81. Dorlands Medical Dictionary hyperinsulinemia (hy·per·in·su·lin·emia) (hi²pschwarin²sschwa-licaron-ne¢me-schwa)excessively high blood insulin levels. 3. hyperinsulinemia. http://www.mercksource.com/pp/us/cns/cns_hl_dorlands.jspzQzpgzEzzSzppdocszSzuszS

82. Tim Kieffer's Lab Many studies indicate that hyperinsulinemia might precede the development of obesity,and may itself be an independent risk factor for ischemic heart disease http://www.physiology.ualberta.ca/kieffer.htm

Timothy J. Kieffer Assistant Professor (Ph.D., University of British Columbia Overview The overall focus of this laboratory is to understand the connection between obesity and type 2 diabetes mellitus. It is currently estimated that 30-35% of the North American population is morbidly obese, and these individuals are at increased risk for cardiovascular disease, stroke, many forms of cancer, and diabetes. Many studies indicate that hyperinsulinemia might precede the development of obesity, and may itself be an independent risk factor for ischemic heart disease, obesity, and diabetes. Investigations aimed at understanding the mechanisms involved in the development of hyperinsulinemia are therefore critical. Program 1 The recently discovered obesity hormone leptin is produced by adipose tissue and acts at the hypothalamus to reduce food intake and to increase energy expenditure. It is currently believed that the elevated levels of leptin in obese individuals reflect defective leptin reception and thus a failure to receive the satiety signal. In the genetic mutant mouse models ob/ob or db/db, leptin deficiency or resistance, respectively, results in severe obesity and a syndrome resembling type 2 diabetes. As in obese humans, one of the earliest manifestations in these mice is hyperinsulinemia, and remarkably, both hyperinsulinemia and hyperglycemia are reduced in leptin-deficient ob/ob mice treated with leptin. These acute changes cannot be entirely ccounted for by alterations in food intake or body weight. These findings suggest that leptin may normally regulate plasma concentrations of insulin and glucose.

83. Pawprint | Critter Central | Hefty 'Hogs Hedgehogs hyperinsulinemia. Simplified a bit, in humans, hyperinsulinemia is adisorder that leads to an overabundance of insulin being released when eating. http://www.pawprintonline.com/central-hedgehog-hefty.html

Hefty 'Hogs By David Flack OnLine Store Breeding ... Album Quick Find Order Now Home Contact Us Site Map Simply stated, an overweight hedgehog is not a healthy animal. The three most common reasons for hefty hedgies are: Overfeeding Most pets get too much food! Be sure you aren't overfeeding your spiny pal. Also, we strongly recommend against free choice feeding. Most hedgehogs eat as long as food is available. Even with quality food choices, this can quickly lead to overweight pets. So, be sure you feed acontrolled quantity of quality food and no more! For more on this topic, visit Hedgehogs 101 Poor food choices Cat food, high-fat foods or other poor choices are likely to lead to weight problems, as well as other health concerns. Also, be sure you aren't overfeeding treats! This is especially important while your pet is dieting. For more on this topic, visit Lack of exercise Hedgehogs needs lots of opportunities for exercise. Daily out-of-cage play time and a roomy enclosure are important for the health of your pet. Also, be sure to provide a safe exercise wheel for your pet. Here at PAWPRINT , we use and recommend the Haba Safety Wheel For more on this topic, visit

84. APStracts 8:0109E, 2001. Effects of antecedent hypoglycemia, hyperinsulinemia, and excess corticosteroneon hypoglycemic counterregulation. Shum, Kathy, Karen http://oac3.hsc.uth.tmc.edu/apstracts/2001/endo/June/109e.html

Effects of antecedent hypoglycemia, hyperinsulinemia, and excess corticosterone on hypoglycemic counterregulation. Shum, Kathy, Karen Inouye, Owen Chan, Julian Mathoo, Debra Bilinski, Stephen G. Matthews, and Mladen Vranic. Departments of 1Physiology, 2Obstetrics and Gynecology, and 3Medicine, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 1A8 APStracts 8:0109E, 2001.

85. "Type 2 Diabetes And Insulin Resistance: What You Need To Know" What is hyperinsulinemia? She writes she's just gone to a doctor who thinks thatshe may have hyperinsulinemia and is trying to find out more about that. http://www.healthtalk.com/den/110101/26.html

(view a sample) "Type 2 Diabetes and Insulin Resistance: What You Need To Know" November 1, 2001 page 26 of 30 What is hyperinsulinemia? Real Player Windows Media Gina: I've got an interesting question here from Cynthia, an e-mail question from Boise. She writes she's just gone to a doctor who thinks that she may have hyperinsulinemia and is trying to find out more about that. Dr. Beaser, what is that? Dr. Beaser: Well, hyperinsulinemia is another term that I think he's using to refer to insulin resistance. What I described earlier in my description of what's causing the hyperglycemia, the high blood sugar in type 2 diabetes, is that you have insulin resistance, and the body tries to overcome that by making more than a normal amount of insulin. Now, if the body is successful in making enough insulin to match the needs imposed by the insulin resistance, then the blood sugars are normal. If they can't make enough insulin, then the blood sugars are high. In this case, I'm just guessing, but it sounds like the patient may have insulin resistance and be able to make enough insulin to normalize the sugar, but if you were to measure the insulin level, it would be more than normal, and that's what the doctor is referring to as hyperinsulinemia. Usually we don't go measuring insulin levels in the office. It's more of a diagnosis of assumption if you have somebody that has a family history and other components of the dysmetabolic syndrome that Dr. Schnure referred to. But it's a term I think that's probably referring to the insulin resistance syndrome.

