41. EMedicine - Marfan Syndrome : Article By Harold Chen, MD, MS, FAAP, FACMG marfan syndrome marfan syndrome is an inherited connective tissue disordertransmitted as an autosomal dominant trait. marfan syndrome. http://www.emedicine.com/PED/topic1372.htm

(advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Pediatrics Genetics And Metabolic Disease Marfan Syndrome Last Updated: August 22, 2002 Rate this Article Email to a Colleague Synonyms and related keywords: Marfan's syndrome, Marfan disease, Marfan's disease AUTHOR INFORMATION Section 1 of 11 Author Information Introduction Clinical Differentials ... Bibliography Author: Harold Chen, MD, MS, FAAP, FACMG , Chief, Professor, Department of Pediatrics, Section of Perinatal Genetics, Louisiana State University Medical Center Harold Chen, MD, MS, FAAP, FACMG, is a member of the following medical societies: American Academy of Pediatrics American College of Medical Genetics American Medical Association American Society of Human Genetics , and Teratology Society Editor(s): James Bowman, MD , Senior Scholar of Maclean Center for Clinical Medical Ethics, Professor Emeritus, Department of Pathology, University of Chicago; Robert Konop, PharmD

42. Tokyo Medical University Genetics Marfan Syndrome Japanese Page is Here. marfan syndrome Images (20K) Autosomal dominantfibrillin1(FBN1) gene mutation. normal(23K). marfan syndrome(22K). http://www.tokyo-med.ac.jp/genet/ms/mrf-e.htm

Tokyo Medical University Department of Paediatircs Genetics Study Group Hironao NUMABE, M.D. E-mail: hnumabe@tokyo-med.ac.jp Japanese Page is Here. Marfan Syndrome Images: Autosomal dominant fibrillin-1(FBN1) gene mutation normal(23K) : Tricuspid valve : Pulmonary valve : Aortic valve : Mitral valve Marfan syndrome(22K) Aortic root dilatationC Aortic regurgitation ( Mitral regurgitation and Mitral valve prolapse ( aneurysms(7K) Aortic aneurysm and Aortic dissection Tokyo Medical University Home Pediatrics Home Genetics Home

43. Marfan Syndrome Reviews the possible role of diet as a factor in marfan syndrome. The page MarfanSyndrome. Does Diet Play A Role? that was formerly at this URL has moved to. http://www.mindspring.com/~sandysimmons/marfan.html

The page: Marfan Syndrome Does Diet Play A Role? that was formerly at this URL has moved to http://www.ctds.info/marfan.html Please click on the link to go to the new URL. If you have bookmarked this site in the past, please update your booksmarks as this forwarding page will be deleted in the near future. Thank you. Medicine being a compendium of the successive and contradictory mistakes of medical practitioners, when we summon the wisest of them to our aid, the chances are that we may be relying on a scientific truth the error of which will be recognized in a few years' time. M. Proust

44. The DNA Files - Interact - Marfan Syndrome INTERACT. marfan syndrome Scenario. Both were initially diagnosed with heartfailure, but further analysis uncovered the real killer marfan syndrome. http://www.dnafiles.org/interact/marfan/

INTERACT Marfan Syndrome Scenario In the U.S., few pursuits provide potential for fame and fortune as much as professional sports. Over recent decades, that fact has brought to light a troubling scenario: young athletes in peak condition dying suddenly, without warning. Flo Hyman, one of the women who brought volleyball to prominence in the U.S., collapsed and died in a matter of moments during a match. At least two highly-touted collegiate basketball stars also succumbed suddenly and unexpectedly, before ever having a chance to play a professional game. Both were initially diagnosed with heart failure, but further analysis uncovered the real killer: Marfan syndrome. Marfan is a genetic disorder that affects connective tissue and sometimes weakens the aorta (a blood vessel attached to the heart) so severely that it can rupture during physical exertion. About 1 in 10,000 people is affected by Marfan, and the condition is not limited to any race, gender, or ethnicity. What would you do if you thought that you - or a family member - had characteristics associated with Marfan? Explore your choices in our

45. Marfan Syndrome marfan syndrome is a heritable condition that affects the connectivetissue. Subscribe now . marfan syndrome. What Is marfan syndrome? http://healthlink.mcw.edu/article/926100176.html

