81. NINDS Inclusion Body Myositis Information Page Inclusion Body myositis (Inflammatory Myopathy) information sheet compiledby NINDS. More about NINDS Inclusion Body myositis Information Page. http://accessible.ninds.nih.gov/health_and_medical/disorders/inclusion_doc.htm

Disorders - National Institute of Neurological Disorders and Stroke (NINDS) Skip menus Main sections of the NINDS web site Home About NINDS Disorders-you are in this section ... Find People Disorders section pages and search Image Description Science For the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system. Select Topic Disorder Quick Links Alzheimer's Autism Cerebral Palsy Chronic Pain Epilepsy Headache Multiple Sclerosis Parkinson's Stroke Traumatic Brain Injury More about NINDS Inclusion Body Myositis Information Page Studies with patients Research literature Press release NINDS Search (search help) Contact us My privacy NINDS is part of the National Institutes of Health Contact us Content for this page NINDS Inclusion Body Myositis Information Page Synonym(s): Inflammatory Myopathy Reviewed 11-08-2001 Get Web page suited for printing Email this to a friend or colleague Table of Contents (click to jump to sections) What is Inclusion Body Myositis? Is there any treatment? What is the prognosis? What research is being done? ... Related NINDS Publications and Information What is Inclusion Body Myositis? Is there any treatment?

82. Myositis Links And Information myositis Links and Information myositis is an inflammatory myopathy. myositis isa rare and chronic disease for which there is no cure at the present time. http://members.tripod.com/sabyrdie/id206.htm

var TlxPgNm='id206'; The ByrdHouse home Family News and Local News/Weather Friends and Family - Links and Photos Pets ... Granny's Brag Book Myositis Links and Information Contact Us! Myositis Links and Information Myositis is an inflammatory myopathy. Inflammatory myopathies include dermatomyositis, polymyositis, and inclusion body myositis. Although all of these diseases result in muscle weakness, each is unique in its development and treatment. All forms of myositis involve chronic muscle inflammation and may be associated with other forms of connective tissue diseases, such as lupus or rheumatoid arthritis. It also can be associated with occult (hidden) malignancy. Dermatomyositis is a form of myositis which involves inflammation of the muscles and results in damage to muscle fibers AND skin. Inflammatory myopathies are thought to be autoimmune disorders. In inflammatory myopathies, inflammatory cells invade and destroy muscle fibers as if they were defective or foreign to the body. This eventually results in muscle weakness. It primarily affects the proximal muscles (those closest to the body). Early signs of myositis may include difficulty rising from a chair, climbing stairs, or lifting the arms. A person may become tired after prolonged standing or walking. In some cases, early signs include trouble swallowing or breathing. Myositis is diagnosed by running a number of tests including a physical examination, blood tests, electromyography (EMG), and muscle biopsy.

83. ClinicalTrials.gov - Linking Patients To Medical Research: Study Details Immune Abnormalities in Sporadic Inclusion Body myositis. This study is currentlyrecruiting patients. Condition. Sporadic Inclusion Body myositis. http://www.clinicaltrials.gov/ct/gui/show/NCT00030212?order=1

84. Juvenile Dermatomyositis - JDMS - Jordan's JDMS Diary - Myositis The diary of a 10 year old girl diagnosed with this rare disease including her treatment and progress.Category Health Conditions and Diseases AutoImmune myositis......JDMS , Juvenile Dermatomyositis , myositis , JDMS , Juvenile Dermatomyositis ,myositis , JDMS , Juvenile Dermatomyositis , myositis , jdms , jdms , jdms http://www.geocities.com/EnchantedForest/Meadow/6709/

Hello. My name is Sherrell and I am the mother of three loving children. My youngest child is a beautiful little girl named Jordan. She was only 10 years old, in 1998, when diagnosed with a rare disease called Juvenile Dermatomyositis. (JDMS) It is so rare, information is hard to come by. I thought I would put her diary on the Internet in hopes of getting more information and also, to let other parents, facing this same nightmare, know that they are not alone. The first months of the diary may be hard to read. It brings tears to my eyes and I wrote it and lived it. But, trust me, there are joyful tears in the months to come. We have been blessed, for God is taking care of our baby. We hope that the information is helpful to each of you. The diary is our personal experience and doesn't necessarily apply to everyone. However, if you share the diary with someone else that has been diagnosed with JDMS or is the parent of a child with JDMS, please encourage them to read the whole diary or at least through December 1998. I just recently found a forum that can connect us and may help answer many questions. You may want to check it out.

