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         Mobius Syndrome:     more detail
  1. The Official Parent's Sourcebook on Mobius Syndrome: Directory for the Internet Age by Icon Health Publications, 2005-01-31
  2. The Low GI Guide to the Metabolic Syndrome and Your Heart by Jennie Brand-Miller, Kaye Foster-Powell, et all 2005-06-06

1. NINDS Mobius Syndrome Information Page
Also known as congenital facial diplegia, an information sheet compiled by NINDS.Category Health Conditions and Diseases mobius syndrome......mobius syndrome (Congenital Facial Diplegia) information sheet compiled bythe National Institute of Neurological Disorders and Stroke (NINDS).
http://www.ninds.nih.gov/health_and_medical/disorders/mobius.htm
National Institute of Neurological Disorders and Stroke Accessible version Science for the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system Browse all disorders Browse all health
organizations
More about
Mobius Syndrome
Studies with patients Research literature Press releases
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NINDS Mobius Syndrome Information Page
Synonym(s):
Congenital Facial Diplegia
Reviewed 07-01-2001 Get Web page suited for printing
Email this to a friend or colleague

Table of Contents (click to jump to sections) What is Mobius Syndrome?
Is there any treatment?
What is the prognosis? What research is being done? ... Organizations What is Mobius Syndrome? Is there any treatment? There is no specific course of treatment for Mobius syndrome. Treatment is supportive and symptomatic. Infants may require feeding tubes or special bottles to maintain sufficient nutrition. Surgery may correct strabismus and improve limb and jaw deformities. Physical and speech therapy may improve motor skills and coordination, and help to better control speaking and eating abilities. Plastic reconstructive surgery may be beneficial in some individuals. Also, in a few cases, nerve and muscle transfers (microvascular muscle transplant) to the corners of the mouth have been performed to provide some ability to smile. What is the prognosis?

2. Mobius Syndrome
Details about this disease, including what it is, the causes, symptoms and treatment options.
http://healthlink.mcw.edu/article/921441372.html
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Mobius Syndrome
Mobius syndrome, a rare genetic disorder characterized by facial paralysis, is caused by the absence or underdevelopment of the 6th and 7th cranial nerves. These nerves control eye movements and facial expression. In newborns, the first symptom is an inability to suck. Excessive drooling and strabismus (crossed eyes) may occur. Other symptoms may include lack of facial expression; inability to smile; feeding, swallowing, and choking problems; eye sensitivity; motor delays; high or cleft palate; hearing problems; and speech difficulties. Deformities of the tongue, jaw, and limbs, such as club foot and missing or webbed fingers, may also occur. Most patients have low muscle tone, especially in the upper body. Mental retardation may also occur. As children get older, lack of facial expression and inability to smile become the dominant visible symptoms. Mobius syndrome may be accompanied by Pierre Robin syndrome, a disease in which there is an abnormally small jaw, downward displacement of the tongue, and a soft, cleft palate. It may also be accompanied by Poland's anomaly, a disease characterized by abnormal development of one side of the chest and limb deformities.

3. HONselect - Mobius Syndrome
Translate this page English mobius syndrome, - Congenital Oculofacial Paralysis, Moebius - Moebius CongenitalOculofacial Paralysis - Moebius Syndrome - mobius syndromes - Moebius
http://www.hon.ch/HONselect/RareDiseases/C10.292.300.825.html
List of rare diseases: English Deutsch
Language:
MeSH term:
Accepted terms:
English: Mobius Syndrome - Congenital Oculofacial Paralysis, Moebius
- Moebius Congenital Oculofacial Paralysis
- Moebius Syndrome
- Mobius Syndromes
- Moebius Syndromes
- Syndrome, Mobius
Français: MOBIUS, SYNDROME Deutsch: Moebius-Syndrom - Gesichtslähmung Español: SINDROME DE MOBIUS Português: SINDROME DE MOBIUS HONselect ressources Definition: Yes Articles: Yes Images: No News: No Conferences: No Clinical trials: No Web sites: English Yes Français No Deutsch No Español No Português No Home About us Site map Feedback ... HONewsletter http://www.hon.ch/HONselect/RareDiseases/C10.292.300.825.html Last modified: Thu Jul 25 2002

