1. IMMUNE DEFICIENCIES immune deficiencies. Meg Reitmeyer, MD. November 21, 1996. immune deficiencieshave become hotbeds of scientific investigation due to the AIDS epidemic. http://hsc.virginia.edu/medicine/clinical/internal/conf/chiefs/immune.htm

IMMUNE DEFICIENCIES Meg Reitmeyer, M.D. Clinical Medicine Conference November 21, 1996 Immune deficiencies have become hotbeds of scientific investigation due to the AIDS epidemic. Research on all aspects of the immune system is booming with exciting new discoveries of the genetics and biochemistry of this intricate process. Defects in the immune system may occur due to genetic anomalies (primary) or be acquired by a vast array of mechanisms. While there are many natural reasons for immunosuppression (malignancies, bone marrow disease, HIV), iatrogenesis causes a number of problems as well. This handout will first briefly outline a sample of primary immunodeficiencies followed by a discussion on acquired immunodeficiencies. The table on the last page summarizes the basic information. Primary Immunodeficiencies X-linked agammaglobinemia This is a pure B cell syndrome with basically no circulating B cells in the blood. There is normal T cell function. The male infants are usually protected by passively transferred maternal antibodies during the first 9-12 months of life, but they then develop recurrent pyogenic infections including sinusitis, pneumonia and otitis media. The primary causative agents are Streptococcus pneumoniae and Hemophilus influenzae . Long-term sequaelae such as COPD and bronchiectasis are common. Persistent viremia especially with enterovirus is problematic. The chronic enteroviremia can lead to chronic meningitis or a skin condition resembling dermatomyositis. These children may also develop polio after exposure to the live vaccine and suffer from chronic giardiasis. Up to 35% complain of a large joint arthritis that resolves with gammaglobulin and is thought to be due to a mycoplasma type organism such as Ureaplasm. The underlying defect is a mutation of the B cell tyrosine kinase (btk) gene. Serum analysis shows less than 100 mg/dL of IgG and no detectable IgM or IgA. Patients are treated with monthly or biweekly gammaglobulin for a total of 350-500 mg/kg/month. There is a risk of hepatitis C, and there are several reports of outbreaks due to contaminated batches.

2. IPOPI - International Patient Organisation For Primary Immunodeficiencies There are a wide variety of primary immune deficiencies. . . (more). Sponsored by Bayer http://www.ipopi.org/

3. Pediatric Primary Immune Deficiency Home Page Pediatric Primary immune deficiencies range from selective IgA deficiency to Severe Combined Immune deficiency (SCID). http://www.pedpid.com/

Pediatric Primary Immune Deficiencies range from selective IgA deficiency to Severe Combined Immune deficiency (SCID). There are over 70 recognized forms of primary immune deficiencies. PID's can be inherited (x-linked). Primary Immune Deficiency is a deficiency in one or more immune globulin or blood antibody levels. Pediatric PID patients are treated with frequent doses of antibiotics, many have permanently inserted IV devices, often have accompanying autoimmune diseases, gastrointestinal diseases as well as pulmonary disease. Many are receiving intravenous immune globulin every 3-4 weeks to replace the antibodies and cells that are deficient in their immune system. Many children with primary immune deficiencies are restricted in their environment and sometimes home schooled to avoid contagious situations. If a child is diagnosed at birth or soon after with a severe combined immune deficiency they can receive a bone marrow transplant with hopes of reconstituting their missing immune system. Many children with SCID are not diagnosed in time and die before their 1st birthday. This site hopes to focus on the education of primary immune diseases in children and their particular situations. We call them our "PID Pumpkins".

4. Www.foodsafety.gov - Consumer Advice: People With Immune Deficiencies for Persons with AIDS or Other immune deficiencies. Federal Government Web Sites http://www.foodsafety.gov/~fsg/immuned.html

Consumer Advice for Persons with AIDS or Other Immune Deficiencies Federal Government Web Sites Food Safety for Persons with AIDS (FSIS) Eating Defensively (FDA) Guidance for People with Severely Weakened Immune Systems Preventing Infections During Travel (CDC) Safe Food and Water (CDC) Additional links to federal, state and local government agencies. www.FoodSafety.gov Privacy Accessibility Webmaster

5. Immune Deficiencies immune deficiencies Physical barrier Hypoperfusion Granulocyte dysfunction Manthey Immunocompromised Previous slide Next slide Back to first slide View graphic version http://www.cdi.pub.ro/CDI/Medical/disc20/tsld043.htm

Immune Deficiencies Physical barrier Hypoperfusion Granulocyte dysfunction Manthey - Immunocompromised Previous slide Next slide Back to first slide View graphic version

