41. Nature Publishing Group Original Article. Digitalislike factor response to hyperinsulinemiain human pregnancy, a model of insulin resistance. EW Seely 1 http://www.nature.com/cgi-taf/DynaPage.taf?file=/jhh/journal/v16/n12/full/100149

42. Nature Publishing Group Paper. Acute stimulation of leptin concentrations in humans during hyperglycemichyperinsulinemia. Influence of free fatty acids and fasting. http://www.nature.com/cgi-taf/DynaPage.taf?file=/ijo/journal/v25/n1/full/0801527

43. Physiological Research - Vol. 51 -Kyselová Et Al. Physiol. Res. 51 591595, 2002. hyperinsulinemia and Oxidative Stress. AOCremained unchanged during hyperglycemia and hyperinsulinemia. http://www.biomed.cas.cz/physiolres/2002/issue6/51_591.htm

Physiol. Res. Hyperinsulinemia and Oxidative Stress P. KYSELOVÁ, M. ŽOUREK, Z. RUŠAVÝ, L. TREFIL1, J. RACEK First Department of Internal Medicine and Department of Clinical and Experimental Biochemistry, University Hospital, Pilsen, Czech Republic Received November 29, 2001 Accepted April 12, 2002 Summary Key words Oxidative stress · Hyperglycemia Hyperinsulinemia Rat Reprint requests Dr. P. Kyselová, Department of Internal Medicine, University Hospital, Alej Svobody 80, 304 60 Pilsen, Czech Republic. E-mail: Kyselova@fnplzen.cz PHYSIOLOGICAL RESEARCH © 2002 by the Institute of Physiology Czech Academy of Sciences ISSN 0862 - 8408 Issue

44. Hyperinsulinemia, Risk Of Cardiovascular Death And Acute Coronary And Cerebrovas hyperinsulinemia and the risk of cardiovascular death and acute coronary and cerebrovascularevents in men the Kuopio Ischaemic Heart Disease Risk Factor Study http://www.uku.fi/neuro/ab0018.htm

U K U N E U R O S C I E N C E P U B L I C A T I O N S Lakka HM, Lakka TA, Tuomilehto J, Sivenius J, Salonen JT. Hyperinsulinemia and the risk of cardiovascular death and acute coronary and cerebrovascular events in men: the Kuopio Ischaemic Heart Disease Risk Factor Study. Arch Intern Med 2000;160:1160-1168 Abstract BACKGROUND: The role of hyperinsulinemia as a cardiovascular risk factor is controversial. We studied whether hyperinsulinemia is independently associated with increased cardiovascular morbidity and mortality. METHODS: Fasting serum insulin level and other cardiovascular risk factors were determined in 1521 men in eastern Finland aged 42 to 60 years with neither cardiovascular disease nor diabetes at baseline. Forty-five cardiovascular deaths, 110 acute coronary events, 48 strokes, and 163 any cardiovascular events occurred during an average follow-up of 9.5 years. A total of 163 cardiovascular events (45 cardiovascular deaths, 110 acute coronary events, and 48 strokes) occurred during an average follow-up of 9.5 years. RESULTS: In Cox regression analysis adjusting for age and examination years, fasting serum insulin level as a continuous variable was directly associated with the risk of cardiovascular death (P = .006), acute coronary events (P = .04), and stroke (P = .02). Men with insulin levels of 52 to 66 pmol/L, 67 to 89 pmol/L, and 90 pmol/L or more (3 highest quartiles) had 1.4-fold (95% confidence interval, 0.5-3.7), 1.4-fold (95% confidence interval, 0.5-3.7), and 2.5-fold (95% confidence interval, 1.0-5.9; P = .05) cardiovascular mortality, respectively, compared with men with insulin levels of less than 52 pmol/L (lowest quartile) (P = .04 for linear trend). Adjustment for serum lipid levels, blood pressure, and obesity reduced the excess cardiovascular mortality in the highest insulin quartile by 7%, 33%, and 67%, respectively. There were no statistically significant differences in the incidence of acute coronary events and stroke between the insulin quartiles.