85. Lyme Disease And Myositis Lyme Disease and myositis. Lyme disease is a serious bacterial infection causedby a tick bite and affects humans and animals. Lyme Disease and myositis. http://www.geocities.com/lymeart3/myositis-links.html

Lyme Disease and Myositis Lyme disease is a serious bacterial infection caused by a tick bite and affects humans and animals. Table of Contents Links to MEDLINE citations on Lyme Disease and Myositis Other resources for Lyme Disease and Myositis Also see - pages related to Lyme Disease and Myositis A note on medical combining forms ... For more information on Lyme disease Lyme Disease and Myositis myositis: muscular discomfort or pain from infection or an unknown cause Merriam-Webster/Medscape Medical Dictionary MeSH definition - Myositis Links to MEDLINE citations on Lyme Disease and Myositis This section contains links to citations and abstracts of medical and scientific articles from the National Institutes of Health (NIH), National Library of Medicine (NLM) MEDLINE database. MEDLINE - ALL myositis AND Lyme disease - 45 on 10 Sep 00 MEDLINE - myositis [in Title] AND Lyme disease - 12 on 15 Sep 00 MEDLINE - myositis AND Lyme disease - 37 on 15 Sep 00 MEDLINE - dermatomyositis AND Lyme disease - 13 on 15 Sep 00 ... MEDLINE - pyomyositis AND Lyme disease - 1 on 15 Sep 00 Other resources for Lyme Disease and Myositis Google Search: myositis lyme disease - 30,900 on 15 Sep 00

86. Inclusion Body Myositis: New Perspective In Etiopathogenesis Department Of Neurology Case of the Month Inclusion Body myositis NewPerspective in Etiopathogenesis Ghazala R. Hayat, MD Navigate http://medschool.slu.edu/departments/neurology/case/mar99.shtml

Department Of Neurology Case of the Month Inclusion Body Myositis: New Perspective in Etiopathogenesis Ghazala R. Hayat, M.D. Navigate Here Case Inclusion Body Myositis Severe Conjunctival Edema 48 year old man with diabetes 20-Month-Old Male Refusal To Bear Weight On The Legs 9 Year Old With Intermittent Episodes Table - Proposed Diagnostic Criteria for Inclusion Body Myositis Click above to view Table Figure 1 Click above to view the Larger Image Figure 2 Click above to view the Larger Image Figure 3 Click above to view the Larger Image CASE PRESENTATION Introduction Immune-mediated inflammatory myopathies (IM) consist of polymyositis, dermatomyositis and inclusion body myositis (IBM). The clinical features, immunopathogenesis, prognosis and therapeutic interventions vary, although polymyositis and IBM share some common pathological features. The pathogenesis of IBM is unknown and new research is pointing toward possible apolipoprotein abnormalities. Clinical Features Inclusion body myositis is commonly seen in males; the usual age of onset is 15 years and over. IBM is the most common IM in males over age 50, is slowly progressive and affects distal and proximal muscles. The characteristic features consist of involvement of quadriceps, dorsiflexors and volar forearm muscles. The proposed diagnostic criteria are outlined in Table I and include duration of illness more than six months, evidence of finger flexor weakness and wrist flexors affected more than the wrist extensors. The serum creatinine phosphokinase can be normal and, when elevated, is noted to be less than 12 times the normal value. IBM may be associated with other immune-mediated conditions(3), mitochondrial diseases, peripheral neuropathy and vasculitis.

87. Wheeless' Textbook Of Orthopaedics Main Menu Home Page myositis Ossificans (Sterner's Tumor). See - HeterotopicOssification - Ossification of Soft Tissue - Discussion http://www.ortho-u.net/o15/93.htm

Main Menu Home Page Myositis Ossificans (Sterner's Tumor) - See: - Heterotopic Ossification Ossification of Soft Tissue - Discussion: involved muscles: quadriceps, brachialis, and deltoid are involved most often; - typically lesions are distant from joints, have decr pain w/ time; - typically occurs in adolescents as a painless, enlarging mass in upper arm, thigh, or buttocks; - associated with an intact cortex; - demonstrate a zonal pattern; - Diff Dx: osteosarcoma: proliferative myositis - Radiographs: - CT Scan: - calcification of the herterotopic bone proceds from the outer margin and progresses centrally; - Bone Scan: - active myositis ossificans appears as intense para-osseous accumulation of tracer activity in acutely damaged muscle on delayed images; - Histology: - Prognosis: - over time, the volume of heterotopic bone will diminish;

