21. EMSA-SG Study group for multiple system atrophy. http://www.emsa-sg.org

22. Association For Patient-Oriented Research multiple system atrophy News. Click figure to go to SDS/MSA Website. 2. MULTIPLESYSTEM ATROPHY RESEARCH NEWS a. Researchers Meet to Test MSA Rating Scale. http://www.mc.vanderbilt.edu/gcrc/aas/patient resources/SD-MSA group.html

Shy-Drager/MSA Support Group Join the Multiple System Atrophy/Shydrager Mailing List Multiple System Atrophy News Click figure to go to SDS/MSA Website February 2003 1. SUPPORT GROUP NEWS a. View the Latest News from Shy-Drager.com i. Annual Russell Wood Lecture - Denver, CO - April 2003 ii. SDS/MSA Support Group Regional Meeting - Houston, TX - May 2003 b. NAF Annual Membership Meeting - Atlanta, GA - March 2003 2. MULTIPLE SYSTEM ATROPHY RESEARCH NEWS a. NIH FUNDED RESEARCH PROJECTS i. Autonomic Disorders Program Project ii. Molecular Substrates of Aging and Neuron Death 3. ODDS AND ENDS a. Charmayne's MSA/Shy-Drager website has moved. January 2003 Table of Contents a. View the Latest News from Shy-Drager.com b. Annual Ataxia Medical Meeting - February 8, 2003 - Rockville, MD 2. MULTIPLE SYSTEM ATROPHY RESEARCH NEWS a. World Leaders in MSA Research to meet in Austria - February 2003 b. NEW NIH FUNDED RESEARCH PROJECT: Bionic Baroreflex System for Blood Pressure Control 3. CLINICAL STUDIES RECRUITING PATIENTS WITH AUTONOMIC DISORDERS

23. MSA What is multiple system atrophy (MSA)? I can only describe MSA asa brutal illness. It is rare and very difficult to diagnose. It http://members.optushome.com.au/wwwombat/interest.htm

What is Multiple System Atrophy (MSA)? I can only describe MSA as a brutal illness. It is rare and very difficult to diagnose. It is not known what causes the illness and there is no cure at this point in time. Very few doctors will actually say for certain that a person has MSA because the only way right now to know for sure that someone had MSA is to do an autopsy. Even if the symptoms all match exactly I don’t think any doctor would say definitely. The best they can do is say "probably". For example, Progressive Supranuclear Palsy (PSP) is very similar to MSA as is Corticobasal Ganglionic Degeneration (CBGD) and Lewy Body Dementia (LBD). When I first started researching MSA across the Internet, I found that there were differing schools of thought as to what MSA is. For me, an excellent description of MSA has been written by Timothy C. Hain, MD Northwestern University Medical School, Chicago, USA. He is without doubt an authority on MSA and you can find him at: http://www.neuro.nwu.edu/meded/MOVEMENT/msa.html

24. The Sarah Matheson Trust For Multiple System Atrophy The Sarah Matheson Trust is the UK charity that offers support and information servicesto people living with multiple system atrophy and all those that care http://www.msaweb.co.uk/

The Sarah Matheson Trust is the UK charity that offers support and information services to people living with Multiple System Atrophy and all those that care for them. It also sponsors research in the cause and treatment of MSA. The site provides information on MSA and outlines the Trust's services and how to access them. sarah matheson trust, msa, multiple system atrophy, multisystem atrophy, autonomic, autonomic dysfunction, cerebellar ataxia, degenerative diseases, glial inclusion bodies, nervous system diseases, neurology, parkinsonism, postural hypotension, shy drager s="na";c="na";j="na";f=""+escape(document.referrer) document.write(""+todaysDate+""); This website provides information for health professionals and people diagnosed with MSA. The information on this site forms part of the range of information leaflets available from the Sarah Matheson Trust. The site is not designed as a diagnostic tool and, as with any medical information, the opinion of your doctor should always be sought. Sarah Matheson Trust, Pickering Unit, St Mary's Hospital, London W2 1NY (phone) 020 7886 1520