45. Essential Hypertension And Cognitive Function. The Role Of Hyperinsulinemia Laakso M. Essential hypertension and cognitive function. The roleof hyperinsulinemia. Hypertension 1993;22771779. Abstract. The http://www.uku.fi/neuro/ab9322.htm

U K U N E U R O S C I E N C E P U B L I C A T I O N S Kuusisto J, Koivisto K, Mykkänen L, Helkala E-L, Vanhanen M, Hänninen T, Pyörälä K, Riekkinen P, Laakso M. Essential hypertension and cognitive function. The role of hyperinsulinemia. Hypertension 1993;22:771-779 Abstract

46. AllYourStrength.com hyperinsulinemia America's Newest Plague. I'm talking about hyperinsulinemia– one of the key factors in the development of cardiovascular disease. http://www.allyourstrength.com/nutrition_hyperinsulinemia.html

Hyperinsulinemia America's Newest Plague Click here to view the nutrition and wellness archives It's killing us in a multitude of ways, ushering in cardiovascular disease, heart attacks and strokes. It's causing us to grossly overeat. The end result is more lives per year than cancer and AIDS put together . In fact the end-result of this disease is killing more people in one year than World War I and II, Vietnam and The Korean War combined. I'm talking about hyperinsulinemia Elevated blood pressure Elevated cholesterol levels, with a marked decrease in HDL Sky-high triglyceride levels Hardening of the arteries Adult-onset diabetes And the list goes on and on. So why have most people never heard of this condition? Good question, one I wish I had a good answer for, but I don't. Scientists and doctors have known for years that elevated insulin levels was deadly over the long-haul, yet few recommend actual dietary changes to their patients. Instead they let the insulin remain high, run it's course, and then put their patients on hypertensive medications, statin drugs, beta blockers, and eventually insulin itself as the pancreas literally stops producing it, worn out from the efforts.

47. Arch Fam Med -- Page Not Found 7;5356, January/February 1998, hyperinsulinemia in Hypertension AssociationsWith Race, Abdominal Obesity, and Hyperlipidemia, John G. Spangler, MD, MPH http://archfami.ama-assn.org/issues/v7n1/ffull/foc6034.html

Select Journal or Resource JAMA Archives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology Surgery MSJAMA Science News Updates Meetings Peer Review Congress The page you requested was not found. The JAMA Archives Journals Web site has been redesigned to provide you with improved layout, features, and functionality. The location of the page you requested may have changed. To find the page you requested, click here HOME CURRENT ISSUE PAST ISSUES ... HELP Error 404 - "Not Found"

48. PLASMA TOTAL HOMOCYSTEINE LEVELS IN SUBJECTS WITH HYPERINSULINEMIA TEKTRAN. PLASMA TOTAL HOMOCYSTEINE LEVELS IN SUBJECTS WITH hyperinsulinemia.Author(s) BARON H KIDRON M FRIELANDER Y BEN-YEHUDA http://www.nal.usda.gov/ttic/tektran/data/000012/59/0000125941.html

TEKTRAN PLASMA TOTAL HOMOCYSTEINE LEVELS IN SUBJECTS WITH HYPERINSULINEMIA Author(s): BAR-ON H KIDRON M FRIELANDER Y BEN-YEHUDA A SELHUB JACOB ROSENBERG IRWIN H FRIEDMAN G Interpretive Summary: Homocysteine is an amino acid which has important function in the body. How ever, it becomes harmful and results in an increased risk of heart disease when blood levels are elevated. We found that people with high blood levels of insulin, which is a sign of diabetes, also have low homocysteine levels. Although homocysteine is lower than in people with normal insulin levels, high homocysteine levels continue to be a risk for heart disease in these patients. Keywords: folate vitamin b12 b6 pyridoxal-5-phoshate homocysteine homocysteinemia sulphur amino acid b affinity hplc bioavailability dysplasia arteriosclerosis Contact: JEAN MAYER HUMAN NUTR. RE 711 WASHINGTON ST., TUFTS BOSTON MA 02111 FAX: Email: jselhub@hnrc.tufts.edu Approved Date: TEKTRAN United States Department of Agriculture Agricultural Research Service Updated:

49. Treatment With Flutamide Improves Hyperinsulinemia In Women Treatment with flutamide improves hyperinsulinemia in women. Treatment withflutamide improves hyperinsulinemia in women with idiopathic hirsutism. http://www.hairsite.com/_disc23/0000000c.htm

[_private/disc23_ahdr.htm] Treatment with flutamide improves hyperinsulinemia in women From: HairSite Date: 16 May 2000 Time: Remote Name: Comments Excerpt from Fertil Steril 1999 Sep;72(3):448-53 "Treatment with flutamide improves hyperinsulinemia in women with idiopathic hirsutism. Paoletti AM, Cagnacci A, Orru M, Ajossa S, Guerriero S, Melis GB Istituto di Ginecologia, Ostetricia e Fisiopatologia della Riproduzione Umana, Universita degli Studi di Cagliari, Italy. Flutamide From: leah Date: Time: 2:56:44 PM Remote Name: Comments Olga, flutamide isn't doing anything. it has been months. another hyped product. ive been advised to try Tacrilomus solution. will let you know. thanks, leah [_private/disc23_aftr.htm]

