61. Florida State University College Of Medicine Digital Library Anemia Access document; megaloblastic anemia Access document; Folic AcidDeficiency Access document. megaloblastic anemia List of documents. http://fsumed-dl.slis.ua.edu/clinical/hematology/anemias/megaloblastic/folate-de

Clinical Resources by Topic: Hematology Folate Deficiency Anemia Clinical Resources Emergency Pediatrics Geriatrics Pathology ... Miscellaneous Resources See also: General Hematology Clinical Resources Folate Deficiency Anemia Patient/Family Resources Harrison's Principles of Internal Medicine 15th Ed.-2001: Table of contents Medical Library subscription INFO Chapter 61: Anemia and Polycythemia: Table of contents Hematopoiesis and the Physiologic Basis of Red Cell Production: Access document Anemia: Access document Clinical Presentation of Anemia: Access document Signs and Symptoms: Access document Approach to the Patient: Access document Definition and Classification of Anemia: Access document Treatment: Access document Chapter 107: Megaloblastic Anemias: Table of contents Introduction: Access document Physiologic and Biochemical Considerations: Access document Folic Acid: Access document Clinical Disorders: Access document Classification of Megaloblastic Anemias: Access document Folic Acid Deficiency: Access document Megaloblastic Disease without Anemia: Access document Diagnosis: Access document Treatment: Access document Hoffman: Hematology: Basic Principles and Practice 3rd Ed.-2000 (MD Consult):

62. Florida State University College Of Medicine Digital Library Anemia Access document; megaloblastic anemia Access document; PerniciousAnemia Access document. megaloblastic anemia List of documents. http://fsumed-dl.slis.ua.edu/clinical/hematology/anemias/megaloblastic/perniciou

Clinical Resources by Topic: Hematology Pernicious Anemia Clinical Resources Emergency Pediatrics Geriatrics Pathology ... Miscellaneous Resources See also: General Hematology Clinical Resources Pernicious Anemia Patient/Family Resources Harrison's Principles of Internal Medicine 15th Ed.-2001: Table of contents Medical Library subscription INFO Chapter 61: Anemia and Polycythemia: Table of contents Hematopoiesis and the Physiologic Basis of Red Cell Production: Access document Anemia: Access document Clinical Presentation of Anemia: Access document Signs and Symptoms: Access document Approach to the Patient: Access document Definition and Classification of Anemia: Access document Treatment: Access document Chapter 107: Megaloblastic Anemias: Table of contents Introduction: Access document Physiologic and Biochemical Considerations: Access document Cobalamin: Access document Clinical Disorders: Access document Classification of Megaloblastic Anemias: Access document Cobalamin Deficiency: Access document Megaloblastic Disease without Anemia: Access document Diagnosis: Access document Treatment: Access document Hoffman: Hematology: Basic Principles and Practice 3rd Ed.-2000 (MD Consult):

63. Ask Jeeves: Search Results For "Megaloblastic Anemia" Popular Web Sites for megaloblastic anemia . Search Results 1 10 Rankedby Popularity, Next . Ask Jeeves a question about megaloblastic anemia http://webster.directhit.com/webster/search.aspx?qry=Megaloblastic Anemia

64. Cook Children's Health Care // 404 Page Not Found     Megaloblastic (Pernicious) Anemia megaloblastic anemia, also called perniciousanemia, is a type of anemia characterized by very large red blood cells. http://www.cookchildrens.com/CC/Ped/hematology/megalob.htm

Site Doctors Donate Now Contact Us Home About Cook Children's ... Wish List Testimonials -Jeff, father of intensive care patient 404 Page Not Found "Four Oh Four." Oops! The page you have requested has moved or is no longer available. Please go to the Cook Children's home page or search our site. [back to top] Related Information Related Physicians Find A Physician Related Pages Find a Physician Find a Service Kids' Health Quiz According to Texas Law, up to what age must children be in EITHER a federally approved safety seat or a safety belt? A 8 years old B 10 years old C 12 years old D 16 years old privacy notice