6. IMMUNE DEFICIENCIES-Medfacts-National Jewish Medical And Research Center immune deficiencies MedFact From National Jewish Medical and Research Center 1 Respiratory Hospital in America. Search our website, immune deficiencies. http://www.nationaljewish.org/medfacts/immune.html

IMMUNE DEFICIENCIES Our immune system is the body's defense against infections and other foreign invaders. Infections can result from being exposed to bacteria, viruses, fungi and parasites which are in our environment. Fortunately, most of these invaders never get past the body's natural barriers such as the skin, hair, secretions of the stomach and the mucus linings of the nose and lungs. Occasionally, a few do break through the natural barriers and are confronted by our immune system. The immune system has two major functions: 1. To recognize substances that are foreign to the body, and 2. To react to them. An immune system that is functioning adequately may defend the body from infectious microorganisms (bacteria, viruses, fungi and parasites) and protect the body from the development of tumors and cancer. The two mechanisms within the body that provide these defenses are the specific immune response involving the T cells, B cells and immunoglobulins and the nonspecific responses. Unfortunately, some individuals have a weakened or absent immune system that is unable to recognize and react to foreign substances. The immune system's ability to kill invading microorganisms and limit the spread of infections may not be functioning well.

7. NORD - National Organization For Rare Disorders, Inc. Offering discussions, resources, links, and synonyms for many immune deficiencies. http://www.rarediseases.org/

Search NORD's Databases NORD maintains three searchable databases and an alphabetical index of disease names. Index of Rare Diseases The A-to-Z of Rare Diseases Rare Disease Database Read about more than 1,100 rare diseases. View sample report Organizational Database Find a support group or other source of help. Orphan Drug Designation Database Find out about new and experimental orphan products. Database Subscriptions Subscriptions provide complete access to NORD's databases at libraries, schools, universities, and hospitals. NORD's Washington Office Read about events on Capitol Hill, funding for rare-disease research, and other topics of interest from NORD's office in Washington, DC. It’s NORD’s 20th Anniversary! NORD has been representing patients and families affected by rare diseases since 1983. ( Go to story Save the Date for 20th Anniversary Gala! The NORD 2003 Tribute Banquet will be on Monday, May 19, at the Capital Hilton Hotel in Washington, DC. This will be a special event in honor of NORD's 20th anniversary. Additional information Congressman Mark Foley (R-FL) with NORD President Abbey Meyers at the 2002 Tribute Banquet.

8. CIPO - What Are Primary Immune Deficiencies ? What are Primary immune deficiencies? Primary immune deficiency diseases(PiDs) are inherited disorders in which part of the body's http://cipo.net/english/pids.htm

Canadian Immunodeficiencies Patient Organization Contact Us Events Guest Book Links ... Home What are Primary Immune Deficiencies? Primary immune deficiency diseases (PiDs) are inherited disorders in which part of the body's immune system is missing or does not function properly. AID's is NOT a PiD. The World Health Organization recognizes approximately 70 primary immune deficiencies including X-Linked Agammaglobulinemia (Bruton's Disease), Common Variable Immune Deficiency (also called CVID or Hypogammaglobulinemia), Selective IgA Deficiency, Severe Combined Immune Deficiency (SCID) and many others.

9. KIDS Foundation Of New Zealand Inc Offer support to children and adults with primary immune deficiencies, immune defects and related blood disorders. http://www.pidsnz.co.nz/home.htm

This page uses frames, but your browser doesn't support them.

10. Immune Deficiencies Check out brief NOTES HERE for more information on immune deficiencies. http://hyper.vcsun.org/HyperNews/mhighfield/get/hs302A/hypoim.html

HSci302A-Pathophysiology HSCi302A Discussion Immune Deficiencies: HypoImmunity Instructions: Using your text or other credible sources answer the following questions. Give a thorough answer that you think will help others in preparing for the exam. As always, ask questions if you have them. Check out brief NOTES HERE for more information on immune deficiencies. Messages Display All Outline All ?Jim Blake, your new patient, has acquired immunodeficiency disease as a result of HIV infection. by meh, 1999, Oct 30 ?Does he have a primary or secondary immunodeficiency? Why? , 1999, Oct 30 re:a primary or secondary immunodeficiency by Susanna Adame, Oct 19, 15:15 re: re:a primary or secondary immunodeficiency by marleen hafer, Nov 07, 18:36 Secondary is one that is a result of some other problem (e.g., HIV infection) by mefh, Oct 26, 21:31 ?To what type of infections is the body more susceptible if there is a T-cell deficiency? What about a B-cell deficiency , 1999, Oct 30 re: ?To what type of infections is the body more susceptible if there is a T-cell deficiency? What about a B-cell deficiency by Wan Poovaviranon, Oct 19, 15:46 re: re: ?To what type of infections is the body more susceptible if there is a T-cell deficiency? What about a B-cell deficiency

