81. MJD And The Sephardic Connection MJD and the Sephardic Connection. PERSONAL THOUGHTS A question that continuesto arise in my mind is the origin of MJD (Machado Joseph disease). http://irmas.freeyellow.com/page2.html

MJD and the Sephardic Connection PERSONAL THOUGHTS A question that continues to arise in my mind is the origin of MJD (Machado Joseph Disease). A disease that once was thought to be contained in my own family and thought of as our "family secret" is now known as a "common ataxia" through out the world. In twenty-five short years a disease that was hidden for over "500 or more years" has now sparked the interest of medical professionals world wide. I am not, nor do I claim to be a medical professional but I would like to present some facts that I believe have a definite connection between a genetic disease (which has been in my family for centuries) and many Sephardic Jews. Machado Joseph Disease (MJD) is an autosomal dominant neurodegenerative disorder. In layman terms a genetic neurological disease or stated simply an inherited disease of the central nervous system. It was first thought that this disease originated in the Azores Islands. If your parent has or had the disease you have a 50/50 chance of getting the disease. This disease does not skip generations nor is it a respecter of persons. This disease progresses year after year, the affected person becomes wheel chair bound, their body becomes stiff, they must depend on others for their primary care, and they are unable to communicate or be understood. The intellect is usually intact which means "one is trapped in a body that does not work; a virtual prison." My father had this disease (he died at 39 yrs. of age), as did his father, generation, after generation.

82. M J D & Sephardic Link MACHADO JOSEPH disease SEPHARDIC LINK by Sheri Bashor. Machado Josephdisease (MJD) is an autosomal dominant neurodegenerative disorder. http://www.saudades.org/mjdsephlink.htm

by Sheri Bashor Machado Joseph Disease (MJD) is an autosomal dominant neurodegenerative disorder. In layman terms a genetic neurological disease or stated simply an inherited disease of the central nervous system. It was first thought that this disease originated in the Azore Islands. If your parent has or communities of Sephardic Jews settled at one time. The Joseph family was from this area. It has been reported that MJD is found in Portugal, with the largest of these families along the Douro River, as far north as Freixo-de-Espada-a-Cinta to the Atlantic coast in Porto. MJD has been found in families in Brazil, Angola, France, and Germany. One Brazilian patient claims to be of Jewish descent from Amsterdam (Coutinho, unpublished observation). Other reported families are from Japan, India, China, Australia, the Netherlands, and Israel! because of a wall of high mountains. I found medical research articles written about MJD in 1996 and 1997 from the Department of Human Genetics, Hadassah Medical Center, Hebrew University Medical School, Jerusalem, Israel. There is one hospital in Israel which provides care for patients with Machado-Joseph disease.

83. NewStandard: 7/14/98 Confronting Machado Joseph disease. Machado Joseph disease, a hereditary anddegenerative neurological disorder, strikes the Portuguese population. http://www.s-t.com/daily/07-98/07-14-98/b01he042.htm

NorthEast Classified Network Confronting Machado Joseph disease Blood test can detect incurable neurological disorder that strikes Portuguese population By Charlene Rocha, Standard-Times correspondent Cultural heritage plays a significant role in the likelihood of contracting certain diseases. African-Americans, for example, are chiefly at risk for sickle-cell anemia and Jews for Tay-Sachs disease. Machado Joseph disease, a hereditary and degenerative neurological disorder, strikes the Portuguese population. Dr. Joseph Monteiro, an internist at St. Anne's Hospital in Fall River, recommends that his Portuguese patients, especially those thinking of having children, take a new blood test to detect the disease. The decision to have children is, naturally, up to the parents, "but they should be informed about the risks involved," Dr. Monteiro said. Dr. Monteiro suggests people undergo the blood test in early adulthood before beginning a family. There is a 50 percent chance that the disease will be passed on from parent to child, he said. Symptoms of Machado Joseph disease include problems with coordination, speech impairment, involuntary eye movements and loss of muscle strength in the legs.