Search Articles: search tips Please Take the HealthLink Survey Email this article Print this article Find related articles: By topic: Cardiac/Heart Eyes Genetics Skin/Dermatology By keywords: Receive Health Link via email! Subscribe now >> Marfan Syndrome What Is Marfan Syndrome? Marfan syndrome is a heritable condition that affects the connective tissue. The primary purpose of connective tissue is to hold the body together and provide a framework for growth and development. In Marfan syndrome, the connective tissue is defective and does not act as it should. Because connective tissue is found throughout the body, Marfan syndrome can affect many body systems, including the skeleton, eyes, heart and blood vessels, nervous system, skin, and lungs. Marfan syndrome affects men, women, and children, and has been found among people of all races and ethnic backgrounds. It is estimated that at least 25,000 people in the United States have the disease. What Are the Characteristics of Marfan Syndrome?

46. Center For Marfan Syndrome And Related Connective Tissue Disorders - Lucile Pack Center for marfan syndrome and Related Connective Tissue Disorders. Outreacheducation regarding marfan syndrome for physicians, patients, and public. http://www.lpch.org/clinicalSpecialtiesServices/ClinicalSpecialties/MarfanSyndro

Cardiologists Cardiothoracic Surgeons Medical Geneticists Ophthalmologists ... Orthopaedic Surgeons Center for Marfan Syndrome and Related Connective Tissue Disorders Location: Stanford Hospital and Clinics 300 Pasteur Drive Stanford, CA 94305 Click here for map Mailing Address: 725 Welch Road Palo Alto, CA 94304 Contact Phone: Fax Number: Email Address: spellone@stanfordmed.org Email is not secure. Do not send private medical information. Days and Hours: Monday 8:00 am - 5:00 pm Services Overview Center for Marfan and Related Connected Tissue Disorders. Diagnostic evaluation and specific therapy for Marfan syndrome and other related heritable disorders of connective tissue. Multidisciplinary approach. Genetic diagnostic and genetic counseling services. Outreach education regarding Marfan syndrome for physicians, patients, and public.  Please visit our department Web site, http://marfan.stanford.edu , for further information. Key contacts Cheryll Gasner, MN, FNP, Center Nurse Practitioner H. Eugene Hoyme, MD David Liang, MD

47. Marfan Syndrome Ask NOAH About Pregnancy. marfan syndrome. Public Health InformationSheet. Introduction; What Is marfan syndrome? What Is marfan syndrome? http://www.noah-health.org/english/pregnancy/march_of_dimes/birth_defects/marfan

Ask NOAH About: Pregnancy Marfan Syndrome Public Health Information Sheet Introduction What Is Marfan Syndrome? What Causes Marfan Syndrome? Is There a Test for Marfan Syndrome? ... Is Any Research Being Done? Introduction Marfan syndrome, which affects about one in 10,000 Americans, is one of the most common inherited disorders of connective tissue. It affects males and females from all racial and ethnic groups. The syndrome is named for Dr. Antoine Marfan who, in 1896, described a 5-year-old patient with long, slender fingers and limbs and other skeletal abnormalities. Symptoms of Marfan syndrome may be mild or severe, and may be present at birth or appear in adult life. The disorder sometimes causes sudden death in adults who were unaware that they had it. This was the case with volleyball star and U.S. Olympic team member Flo Hyman, who died in 1986 from complications of Marfan syndrome. What Is Marfan Syndrome? It is a variable pattern of abnormalities that may affect the heart, blood vessels, lungs, eyes, bones and ligaments. It is one of the more than 100 inherited disorders of connective tissue (material that holds tissues of the body together). Affected individuals are often tall, slender, and loose-jointed. Arms and legs may be unusually long in proportion to the torso. The spine may have a spiral curve (scoliosis), and the breastbone may protrude or look caved in. The face may be long and narrow, with a high roof of the mouth and crowded teeth. Heart and blood vessels nearly always are affected. Heart valves, pairs or trios of flaps that keep the blood flowing in one direction through the heart, usually are oversized and floppy. Their motion during heartbeats may allow brief reverse blood flow and cause a heart murmur (an abnormal sound heard through a stethoscope).