11. Immune Deficiency Foundation - Illinois Chapter Includes resources and support for patients with various Primary immune deficiencies (PID). Features meeting and events calendar, publications and videos. http://my.inil.com/~lemur/

12. Viacell.com :: Home Involved in the development of treatments for cancer, genetic diseases, immune deficiencies and neurological diseases. http://www.viacellinc.com

Learning More, Doing More Selective Amplification

13. IPOPI - International Patient Organisation For Primary Immunodeficiencies Summer 2000. Chairperson’s Report GENE THERAPY OF immune deficiencies.We are privileged to witness the work of Professor Alain http://www.ipopi.org/publications/update/2000summer/01.htm

Summer 2000 Chairperson’s Report: GENE THERAPY OF IMMUNE DEFICIENCIES We are privileged to witness the work of Professor Alain Fischer and his team in Paris who have created a medical milestone for a significant group of children affected by primary immunodeficiency disorders. Professor Fischer, we salute you and hope you wear our honour of you with pride. Of course, this therapeutic method can be applied to hereditary immune deficiencies once the gene of the specific disease is known. It is the case today for a large number of immune deficiencies, since we know the genetic origin of more than 40 hereditary immune deficiencies, especially those of the most severe forms. The classical treatment of this disease is allogeneic of bone marrow transplantation. When there is an identical HLA donor this therapy is efficient in most cases, so that there is no need for another form of treatment. On the other hand, in all the other cases (more than 8 patients out of 10) the result obtained by the bone marrow transplants is not satisfactory enough. This justifies the efforts to develop a gene therapy. Six years ago, we decided to try to establish such a form of treatment, considering the severity of the disease (cf supra), and considering the fact that this disease constitutes a situation where the chances of success of the gene therapy are greater than those met in other diseases.

14. The Life Sciences Institute Of Mind-Body Health:Immune Deficiencies immune deficiencies. It is now been established that the brain and the immunesystem communicate directly with each other on every biological level. http://www.cjnetworks.com/~lifesci/immune_defic.htm

Immune Deficiencies It is now been established that the brain and the immune system communicate directly with each other on every biological level. Stress and depression are known to interfere with immune competence through both neural and chemical mechanisms. Conversely, the immune system can be enhanced through a variety of self-regulation strategies has captured the attention of researchers and treaters alike. We have pioneered application of concepts within the domain of "psychoneuroimmunology" in helping many individuals to resolve problems in this area. Autonomic Control Breathing Visualization and Imagery Diet ... Urinary Incontinence

15. The Life Sciences Institute Of Mind-Body Health: Self-Regulation For Immune Syst Related Disorders Addictive Disorders Attention Deficit Disorder Closed HeadInjury Depression and Anxiety immune deficiencies Urinary Incontinence http://www.cjnetworks.com/~lifesci/immu.htm

Self-Regulation for Immune System Disorders Patricia Norris, Ph.D., Life Sciences Institute of Mind-Body Health, Topeka, Kansas Introduction Protocol - A Wellness Model Nutrition Exercise ... Urinary Incontinence

16. Buy The Research Report "Primary Immune Deficiencies - An Overview" Buy The Rese What are Primary immune deficiencies? Primary immune deficiency diseases (PiDs) are inherited disorders in which part http://redirect-west.inktomi.com/click?u=http://www.findmarketresearch.com/marke

17. Glutamine And Immune Deficiencies (HIV/AIDS) The Benefits of the Immune System Booster. Immune System Booster Product 122in Economysize jar and Product 110 as single dose packs) is recommended. http://www.cambridgenutra.com/consumers/immune.shtml

Nutritional Management of Patients requiring Cellular Immunity Support: - HIV, AIDS and others The Benefits of the Immune System Booster Usage Recommendations Recommended Products Syst-Amune Glutamine -Enhanced Antioxidant Formula 650 gram jar Syst-Amune Glutamine - Single Dose Packets Sympt-X Plain Glutamine - Regular Formula (480 gram jar) Sympt-X G.I. Glutamine Regular Formula - Single Dose Packets The Benefits of the Immune System Booster The function of our intestinal tract is to absorb nutrients and calories and to protect our bodies from foreign substances that enter the G.I. tract. Preserving one's intestinal integrity and function is critical to maintaining or gaining weight and protecting against infection. Glutamine has been shown to play an important role in the nutritional management of patients with HIV and AIDS. HIV is known to grow in the cells that line the small intestine - especially in the lower part (the ileum). Functional loss of the ileum results in poor absorption of many nutrients. Tests among people with AIDS demonstrate lower levels of vitamins, bile acids and essential lipids in their bodies. When absorption of essential nutrients is poor, immunity is lowered, allowing bacteria and pathogens to invade the intestinal cells and cause irritation, malabsorption and diarrhea.