25. Multiple System Atrophy multiple system atrophy (MSA). Timothy C. Hain, MD Chicago, USA. Survival ofpatients with pathologically proven multiple system atrophy A meta analysis. http://www.tchain.com/otoneurology/disorders/central/movement/msa.html

Multiple System Atrophy (MSA) Timothy C. Hain, MD Chicago, USA Last update: 12/15/2002 Please read our Multiple system atrophy is a rare neurological disorder characterized by a combination of parkinsonism, cerebellar and pyramidal signs, and autonomic dysfunction. The term "Multiple System Atrophy" is synonymous with striatonigral degeneration (SND) when Parkinsonism predominates, olivopontocerebellar atrophy (OPCA) when cerebellar signs predominate, and Shy-Drager syndrome when autonomic failure is dominant. The incidence (new case per 100,000 person years) for ages 50 to 99 years is 3.0 (Bower et al, 1997), or about half as frequent as progressive supranuclear palsy (PSP) . The mean age of onset is 54. The Parkinsonism of MSA is generally an akinetic rigid syndrome, similar to that of PSP . Rest tremor may occur but is not a predominant feature. Postural instability is common. Parkinsonism is generally the most common initial sign and eventually develops in about 90% of all patients. The cerebellar signs inlude finger-to-nose or heel-shin dysmetria, gait ataxia, intention tremor and nystagmus. Cerebellar signs are the first feature on only about 5% of patients. Cerebellar signs are observed in 50% of cases (Ben-Shlomo et al, 1997). Sporadic OPCA evolves into MSA in roughly 25% of cases within 5 years.

26. Multiple System Atrophy Following Chronic Carbon Disulfide Exposure Citation in PubMed Related Articles . multiple system atrophyFollowing Chronic Carbon Disulfide Exposure. Howard Frumkin. Department http://ehpnet1.niehs.nih.gov/docs/1998/106p611-613frumkin/abstract.html

Environmental Health Perspectives Volume 106, Number 9, September 1998 Case Study from the Emory Clinic and the Rollins School of Public Health of Emory University Citation in PubMed Related Articles Multiple System Atrophy Following Chronic Carbon Disulfide Exposure Howard Frumkin Department of Environmental and Occupational Health, Rollins School of Public Health of Emory University, Atlanta, GA 30322 USA Abstract Key words : carbon disulfide, cellulose, environmental diseases, movement disorders, multiple system atrophy, occupational diseases, olivopontocerebellar atrophy, rayon, textiles. Environ Health Perspect 106:611-613 (1998). [Online 18 August 1998]. http://ehpnet1.niehs.nih.gov/docs/1998/106p611-613frumkin/abstract.html Address correspondence to H. Frumkin, Department of Environmental and Occupational Health, Rollins School of Public Health of Emory University, 1518 Clifton Road, Atlanta, GA 30322 USA. This work was supported in part by NIEHS Environmental/Occupational Medicine Academic Award 5 KO7 ESO0257. Received 30 July 1998; accepted 3 August 1998.

27. Treatment Of Multiple System Atrophy, Mayo Clinic In Jackosnville, Fla. Mayo Clinic Jacksonville Medical Services multiple system atrophy. Treatmentof multiple system atrophy at Mayo Clinic in Jacksonville. http://www.mayoclinic.org/multiplesystematrophy-jax/