65. Megaloblastic Anemia First Previous Next Last Index Home Text. Slide 23 of 33. http://www.pathology.vcu.edu/education/dental2/Dental_rbc/sld023.htm

66. Megaloblastic Anemia First Previous Next Last Index Home Text. Slide 21 of 33. http://www.pathology.vcu.edu/education/dental2/Dental_rbc/sld021.htm

67. Kjms Hemolytic Anemias Masquerading as megaloblastic anemia. Bonemarrow aspirationrevealed numerous megaloblasts suggestive of megaloblastic anemia. http://www.kjmsonline.com/sep98/anemia.htm

Hemolytic Anemias Masquerading as Megaloblastic Anemia Adhikari Prabha M R., Pratibha Pereira, John Thomas R Hemolytic anemias generally present with moderate anemia. However they can present with severe aneemia due to megaloblastic crisis or aplastic crisis, thus masking the underlying hemolytic anemia. Here we report two cases of hemolytic anemia with megaloblastic crisis, one a case of auto immune hemolytic anemia in a young boy of 14, and the other thalassemia intermeida in a 48 year old male. CASE REPORT Case 1: A 14 old boy presented to our hospital with history of weakness of 2 month duration, fever of 12 days duration, headache, vomiting and restlessness of 2 days duration. He was provisionally treated for malaria in a local hospital. On examination, he was severely anemic, mildly icteric and had moderate hepatosplenomegaly. He was irritable and restles,s had no signs of meningeal irritation. His Hb% was 3.6G%. Total WBC count was 19,400 cells/cmm. Differential count showed neutrophils 76%, Eosinophils 1% lymphocytes 23%. Peripheral smear showed normocytic picture with few macrocytes, polychromasia and occasional nucleated RBCs. His reticulocyte count was 20%. Bonemarrow aspiration revealed numerous megaloblasts suggestive of megaloblastic anemia.

68. Health Library - Anemia, Megaloblastic Anemia, Megaloblastic. megaloblastic anemia is a rare blood disorder characterizedby the presence of large, abnormal, immature red blood cells (megaloblasts). http://health_info.nmh.org/Library/HealthGuide/IllnessConditions/topic.asp?hwid=

69. Ask NOAH About: Anemia Methodist Healthcare System, Houston TX (also in Spanish) Nutritional Deficienciesand Anemia InteliHealth megaloblastic anemia (See Pernicious Anemia http://www.noah-health.org/english/illness/blood/anemia.html

Ask NOAH About: Anemia What is Anemia? Care and Treatment Information Resources Basic Descriptions Anemia in Children ... Organizations What Is Anemia? Basic Descriptions About Anemia - KidsHealth All About Anemia - Anemia Life Line Anaemia Due to Red Cell Loss - BUPA Anemia - KidsHealth ... Anemia - Methodist Healthcare System, Houston TX (also in Spanish Anemia: When Low Iron is the Cause - American Academy of Family Physicians (also in Spanish Anemia, General - Mayo Clinic Anemia in Young Women - InteliHealth Anemias - ... Women's Health: Anemia - American Institute of Preventive Medicine Blood Basics Blood - TeensHealth Facts About Blood - Methodist Healthcare System, Houston TX Introduction to Hematology - Puget Sound Blood Center Red Blood Cells - Puget Sound Blood Center ... Anemia in Pregnancy Anemia in Children About Anemia - KidsHealth Anemia - KidsHealth Aplastic Anemia - Lucile Packard Children's Hospital Hemolytic Anemia - Lucile Packard Children's Hospital ... Thalassemia Anemia in Teens Iron and Teens: A Guide to Anemia Prevention - Children's Hospital, Boston MA

70. FitnessHeaven | Healthy Lifestyle Solutions Home Medical Encyclopedia Article, megaloblastic anemia. Deficiencies of vitaminB12 and folic acid are the most common causes of megaloblastic anemia. http://www.fitnessheaven.com/res/adam/ency/article/000567.asp

