Home Text. Slide 18 of 35. http://www.curriculum.som.vcu.edu/m2/renal/ppt/GlomerulonephritisBasics/sld018.h

39. Glomerular Diseases - Condition, Disease, Or Disorder Article glomerular diseases Article relating to particular medicaldisease, condition, or disorder. glomerular diseases. http://www.stopgettingsick.com/Conditions/condition_template.cfm/2296/248/1

Guest search My Health Focus Immunity Alternative and Complementary Therapies Diseases and Conditions ... Healing Stories Forums General Health Home Remedies The Water Cooler Feedback ... My Profile Last updated 03/28/03 14:30 PST Glomerular Diseases What Are the Kidneys and What Do They Do? How Do Glomerular Diseases Interfere with Kidney Function? What Are the Symptoms of Glomerular Disease? How Is Glomerular Disease Diagnosed? ... Points To Remember Many diseases affect kidney function by attacking the tiny units within the kidney where blood is cleaned. Glomerular diseases include many conditions with a variety of genetic and environmental causes, but they fall into two major categories: Glomerulonephritis (gloh-MAIR-yoo-loh-neh-FRY-tis) describes the inflammation of the membrane tissue in the kidney that serves as a filter, separating wastes and extra fluid from the blood. Glomerulosclerosis (gloh-MAIR-yoo-loh-skleh-ROH-sis) describes the scarring or hardening of the tiny blood vessels within the kidney. Although glomerulonephritis and glomerulosclerosis have different causes, they can both lead to end-stage renal disease (ESRD).

40. Healthfinder® — Glomerular Diseases Overview of kidney function and glomerular diseases and their causes,symptoms, and diagnosis. glomerular diseases. internet URL. http://www.healthfinder.gov/Scripts/ShowDocDetail.asp?doc=6507&lang=1

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