search: Mayo Clinic Locations: Arizona Florida Minnesota Mayo Clinic ... Medical Services Multiple System Atrophy Multiple System Atrophy Treatment Appointments Clinical Trials Other Web Resources ... Medical Services Treatment of Multiple System Atrophy at Mayo Clinic in Jacksonville (Synonyms: Shy-Drager syndrome) According to the American Autonomic Society, Multiple System Atrophy (MSA) is a sporadic, progressive, adult-onset disorder characterized by autonomic dysfunction, parkinsonism and ataxia (a failure of muscular coordination) in any combination. The features of the disorder include: Parkinsonism Cerebellar or corticospinal signs Orthostatic hypotension, impotence, urinary incontinence or retention, usually preceding or within two years after the onset of the motor symptoms Parkinsonian and cerebellar features commonly occur in combination. However, certain features may predominate. The condition is evaluated and treated in Mayo Clinic's Movement Disorders Program The term Shy-Drager syndrome, named after the two physicians who first described the neurologic symptoms, is still used to refer to Multiple System Atrophy. However, Shy-Drager more specifically describes an MSA whose symptoms involve a failure of the autonomic nervous system. Those symptoms include orthostatic hypotension, an abnormal drop in blood pressure when a person sits or stands that causes lightheadness and blackouts, as well as tiredness, blurred vision, lack of muscle coordination and pain in the back of the neck. Other symptoms of MSA are the tremors and muscle rigidity associated with Parkinson's disease and decreased mobility and motor function, causing balance problems or a tendency to fall.

28. Other Web Resources About Multiple System Atrophy, Mayo Clinic In Jacksonville, Other Web Resources about multiple system atrophy, Mayo Clinic in Jacksonville,Fla. Mayo Clinic Jacksonville Medical Services multiple system atrophy. http://www.mayoclinic.org/multiplesystematrophy-jax/resources.html

search: Mayo Clinic Locations: Arizona Florida Minnesota Mayo Clinic ... Medical Services Multiple System Atrophy Multiple System Atrophy Treatment Appointments Clinical Trials Other Web Resources ... Medical Services Other Web Resources Below are some helpful Internet resources on this topic. Mayo Clinic does not own or control any of these sites and is not responsible for their content. Inclusion of these sites does not imply endorsement by Mayo Clinic. To return to the mayoclinic.org Web site, click on your browser's back button. MEDLINEplus National Library of Medicine National Institute of Neurological Disorders and Stroke About Mayo Clinic Contact Mayo ... Home

29. 1Up Health > Multiple System Atrophy > Causes, Incidence, And Risk Factors Of Mu Comprehesive information on multiple system atrophy (Neurologic orthostatic hypotension,Parkinson's plus syndrome, ShyDrager Syndrome, Shy-McGee-Drager http://www.1uphealth.com/health/multiple_system_atrophy_info.html

1Up Health Multiple system atrophy Alternative Medicine Clinical Trials ... Health Topics A-Z Search 1Up Health Multiple system atrophy Information Multiple system atrophy Causes, Incidence, and Risk Factors Alternative names : Neurologic orthostatic hypotension, Parkinson's plus syndrome, Shy-Drager Syndrome, Shy-McGee-Drager syndrome Definition : A degenerative disorder characterized by progressive damage to the autonomic nervous system (the portion of the nervous system that controls involuntary functions such as blood pressure, heart rate, digestion and sexual function), muscle tremor and rigidity, slow movement, and other widespread neurologic losses. Causes, Incidence, and Risk Factors Multiple system atrophy (MSA) is a rare degenerative condition. It is a condition that appears similar to Parkinson's disease in that patients may be slow moving, tremulous and have a shuffling gait but with more widespread neurologic damage and damage to the autonomic nervous system (the portion of the nervous system that controls involuntary functions). The cause is unknown. There is progressive damage (degeneration) of the nervous system, with damage to all parts of the nervous system. The disorder develops gradually. It is most often diagnosed in men over 60 years old.