50. NEJM -- Familial Hyperinsulinemia Due To A Structurally Abnormal Insulin. Defini Original Article from The New England Journal of Medicine Familialhyperinsulinemia due to a structurally abnormal insulin. Definition http://content.nejm.org/cgi/content/short/310/20/1288

HOME SEARCH CURRENT ISSUE PAST ISSUES ... HELP Previous Volume 310:1288-1294 May 17, 1984 Number 20 Next Familial hyperinsulinemia due to a structurally abnormal insulin. Definition of an emerging new clinical syndrome M Haneda, KS Polonsky, RM Bergenstal, JB Jaspan, SE Shoelson, PM Blix, SJ Chan, SC Kwok, WB Wishner, A Zeidler, and et al. Table of Contents Find Similar Articles in the Journal Notify a friend about this article Add to Personal Archive ... Related Articles in Medline Articles in Medline by Author: Haneda, M. Medline Citation Abstract This article has been cited by other articles: O'Rahilly, S., Gray, H., Humphreys, P. J., Krook, A., Polonsky, K. S., White, A., Gibson, S., Taylor, K., Carr, C. (1995). Impaired Processing of Prohormones Associated with Abnormalities of Glucose Homeostasis and Adrenal Function. N Engl J Med [Full Text] HOME SEARCH CURRENT ISSUE ... HELP Comments and questions? Please contact us The New England Journal of Medicine is owned, published, and Massachusetts Medical Society

51. NEJM -- Hyperinsulinemia As An Independent Risk Factor For Ischemic Heart Diseas Original Article from The New England Journal of Medicine hyperinsulinemiaas an Independent Risk Factor for Ischemic Heart Disease. http://content.nejm.org/cgi/content/short/334/15/952

HOME SEARCH CURRENT ISSUE PAST ISSUES ... HELP Previous Volume 334:952-958 April 11, 1996 Number 15 Next Hyperinsulinemia as an Independent Risk Factor for Ischemic Heart Disease Table of Contents Full Text of this article PDF of this article Related Letters to the Editor ... Related Articles in Medline Articles in Medline by Author: Lupien, P.-J. Medline Citation Coronary Disease Endocrinology ... Related Chapters at Harrison's Online ABSTRACT Background Prospective studies suggest that hyperinsulinemia may be an important risk factor for ischemic heart disease. However, it has not been determined whether plasma insulin levels are independently related to ischemic heart disease after adjustment for other risk factors, including plasma lipoprotein levels. Methods In 1985 we collected blood samples from 2103 men from suburbs of Quebec City, Canada, who were 45 to 76 years of age and who did not have ischemic heart disease. A first ischemic event (angina pectoris, acute myocardial infarction, or death from coronary heart disease) occurred in 114 men (case patients) between 1985 and 1990. Each case patient was matched for age

52. Reuters Health Information (2002-12-03): Naloxone Improves Hyperinsulinemia In P Clinical. Naloxone improves hyperinsulinemia in postmenopausal women.Last Updated 200212-03 93018 -0400 (Reuters Health). NEW http://www.kissei.co.jp/mnews/gynecology/news/200212/20021203clin011.html

var viewer_width=276; var viewer_height=228; rl_values(viewer_width, viewer_height); Clinical Naloxone improves hyperinsulinemia in postmenopausal women Last Updated: 2002-12-03 9:30:18 -0400 ( Reuters Health NEW YORK ( Reuters Health ) - Treatment with the opioid antagonist naloxone decreases insulin secretion in postmenopausal women with hyperinsulinemia, according to a report published in the November issue of Fertility and Sterility Dr. Francesco Cucinelli, from the Catholic University of the Sacred Heart in Rome, and colleagues assessed the carbohydrate metabolic effects of naloxone in 21 postmenopausal women . Nine of the women had elevated blood insulin levels and 12 were normoinsulinemic. Glucose, insulin , and c-peptide levels were determined during fasting conditions and when oral glucose tolerance testing (OGTT) was performed with saline or naloxone . In both groups of women, OGTT was conducted before treatment , after receiving estrogen replacement therapy (ERT) for 12 week, and after receiving estrogen-progestin combined therapy (HRT) for 12 additional weeks. Compared with saline treatment naloxone treatment was associated with a significant reduction in the insulin response to OGTT in the hyperinsulinemic group but in not the normoinsulinemic group Furthermore, in hyperinsulinemic women, ERT increased