84. Health In The XXI Century: A Vision Of The European Youth Machado Joseph disease. Text produced by the researcher. Machado Josephdisease (MJD) is a hereditary neurological disease, with a http://www.cienciaviva.pt/healthXXI/topics.asp?lang=en&accao=ibmc2_doc_en

85. NORD - National Organization For Rare Disorders, Inc. Degeneration; Azorean Neurologic disease; MJD; Machado disease; MachadoJosephdisease; Nigrospinodentatal Degeneration; Spinocerebellar http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Joseph's Dise

86. Joseph Disease Image that's a link to Genetics Education Center Support Page Joseph disease.Machado Joseph disease (MJD) International Joseph disease Foundation, Inc. http://www.kumc.edu/gec/support/joseph.html

Joseph Disease Machado Joseph Disease (MJD) International Joseph Disease Foundation, Inc. PO Box 2550 Livermore, CA 94551-2550 Phone: (510) 371-1287 Fax: 510-371-1288 Web site: http://www.freeyellow.com/members8/ijdfnonprofit/index.html E-mail: bashor@IJDF.net Also See: National organizations information on genetic conditions or birth defects Information for Siblings and Family Members Information NHIC To locate a genetic counselor or clinical geneticist in your area: Professional Genetics Societies Genetic clinics, centers, departments Genetic Societies Clinical Resources ... Search Genetics Education Center Debra Collins, M.S. CGC , Genetic Counselor, dcollins@kumc.edu This site subscribes to the principles of the HONcode (Health on the Net, Code of Conduct for Medical and Health Web Sites) of the Health On the Net Foundation

87. Machado Joseph Disease Machado Joseph disease. Machado Joseph disease (MJD)/SpinocerebellarAtaxia Type 3(SCA3) are autosomal dominantly inherited ataxias. http://genetics.co.jp/dna-20.htm

Machado Joseph Disease Machado Joseph Disease (MJD)/Spinocerebellar Ataxia Type 3(SCA3) are autosomal dominantly inherited ataxias. Molecular testing is available for defferential diagnoses suggesting MJD/SCA3. The gene for MJD/SCA3 which maps to chromosome 14q32.1 contains an unstable CAG trinucleotide repeat which is expanded in patients with MJD/SCA3. Normal individuals have up to 36 CGA repeats, while clinically affected individuals have 66 or more copies of the repeat. Correlations of length of the repeat with age of onset of disease are not precise enough to be usud clinically. Machado-Joseph•a

88. International Joseph Diseases Foundation Email MJD@ijdf.net. Conditions Spinocerebellar Ataxia Type 3 (SCA 3); Machado-Josephdisease; Joseph disease. Voicemail yes Year Established 1977. http://www.geneticalliance.org/Resources/displayorganization.html?orgname=Intern

89. Cerebrum Of Joseph Disease The summary for this Japanese page contains characters that cannot be correctly displayed in this language/character set. http://www.saigata-nh.go.jp/nanbyo/scd/mjdpath1.htm

90. Huntington's Disease Group group is the analysis of the molecularpathomechanisms of inherited polyglutaminediseases like Huntington's disease (HD) or Machado Joseph disease (SCA3). http://www.molgen.mpg.de/~agwanker/OLD/

H U N T I N G T O N The main focus of our research group is the analysis of the molecularpathomechanisms of inherited polyglutamine diseases like Huntington's disease (HD) or Machado Joseph disease (SCA3). Recently, we found that the huntingtin protein, containing an expanded polyglutamine stretch, can form amyloid-like protein aggregateswhich are likely to be responsible for the selective neurodegeneration. A second focus of the group is on the identification of novel protein-protein interactionswith potential biomedical relevance. In particular, using the yeast two-hybridsystem, we identified a huntingtin interacting protein (HIP1), which is a novel proteinwith significant homology to the yeast protein Sla2, which indicates thathuntingtin is associated with the neuronal cytoskeleton. Following projects are in progress: Molecular Analysis of Huntingon's Disease Machado-Joseph Disease and other Polyglutamine Disorders Development of an Automated Yeast Two-Hybrid System Dr. Erich Wanker - groupleader Ihnestr. 73

91. Goto Jun Year, 1999. Title, Study of three intragenic polymorphisms in the MachadoJosephdisease gene (MJD1) in releation to genetic instability of the (CAG)n tract. http://www.adm.u-tokyo.ac.jp/IRS/IntroPage_E/intro71114876_e.html

92. ? ?, 1999. , Study of three intragenic polymorphisms in the MachadoJosephdisease gene (MJD1) in releation to genetic instability of the (CAG)n tract. http://www.adm.u-tokyo.ac.jp/IRS/IntroPage_J/intro71114876_j.html

93. Southcoast Health System Return to News Releases. Charlton's Jarabek Center to host MachadoJosephDisease Clinic. For Immediate Release, Contact Joyce Faria Brennan. http://www.southcoast.org/news/releases/2002/091302.html