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71. Gene: [05q1/DHFR] Dihydrofolate Reductase; Megaloblastic Anemia (dihydrofolate R Gene 05q1/DHFR dihydrofolate reductase; megaloblastic anemia (dihydrofolatereductase deficiency);. COM. Two series of studies http://obi.img.ras.ru/humbio/hugen/05q1_dhfr.htm

Óâàæàåìûé ïîëüçîâàòåëü! Äëÿ îïðåäåëåíèÿ íàïðàâëåíèÿ ðàçâèòèÿ íàøåé áàçû íàì íåîáõîäèìî çíàòü ñîñòàâ àóäèòîðèè ïîëüçîâàòåëåé. Ïîæàëóéñòà, âûáåðèòå îäèí èç ïóíêòîâ è íàæìèòå êíîïêó "Îòïðàâèòü": Gene: [05q1/DHFR] dihydrofolate reductase; megaloblastic anemia (dihydrofolate reductase deficiency); COM Two series of studies (both are convincing) have given incompatible results concerning the regional location of the DHFR gene: using hybridization of the genomic DNA from somatic hybrid cells carrying different portions of human chr 5 (and direct in situ hybridization), Anagnou-1988 as well as Funanage-1984 assigned DHFR to q11.1-13.2 (at least not distal than q22). However, using hybridization with cells carrying several 5q deletions, Maurer-1985 located the DHFR on subsegment 5q23. One of the DHFR pseudogenes seems to be located in this region." GEN The gene length: 30 kb. Exons: 6. Introns: 5 (the length is in the range from 362 to 12 kb). The major mRNA size is 3.8 kb, minor mRNAs are 0.8 and 1.0 kb." FUN Systematic name: 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase. The reaction catalyzed: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH."

72. Online Health Analysis: Conditions: Anemia, Megaloblastic Anemia, Megaloblastic, CAUTION It is always important to discover theunderlying deficiency that is causing a megaloblastic anemia. http://www.digitalnaturopath.com/cond/C363969.html

Anemia, Megaloblastic Last updated: Mar 11, 2003 THE ANALYST TM Home FAQ Start The Analyst Anemia, Megaloblastic Signs, symptoms and indicators Conditions that suggest it Contributing risk factors Other conditions that may be present ... Recommendations Megaloblastic anemia is a blood disorder characterized by red blood cells that are larger than normal resulting from certain nutritional deficiencies, absorption problems or other conditions. Problems with vitamin B12 and folic acid are the most common causes of megaloblastic anemia CAUTION: It is always important to discover the underlying deficiency that is causing a megaloblastic anemia. Higher doses of folic acid (greater than 1 mg per day) may improve or mask the anemia caused by a insufficiency. Unless the B12 deficiency is corrected, permanent nervous system damage may result. In other words, don’t treat a B12 deficiency with high doses of folic acid! Pernicious Anemia People with pernicious anemia loose their ability to make intrinsic factor (IF), a substance that enables vitamin B12 to be absorbed from the intestine. The result is vitamin B12 deficiency, which gradually affects sensory and motor nerves, causing neurological, gastrointestinal and cardiovascular problems. The disease can affect all racial groups, but the incidence is higher among people of Scandinavian or Northern European descent.

73. Health Content Encyclopedia Article Megaloblastic Anemia megaloblastic anemia is a blood disorder characterized by anemia, with red bloodcells that are larger than normal, usually resulting from a deficiency of http://www.baptisteast.com/adamcontent/ency/article/000567.asp

74. Health Content Encyclopedia Image Page Megaloblastic Anemia - Health Content Encyclopedia Image Page megaloblastic anemia viewof red blood cells. Search Health Encyclopedia Image Page Click http://www.baptisteast.com/adamcontent/imagepages/1214.asp

75. PERNICIOUS ANEMIA AND OTHER MEGALOBLASTIC ANEMIAS platelets, all with a shortened life span, hence the pancytopenia (anemia, leucopenia,and thrombopenia), characteristic of fullblown megaloblastic anemia. http://www.victorherbert.com/Conn'sCurrentTherapy2003.htm