88. Traumatic Myositis Ossificans TRAUMATIC myositis OSSIFICANS. A CASE 1996. 1. TRAUMATIC myositis OSSIFICANS.Ossifying hematoma. myositis ossificans circumscripta. myositis http://www.uic.edu/depts/doms/rounds-4.html

TRAUMATIC MYOSITIS OSSIFICANS A CASE REPORT AND REVIEW OF THE LITERATURE RUSSELL P. SPINAZZE D.D.S. ORAL AND MAXILLOFACIAL SURGERY UNIVERSITY OF ILLIONIS NOVEMBER 18, 1996 1. TRAUMATIC MYOSITIS OSSIFICANS Ossifying hematoma Myositis ossificans circumscripta Myositis ossificans progressiva - an entirely different entity discussed in greater detail later in the presentation 2. HISTORY Thoma 1963 : described myositis ossificans traumatica (MOT) as generally due to calcification of an intramuscular hematoma following trauma and progressive ossification Kostrubala; Croodsell; Thester 1948-69: reported a total of six cases in the literature with the Masseter M. being the primary muscle involved in the head and neck 3. HISTORY Arima et. al., 1984: literature producing 26 cases involving the head and neck Single muscles usually involved Masseter > Temporalis > Genioglossus > Buccinator > Pterygoids Only 1O% of the cases reported involved more than one muscle 4. HISTORY Men: Women 23:3 ratio Age range of 15 - 50 years with a predominance of occurrence in the 3rd to 4th decades of life 5. FORMS OF MYOSITIS OSSIFICANS

89. Neuromuscular Disease Research: Inclusion Body Myositis Inclusion Body myositis. Inclusion body inclusions. At present thereis no effective treatment for inclusion body myositis. Several http://www.bcm.tmc.edu/neurol/research/nmus/nmus3a3.html

Inclusion Body Myositis Inclusion body myositis, an inflammatory myopathy, has increasingly been recognized as the most common cause of muscle weakness diagnosed in older individuals. In addition, several patients with refractory polymyositis have, upon reevaluation of their diagnosis, been diagnosed with inclusion body myositis. The symptoms differ slightly from the other inflammatory myopathies in that the weakness seems to affect the distal and flexor muscles of the hands and quadriceps muscles more severely than other muscle groups. At present there is no effective treatment for inclusion body myositis. Several treatments using various immunosuppressants have not shown significant benefit, although there are anecdotal reports of certain patients responding to various immunosuppressive medications. Recent reports suggesting a beneficial effect of treatment with high doses of intravenous gamma globulin in a very small group of patients awaits confirmation. Click the pictures for larger version Rimmed Vacuoles Eosinophilic Inclusions Department of Neurology, Baylor College of Medicine

90. Myositis Z . Back Home Next. myositis American Autoimmune Related Diseases Association,Inc. (AARDA) . Association. myositis Association of America (MAA). http://www.ability.org.uk/Myositis.html

Our Aims Services Stats ... Z Myositis American Autoimmune Related Diseases Association, Inc. (AARDA) Jordan's Juvenile Dermatomyositis Diary MDA Dermatomyositis page - Background and references for Dermatomyositis. Provided by the Muscular Dystrophy Association. Myositis Association of America (MAA) National Organization for Rare Disorders, Inc. (NORD) Rob's Find-a-way page - Rob is a teenager with Dermatomyositis. Site includes links and a chat room. Webmaster . Site Design by Ability "see the ability, not the disability" Acknowledgments

91. Health Library - Myositis myositis. Self Help Clearinghouse. myositis Association of America.National network. Founded 1993.Dedicated to serving http://yalenewhavenhealth.org/Library/HealthGuide/SelfHelp/topic.asp?hwid=shc29m

92. Health Library - Myositis myositis. Self Help Clearinghouse. myositis Association of America.National network. Founded 1993.Dedicated to serving http://bhagh.nhshealth.org/Library/HealthGuide/SelfHelp/topic.asp?hwid=shc29mys

93. Inclusion Body Myositis inclusion body myositis. common form of inflamatory myopathy most commonin the elderly; equal sex incidence. sporadic idiopathic disease http://chorus.rad.mcw.edu/doc/02037.html

