81. Hughes' Syndrome/Antiphospholipid Syndrome Resources for Patients with hughes' syndrome, Antiphospholipid antibodysyndrome,Antiphospholipid syndrome, Lupus Anticoagulant, Sticky Blood. http://homepages.phonecoop.coop/veganelf/

Antiphospholipid Antibody Syndrome, Antiphospholipid Syndrome, Lupus Anticoagulant, Sticky Blood Hughes' Syndrome is an illness where the person's blood clots abnormally, and is also known as "sticky blood" or Antiphospholipid Antibody Syndrome. It is a rare condition but if you have it there is no need to feel alone, you are not the only one. This web page provides information resources and facilities for contacting others who also have the condition. Web sites http://www.hughes-syndrome.org/ Official Home Page of the Hughes Syndrome Foundation. It provides information on Hughes Syndrome (Antiphospholipid Syndrome or 'sticky blood') and the work of the Foundation. Links to some e-groups too. http://www.netdoctor.co.uk/diseases/facts/antiphospholipid.htm Net Doctor Fact sheet about Antiphospholipid Syndrome (Hughes' Syndrome). Unfortunately print is very small. http://pages.ivillage.com/ashley_dea/liveandlearn/id6.html Ashley's website, with her own experience of Hughes' Syndrome http://groups.yahoo.com/group/APLSUK/ Link to web site for e-group and mailing list about Hughes Syndrome (Antiphospholipid Syndrome) Email Me ... herbwormwood@lycos.co.uk

82. The Parents Network factor V Leiden mutation, FVL, APC resistance. hughes' syndrome, APS, - antiphospholipidantibodies. G. hughes MD, FRCP. A Patients Guide to hughes' syndrome. http://www.theparentsnet.co.uk/thrombosis.htm

THROMBO EMBOLISM, STROKE - THE ORAL CONTRACEPTIVE PILL INTRODUCTION Which inherent, acquired, or social conditions put a woman on the Pill at increased risk from suffering thrombo-embolism, stroke? Thrombophilics - persons are thrombophilic when they suffer the following blood disorders: factor V Leiden mutation, FVL - APC resistance Hughes' Syndrome, APS - antiphospholipid antibodies Whilst the two disorders are genetic, they can be acquired through oral contraceptive use. Migraine sufferers Persons overweight Smokers Passengers after a long haul flight Users of legal or illegal drug substances Persons with an allergy to the ingredients of OC Epileptics Intro (top) Factor V / Leiden Hughes' Syndrome Associated drug risks Picture Poem ... Printer friendly page WHAT IS FACTOR V (5) LEIDEN MUTATION?

83. APS Information Links Let me know you were here, sign my guestbook. hughessyndrome Foundation- Official homepage, hughes' syndrome - A patients guide to APS, http://canadianflower.tripod.com/apslinks.htm

These are links that I have found with information and/or support for APS, if you have a page you'd like to see listed, please contact me . Let me know you were here, sign my guestbook Hughes-Syndrome Foundation - Official homepage Antiphospholipid Syndrome Forum on Delphi - This is a great support board! APS Forum on Yahoo Hughes' Syndrome - A patients guide to APS APS on the Net - Information and Links concerning UCLA APS Page - A technical look at APS Medicine.net - Their page on APS Neuroland - Information on APS E-Medicine - Article on APS ANTIPHOSPHOLIPID ANTIBODY SYNDROME - By Thomas G. DeLoughery UMHS - Antiphospholipid Syndrome Antiphospholipid Syndrome - Another site with information. AsiaMedicineNet.com - Antiphospholipid Syndrome. Coumadin Home Page - Information on coumadin, the most common drug used to treat APS SLR APS Homepage - They have a registry for people with APS Lupus Site (SLE) - Not APS but it is a similar autoimmune disease. Many people with APS have Lupus also. This is a very in depth and useful site. View My Guestbook Sign My Guestbook Phenomenal Women Of The Web® Home ... APS Links This page was designed and created by me

84. Antiphospholipid Syndrome References. Amengual, O., Atsumi, T., Khamashta, MA, and hughes, GR(1998) Advances in antiphospholipid (hughes') syndrome. Annals http://www.nurseminerva.co.uk/antiphospholipid_syndrome.htm