48. Marfan Syndrome, Cincinnati Childrens Hospital Medical Center marfan syndrome manifestations, causes, diagnosis, treatment, and prognosis informationfrom the Heart Encyclopedia by Cincinnati Children's Hospital Medical http://www.cincinnatichildrens.org/Health_Topics/heart-encyclopedia/disease/synd

Heart Center Encyclopedia Introduction Cardiac Anomalies / Congenital Heart Defects Heart Diseases ... Down Syndrome Marfan Syndrome Velo-Cardio-Facial Syndrome VACTERL (VATER) Association Signs and Symptoms Cardiac-Related Diagnostic Methods ... Glossary Heart-Related Syndromes Marfan Syndrome Manifestations, Causes, Diagnosis, Treatment, Prognosis Explanation Manifestations Causes Diagnosis ... Prognosis What is Marfan syndrome? The Marfan syndrome is a genetic disorder that affects the body's connective tissues, or the tissues in between the main cells of each organ of the body. All organs contain connective tissue and, hence, the manifestations of Marfan syndrome appear in many parts of the body, especially the skeletal system, the eyes, the heart and blood vessels and the lungs. The term "syndrome" refers to the collection of physical findings that occur together often enough to provide a recognizable pattern that allows the diagnosis to be made. It was first described in a six year old girl by the French pediatrician, Antoine Marfan, in 1896. Manifestations of Marfan syndrome The heart is affected in nearly 80 percent of patients with this syndrome. The most important finding is enlargement or dilation of the aorta, the main blood vessel that carries blood to the body. This abnormality in connective tissue of the first few inches of the aorta allows the aorta to stretch sufficiently to cause tearing or rupture.

49. Page Not Found, Cincinnati Childrens Hospital Medical Center marfan syndrome / ehlers danlos syndrome clinic. Clinic Services TheMarfan / Ehlers Danlos Syndrome Clinic at Cincinnati Children's http://www.cincinnatichildrens.org/Services/Programs_And_Services/marfan-ehlers-

Sorry Page Not Found The page that you requested does not currently exist on the Cincinnati Children's Hospital and Medical Center Web site. Quite possibly, during a recent renovation, the page was moved. Our powerful search engine can assist you in finding the page. The search engine is just a click away. Useful Features send this page to a friend send an ecard to a patient make a donation rate this page ... printer friendly page 3333 Burnet Avenue, Cincinnati, Ohio 45229-3039 Legal Notice Serving infants to adolescents, Cincinnati Children's Hospital Medical Center is an international leader in pediatric health care, research and education. Home Contact Us Site Map Go to Advanced Search

50. Marfan Syndrome - Stanford Hospital And Clinics marfan syndrome. Stanford Hospital Clinics hosts one of the premier centersfor the study and treatment of marfan syndrome in the nation. http://www.stanfordhospital.com/clinicsmedServices/COE/heart/marfansyndrome.html

Overview Our Team Cardiac (Heart) Surgery Congenital Heart Disease ... Keeping an Eye on Skin Cancer: Skin Cancer Screening Marfan Syndrome Location: Boswell Building 300 Pasteur Drive Stanford, CA Click here for map Mailing Address: 300 Pasteur Drive, Rm. H2157 Stanford, CA 94305 Contact Phone: Fax Number: Email Address: spellone@stanfordmed.org Email is not secure. Do not send private medical information. Days and Hours: Monday-Friday 8:00 am - 5:00 pm Marfan syndrome is an inherited disorder of connective tissue that strikes at least one in 5,000 individuals. The genetic defect that causes the Marfan syndrome involves the connective tissues within several organs such as the heart, aorta, eyes, and musculoskeletal system. Marfan syndrome affects both men and women, children and adults, and all races and ethnic groups. Without appropriate diagnosis and treatment, many Marfan patients die prematurely of cardiovascular complications. Marfan-related disorders include: Ehlers-Danlos Syndrome Annuoloaortic ectasia Homocystinuria Familial aortic aneurysms Mitral valve prolapse The diagnosis of Marfan syndrome and related disorders is challenging for clinicians because no single symptom, sign, or clinical test provides a definitive diagnosis. The Stanford Center for Marfan Syndrome and Related Connective Tissue Disorders provides a comprehensive consultative service to referring physicians for diagnosis, as well as specialists in:

51. Treatment Of Marfan Syndrome, Mayo Clinic In Rochester, Minn. Treatment of marfan syndrome at Mayo Clinic in Rochester. marfan syndrome isa disorder of the connective tissue in the body. marfan syndrome Clinic. http://www.mayoclinic.org/marfan-rst/

