61. Info multiple system atrophy Information. A lay Guide for Patients and their Carers. SymptomsDiagnosis Treatment What happens next? What is multiple system atrophy? http://glaxocentre.merseyside.org/msainfo.html

Autonomic Disorders Association Sarah Matheson Trust Registered Charity Number 1062308 Multiple System Atrophy Information A lay Guide for Patients and their Carers Index What is Multiple System Atrophy? Symptoms Diagnosis Treatment ... What happens next? What is Multiple System Atrophy? Multiple System Atrophy (MSA) is a neurological disorder caused by degeneration of cells in certain areas of the brain. These control a number of different body systems; hence the name. They include functions of the autonomic nervous system (such as the control of blood pressure, sweating, bladder function) and the motor systems (such as muscle activation, movement and balance). MSA affects both men and women. Symptoms usually start between 40 and 60 years of age. The cause of MSA is not known, but is neither inherited nor contagious. You may also hear it referred to as Shy Drager Syndrome. Symptoms MSA can manifest in a variety of different ways and progresses in an unpredictable sequence and time scale for each patient. It is important to understand that having a diagnosis of MSA does not mean that you will experience all the symptoms from the range below. The initial symptoms may resemble Parkinson's Disease, with slowness of movement, stiffness of limbs and occasionally tremor. Some patients may have been given anti-parkinsonian drug treatment for these problems (with mixed results). A poor response to these drugs and the appearance of some of the following symptoms are indicators of MSA:-

62. Additional MSA Links multiple system atrophy Autonomic Disorder Appears in Many Guises . http//www.advanceformrc.com/mrMSA.html. MultipleSystem Atrophy by Horacio Kaufmann. http://www.shy-drager.com/additional_msa_links.htm

"Multiple System Atrophy: Autonomic Disorder Appears in Many Guises" http://www.advanceformrc.com/mrMSA.html UNIVERSITY HOSPITALS OF CLEVELAND - Autonomic Laboratory http://mediswww.cwru.edu/dept/autonomic/anshome.htm MSA Booklet by University of Minnesota Movement Disorders Clinic http://www.clinical-services.med.umn.edu/movement-disorders/msa.htm Multiple System Atrophy : Information from the Parkinson Institute http://www.parkinsonsinstitute.org/movement_disorders/multiple_system.html Multiple System Atrophy : by Horacio Kaufmann. Note you need Adobe Acrobat Reader to view this file. http://www.mssm.edu/neurology/autodis/disorders/msa/msapaper.pdf Multisystem Atrophy : http://neurologychannel.com/msa/ Differential Diagnosis of Parkinson Plus Disorders : http://www.parkinsons-information-exchange-network-online.com/archive/091.html MSA Information for medical students and neurology residents : 1998 article by Dr.Timothy Hain, Northwestern University, Chicago http://www.neuro.nwu.edu/meded/MOVEMENT/msa.html MSA Shy-Drager Mini Information Sheet : June 2000 information published by the National Institutes of Health, Bethesda, MD

63. SDS Support Group What is ShyDrager Syndrome/multiple system atrophy? In 1960, Dr.Milton Shy, assigned to the National Institute of Health, and http://www.shy-drager.com/sdssg.htm

What is Shy-Drager Syndrome/Multiple System Atrophy? autonomic nervous system. The second patient subsequently expired and the postmortem examination provided evidence that he had a distinct and unique disease. Drs. Shy and Drager recognized that there was a link between low blood pressure during erect posture (orthostatic hypotension) and disturbances in the central autonomic system. To acknowledge their contribution, this disorder is known as "Shy-Drager Syndrome" (SDS). Today, Shy-Drager Syndrome (also called Multiple System Atrophy ) is a neurological disease resulting from degeneration of certain nerve cells in the brain and spinal cord. Body functions controlled by these areas of the brain and spinal cord function abnormally in patients with this disease. These include the autonomic nervous system or involuntary nervous system (which controls blood pressure, heart rate, and bladder function) and the motor system (control of balance and muscle movement). People in all parts of the world are affected, with onset usually between ages 45 and 60. Approximately 75,000 Americans have this disease. The cause of the disease is not known. It is not inherited and it is not contagious. Depending upon which part of the brain is affected first, the MSA may appear in different ways.