30. Arch Neurol -- Page Not Found multiple system atrophy The Putative Causative Role of Environmental Toxins AuthorInformation Philip A. Hanna, MD; Joseph Jankovic, MD; Joel B. Kirkpatrick http://archneur.ama-assn.org/issues/v56n1/abs/noc7799.html

Select Journal or Resource JAMA Archives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology Surgery MSJAMA Science News Updates Meetings Peer Review Congress The page you requested was not found. The JAMA Archives Journals Web site has been redesigned to provide you with improved layout, features, and functionality. The location of the page you requested may have changed. To find the page you requested, click here HOME CURRENT ISSUE PAST ISSUES ... HELP Error 404 - "Not Found"

31. Charmayne's Multiple System Atrophy/Shy-Drager Pages - General Information multiple system atrophy (MSA), ShyDrager (SDS), OlivopontocerebellarAtrophy (OPCA), Striatonigral Degeneration, ParkinsonPlus. http://www.bischel.com/general.html

WELCOME! 01/01/03 - PLEASE NOTE!: Due to changes in the direction of my own personal life, I am no longer actively watching for additions/changes/corrections/updates to these pages. Should you desire an addition or update to these pages, please do contact me via email at charmayne@bischel.com General MSA Information These links generally mirror the Shy-Drager mail-list at http://groups.yahoo.com/group/shydrager/links/ ~ by Pam Bower *** NEW *** MSA Diagnostic Criteria ~ October 2001 report co-authored by Andre Diedrich and Dr. David Robertson, Vanderbilt University *** NEW *** Cellular and Molecular Pathology of Multiple System Atrophy: A Review and Recent Developments ~ Keynote Lecture by P L Lantos *** NEW *** Darlene Turner's Shy-Drager Tribute Page *** NEW *** Multi System Atrophy and My Story ~ by Tim Foley from Trumbull, Connecticut, USA *** NEW *** Multiple System Atrophy ~ June 2001 article by H U Rehman *** NEW *** Shy-Drager Syndrome ~ by Carol A Turkington *** NEW *** Sporadic Cerebellar Degeneration ~ March 2001 presentation by Dr. Sid Gilman. Also see: http://accesswave.ca/~pbower/msa_gilman.htm

32. CHARMAYNE's Home Sweet Web Home LogoMSA/SDS multiple system atrophy/Shy-Drager - multiple system atrophy hasthree forms 1. Shy-Drager Syndrome (SDS) 2. Sporadic Olivopontocerebellar http://www.bischel.com/

from Portland, Oregon, USA The Charmayne/Charmaine Club - I love my name and share it with many others who spell it in a variety of ways: Charmaine, Charmayne, Charmain, Charmane, Charmagne, Charmeyn, Sharmaine, Sharmayne, etc. It is now associated with the Picture "What Price Glory" from 1926. You can meet many of 'us' on this page! Multiple System Atrophy/Shy-Drager - Multiple System Atrophy has three forms: 1. Shy-Drager Syndrome (SDS) 2. Sporadic Olivopontocerebellar Atrophy (OPCA) 3. Striatonigral Degeneration (SND) Multiple System Atrophy is a rare, progressive neurological disorder characterized by progressive failure of the central and autonomic nervous system. IT IS OFTEN MIS-DIAGNOSED!! Bandfield/Smith /Radish/Hurst/Robinson/Messmore/Brink/Corda Nordman/Reichert /Nordmann/Spohr/Meier/Dierks/Kahle/Kleinschmidt/ Krummwiede/Freitag/Niemeyer Bischel/Brown /Peeler/Becker/Boehl/Carlock/Freeney/Jones/Williams Hydeman/Pierce /Johnson/Grace/Sheedy/Baker/Kimball/Maltby/Hill/Pattee

33. Multiple System Atrophy - Www.ezboard.com Author, Comment. Pam Unregistered User (2/2/01 31837 pm) Reply, Multiple SystemAtrophy multiple system atrophy and Olivopontocerebellar atrophy mentioned. http://pub50.ezboard.com/fopcafrm4.showMessage?topicID=2.topic

34. Multiple System Atrophy News - September 2002 - Www.ezboard.com document.write(myLogin); OPCA Discussion Board General Discussion multiple system atrophy News September 2002, http://pub50.ezboard.com/fopcafrm1.showMessage?topicID=61.topic