Mayo Clinic Locations: Arizona Florida Minnesota Mayo Clinic ... Medical Services Marfan Syndrome Marfan Syndrome Treatment Features and Diagnosis Heart Surgery Frequent Questions ... Medical Services Treatment of Marfan Syndrome at Mayo Clinic in Rochester Marfan syndrome is a disorder of the connective tissue in the body. It can affect the skeletal system, blood vessels, heart, lungs, eyes and other organ systems. Marfan syndrome can be inherited from either parent, or it can result from a new change in genetic material. There is a 50-50 chance that children will inherit the disorder from their parent. Approximately 200,000 people in the United States have Marfan syndrome, and it can occur in men or women of any race or ethnic group. Many affected individuals are young adults, adolescents or children. Marfan Syndrome Clinic cardiac and vascular surgeons Treatment of Marfan syndrome may vary, depending on the patient's affected organ systems. Currently, a cure does not exist, but medical care can improve prognosis and life span. Patients at Mayo Clinic work closely with their team of specialists to create a treatment plan that meets their individual needs. Genetic and reproductive counseling will be provided. This is an important part of the management of patients and families with Marfan syndrome.

52. Research On Marfan Syndrome, Mayo Clinic In Rochester, Minn. marfan syndrome Research. The following Mayo Clinic research abstracts and publicationsare related to marfan syndrome. The marfan syndrome and cardiac surgery. http://www.mayoclinic.org/marfan-rst/clintrials.html

Mayo Clinic Locations: Arizona Florida Minnesota Mayo Clinic ... Medical Services Marfan Syndrome Marfan Syndrome Treatment Appointments Research Other Web Resources ... Medical Services Marfan Syndrome Research The following Mayo Clinic research abstracts and publications are related to Marfan syndrome. For a detailed view of the abstract, please see PubMed, a service provided by the National Library of Medicine. Mayo Clinic Publications Zehr KJ, Matloobi A, Connolly HM, Orszulak TA, Puga FJ, Schaff HV. Surgical Management Of The Aortic Root In Patients With Marfan Syndrome. Second Biennial Meeting of The Society for Heart Valve Disease - June 28, 2003 - Palais des Congres, Porte Maillot, Paris France. Chatrath R, Beauchesne LM, Connolly HM, Michels VV, Driscoll DJ. Is there intrinsic left ventricular dysfunction in Marfan syndrome? J Am Coll Cardiol 2002; 39 (9): Suppl B, 356 B. [No Abstract Available] Beauchesne LM, Connolly HM, Michels VV, Heise-Olson CL, Warnes CA, Zehr KJ. Natural and Unnatural History of 219 Patients with Marfan Syndrome: A Four Decade Single Institution Experience. Circulation Supplement II 2001;104 (17S), II-562. [No Abstract Available] Zehr KJ, Connolly HM, Beauchesne LM, Heise-Olson CL, Orszulak TA, Schaff HV. Aortic root reconstruction for Marfan syndrome results and comparison with a non-operated cohort over 40 years. Circulation 2001;104:II633(Suppl II). [No Abstract Available]

53. A Diary About Marfan's Marfan's patients diary of the diseases events in her life. Includes a list of links.Category Health Conditions and Diseases marfan syndrome......MARFAN'S SYNDROME. The vessels. The marfan syndrome affects both men andwomen of any race or ethnic group. MY REACTION TO MARFAN'S SYNDROME. http://www.angelfire.com/ms2/CysticFibrosisMarfan/standingtall.html

MARFAN'S SYNDROME The Marfan's syndrome is a heritable disorder of the connective tissue that affects many organ systems, including the skeleton, lungs, eyes, heart and blood vessels. The Marfan syndrome affects both men and women of any race or ethnic group. MY REACTION TO MARFAN'S SYNDROME Tuesday 7th August 2001 : Yesterday I received a letter about Tristan’s appointment last week for his heart murmur at the Royal Children’s Hospital. I would like to share it with you all. Dear Kathryn, I am writing to summarise our discussion in the Genetics Clinic following your visit with Tristan. Dr. T referred Tristan to discuss whether he might have the same genetic condition as you, Marfan syndrome, as he was recently found to have a heart murmur. As you have Marfan’s Syndrome you have 1 in 2 chance of passing the condition on to your children. When we examined Tristan he does not have any features of Marfan syndrome. About 5% of boys of Tristan’s age have an extra heart sound (a murmur) and the large majority of these are innocent. For reassurance I will ask Dr T, to organise an echocardiogram for Tristan to look at the structure of his heart. We did not have time to discuss Marfan syndrome in you but it would be important that you are under regular review if you are not already. Genetic Health holds a clinic for Adult patients with Marfan’s syndrome at the Alfred Hospital. If you do not already attend the clinic, I would suggest the Dr T refer you. I enclose a leaflet giving you the details.