64. Multiple System Atrophy Among these other neurodegenerative disorders is multiple system atrophy (MSA), inwhich degeneration in diverse brain regions leads to problems in the control http://myhome.naver.com/acutemi/study_msa.htm

Multiple Systemic Atrophy Adult Onset Olivopontocerebellar Atrophy ; ataxia Striatonigral Degeneration ; parkinsonism Shy-Drager Syndrome ; autonomic dysfuction Although the cause of idiopathic Parkinson¡¯s disease is unknown, Parkinson's disease is probably the best characterized of the neurodegenerative disorders. The loss of dopamine in the striatum is the major contributor to the disorder. However, there are several other neurodegenerative disorders involving several different systems in the brain, in which striatal dopamine loss is also found. Among these other neurodegenerative disorders is multiple system atrophy (MSA), in which degeneration in diverse brain regions leads to problems in the control of movement, balance, blood pressure, and sexual and urinary tract function. MSA is often accompanied by some striatal dopamine loss and in certain patients typical parkinsonian symptoms are either the first noted or the most prominent. When MSA begins with non-autonomic features, imbalance is the most common feature. This difficulty in maintaining balance may be due to either cerebellar or Parkinsonian abnormalities. Some patients complain of stiffness, clumsiness, or a change in handwriting at the onset of MSA. The concurrent involvement in MSA of multiple brain systems subserving movement, including the striatum, cerebellum, and cortex, leads to the movement disorder as often being the most profound disability. Hoarseness or even vocal paralysis are relatively common, as are sleep disturbances, including snoring and sleep apnea. The ability to swallow foods and liquids may be impaired.

65. Multiple System Atrophy multiple system atrophy PubMed Medline search on multiple system atrophyInformation sheet on multiple system atrophy (WeMove). Support Groups. http://www.ion.ucl.ac.uk/library/patient/msa.htm

Multiple System Atrophy Medline NLM definition : A syndrome complex composed of three conditions which represent clinical variants of the same disease process: STRIATONIGRAL DEGENERATION; SHY-DRAGER SYNDROME; and the sporadic form of OLIVOPONTOCEREBELLAR ATROPHIES. Clinical features include autonomic, cerebellar, and basal ganglia dysfunction. Pathologic examination reveals atrophy of the basal ganglia, cerebellum, pons, and medulla, with prominent loss of autonomic neurons in the brain stem and spinal cord. PubMed Medline search on Multiple System Atrophy Information sheet on Multiple System Atrophy (WeMove) Support Groups The Autonomic Disorders Association Sarah Matheson Trust Imperial College School of Medicine, St. Mary's Hospital, Praed Street, London, W2 1NY Tel: 020 7861 520 Fax: 020 7861 540 Aims to provide information and support via:- telephone contact by professionals who have an interest and experience in the disease high quality written information, which is user friendly and structured to meet individual needs contact via a regular newsletter developing contact with other patients and carers in a sensitive and supportive environment co-ordinating services for people with MSA collecting information useful for research purposes to further our knowledge of MSA free registration.

66. Multi System Atrophy Links Parkinsonism More Common Than Thought. multiple system atrophy NDRF. MultipleSystem Atrophy (MSA). Sarah Matheson Trust for multiple system atrophy. http://msainfo.tripod.com/msalinks.html

There is no order to these links under the heading. They are randomly placed by me. General Information Neuroscience Web Search Nervous System Diseases DIFFERENTIAL DIAGNOSIS OF PARKINSON'S DISEASE AND THE PARKINSONISM PLUS SYNDROMES Parkinsonism More Common Than Thought ... Multiple System Atrophy NDRF Multiple System Atrophy (MSA) MultiSystem atrophy -Neurology Channel We Move Autonomic Disorders Editorial: Autonomic Disorders and Their Recognition Anaesthetic Implications and Shy-Drager ... Multiple System Atrophy Articles relating to Parkinson's or Parkinsonisms NIH Researchers Find First Parkinson's Disease Gene Drugs Health touch Online Drug Information Midodrine (ProAmitine) ... Sinemet (Carbidopa; Levodopa) Caregivers A Caregiver's Bill of Rights Caregiving Caregiver Survival Resources Caregiving Support: AARP ... National Family Caregivers Association (NFCA) Hospitals, Studies, and Medical Reports University of Kentucky: Movement Disorders Clinic University Hospitals of Cleveland: Autonomic Laboratory Case study of the Month - Baylor University Case of the Month (A test for students taking neurology) ... GPI-1046 - Nerve Growth (Press Release) Support Groups and Organizations American Autonomic Society Home Page Worldwide Education and Awarness for Movement Disorders (WEMOVE ) National Ataxia Foundation Support Groups Problems Associated with MSA

67. Ask Jeeves: Search Results For "Multiple System Atrophy" Popular Web Sites for multiple system atrophy . Search Results 1 10Ranked by Popularity, Next . 1. WE MOVE - multiple system atrophy http://webster.directhit.com/webster/search.aspx?qry=Multiple System Atrophy