35. The Contact A Family Directory - MULTIPLE SYSTEM ATROPHY printer friendly, multiple system atrophy, multiple system atrophy MSAShy Drager Syndrome. multiple system atrophy is a neurological http://www.cafamily.org.uk/Direct/m46.html

printer friendly MULTIPLE SYSTEM ATROPHY home more about us in your area conditions information ... how you can help search this site Multiple System Atrophy: MSA: Shy Drager Syndrome Multiple System Atrophy is a neurological disorder caused by degeneration of cells in certain areas of the brain. These control a number of different body systems; hence the name. They include functions of the autonomic nervous system (such as the control of blood pressure, sweating, bladder function) and the motor systems (such as muscle activation, movement and balance). MSA affects both men and women. Symptoms usually start between 40 and 60 years of age. The cause of MSA is not known, but is neither inherited nor contagious. MSA can manifest in a variety of different ways and progresses in an unpredictable sequence and time scale for each patient. It is important to understand that having a diagnosis of MSA does not mean that you will experience all the symptoms from the range below. The initial symptoms may resemble Parkinson's Disease with slowness of movement, stiffness of limbs and occasionally tremor. Some patients may have been given anti-parkinsonian drug treatment for these problems (with mixed results). A poor response to these drugs and the appearance of some of the following symptoms are indicators of MSA:

36. Multiple System Atrophy multiple system atrophy. This article submitted by on 1/31/99. Email VOLUMEXIX ISSUE 2 / Spring 1998. multiple system atrophy. By http://neuro-www.mgh.harvard.edu/forum/Pr.SupranuclearPalsyF/1.31.996.36PMMultip

Multiple System Atrophy This article submitted by on 1/31/99. Email Address: http://www.parkinson.org/atrophy.htm Parkinson's Report National Parkinson's Foundation, Inc. VOLUME XIX - ISSUE 2 / Spring 1998 Multiple System Atrophy By members of the National Parkinson Foundation Center of Excellence at Vanderbilt University, including David A. Robertson, Director, Nathan S. Blaser Shy-Drager Research Laboratories; Thomas L. Davis, Director, Movement Disorder Clinic; and Ariel Y. Deutch, Director, NPF Center of Excellence Although the cause of idiopathic Parkinson’s disease is unknown, Parkinson’s disease is probably the best characterized of the neurodegenerative disorders. The loss of dopamine in the striatum is the major contributor to the disorder. However, there are several other neurodegenerative disorders involving several different systems in the brain, in which striatal dopamine loss is also found. Among these other neurodegenerative disorders is multiple system atrophy (MSA), in which degeneration in diverse brain regions leads to problems in the control of movement, balance, blood pressure, and sexual and urinary tract function. MSA is

37. Multiple System Atrophy Facts replies. No messages are screened for content. multiple system atrophyFacts. VOLUME XIX ISSUE 2 / Spring 1998. multiple system atrophy. By http://neuro-www.mgh.harvard.edu/forum_2/ShyDragerF/7.1.996.59PMMultipleSyste.ht

This Web Forum is not moderated in any sense. Anyone on the Internet can post articles or reply to previously posted articles, and they may do so anonymously. Therefore, the opinions and statements made in all articles and replies do not represent the official opinions of MGH and MGH Neurology. Neither is MGH or MGH Neurology responsible for the content of any articles or replies. No messages are screened for content. Multiple System Atrophy Facts This article submitted by on 7/1/99. Email Address: http://www.parkinson.org/atrophy.htm Parkinson's Report National Parkinson's Foundation, Inc. VOLUME XIX - ISSUE 2 / Spring 1998 Multiple System Atrophy By members of the National Parkinson Foundation Center of Excellence at Vanderbilt University, including David A. Robertson, Director, Nathan S. Blaser Shy-Drager Research Laboratories; Thomas L. Davis, Director, Movement Disorder Clinic; and Ariel Y. Deutch, Director, NPF Center of Excellence Although the cause of idiopathic Parkinson’s disease is unknown, Parkinson’s disease is probably the best characterized of the neurodegenerative disorders. The loss of dopamine in the striatum is the major contributor to the disorder. However, there are several other neurodegenerative disorders involving several different systems in the brain, in which striatal dopamine loss is also found.