PERNICIOUS ANEMIA AND OTHER MEGALOBLASTIC ANEMIAS. Method of Victor Herbert, M.D., J.D., M.A.C.P., F.R.S.M. (London) New York, NY. Megaloblastic (Greek: megalo=giant; blast=germ cell) anemias are those anemias resulting from pathologic slowing, by any cause, of the doubling of the nuclear DNA necessary for bone marrow nucleated cells to divide, with only minor slowing of the synthesis of cytoplasmic RNA. This nuclear-cytoplasmic dissociation becomes greater with each daughter germ cell division, until either the cells die or omit terminal division, surviving in the marrow as end stage giant red cells, white cells, and platelets. These are extruded into the peripheral blood as macroovalocytes, hypersegmented neutrophils, and giant platelets, all with a shortened life span, hence the pancytopenia (anemia, leucopenia, and thrombopenia), characteristic of full-blown megaloblastic anemia. The most common causes of megaloblastic anemia are deficiencies of vitamin B (cobalamin) and/or folate (folic acid). As with any nutrient deficiency, these two B-vitamin deficiencies may arise from any of 3 inadequacies (inadequate ingestion, absorption, or utilization), or any of 3 excesses (excessive requirement, destruction, or excretion).

76. ENLmedical.com: Conditions And Concerns: Medical Encyclopedia: Megaloblastic Ane Table of content. megaloblastic anemia. Causes and Risks Deficiencies of vitaminB12 and folic acid are the most common causes of megaloblastic anemia. http://www.enlmedical.com/article/000567.htm

Medical Dictionary Naturapathic Glossary Aphrodisiacs Immune System ... Table of content Megaloblastic anemia Causes and Risks: Deficiencies of vitamin B-12 and folic acid are the most common causes of megaloblastic anemia. Other causes are leukemia myelofibrosis multiple myeloma , certain hereditary disorders, drugs that affect nucleic acid metabolism such as chemotherapy agents (methotrexate), and other causes. Risk factors relate to the causes. (See also pernicious anemia Prevention: Adequate intake of vitamin B-12 and folic acid is helpful. Symptoms: loss of appetite diarrhea tingling and numbness of hands and feet pale skin color tiredness headaches sore mouth and tongue pale skin color or jaundice Signs and Tests: Examination of neurological signs shows abnormal reflexes, decreased position sense, and decreased vibration sense. Tests include: CBC results showing low hematocrit with elevated MCV bone marrow examination serum LDH below normal serum B12 level Schilling test serum folate level elevated ferritin Treatment: The objective of treatment is to determine the cause of the anemia , and the treatment depends upon the cause.

77. THE MERCK MANUAL, Sec. 18, Ch. 251, Pregnancy Complicated By Disease For megaloblastic anemia due to folic acid deficiency, treatment isfolic acid 1 mg bid. Severe megaloblastic anemia may require http://www.merck.com/pubs/mmanual/section18/chapter251/251k.htm

This Publication Is Searchable The Merck Manual of Diagnosis and Therapy Section 18. Gynecology And Obstetrics Chapter 251. Pregnancy Complicated By Disease Topics [General] Heart Disease Thromboembolic Disease Hypertension ... Disorders Requiring Surgery Anemia The Hct in women who are not pregnant is normally 38 to 45%, but in pregnant women, normal values can be much lower (eg, 34% in a single and 30% in a multiple pregnancy), even when stores of iron, folic acid, and vitamin B are adequate. This lower range represents the physiologic hydremia of pregnancy and does not indicate a decrease in O -carrying capacity or true anemia. Normally, a pregnant patient has erythroid hyperplasia of the marrow and a measurable increase in red cell mass; a disproportionate rise in plasma volume results in hydremia. Unless excessive blood loss occurs at delivery, the Hct generally rises in the immediate postpartum period. Absence of the dilutional effect in late pregnancy suggests inadequate blood volume expansion, which has been associated with growth retardation, pregnancy-induced hypertension, and fetal death. Iron deficiency is responsible for 95% of cases of anemia during pregnancy. The deficiency is usually due to inadequate dietary intake (especially in teenage girls), to a previous pregnancy, or to the normal loss of iron in blood with menses (which approximates the amount normally ingested each month, so that iron stores are never built up).