4. Mobius Syndrome
mobius syndrome. mobius syndrome, a rare genetic disorder characterized by facial paralysis, is caused by the absence or
http://oci.mcw.edu/article/921441372.html
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Mobius Syndrome
Mobius syndrome, a rare genetic disorder characterized by facial paralysis, is caused by the absence or underdevelopment of the 6th and 7th cranial nerves. These nerves control eye movements and facial expression. In newborns, the first symptom is an inability to suck. Excessive drooling and strabismus (crossed eyes) may occur. Other symptoms may include lack of facial expression; inability to smile; feeding, swallowing, and choking problems; eye sensitivity; motor delays; high or cleft palate; hearing problems; and speech difficulties. Deformities of the tongue, jaw, and limbs, such as club foot and missing or webbed fingers, may also occur. Most patients have low muscle tone, especially in the upper body. Mental retardation may also occur. As children get older, lack of facial expression and inability to smile become the dominant visible symptoms. Mobius syndrome may be accompanied by Pierre Robin syndrome, a disease in which there is an abnormally small jaw, downward displacement of the tongue, and a soft, cleft palate. It may also be accompanied by Poland's anomaly, a disease characterized by abnormal development of one side of the chest and limb deformities.

5. NINDS - News And Events
Paresthetica Metachromatic Leukodystrophy Microcephaly Miller Fisher Syndrome MiniStrokesMitochondrial Myopathies mobius syndrome Monomelic Amyotrophy Motor
http://www.ninds.nih.gov/health_and_medical/news.htm
National Institute of Neurological Disorders and Stroke Accessible version Science for the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system Browse all disorders Browse all health
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6. MOBIUS SYNDROME
mobius syndrome is a rare congenital disturbance consisting of varying involvement of facial and lateral gaze paresis.
http://members.aol.com/scottolitsky/mobius.htm
MOBIUS SYNDROME
Mobius syndrome is a rare congenital disturbance consisting of varying involvement of facial and lateral gaze paresis. Mobius first suggested that congenital bilateral abducens-facial paralysis might be an independent pathologic entity, thus gaining eponymic distinction. Clinical Manifestations Mobius syndrome is characterized by unilateral or bilateral inability to abduct the eyes. Although horizontal movements are usually lacking, vertical movements and convergence are intact. Pupillary constriction, vision, and the retina are generally normal. Congenital esotropia is common in children with Mobius syndrome. In a retrospective study of 61 patients with this syndrome, 38 per cent had early-onset esotropia. The unilateral or bilateral complete or incomplete facial palsy is usually observed during the first few weeks of life because of difficulty with sucking and feeding, and incomplete closure of the eyelids during sleep. These patients typically have masklike faces with an inability to grin and wrinkle the forehead. Mobius syndrome is frequently associated with paresis of other muscles supplies by the cranial nerves. Often, there is partial atrophy of the tongue with inability to protrude the tongue beyond the lips. Paralysis of the soft palate and muscles of mastication may also occur. Various skeletal and muscle defects are common, including absence or hypoplasia of the pectoral muscles, syndactyly, club feet, and congenital limb amputations.

7. Biology - Past Issues Of Weekly Features
Symptoms, diagnosis, and treatment of mobius syndrome. Information on research, community outreach and support.
http://genetics.about.com/science/genetics/library/blmob.htm
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8. Healthlink Template
Disease; Megalencephaly; Menkes Disease; Metachromatic Leukodystrophy;Microcephaly; mobius syndrome; MultiInfarct Dementia; Muscular
http://healthlink.mcw.edu/search/search-page.php?neurology

9. Rd.com:
A list of alternate names for mobius syndrome, along with a general discussion and resources.
http://www.rd.com/common/nav/index.jhtml?articleId=8612437

10. Mobius Syndrome
mobius syndrome. This article submitted by Shawn K. Centers, DO on4/14/95. mobius syndrome is a conginital disorder involving (1
http://neuro-www.mgh.harvard.edu/neurowebforum/ChildNeurologyArticles/MobiusSynd
Mobius Syndrome
This article submitted by Shawn K. Centers, DO on 4/14/95.
Mobius syndrome is a conginital disorder involving (1)complete or partial VIIth nerve palsy (2)abducens palsy (3) limb malformations especially talipes (3) less commonly there may be palsies of the Vth, IXth, and XXIIth CN's. There have been less than 80 reported cases in the literature.
I am interested in the pathogenesis of this disorder and any additional known cases. Next Article
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11. Mobius Syndrome
mobius syndrome. As I understand it, current thinking suggests thatmobius syndrome may result from a vascular field defect (ie.
http://neuro-www.mgh.harvard.edu/neurowebforum/ChildNeurologyArticles/MobiusSynd
Mobius Syndrome
This response submitted by Barry Kosofsky- MGH Child Neuro on 5/16/95.
Dr. Centers, Sorry for the delay, but we are just coming on-line. As I
understand it, current thinking suggests that Mobius Syndrome
may result from a vascular field defect (ie. failure of
perfusion of a specific vessel during fetal life, with maldevelopment
of the neural, muscular, and other tissue structures normally perfused
by that vessel). There was an article that you should be able to pull from
a literature search of "Mobius Syndrome" that was published (? in Peds
or J Peds, or Teratology) about 2 years ago that dicusses this
theory (and other field defects such as POLAND Syndrome). Good Luck, Barry E. Kosofsky, M.D., Ph.D. Next Article
Return to Main Article
Article complete. Click HERE to return to the Neurology Web-Forum Menu.