68. Ask Jeeves: Search Results For "Atrophy" http//www.sleeptight.com/EncyMaster/A/atrophy.html 2. WE MOVE Multiple SystemAtrophy multiple system atrophy (MSA) is a neurodegenerative disease marked by http://webster.directhit.com/webster/search.aspx?qry=Atrophy

69. Multiple Systems Atrophy (MSA)-Professor David A. Lehman, P.T., Ph.D. - Universi WE MOVE multiple system atrophy. multiple system atrophy NorthwesternMedical School. AltaVista Simple Query multiple system atrophy. http://www.usa.edu/lehman/msa.htm

Welcome to the Neuropathology website created by Professor David A. Lehman, P.T., Ph.D. Multiple Systems Atrophy (MSA) Other information about MSA: WE MOVE - Multiple System Atrophy Multiple System Atrophy: Northwestern Medical School AltaVista Simple Query Multiple System Atrophy Pub Med Search on MSA : added 02/00

70. UMHS Department Page Robertson D, Schatz I, Wenning GK. Consensus statement on the diagnosisof multiple system atrophy. J Autonomic Nervous System 1998;74 http://www.med.umich.edu/neuro/gilman.htm

Neurology Home Page Neurology Faculty Neurology Home Page Neurology Faculty Sid Gilman, M.D., Wm J Herdman Professor of Neurology and Chair Phone: Fax: E-mail: sgilman@umich.edu William J. Herdman Professor of Neurology Chair, Department of Neurology Director, Michigan Alzheimer's Disease Research Center M.D.: University of California, Los Angeles Residency: Boston City Hospital, Harvard Medical School (Boston, MA) Fellowship: Harvard Medical School (Boston, MA); National Institutes of Health (Bethesda, MD) Curriculum Vitae Clinical Activities: Ataxia Clinic Research Interests: Cerebellar and basal ganglia diseases Dementia Positron Emission Tomography Representative Publications: Gilman S: Imaging the brain. First of two parts. N Engl J Med 1998;338:812-820.

71. The Health Library — Nervous System And Brain University of Washington. multiple system atrophy. Multiple SystemAtrophyWe Move. Multisystem AtrophyNeurology Channel. Genes and http://healthlibrary.stanford.edu/resources/internet/bodysystems/nervoussystem2.

Diseases and Disorders Use these links to jump directly to your topic of interest: Anatomy Autoimmune Nervous System Diseases Brain Diseases Brain Injury ... Transplantation Nervous System and Brain: Page 1 Page 3 Page 4 Page 5 ... Page 9 Dementias General Information Dementia:MEDLINEplus Forgetfulness:It's Not Always What You Think: National Institute on Aging (NIA) Dementia:Family Caregiver Alliance Mild Cognitive Impairment (NIA Memory Impairment Study):NIA ... Tauopathies: New Discoveries, New Knowledge:NIA Alzheimer's Disease Alzheimer's Disease:MEDLINEplus Alzheimer's Disease:National Institute of Mental Health (NIMH) About Alzheimer's Disease:NIA Alzheimer's Disease,Unraveling the Mystery: NIA ... Let's Talk About When Someone You Love Has Alzheimer's Disease:netLibrary [for Kids] Speaking Our Minds : Personal Reflections From Individuals With Alzheimer's:netLibrary Early-Stage Alzheimer's Disease:Family Caregiver Alliance Alzheimer's Disease and Plaques:Society for Neuroscience Interpreting Alzheimer's Abnormalities:Society for Neuroscience ... Early-Onset Familial Alzheimer Disease:GeneReviews, University of Washington See also Senior Health, Alzheimer's Care

72. Health Library Find Information On Multiple System Atrophy At Find information on multiple system atrophy at MerckSource. Learn moreabout multiple system atrophy. Definition A degenerative disorder http://www.mercksource.com/pp/us/cns/cns_hl_adam.jspzQzpgzEzzSzppdocszSzuszSzcns

73. Mouse With Iron Disorder Offers Clues To Parkinson’s, Similar Diseases The progressive deterioration of the mice's nervous system is like that seen inpeople with Parkinson's Disease and multiple system atrophy (also known as http://www.nichd.nih.gov/new/releases/parkinson.cfm