Home anaesthesia asthma biorhythms ... pathology question received: Can you tell me what is the antifosfolipidic syndrome, my wife has it? She has thrombocitopenia too. Her platelets are 100. response: Can you tell me what is the antifosfolipidic syndrome, my wife has it? She has thrombocitopenia too. Her platelets are 100. th February 2001 During the late 1970s it was recognized that blood clotting disorders can be linked with the appearance of certain antibodies in the blood. Then in 1983 Hughes provided the first detailed description of the antiphospholipid syndrome (described in Amengual et al , 1998). The main clinical features of this syndrome are the repeated formation of inappropriate blood clots (thromboses) in arteries and veins, miscarriages during pregnancy, and commonly a reduction in the number of platelets in the blood. Platelets are also known as thrombocytes because of their contribution to the process of blood clotting, and if they are present in reduced numbers the condition is called thrombocytopenia. Thrombocytopenia occurs in approximately 20 to 40% of the patients with antiphospholipid syndrome (Galli, Finazzi, and Barbui, 1996). Antiphospholipid syndrome may occur on its own or it may be associated with other autoimmune diseases such as systemic lupus erythematosus (Gromnica-Ihle and Schossler, 2000). The blood clots that occur in antiphospholipid syndrome can affect vessels of all sizes (Khamashta and Hughes, 1995).

85. Lupus Site(SLE) - Factsheet hughes' syndrome (antiphospholipid syndrome). This is often called“sticky blood” in that the patients have a tendency to clots http://www.uklupus.co.uk/fact18.html

Home Lupus information Lupus FAQ Lupus factsheets ... (UK customers) Please help to support this site by visiting our Store Message Board Lupus store Site updates ... Search Lupus and Associated Conditions Taking Charge of Lupus UK customers Hughes' syndrome (antiphospholipid syndrome) This is often called “sticky blood” in that the patients have a tendency to clots both in the veins and arteries. The thrombosis may present either dramatically or over a period of time with clots in major vessels, even including the brain. It is vital that this diagnosis is made (a simple blood test for antiphospholipid antibodies is available in most major hospitals). Pregnant women who have antiphospholipid antibodies have a tendency to clot the placenta and develop recurrent miscarriages and these can be prevented by diagnosis and treatment. Although this syndrome was first discovered in lupus patients it is now recognised that many, if not the majority, of patients with Hughes’ syndrome have no other features of lupus nor will they develop lupus in the future. Sjögren's syndrome Sjögren - a Swedish ophthalmologist - noticed that some of his patients had dryness of the eyes and mouth. In addition, they developed aches and pains with a disease very much resembling lupus. The illness is often regarded as a 'half way house' between lupus and rheumatoid arthritis. As far as the prognosis is concerned Sjögren's syndrome resembles mild lupus, usually without kidney involvement. It is generally treated conservatively, either with no drugs or with antimalarials. Artificial tears are used to protect the eyes.

86. OUP: Lupus: Hughes patient; Lupuslike diseases; The antiphospholipid syndrome (hughes'syndrome); Discoid lupus; Sjogren's syndrome; Scleroderma and other http://www.oup.co.uk/isbn/0-19-263145-4

VIEW BASKET Quick Links About OUP Career Opportunities Contacts Need help? oup.com Search the Catalogue Site Index American National Biography Booksellers' Information Service Children's Fiction and Poetry Children's Reference Dictionaries Dictionary of National Biography Digital Reference English Language Teaching Higher Education Textbooks Humanities International Education Unit Journals Law Medicine Music Oxford English Dictionary Reference Rights and Permissions Science School Books Social Sciences World's Classics UK and Europe Book Catalogue Help with online ordering How to order Postage Returns policy ... Table of contents Lupus - The Facts Graham Hughes , Consultant Rheumatologist and Head of the Lupus Research Unit, St Thomas's Hospital, London Publication date: 2 December 1999 136 pages, 196mm x 129mm Series: The Facts Search for titles in the same series Ordering Individual customers order by phone, post, or fax Teachers in UK and European schools (and FE colleges in the UK): order by phone, post, or fax Lupus affects a vast number of people world-wide (1 million sufferers in the USA) Very few patient-orientated books on Lupus available Lupus the Facts presents an authoritative, yet compassionate guide to the subject