54. The Contact A Family Directory - MARFAN SYNDROME printer friendly, marfan syndrome, A person with marfan syndrome willusually be characteristically tall and slim, with lax joints. http://www.cafamily.org.uk/Direct/m15.html

printer friendly MARFAN SYNDROME home more about us in your area conditions information ... how you can help search this site A person with Marfan syndrome will usually be characteristically tall and slim, with lax joints. This heritable disorder of connective tissue is due to a mutation in the gene for fibrillin, located on chromosome 15. Fibrillin is an important protein component of blood vessel walls, eyes, tendons and ligaments, and lung. Marfan syndrome is therefore diagnosed when classical signs of weakness in at least two systems (heart, eyes, skeleton) are found. Diagnosis is made on the basis of family history, physical examination including slit lamp examination for possible dislocated lens, and echocardiogram. Linkage to the gene on chromosome 15 may be studied if affected family members in two generations are available. Complications may arise, but it is important to note that the range of complications caused by Marfan Syndrome, and their severity, varies considerably between individuals. These complications may include: Cardiovascular Aortic aneurysm, aortic dissection (tears in the wall of the aorta), and mitral valve prolapse sometimes requiring surgical repair. For this reason, each person suspected of this diagnosis should have an echocardiogram (a harmless ultrasound picture of the heart and big blood vessels)

55. Marfan Syndrome marfan syndrome information and resources, links to national and international supportgroups, clinics with genetic counselors and geneticists. marfan syndrome. http://www.kumc.edu/gec/support/marfan.html

Marfan Syndrome The National Marfan Foundation (NMF 382 Main St Port Washington, NY 11050 Phone: (800) 8-MARFAN E-Mail: staff@marfan.org Web site: http://www.marfan.org/ Physical Education and Activity Guidelines Resource Manuel Canadian Marfan Association , includes Similar Disorders to Marfan Syndrome [Beals Congenital Contractual Arachnodactyly), Ehlers Danlos, Hajdu Cheney] Marfan Association United Kingdom Contactgroep Marfan Nederland (Dutch) Marfan Network Japan Pomagamy chorym z Zespolem Marfana i ich rodzinom , Marfan Association Poland Other Sites: Stanford University Center for Marfan Syndrome Adult Congenital Heart Network , Canadian Adult Congenital Heart Network, Toronto Congenital Cardiac Centre for Adults, and International Society Of Adult Congenital Cardiac Disease The Humble Hands individual with Marfan Syndrome Marfan Syndrome Web Site , individual with Marfan Syndrome Clinical Operational Research Unit , University College London, includes Marfan Syndrome Survey, TYWChow , and Timing of Elective Aortic Root Replacement in the Marfan Syndrome: Computerized decision support alt.support.marfan

56. Marf Features forums, @marfanssyndrome.net email addresses and contains symptoms as well as guestbooks Category Health Conditions and Diseases marfan syndrome...... Skip Intro . http://www.marfanssyndrome.net/

Skip Intro Skip Intro

57. Marfan Syndrome marfan syndrome up. marfan syndrome / genetics marfan syndrome /genetics. GeneReviews congenital contractural arachnodactyly, http://omni.ac.uk/browse/mesh/detail/C0024796L0024796.html