18. Glutamine And Immune Deficiencies (HIV/AIDS) Disease States immune deficiencies. Syndrome. Cancer Treatment duringchemo/radiation. immune deficiencies - HIV, AIDS and Other. Food http://www.cambridgenutra.com/consumers/immune.html

Disease States: Immune Deficiencies The Benefits of the Immune System Booster Testimonials Dosage Recommendations Recommended Products Special Immune Deficiency Formula - 650 gram jar Immune Deficiency Formula - Single Dose Packets 100% Pure Powdered Glutamine - (480 gram jar) Rapid Release Glutamine Crystals - Single Dose Packets Important Synergistic Supplements Coenzyme-Q10 - (100 capsules) - (60 capsules) Acidophilus/ Bifidus/FOS - (90 capsules) Carnitine - (60 capsules) The Benefits of the Immune System Booster The function of our intestinal tract is to absorb nutrients and calories and to protect our bodies from foreign substances that enter the G.I. tract. Preserving one's intestinal integrity and function is critical to maintaining or gaining weight and protecting against infection. Glutamine has been shown to play an important role in both of these conditions which are vital in the treatment of HIV and AIDS. HIV is known to grow in the cells that line the small intestine - especially in the lower part (the ileum) Functional loss of the ileum results in poor absorption of many nutrients. Tests among people with AIDS demonstrate lower levels of vitamins, bile acids and essential lipids in their bodies. When absorption of essential nutrients is poor, immunity is lowered, allowing bacteria and pathogens to invade the intestinal cells and cause irritation, malabsorption and diarrhea. The thin layer of cells that line the intestinal tract are the only defense against the millions of microbes and bacteria that are found in the G.I. tract

19. Immune Deficiencies Inherited immune deficiencies. This module will help immune deficienciesare associated with recurrent infections. A battery of tests http://microvet.arizona.edu/Courses/MIC419/SystemModules/deficiencies.html

System Modules SystemModules ToolBox Abbreviations Glossary Inherited Immune Deficiencies This module will help you understand the immune system better by looking at the impact of immune deficiencies. l earn some of the characterized congenital immune deficiency diseases. t est your knowledge and immunology problem-solving skills. Congenital deficiencies in immune effector mechanisms have contributed greatly to our understanding of the immune system. For example, children born with DiGeorge's syndrome who were found to lack a thymus provided evidence that the thymus was important for immune function decades before its role in T cell development was understood. Many of these deficiencies are summarized in the table below. Some deficiencies lead to increased bacterial or viral infections that can be treated with antibiotics or administration of passive antibodies, while others eliminate adaptive immunity and are fatal within the first year of life. Since before the advent of antibiotics all immune deficiencies were fatal, mutant genes responsible for inherited deficiencies are generally recessive. Production of knock-out mice has allowed us to identify genes controlling other immune functions (see Designer Mice Immune deficiencies are associated with recurrent infections. A battery of tests is available for diagnosing specific immune deficiencies (see

20. Deficiencies immune deficiencies The Interconnectedness of the Immune System. Combined ImmuneDeficiencies. Specific Lymphocyte Deficiencies Deficiencies in Innate Immunity. http://microvet.arizona.edu/Courses/VSC519/Secure/Deficiencies.html

Immune Deficiencies The Interconnectedness of the Immune System Genesis of Immune Deficiencies o Inherited o Spontaneous mutation o Acquired Combined Immune Deficiencies Specific Lymphocyte Deficiencies Deficiencies in Innate Immunity Evaluating Immune Function Detecting Serum Igs: Immuno Electrophoresis Ig Levels in Children Histology o Appearance of germinal centers in lymph node biopsy Treatments for Immune Deficiencies o Vaccination o Gamma globulin o Bone marrow transplantation o Gene therapy - experimental What You Should Know o Immune system organs, cells, and molecules and their functions Vaccines Boosting Immune Function Vaccine Misconceptions : CDC Diseases had already begun to disappear before vaccines were introduced, because of better hygiene and sanitation Response: not true for diseases for which we vaccinate Deaths Due to Vaccine-Preventable Diseases: US o 40,000/year: flu, pneumococcal diseases, hepatitis. Vaccine Misconceptions: CDC Vaccine-preventable diseases have been virtually eliminated from the United States Response: when vaccination rates fall, diseases reappear

A  B  C  D  E  F  G  H  I  J  K  L  M  N  O  P  Q  R  S  T  U  V  W  X  Y  Z

Page 1     1-20 of 100    1  | 2  | 3  | 4  | 5  | Next 20