86. Insulin Resistance Suspect In Hypertension The resulting hyperinsulinemia can be responsible for an array of untoward effectsthat predispose the patient to other cardiovascular complications. http://www.powerpak.com/PowerGraphs/1997/November/InsulinResistance.cfm

November 1997 Vol 1. No 4. Insulin Resistance Suspect in Hypertension Insulin resistance, an impaired response to normal amounts of insulin, occurs in half of all patients with essential hypertension and is suspected as a major cause of such hypertension. It is a significant factor in 90% of patients with diabetes and is seen in up to 20% of non-diabetics. The reduced response to insulin, in addition to problems attendant to dysfunctional glucose metabolism as a precursor to diabetes, usually stimulates the pancreas to deliver and maintain insulin levels that are considerably higher than normal; and one theory suggests that diabetes is likely to ensue simply because the islet cells must work so much harder that they simply wear out. Ingestion of food normally produces a temporary increase in activity of the sympathetic nervous system evidenced by higher levels of norepinephrine detectable in the urine. The sustained higher levels of insulin in the insulin resistant, though, perpetuate this elevated norepinephrine level, mimicking the effects of ingesting a meal and maintaining a higher level of sympathetic stimulation, which of course can result in elevated blood pressure. In addition, the higher levels of insulin increase sodium reabsorption in the kidneys (also detectable by lower sodium levels in the urine) which contributes to elevated blood pressure by increasing blood levels of sodium. A number of factors have been shown to contribute to the development of hyperinsulinemia, not the least of which is advancing age. It appears that in spite of increased sympathetic nervous system stimulation, which would presume peripheral vasoconstriction, hyperinsulinemia also causes a concomitant direct dilation of blood vessels which has yet to be explained. This paradoxical dilation, assumed a compensatory mechanism, is notably reduced in the elderly and the level of sympathetic nervous activity is also increased in the elderly.

87. Diagnose-Me: Conditions: Elevated Insulin Levels Elevated insulin levels (hyperinsulinemia) cause the body to have difficulty breakingdown fat also. hyperinsulinemia often predates diabetes by several years. http://www.diagnose-me.com/cond/C312817.html

Home FAQ Start The Analyst Last updated: Dec 20, 2002 Elevated Insulin Levels Signs, symptoms and indicators Conditions that suggest it Contributing risk factors Other conditions that may be present ... Chronic exposure to refined carbohydrates and simple sugars can cause elevated levels of insulin , which drives glucose levels down. This can result in hypoglycemia (low blood sugar). Over time, tissues may become less sensitive to insulin and as a result glucose cannot enter the cells as easily. This means more glucose in the bloodstream and a greater tendency to convert it into fat instead of energy. Elevated insulin levels (hyperinsulinemia) cause the body to have difficulty breaking down fat also. Indications of hyperinsulinemia include weight gain (especially around the waste producing the apple shape, not the pear shape), increased blood pressure and cholesterol . Testing for elevated insulin levels can be an important step toward better health, and the prevention of diabetes and chronic disease processes later in life. Lab Values - Common High systolic blood pressure High diastolic blood pressure Symptoms - Hair Early male pattern baldness Although early baldness on the top of the head may be a non-modifiable risk factor for heart disease, it may serve as a useful clinical marker to identify men at increased risk of

88. ScienceDaily News Release: High Blood Levels Of Insulin Possible Independent Pre In today's Circulation Journal of the American Heart Association, Finnish researcherssay measuring a person's extent of hyperinsulinemia a condition that http://www.sciencedaily.com/releases/1998/08/980814065131.htm

Search Our Archives Keywords: Order by: date relevance More options Get ad-free access with email updates sign up or log in Text size: A A A Welcome Home page About this site Awards, reviews News Summaries Headlines Topics Shop Our stuff Browse books Magazines Software Contribute Register free Post release Edit profile Review hits Advertise Media kit Traffic stats Contact us Previous Story ... Related Stories Next Story Source: American Heart Association Date: High Blood Levels Of Insulin Possible Independent Predictor Of Heart Attack Risk DALLAS, Texas, Aug. 4, 1998 Many people with diabetes develop heart disease, but a new study says that determining who has high levels of insulin in the blood a condition that precedes diabetes may better predict who is at risk for having a heart attack. When compared to other risk factors, insulin levels were the most statistically significant predictor of heart attack risk during the study. As participants in the study grew older, blood pressure became a significant predictor. After the first 10 years of the study, smoking predicted heart attack risk. The researchers say that body mass index, blood levels of the fat triglyceride, and physical inactivity showed no association to heart attack risk. The study was based on a group of 970 men, 34 to 64 years of age, who were free of cardiovascular disease and diabetes. During the 22-year span of the study, 164 of them had a heart attack.