38. Multiple System Atrophy Subject multiple system atrophy Topic Area Multiple Sclerosis Forum The Neurologyand Neurosurgery Forum Question Posted By Bill on Monday, April 28, 1997 http://www.medhelp.org/forums/neuro/archive/242.html

Advertisement Welcome to Med Help International A not-for-profit organization Questions in The Neurology Forum are being answered by doctors from The Cleveland Clinic , consistently ranked one of the best hospitals in America. Subject: Multiple System Atrophy Topic Area: Multiple Sclerosis Forum: The Neurology and Neurosurgery Forum Question Posted By: Bill on Monday, April 28, 1997 Posted by ccf neuro M.D. on May 05, 1997 at 13:54:04: In Reply to: Multiple System Atrophy posted by Bill on April 28, 1997 at 17:12:09: : I have a friend who has recently been diagnosed with Multiple System Atrophy. We are looking for more information that would be helpful for her and her family to understand and deal with her condition. we have found a few things at the NIDS web site and MGH web site, but are still hoping to find other info. Knowing what you're facing is the first part of the battle. Thanks for any help. Bill The Neurology Forum Neurology Forum Archives Med Help Home Information contained within this forum is intended solely for general educational purposes and is not intended nor implied to be a substitute for professional medical advice relative to your specific medical condition or question. Always seek the advice of your physician or other health provider for any questions you may have regarding your medical condition. Only your physician can provide specific diagnoses and therapies. By using this site you agree to the following Terms and Conditions If you would like to make an appointment at the Cleveland Clinic, please call

39. Multiple System Atrophy Subject multiple system atrophy Forum The Neurology and NeurosurgeryForum Topic Area Posted by Bill on April 28, 1997 at 171209 http://www.medhelp.org/forums/neuro/archive/197.html

Advertisement Welcome to Med Help International A not-for-profit organization Questions in The Neurology Forum are being answered by doctors from The Cleveland Clinic , consistently ranked one of the best hospitals in America. Subject: Multiple System Atrophy Forum: The Neurology and Neurosurgery Forum Topic Area: Posted by Bill on April 28, 1997 at 17:12:09: I have a friend who has recently been diagnosed with Multiple System Atrophy. We are looking for more information that would be helpful for her and her family to understand and deal with her condition. we have found a few things at the NIDS web site and MGH web site, but are still hoping to find other info. Knowing what you're facing is the first part of the battle. Thanks for any help. Bill The Neurology Forum Neurology Forum Archives Med Help Home Information contained within this forum is intended solely for general educational purposes and is not intended nor implied to be a substitute for professional medical advice relative to your specific medical condition or question. Always seek the advice of your physician or other health provider for any questions you may have regarding your medical condition. Only your physician can provide specific diagnoses and therapies. By using this site you agree to the following Terms and Conditions If you would like to make an appointment at the Cleveland Clinic, please call

40. (9[4]:721-732) Multiple System Atrophy: A Sporadic Synucleinopathy (94721732) multiple system atrophy A Sporadic Synucleinopathy Dennis W. Dickson,Wen-lang Lin, Wan-Kyun Liu and Shu-Hui Yen multiple system atrophy (MSA http://www.brainpathology.com/abstracts/vol9/0904/0904a9.htm

Multiple System Atrophy: A Sporadic Synucleinopathy Dennis W. Dickson, Wen-lang Lin, Wan-Kyun Liu and Shu-Hui Yen (Download PDF: 680 KB)

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