53. Treatment Of Hyperinsulinemia In Polycystic Ovary Treatment of hyperinsulinemia in polycystic ovary? MT Meamarzadeh. Obstetrics Gynecology Department, Iran Medical University, Tehran, Iran. http://www.erc-iran.com/iced/5/poster/Treatment of hyperinsulinemia in polycysti

Treatment of hyperinsulinemia in polycystic ovary? M.T. Meamarzadeh PCOS was a dilemma in infertility and internal medicine. So every day a new treatment is been examined and now oral antidiabetic drugs are in experience. Several drugs for treatment of hyperinsulinemia are investigated such as metformin, diazoxide and troglitazone. Metformin inhibits hepatic glucose production and enhances sensitivity to insulin in peripheral tissues. Nestler et al (1996) recently reported a reduction of ovarian cytochrome P450c17a activity on the amelioration of hyperandrogenism in obese PCOS patients treated with metformin. So we in my private clinic and university infertility center we tried to exam the effects of metformin in PCOS patients. The patiens who are going to be ovulated by induction are randomly divided into two groups, one group take metformin 500mg 3 times a day for 3 months ago befor induction ovulation and other group have not take this drug. I see that in the first group a good result of ovulation and pregnancy was seen in the first cycle. Conclusion:

54. FASTING HYPERINSULINEMIA, ANGINA PECTORIS, AND POST-MENOPAUSAL WOMEN Fasting hyperinsulinemia, angina pectoris, and postmenopausal women. YarahmadiSh, Larijani B, Nikdoost F, Sanati A, Pajouhi M, Bastanhagh http://www.erc-iran.com/iced/6/abstract/FASTING HYPERINSULINEMIA, ANGINA PECTORI

Fasting hyperinsulinemia, angina pectoris, and post-menopausal women Yarahmadi Sh , Larijani B , Nikdoost F , Sanati A , Pajouhi M , Bastanhagh MH, Javadi E ., Mahmoodi M , Baradar-Jalili R , Shafaie A , Zahedi F Endocrine and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran Introduction: The syndrome of angina or angina-like chest pain with a normal coronary arteriogram, often referred to as “syndrome x” by cardiovascular dysfunction and abnormal pain sensitivity are presented in patients. This syndrome demonstrated a spectrum ranging from normal coronary arteries to atheromatous plaque. On the other hand, the insulin resistance syndrome (The metabolic syndrome) is also responsible for a large number of CVD cases. The association between “syndrome X” and insulin resistance syndrome needs to be investigated. The aim of this study was to examine hyperinsulinemia as a manifestation of insulin resistance in postmenopausal women. A total of 149 post-menopausal women matched for age (48-58 years) and duration of menopause period were examined for sex hormones, fasting insulin, blood pressure, and body mass index (BMI) in this study. Subjects with clinical angina pectoris with normal (Angio-, n=50) and abnormal (Angio+ group n=50) arteriogram compared to healthy (control, n=49) subjects. Results: FSH, LH, Estradiol and progesterone concentrations and FSH/LH ratio were similar among three groups. Both Angio (-) and Angio (+) groups had greater BMI compared to controls. Fasting insulin concentration was significantly higher in both Angio (-) and Angio (+) groups than in controls (123.78

55. Fasting Hyperinsulinemia In Human Immunodeficiency Virus- Click here to return to AIDSLINE main menu Fasting hyperinsulinemia in human immunodeficiencyvirusinfected men relationship to body composition, gonadal http://www.aegis.com/pubs/aidsline/2000/apr/A0040800.html

Important note: Information in this article was accurate in 2000. The state of the art may have changed since the publication date. Fasting hyperinsulinemia in human immunodeficiency virus-infected men: relationship to body composition, gonadal function, and protease inhibitor use. J Clin Endocrinol Metab. 2000 Jan;85(1):35-41. Unique Identifier : AIDSLINE MED/20097826 Hadigan C; Corcoran C; Stanley T; Piecuch S; Klibanski A; Grinspoon S; Neuroendocrine Unit, Massachusetts General Hospital and Harvard; Medical School, Boston, 02114, USA. Abstract: Keywords: CLINICAL TRIAL JOURNAL ARTICLE Adipose Tissue/PHYSIOLOGY Adult Analysis of Variance Blood Glucose/METABOLISM Body Composition/DRUG EFFECTS/*PHYSIOLOGY Cross-Sectional Studies CD4 Lymphocyte Count Human Hyperinsulinism/*BLOOD HIV Infections/*BLOOD/DRUG THERAPY HIV Protease Inhibitors/*ADVERSE EFFECTS/THERAPEUTIC USE Insulin Resistance Longitudinal Studies Male Phenotype Support, U.S. Gov't, P.H.S. Testosterone/*BLOOD National Library of Medicine . Reproduced under license with the National Library of Medicine, Bethesda, MD. AEGiS is made possible through unrestricted grants from Boehringer Ingelheim iMetrikus, Inc.