12. NINDS Mobius Syndrome Information Page
mobius syndrome (Congenital Facial Diplegia) information sheet compiled by the National Institute of Neurological Disorders and Stroke (NINDS). What is mobius syndrome? mobius syndrome, a rare genetic disorder characterized by facial paralysis, is caused by the
http://accessible.ninds.nih.gov/health_and_medical/disorders/mobius.htm
Disorders - National Institute of Neurological Disorders and Stroke (NINDS) Skip menus
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More about NINDS Mobius Syndrome Information Page
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    Content for this page
    NINDS Mobius Syndrome Information Page
    Synonym(s): Congenital Facial Diplegia Reviewed 07-01-2001 Get Web page suited for printing
    Email this to a friend or colleague

    Table of Contents (click to jump to sections)
    What is Mobius Syndrome?

    Is there any treatment?

    What is the prognosis?

    What research is being done?
    ...
    Organizations

    What is Mobius Syndrome?
    Is there any treatment?

    13. MOBIUS SYNDROME
    mobius syndrome. mobius syndrome is a rare congenital disturbance consistingof varying involvement of facial and lateral gaze paresis.
    http://www.members.aol.com/scottolitsky/mobius.htm
    MOBIUS SYNDROME
    Mobius syndrome is a rare congenital disturbance consisting of varying involvement of facial and lateral gaze paresis. Mobius first suggested that congenital bilateral abducens-facial paralysis might be an independent pathologic entity, thus gaining eponymic distinction. Clinical Manifestations Mobius syndrome is characterized by unilateral or bilateral inability to abduct the eyes. Although horizontal movements are usually lacking, vertical movements and convergence are intact. Pupillary constriction, vision, and the retina are generally normal. Congenital esotropia is common in children with Mobius syndrome. In a retrospective study of 61 patients with this syndrome, 38 per cent had early-onset esotropia. The unilateral or bilateral complete or incomplete facial palsy is usually observed during the first few weeks of life because of difficulty with sucking and feeding, and incomplete closure of the eyelids during sleep. These patients typically have masklike faces with an inability to grin and wrinkle the forehead. Mobius syndrome is frequently associated with paresis of other muscles supplies by the cranial nerves. Often, there is partial atrophy of the tongue with inability to protrude the tongue beyond the lips. Paralysis of the soft palate and muscles of mastication may also occur. Various skeletal and muscle defects are common, including absence or hypoplasia of the pectoral muscles, syndactyly, club feet, and congenital limb amputations.

    14. Google Directory - Health > Conditions And Diseases > Genetic Disorders > Mobius
    Moebius Syndrome Foundation http//www.ciaccess.com/moebius/ Bringing together information from and links to medical and lay support for those affected by Moebius syndrome. mobius syndrome - http// www. Search only in mobius syndrome Search the Web. mobius syndrome
    http://directory.google.ch/Top/Health/Conditions_and_Diseases/Genetic_Disorders/
    Directory Help
    Search only in Mobius Syndrome Search the Web
    Mobius Syndrome
    Health
    Conditions and Diseases Genetic Disorders Go to Directory Home
    Web Pages Viewing in Google PageRank order View in alphabetical order Moebius Syndrome Foundation http://www.ciaccess.com/moebius/
    Bringing together information from and links to medical and lay support for those affected by Moebius syndrome. Mobius Syndrome http://www.ninds.nih.gov/health_and_medical/disorders/mobius.htm
    Also known as congenital facial diplegia, an information sheet compiled by NINDS. MCW Healthlink: Mobius Syndrome http://healthlink.mcw.edu/article/921441372.html
    Details about this disease, including what it is, the causes, symptoms and treatment options. About.com with Laura L. Jelliffe, Ph.D. http://genetics.about.com/science/genetics/library/blmob.htm
    Symptoms, diagnosis, and treatment of mobius syndrome. Information on research, community outreach and support. Readers Digest Health http://www.rd.com/common/nav/index.jhtml?articleId=8612437
    A list of alternate names for mobius syndrome, along with a general discussion and resources.