78. ANEMIA These last two may lead to a condition called megaloblastic anemia. Anelevated MCV greater than 95100 may suggest megaloblastic anemia. http://www.healthevolution.com/Articles/Anemia.html

ANEMIA Background Risk Factors Younger women who have moderate to heavy menstrual flows are more likely to develop anemia. Use of prophylactic devices such as the intrauterine device (IUD) may lead to increased loss of blood (and thus iron) during menstruation. During pregnancy, women are at much higher risk of developing anemia since her body's iron supply is compromised and her body must supply enough oxygen for itself and for the fetus. Deficiencies in certain vitamins (B12) may lead to an impaired ability to produce RBCs. Demographically, African-American and other minority women seem to have a much great chance of developing anemia than do their Caucasian counterparts. The reasons for this disparity are unknown. Finally, young women who suffer from the eating disorder anorexia have a significantly great risk of developing anemia than other women. Women who suffer from mild cases of this condition often do not experience any serious symptoms. More advanced stages of anemia produce fatigue, lightheadedness, paleness, sore tongue, headaches, and even unusual cravings. Weight loss, jaundice, constipation and diarrhea, and abdominal cramps may follow the initial symptoms if the condition is left untreated. In severe cases tachycardia (increased heart rate) and/or hypotension (low blood pressure) may develop. Diagnosis When a physician suspects that a woman has developed anemia, the medical practitioner will order a complete blood count (CBC) in order to determine the exact amount of red blood cells (hemacrit level) are in the body. An idea about the shape and appearance the red blood cells also helps in the diagnosis. A complete medical history will also assist in the diagnosis. Tests are also performed to determine the underlying cause of iron deficiency. A low mean corpuscular volume (MCV) obtained from the CBC may suggest iron deficiency (MCV less than 79). An elevated MCV greater than 95-100 may suggest megaloblastic anemia. In cases of megaloblastic anemia it is important to establish whether intrinsic factor is present in the stomach. Without the intrinsic factor B-12 can not be absorbed by the small intestine.

79. MEGALOBLASTIC ANEMIA ASSESSR(TM) megaloblastic anemia ASSESSR(TM) Marquette General Health System General Info AlphaCode. MISC. MGH LIS Test No. Schedule. TuesdaySaturday. Testing Time. 1-4 days. http://www.mgh.org/lab/CATALOG/TESTS/3499.HTM

MEGALOBLASTIC ANEMIA ASSESSR(TM) Marquette General Health System General Info Alpha Code MISC MGH LIS Test No Schedule Tuesday-Saturday Testing Time 1-4 days Testing Lab Specialty Labs, Inc. Specimen Info Type Serum Volume 3.0 (2.0) mL Temperature Frozen Preservative Collection Info Split into 2 plastic vials before freezing. Methods Clinical Utilities CPT Codes Reference Range Component Information Name HOMOCYST(E)INE ULTRAQUANT(TM) Method HPLC/FPIA CPT Code Units nmol/mL Ref Range Reflex Reason Name METHYLMALONIC ACID Method GC-MS CPT Code Units umol/L Ref Range Less than 0.4 Reflex Reason Collection Notes Additional Comments Questions or Comments email support@mgh.org Reference Lab Home Page Laboratory Main Page Marquette General Health System Home Page

80. DR RATH HEALTH FOUNDATION Home Page Anemia in pregnancy; Comparison of effects of folic acid and folinicacid in experimental megaloblastic anemia; megaloblastic anemia http://www.dr-rath-health-foundation.org/makehealthnotwar/naturaleradication2.ht

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