56. Endotext.com - Diabetes, Insulin Resistance, Hyperinsulinemia, And Coronary Hear http://www.endotext.com/diabetes/diabetes9/diabetesframe9.htm

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57. Hyperinsulinemia And Carotid Atherosclerosis Risk factors and carotid atherosclerosis in hypertensive and control subjects. Prev,Chapter 5. Results, Next. 5.4. hyperinsulinemia and carotid atherosclerosis. http://herkules.oulu.fi/isbn9514264657/html/chapter5_4.html

Risk factors and carotid atherosclerosis in hypertensive and control subjects Prev Chapter 5. Results Next 5.4. Hyperinsulinemia and carotid atherosclerosis Data on parameters of fasting insulin and insulin response in the OGTT and carotid artery ultrasonography were available for 518 control and 513 hypertensive subjcts. Various parameters and calculated variables of fasting insulin and insulin response in the OGTT are shown in Table 2. The maximal IMT values and the mean and far-wall IMT and CPIMT values were presented above in 5.3. et al. 1985) and the area under curve (trapezoidal method), were statistically tested with IMT. The most powerful and most consistent predictor of IMT among the different insulin parameters in stepwise regression analyses was the 2-hour post-load insulin, which was used in the following analyses alone without any other insulin parameters in order to prevent multicollinearity. In the control groups 2-hour insulin had a weak non-significant positive correlation with IMT, but in the hypertensive groups it had a weak non-significant negative correlation with IMT. To determine whether an independent association between IMT and the different insulinemic measures existed, multiple forward and backward stepwise regression analyses (Table 9) were performed with different IMT parameters as the dependent variables and age, pack-years of smoking, LDL cholesterol, systolic BP and 2-hour insulin (data on serum 1-hour and 2-hour insulin concentrations, ISI, IRI and insulinemic area under curve not shown) as the independent variables. The independent variables were selected on the basis of predictive power and consistency in the different groups. Age was the most powerful independent predictor of IMT in all analyses and most consistently in the study groups (R

58. Endotext.com - Diabetes, Insulin Resistance, Hyperinsulinemia, And Coronary Hear http://www.mdtext.com/diabetes/diabetes9/diabetesframe9.htm

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59. Relationship Among Hyperinsulinemia, Insulin Resistance, And Hypertension Is Dep SignUp Sheet Relationship among hyperinsulinemia, insulin resistance,and hypertension is dependent on sex. AJP 283H562-H567 Follow http://www.csupomona.edu/~lafoster/Sign-Upsheet/33.html

Sign-Up Sheet Relationship among hyperinsulinemia, insulin resistance, and hypertension is dependent on sex. AJP 283:H562-H567 Follow Ups Post Follow Up Sign-Up Sheet Posted by Vanessa Padilla on October 07, 202 at 21:41:23: Follow Ups: Post a Follow Up: Name: E-Mail: Subject: Comments: Follow Ups Post Follow Up Sign-Up Sheet

60. Cortisol,Hyperinsulinemia,Fatigue,Depression,etc. Cortisol,hyperinsulinemia,Fatigue,Depression,etc. Follow Ups Re Cortisol,hyperinsulinemia,Fatigue,Depression,etc.pamela 154537 10/30/2002 (0) http://www.hhumor.com/ironman/wwwboard/messages/1235.html

Cortisol,Hyperinsulinemia,Fatigue,Depression,etc. Follow Ups Post Followup IRONMAN BLOOD BANK Posted by Isabelle on October 30, 2002 at 13:47:19: Thanks so much for all your posts...As soon as I get a chance I will follow-up on your suggestions. I think I should go to an Endocrinologist. To find one in this area that is competent will be a challenge. I may have to go to the Western Shore and the research will take a little time. Regards, I always wish you the best, Isabelle. Follow Ups: Re: Cortisol,Hyperinsulinemia,Fatigue,Depression,etc. pamela Post a Followup Name: E-Mail: Subject: Comments: : Thanks so much for all your posts...As soon as I get a chance I will follow-up on your suggestions. I think I should go to an Endocrinologist. To find one in this area that is competent will be a challenge. I may have to go to the Western Shore and the research will take a little time. Regards, I always wish you the best, Isabelle. Your Web Site URL (optional): Your Site Name (optional): Add Image URL (optional): Follow Ups Post Followup IRONMAN BLOOD BANK

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