Marfan Syndrome [up] Marfan Syndrome / genetics Related topics: broader Abnormalities, Multiple Connective Tissue Diseases Genetic Diseases, Inborn Heart Defects, Congenital other Angelman Syndrome Ataxia Telangiectasia Cellulitis Collagen Diseases ... Marfan Association UK The Web site for the Marfan Association in the UK, providing a fact sheet for patients about the syndrome, news, events, a contact list of support groups, and a list of publications. Charities Great Britain Marfan Syndrome Marfan Syndrome / genetics GeneReviews : congenital contractural arachnodactyly Notes for physicians on congenital contractural arachnodactyly (CCA, Beals Syndrome). This document includes diagnosis, a clinical description, differential diagnosis, management, genetic counselling, and molecular genetics. Posted in January 2001, this resource forms part of GeneReviews (formerly GeneClinics profile), a peer-reviewed clinical genetic information resource that is funded by the US National Institutes of Health (NIH) and produced by the University of Washington, Seattle. This resource contains a summary and bibliographical references of the review. Free access to the full-text version of the review requires brief registration. Marfan Syndrome / genetics Last modified 28/Mar/2003 [Low Graphics]

58. MoSt GeNe/Genetic Drift/Management Of Common Genetic Disorders marfan syndrome. marfan syndrome is an autosomal dominant, highly penetrant, disorderof connective tissue with extremely variable clinical expression. http://www.mostgene.org/gd/gdvol16e.htm

Previous Section This Issue- Table of Contents Next Section Management of Common Genetic Disorders Vol. 16: Summer, 1998 Marfan Syndrome Introduction Marfan syndrome is an autosomal dominant, highly penetrant, disorder of connective tissue with extremely variable clinical expression. The frequency is 1 to 10 per 100,000 live births. About 15% of individuals with Marfan syndrome have new mutations; the rest are familial. It is caused by a defect in the fibrillin-1 gene (FBN1) on chromosome 15. Many different mutations of FBN1 have been identified, which may contribute to the variability seen in the disorder. Currently, no single gene probe or group of probes can detect most FBN1 mutations. Sequencing the entire gene for mutations is tedious, and often detects mutations that may represent normal variation, resulting in both false positives and false negatives. Immunohistological evaluation of skin for abnormal fibrillin has been reported but is not widely available. For now, diagnosis of Marfan syndrome remains a clinical one. Clinical Features Marfan syndrome typically affects three major body systems: cardiovascular, skeletal, and ocular. Lungs and/or skin may also be involved.

59. Marfan Syndrome marfan syndrome. What Are the Symptoms? marfan syndrome can cause one ormore of these symptoms Heart problems an enlarged blood vessel. http://www.arthritis.org/conditions/DiseaseCenter/marfan_syndrome.asp

Welcome! Log In Create Profile advanced search Español ... 51 Ways to Be Good to Your Joints Marfan Syndrome If your question is not answered here, please contact one of our information specialists. What Is It? What Are the Symptoms? What Causes It? How Is It Diagnosed? ... Resources and Suggestions What Is It? Marfan syndrome is a rare inherited disorder which causes weakening of the body's connective tissue, a vital component of all body organs that supports and protects other body tissues. A mutant gene causes the body to produce defective fibrillin a protein in connective tissue. What Are the Symptoms? Marfan Syndrome can cause one or more of these symptoms: Heart problems an enlarged blood vessel. Tall stature unusually tall and slender, with particularly long arms, legs and fingers. Eye problems Nearsightedness (myopia) is a common problem with lens becoming "dislocated." Spine problems curvature of the spine (scoliosis). Breast bone may become indented.

60. Marfan Syndrome marfan syndrome. cv130.jpg (67498 bytes). The hand at the left is that of a youngwoman with Marfan's syndrome, while the hand at the right is a normal male. http://medgen.genetics.utah.edu/photographs/pages/marfan_syndrome.htm

Marfan Syndrome view 613 KB version view 3 KB version A young man with Marfan syndrome, showing characteristically long limbs and narrow face. view 369 KB version view 5 KB version Arachnodactyly in an 8-year-old girl with Marfan syndrome. The hand at the left is that of a young woman with Marfan's syndrome, while the hand at the right is a normal male. Both persons were of the same height, 188 cm. However, note that the hand at the left demonstrates arachnodactyly. This mucin stain of the wall of the aorta demonstrates cystic medial necrosis, typical for Marfan's syndrome and causes the connective tissue weakness that explains the aortic dissection. Pink elastic fibers, instead of running in parallel arrays, are disrupted by pools of blue mucinous ground substance. This view of the mitral valve in a patient with Marfan's syndrome depicts a floppy mitral valve. The leaflet on the lower left has ballooned upward and the prolapse has resulted in contusion of the top of the leaflet, with a red black area of discoloration. Examinations Photographs Movies Links ... noJava Home

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