News Releases Southcoast In the News Experts List ... [Return to News Releases] Charlton's Jarabek Center to host Machado-Joseph Disease Clinic For Immediate Release Contact: Joyce Faria Brennan September 13, 2002 brennanj@southcoast.org Get this release in Word format (200K) FALL RIVER, Mass. - Patients and families who wish to learn more about the rare and fatal genetic disorder that occurs primarily in people of Portuguese ancestry called Machado-Joseph Disease (MJD) are invited to attend a presentation and clinic at Charlton Memorial Hospital on Saturday, Sept. 28. An update on advances in medical research related to MJD will be presented by Henry L. Paulson, MD, PhD, neurologist at the University of Iowa. Dr. Paulson is currently participating in a clinical trial by the National Institute of Neurological Disorders to help scientists find a cure for Machado-Joseph Disease and similar disorders. More information can be found at http://www.ataxiamjd.org/ "It is important that we continue to provide the community with the latest information and screenings for this fatal and debilitating disease which affects so many South Coast residents," said Judith A. Pearson, RN, ONC, Jarabek Diagnostic and Treatment Center, Charlton Memorial Hospital and organizer of the MJD clinic. "MJD occurs primarily in people of Portuguese/Azorean ancestry, but it has also been found in other ethnic groups, nationalities and races. We urge anyone who thinks they might have the disorder to call and make an appointment."

94. õˆømMn The summary for this Japanese page contains characters that cannot be correctly displayed in this language/character set. http://www.so-net.ne.jp/medipro/hypref/hyper/index/m.html

õˆømMn m ”ŽšE‰¢•¶õˆø‚É–ß‚é n ƒÊŒ^H½•a H½•a [ŒŒ‰t] MAC ‘m–X•Ù—֐ΊD‰» [zŠÂŠí] Machado-Joseph disease [_Œo] Machado-Joseph•a [_Œo] Machado-Joseph•a [_Œo] Machado-Joseph•a [_Œo] macroglobulinemia [ŒŒ‰t] macronodular cirrhosis ŠÌd•Ï [ŠÌE’_EäX] macrothrombocytic thrombopathia Bernard-SoulierÇŒóŒQ [ŒŒ‰t] magnesium magnetic field disturbance Ž¥êáŠQ [’†“ŁEŠÂ‹«] MAHC ˆ««Žîᇐ”º«‚CaŒŒÇ malabsorption syndrome ‹zŽû•s—ǏnjóŒQ malaria Malayan filariasis ‘gDŠñ¶ü’ŽÇ male hypergonadism male hypogonadism malignancy associated hypercalcemia ˆ««Žîᇐ”º«‚CaŒŒÇ malignant hepatoma ŠÌ×–EŠà [ŠÌE’_EäX] malignant histiocytosis ˆ««‘gD‹ Ç [ŒŒ‰t] malignant hypertension [tE”A˜H] malignant limb-girdle muscular dystrophy is«‹ØƒWƒXƒgƒƒtƒB[ [_Œo] malignant rheumatoid arthritis [–ƉuƒAƒŒƒ‹ƒM[] malignant syndrome §“f–ò’†“Å [_Œo] ƒtƒFƒmƒ`ƒAƒWƒ“ŒnŒü¸_–ò’†“Å [_Œo] malignant tumor [tE”A˜H] malignant tumor of the small intestine Mallory-Weiss syndrome Mallory-WeissÇŒóŒQ Mallory-WeissÇŒóŒQ Mallory-WeissÇŒóŒQ malnutrition-related DM “œ”A•a manganase poisoning [’†“ŁEŠÂ‹«] MAO ƒ‚ƒmƒAƒ~ƒ“ƒIƒLƒVƒ_[ƒ[ Marburg disease Marburg virus disease march hemoglobinuria ÔŒŒ‹ ‹@ŠB“IáŠQ«—nŒŒ«•nŒŒ [ŒŒ‰t] Marchiafava-Bignami disease Marchiafava-BignamiÇŒóŒQ [_Œo] Marchiafava-Bignami syndrome Marchiafava-BignamiÇŒóŒQ [_Œo] Marchiafava-BignamiÇŒóŒQ Marchiafava-BignamiÇŒóŒQ [_Œo] Marchiafava-Micheli syndrome ”­ì«–éŠÔƒwƒ‚ƒOƒƒrƒ“”AÇ [ŒŒ‰t] Marfan's syndrome MarfanÇŒóŒQ [–ƉuƒAƒŒƒ‹ƒM[] MarfanÇŒóŒQ MarfanÇŒóŒQ [–ƉuƒAƒŒƒ‹ƒM[] marginal abscess

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