    15. Untitled
    Sixth Nerve Palsy(Abducens Nerve Palsy). Double Elevator Palsy. Duane's RetractionSyndrome. Brown's Syndrome. mobius syndrome. Congenital Fibrosis Syndrome.
    http://www.members.aol.com/scottolitsky/webbook.htm
    Strabismus Web Book
    Authors
    Scott E. Olitsky, M.D. The Children's Mercy Hospital, Kansas City
    Leonard B. Nelson, M.D. Wills Eye Hospital, Philadelphia
    Chapters
    Pseudoesotropia
    Congenital Esotropia Accommodative Esotropia Intermittent Exotropia ... Third Nerve Palsy (Oculomotor Nerve Palsy) Fourth Nerve Palsy (Superior Oblique Palsy) Sixth Nerve Palsy (Abducens Nerve Palsy) Double Elevator Palsy Duane's Retraction Syndrome Brown's Syndrome Mobius Syndrome ... Congenital Fibrosis Syndrome

    16. 1Up Health > Mobius Syndrome [Congenital Facial Diplegia] - Birth Defects & Gene
    Variants of mobius syndrome and Central Neurologic Impairment Lindeman Procedure in Children.
    http://www.1uphealth.com/medical/disease/birth-defects-genetic-disease/mobius-sy
    Home Contact Us Privacy Caring For Your Well Being Alternative Medicine Clinical Trials Health News Poisons ... Health Topics A-Z Search 1Up Health 1Up Health Mobius Syndrome [Congenital Facial Diplegia]
    Diseases and Conditions A B C D ... Z
    Mobius Syndrome [Congenital Facial Diplegia] Selected references Miller, M, et. al.
    Mobius and Mobius-like Syndrome. Journal of Pediatric Ophthalmology and Strabismus, 26:4; 176-188 (July-August 1989). Raroque, H, et. al.
    Mobius Syndrome and Transposition of the Great Vessels. Neurology, 38; 1894-1895 (1988). Cohen, S, and Thompson, J.
    Variants of Mobius Syndrome and Central Neurologic Impairment: Lindeman Procedure in Children. Annals of Otology, Rhinology, and Laryngology, 96; 93-100 (1987). Previous Next What is Mobius Syndrome?
    Is there any treatment?
    ...
    Mobius Syndrome [Congenital Facial Diplegia]
    Acknowledgement
    National Institute of Neurological Disorders and Stroke (NINDS)
    National Institutes of Health (NIH)
    Related Main Page Health Articles Diseases-Conditions Surgery-Procedure Medical Tests More.....

    17. HON - List Of Rare Diseases
    Mikulicz' Disease, Miller Fisher Syndrome. mobius syndrome, MoyamoyaDisease. Mucocutaneous Lymph Node Syndrome, Mucopolysaccharidosis I.
    http://www.hon.ch/HONselect/RareDiseases/
    List of rare diseases: English Deutsch Acrocephalosyndactylia
    Acrodermatitis
    ... HONewsletter http://www.hon.ch/HONselect/RareDiseases/index.html Last modified: Thu Sep 26 2002

    18. Mobius Syndrome
    mobius syndrome. Synonym(s) Congenital Facial Diplegia What is mobius syndrome? Thereis no specific course of treatment for mobius syndrome.
    http://www.clevelandclinic.org/health/health-info/docs/1300/1307.asp?index=6064

    19. Show-documents.asp
    mobius syndrome Written Information. Care Treatment., mobius syndrome. New Search. Health Extra Menu.
    http://www.clevelandclinic.org/healthextra/do-query.asp?TopicId=1329

    20. Mobius, Syndrome : Sites Et Documents Francophones
    Translate this page Voir aussi paralysie faciale . Arborescence(s) du thesaurus MeSHcontenant le mot-clé Mobius, syndrome mobius syndrome
    http://www.chu-rouen.fr/ssf/pathol/mobiussyndrome.html
    Mobius, Syndrome Menu général CISMeF Voir aussi paralysie faciale
    Arborescence(s) Mobius, syndrome Mobius syndrome
    maladies et malformations congénitales, héréditaires et néonatales
    système nerveux, maladies Position du mot-clé dans l' (les) arborescence(s) : Vous pouvez consulter 20 janvier 2003
    courriel
    Menu général CISMeF Haut de page © CHU de Rouen . Toute utilisation partielle ou totale de ce document doit mentionner la source.

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