89. Article: Insulin Resistance A frequent feature of women with PCOS is insulin resistance accompanied bycompensatory hyperinsulinemia, and increasing evidence suggests that http://sharedjourney.com/articles/insulin.html

Fertility: An Insulin Resistance Problem? JOHN E. NESTLER, MD Polycystic Ovary Syndrome: The Insulin Story The polycystic ovary syndrome (PCOS) is a prevalent disorder affecting ~6% of women of reproductive age, and is characterized by anovulation and hyperandrogenism. A frequent feature of women with PCOS is insulin resistance accompanied by compensatory hyperinsulinemia, and increasing evidence suggests that hyperinsulinemia play an important role in the pathogenesis of PCOS. Hyperinsulinemia produces hyperandrogenism in women with PCOS via two distinct and independent mechanisms: 1) by stimulating ovarian androgen production, and 2) by directly and independently reducing serum SHBG levels. The net result of these actions is to increase circulating free testosterone concentrations. An inherent (genetically determined) ovarian defect likely is present in women with PCOS, which makes the ovary either susceptible to or more sensitive to insulin’s stimulation of androgen production. Limited evidence suggests that hyperinsulinemia might also promote ovarian androgen production by influencing pituitary release of gonadotropins, but this has not been critically evaluated. In addition to promoting hyperandrogenism, recent evidence indicates that hyperinsulinemia contributes to the anovulation of PCOS. Hyperinsulinemia could adversely affect folliculogenesis and impede ovulation by increasing intraovarian androgen production, altering gonadotropin secretion, or directly affecting follicular development.

90. STOP-NIDDM - Study Rationale It is generally accepted that insulin resistance with hyperinsulinemiais a first abnormality leading to the development of type 2 diabetes. http://www.stop-niddm.com/study/intro.htm

STOP-NIDDM (Study to Prevent non insulin dependent diabetes) The STOP-NIDDM study is the first international study in subjects with Impaired Glucose Tolerance (IGT) investigating the primary prevention of type 2 diabetes comparing pharmacological intervention to placebo for a treatment duration ranging from three to five years. Rationale It is generally accepted that insulin resistance with hyperinsulinemia is a first abnormality leading to the development of type 2 diabetes. As long as the beta cells can compensate by increased insulin secretion, normal glucose tolerance will be maintained. It is only with the appearance of beta cell defect resulting in decreased insulin secretion capacity that abnormal glucose tolerance will develop resulting in IGT and, with further deterioration of the beta cell, in type 2 diabetes. It is also accepted that insulin resistance and hyperinsulinemia precede the development of arterial hypertension and a number of studies have suggested a cause and effect relationship. In fact improvement of insulin resistance with decreased hyperinsulinemia is associated with a reduction in blood pressure. IGT, type 2 diabetes, and hypertension have one thing in common: insulin resistance and hyperinsulinemia. In fact, a number of studies have suggested that insulin resistance with hyperinsulinemia could be causally related to atherosclerosis and cardiovascular disease.

91. An Interview With Gerald Reaven Syndrome X -The Risks Of Insulin Resistance Syndrome X is, therefore, insulin resistance plus compensatory hyperinsulinemia,which prevents the evolution into type 2 diabetes. http://www.cacr.ca/news/2000/0009reaven.htm

about us education HeartTalk jobs ... Newsletter September An Interview with Gerald Reaven: Syndrome X : The Risks of Insulin Resistance Gerald Reaven, M.D., is Professor Emeritus (Active) of Medicine at Stanford University. He has served as director of the Division of Endocrinology and Metabolism, the Division of Gerontology, and the combined Divisions of Endocrinology-Metabolism-Gerontology at Stanford's School of Medicine. He first described Syndrome X at the 1988 Banting Lecture of the annual meeting of the American Diabetes Association. CACR newsletter editor Louise Morrin spoke to him by phone in Palo Alto California. Q: What is insulin resistance and how does it lead to Syndrome X? A: and compensatory hyperinsulinemia, to result in the various manifestations. Q: How do the terms "the lipid triad" or "the metabolic syndrome" relate to Syndrome X? A.

92. Granum: Julkaisun Tiedot Obesity, hyperinsulinemia and atherosclerotic cardiovascular diseases HannaMaariaLakka(diss) 113 s. Hinta 18.15 EUR + mahdolliset postikulut 2001 951-781-848 http://granum.uta.fi/cgi-bin/tuote.cgi?6199

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