Home Search Sitemap Contact ... Back January 30, 2001 Mouse with Iron Disorder Offers Clues to Parkinson's, Similar Diseases Mice engineered to lack a gene involved in iron metabolism may provide important clues for deciphering the nature of a group of brain disorders-similar to Parkinson's Disease-affecting movement, according to a study by researchers at the National Institute of Child Health and Human Development (NICHD). The researchers reported in the February issue of Nature Genetics that mice lacking the gene for iron regulatory protein 2 (IRP2) develop iron deposits in key areas of the brain. The progressive deterioration of the mice's nervous system is like that seen in people with Parkinson's Disease and Multiple System Atrophy (also known as Parkinson's Plus). "Researchers have long debated whether the characteristic iron deposits of these diseases are the cause or the result of the disease process," said Duane Alexander, M.D., Director of the NICHD. "This is a strong clue that iron may play a causative role in Parkinson's and similar disorders." Diseases in which excess brain iron has been observed include Parkinson's Disease, Friedreich's Ataxia and Hallervorden-Spatz disease. However, the brain areas affected differ from those in the IRP 2 deficient mice, and it is unlikely that IRP 2 is involved in these human diseases, said the study's senior investigator, Tracey A. Rouault, M.D., of NICHD's Cell Biology and Metabolism Branch. Still, the NICHD finding suggests that other genes involved in iron metabolism may be good candidates for investigations into the causes of these disorders.

74. PD INDEX: A Directory Of Parkinson's Disease Information On The Internet BMJ Sinemet questions. P Nausieda MD multiple system atrophy (ShyDragersyndrome) An algorithm for the management of Parkinson's disease. http://www.pdindex.org/isrdm.htm

PD INDEX: A Directory of Parkinson's Disease Information on the Internet Information sources under area RELATED DISEASES for topics beginning with "M": melanoma risk Occurrence of different cancers in patients with Parkinson's disease. BMJ Sinemet questions. P Nausieda MD multiple system atrophy (Shy-Drager syndrome) An algorithm for the management of Parkinson's disease. C Olanow MD, W Koller MD PhD. 1998 Multiple system atrophy. D Robertson NS et al Parkinson's "Plus" Syndromes. The Canadian Movement Disorder Group Shy-Drager syndrome fact sheet from NIH/NINDS myoclonus Abnormal involuntary movements (dyskinesia). P May MD An algorithm for the management of Parkinson's disease. C Olanow MD, W Koller MD PhD. 1998 General information on myoclonus from the Cleveland Clinic Managing common adverse effects of levodopa. D Forzese. Amer Soc Consult Pharm ... Restless legs syndrome: diagnosis and treatment. W Hening MD, PhD See also dystonia as a distinct condition (primary dystonia) Display all topics for this area Go to top of page Go to home page ... Go to alphabetical topic index

75. Welcome To ENH.org - Health Encyclopedia: Multiple System Atrophy multiple system atrophy. Causes, incidence, and risk factors Multiplesystem atrophy (MSA) is a rare degenerative condition. It http://www.enh.org/Encyclopedia/ency/article/000757.asp

Disease Reference Injury Reference Test Reference Nutrition Reference ... Symptoms Reference Multiple system atrophy Disease Injury Nutrition Poison ... Z Definition: A degenerative disorder characterized by progressive damage to the autonomic nervous system (the portion of the nervous system that controls involuntary functions such as blood pressure, heart rate, digestion and sexual function), muscle tremor and rigidity, slow movement, and other widespread neurologic losses. Alternative Names: Shy-Drager Syndrome; Neurologic orthostatic hypotension; Shy-McGee-Drager syndrome; Parkinson's plus syndrome Causes, incidence, and risk factors: Multiple system atrophy (MSA) is a rare degenerative condition. It is a condition that appears similar to Parkinson's disease in that patients may be slow moving, tremulous and have a shuffling gait but with more widespread neurologic damage and damage to the autonomic nervous system (the portion of the nervous system that controls involuntary functions). The cause is unknown. There is progressive damage (degeneration) of the nervous system, with damage to all parts of the nervous system. The disorder develops gradually. It is most often diagnosed in men over 60 years old. Symptoms: Dizziness or fainting when arising or after standing still Impotence Loss of sweating of any part of the body Loss of control of bowels or bladder Vision changes, decreased or

76. Parkinson's & The Parkinson's Plus Disorders geocities.com/sweekes99/ALStitle.html Neurology Forum Multisystem atrophy (MSA)http//www.neurologychannel.com/msa/ multiple system atrophy (MSA) http//www http://www.geocities.com/murraycharters/002.html