87. Pierang Pierangeli SS, Gharavi AE, Harris EN. Anticardiolipin Testing (In The “hughes”syndrome) ed by MA Khamashta and GRV hughes. (pp 205213).Springer-Verlag. http://www.msm.edu/micro_immuno/pierang.htm

Silvia S. Pierangeli, Ph.D Associate Professor Department of Microbiology/Immunology Morehouse School of Medicine 720 Westview Dr., MEB Building, Room number 1236 Atlanta, GA 30310-1495 Phone: 404-752-1882 Fax: 404-752-1644 Email: pierans@msm.edu RESEARCH INTERESTS My laboratory is devoted to research in the area of antiphospholipid antibodies and systemic lupus erythematosus. Antiphospholipid antibodies are associated with recurrent arterial and/or venous thrombosis and fetal losses. The affected patients are usually young and the disease has devastating consequences. The antibodies re believed to bind negatively charged phospholipids and to affect several phospholipid dependent clotting reactions. Some of the affected coagulation reactions are natural anticoagulant mechanisms (i.e.: The conversion of protein C in activated protein C). Thus this may prone the patient to thrombosis. By using specific chromogenic assays, we have determined that these antibodies indeed affect coagulation reactions in vitro. By using a unique animal model of thrombosis in mice we have been able to determine the effects of these antibodies in vivo and we are working to establish the mechanism(s) of thrombosis in vivo. We are also studying the fine specificity of these antibodies utilizing infrared spectroscopy, elipsometry and crystallography. Current studies involve production and characterization of antiphospholipid antibodies by immunization with phospholipid binding proteins and apolipoproteins.

88. Hughes – Stovin Syndrome Professionals only. hughes – stovin syndrome,, Print this article, (JohnPatterson hughes – stovin syndrome, Fig. 1 Contrastenhanced CT http://www.amershamhealth.com/medcyclopaedia/Volume V 1/HUGHES STOVIN SYNDROME.

Medcyclopaedia About Medcyclopaedia Amersham Health Search for: Type a word or a phrase. All forms of the word are searchable. Advanced search Browse entry words starting with: A B C D ... Other characters Try our Medcyclopaedia Premium Edition with added tools and functionality tailored to make your working day easier. The following tools are presently available: Expanded search *For Medical Professionals only, registration required Hughes – stovin syndrome, (John Patterson Hughes, 20th century, British physician and Peter George Ingle Stovin, 20th century, British physician), a variant of Behcets disease . It is even more rare than Behcet's disease, most patients being young adult males in the second to fourth decades. The major features are: systemic venous thrombi involving the vena cava, cerebral sinuses and limb veins; pulmonary artery occlusions due to emboli or thrombi; and one or more segmental pulmonary artery aneurysms Common clinical presentations include venous thrombosis, fever and haemoptysis. Radiological features are similar to those of Behcets disease Fig.1

89. What The Heck Is Antiphospholipid Syndrome? http://members.aol.com/AMAmail/Antiorg

Cardiolipin Antibody It aint so Bad! All Links Checked 5/15/2000 The antiphospholipid syndrome. Hughes GR Lupus Research Unit, Rayne Institute, St. Thomas' Hospital, London, UK. The antiphospholipid syndrome, now 13 years old, embraces almost all specialties. After a slow start-possibly because many early descriptions were published largely in the rheumatology literature, the syndrome has become recognised worldwide as a major cause of venous-arterial thrombosis, strokes, valvular disease and recurrent abortion. Its prevalence may soon overtake that of its "parent' disease, Lupus There are several kinds of antiphospholipid antibodies. The most widely measured are the lupus anticoagulant and anticardiolipin antibody. These antibodies react with phospholipid, a type of fat molecule that is part of the normal cell membrane. Lupus anticoagulant and anticardiolipin antibody are closely related, but are not the same antibody. This means that someone can have one and not the other. There are other antiphospholipid antibodies, but they are not commonly measured. Antiphospholipid antibodies interfere with the normal function of blood vessels, both by causing narrowing and irregularity of the vessel (called "vasculopathy"), and by causing clots in the vessel (called "thrombosis"). These blood vessel problems can then lead to complications such as stroke, heart attack, and miscarriage.

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