Parkinson's Plus Disorders previous home contents contact ... next Topic 02: parkinson's plus links This site contains education and research URL's book-marked by a Parkinson's patient. Nothing you read in these pages should be considered an endorsement or medical advice. What Are The Other Forms of Parkinsonism? http://www.1uphealth.com/... Neurologic Movement Disorders Include... http://www.wemove.org/mov.html Parkinson Plus http://dem0nmac.mgh.harvard.edu/neurowebforum/... Parkinson's Plus - An Excerpt http://alumni.engin.umich.edu/~jxm/parkguide.html Worldwide Education for Movement Disorders http://www.wemove.org/ Parkinson's Disease http://www.neuro.nwu.edu/meded/MOVEMENT/parkinsons.html Progressive Supranuclear Palsy Europe Association http://www.ion.ucl.ac.uk/PSPeur/ What is PSP? http://www.ion.ucl.ac.uk/PSPeur/web_whatis.htm Progressive Supranuclear Palsy: A Survey of the Disease Course (supplement) http://www.alfalab.ca/santa97t.html Progressive Supranuclear Palsy http://www.neuro.nwu.edu/meded/MOVEMENT/psp2.htm

77. MSAnewsTOC _ multiple system atrophy News January 2003 Table http://www.geocities.com/azataxiasg/MSAnewsTOC.html

Questions or comments about this site? Please contact the Webmaster Page last modified January 17, 2003 MSA News TOC iiii iiii Multiple System Atrophy News - January 2003 Table of Contents Page 1: a. View the Latest News from Shy-Drager.com b. Annual Ataxia Medical Meeting - February 8, 2003 - Rockville, MD Page 2: MULTIPLE SYSTEM ATROPHY RESEARCH NEWS a. World Leaders in MSA Research to meet in Austria - February 2003 b. NEW NIH FUNDED RESEARCH PROJECT: Bionic Baroreflex System for Blood Pressure Control Page 3: CLINICAL STUDIES RECRUITING PATIENTS WITH AUTONOMIC DISORDERS a. Positron Emission Tomographic (PET) Scanning of Sympathetic Innervation and Function in Patients with Neurocardiologic Disorders b. Blood Sampling for Neurochemical and Genetic Testing Page 4: ODDS AND ENDS a. VIDEO: "Bringing attention to the rare disease Ataxia" AASG Home

78. Parkinson's Disease Center And Movement Disorders Clinic multiple system atrophy Joseph Jankovic, MD. Download Summary (PrinterFriendly),Download Acrobat Reader 5.0. What is multiple system atrophy (MSA)? http://www.bcm.tmc.edu/neurol/jankovic/educ_msa.htm

Parkinson's Disease Center and Movement Disorders Clinic Multiple System Atrophy Joseph Jankovic, M.D. Previous What and How Next Download Summary ( Printer-Friendly) What is Multiple System Atrophy (MSA)? A. What is Shy-Drager Syndrome (SDS)? Diagnosis is sometimes aided by testing autonomic nervous system function, for example, by measuring blood pressure and heart rate with the patient laying down compared with standing up. A polysomnogram, or sleep study, can document sleep apnea (gaps in breathing during sleep). Brain imaging with CT and MRI are usually helpful in differentiating typical Parkinson's disease from atypical parkinsonism. B. What is Striatonigral Degeneration (SND)?

79. Life Extension What's Hot Archive: January 2001 January 31, 2000. Iron likely plays causative role in Parkinson's andmultiple system atrophy. In research conducted by the National http://www.lef.org/whatshot/2001_01.html

LEF Site Search All categories Protocols Health Conditions Products LE Magazine Medical Abstracts What's Hot FDA Information About LEF LEF News LEF Membership What is LEF? Benefits Become a Member Renewals ... Become a Subscriber Products Product Index Alphabetical List New Products Blood Testing ... What's New Research Health Concerns Funded Research Track Record Innovative Doctors ... Scientific Advisory Free Product Directory Click for a FREE copy of our Product Directory Our call center has now expanded its hours Monday thru Friday: 8:30am to 12:00am EST 5:30am to 9:00pm PST Saturday hours are: 9:00am to 8:00pm EST 6:00am to 5:00pm PST Sunday hours are: 11:00am to 7:00pm EST 8:00am to 4:00pm PST If you'd like to order by phone or speak to a live person for help, just call toll free: Customer Service Info Privacy Policy We subscribe to the HONcode principles. Verify here January 2001 Search the What's Hot Archive: Iron likely plays causative role in Parkinson's and Multiple System Atrophy Vitamin E improves immune function, reduces oxidative stress in humans

80. Multiple System Atrophy?? From JACK TIBBS <101605.3242@COMPUSERVE.COM> Subject multiple system atrophy I am now told that my Parkinson s ismultiple system atrophy which is why I am writing to Parkinsn. http://parkinsn.coles.org.uk/Parkinsons/PARKINSNLog.nsf/82dd4bfc8da01667802567fc

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