CHORUS Collaborative Hypertext of Radiology Musculoskeletal system Feedback Search inclusion body myositis common form of inflamatory myopathy most common in the elderly equal sex incidence sporadic idiopathic disease (very rarely familial) misdiagnosed as steroid-resistant polymyositis symptoms presents as a painless slowly progressive proximal myopathy may cause dysphagia mild to moderate muscle wasting diagnosis serum creatine kinase levels usually normal or only slightly elevated EMG may show non-specific myopathic features diagnosis on muscle biopsy inclusion bodies seen in rimmed vacuoles in skeletal muscle fibres treatment steroids and immunosuppression generally ineffective rare patients reported who have made a response to treatment pathogenesis unknown ubiquitin, prion protein, tau protein found in inclusions abnormal mitchondria seen in some case James Lowe, DM BM BS MRCPath - 13 November 1997 Last updated 14 March 2001 Medical College of Wisconsin

94. Health Library - Myositis Saint Luke's Health System eLibrary. myositis. Self Help Clearinghouse.myositis Association of America. National network. http://hvelink.saint-lukes.org/library/healthguide/SelfHelp/topic.asp?hwid=shc29

95. Childhood Myositis And Dermatomyositis Studies Childhood myositis and Dermatomyositis Studies. Childhood myositisHeterogeneity Study Calcinosis Specimens from myositis Patients. http://childneurologyfoundation.org/0.02/studies/008.study.html

Childhood Myositis and Dermatomyositis Studies Childhood Myositis Heterogeneity Study: Patients are needed to define clinical, immunologic, and immunogenetic subsets of patients with juvenile myositis. They are studying patients with any form of inflammatory muscle disease whose onset occured at 18 yr of age, including patients dx as having juvenille dermatomyositis, polymyositis, myositis associated with another connective tissue disease, inclusion body myositis, focal myositis, ocular myositis, and cancer associated myositis. Patients may have any level of disease activity, incluyding inactive disease. Participation requires completion of detailed questionaire and a collection of a blood sample. Calcinosis Specimens from Myositis Patients Myositis muscle bx study We are organizing a study involving muscle biopsies of juvenile polymyositis and dermatomyositis patients for a systematic examination of immunohistochemistry and other immune markers. Paraffin-embedded and/or frozen tissue blocks are needed for this study. Please contact Fred Miller or Lisa Rider if you are able to contribute any samples. Vaccine-associated Myositis Study Patients who develop any form of myositis within 6 months of receiving any immunization (vaccination) are needed for study. Patients with myositis not developing within 6 months of immunization (vaccination), as well as normal controls who received the same immunization (vaccination ) are also neeed for study. Participation consists of completing a questionnaire and collecting a blood sample from a local physician.

96. Klonering En Expressie Van Myositis-specifieke Auto-antigenen STW, Klonering en expressie van myositisspecifieke auto-antigenen. KUN Kloneringen expressie van myositis-specifieke auto-antigenen (NCH.3699). http://www.stw.nl/projecten/N/nch3699.html

Klonering en expressie van myositis-specifieke auto-antigenen Titel van het onderzoek Klonering en expressie van myositis-specifieke auto-antigenen (NCH.3699) Omschrijving van het onderzoek De epitopen op de verschillende eiwit-antigenen (m.n. tRNA synthetasen en SRP-eiwitten) worden zo nauwkeurig mogelijk gekarakteriseerd, mede om na te gaan of de actieve centra van de enzymen het precieze doelwit van de autoantistoffen zijn. Daarnaast wordt nagegaan hoe frequent antistoffen tegen specifieke tRNA's voorkomen en welke RNA-epitopen door de autoantistoffen herkend worden. Cloning and expression of myositis-specific autoantigens. Resultaten van het onderzoek Er zijn nog geen resultaten bekend. Gebruikers Projectleider Prof.dr. W.J. van Venrooij Universiteit Nijmegen, Lab. voor Biochemie Status van het project Gestart: 01/12/1995 Einddatum: 01/01/2000 Trefwoorden biochemie, neurologie, geneeskunde, antigenen, autoantigenen, immunologie, myositis, diagnostiek, enzymen, tRNA synthetase, DNA, medische biotechnologie, transfectie, transcriptie, kloneren, Jo-1. Laatste wijziging: 21-11-1999 Reacties naar webmaster@stw.nl

97. Quadriceps Contusions And Myositis Ossificans Quadriceps Contusions and myositis Ossificans. Christopher M. Larson, MD. 2,7.GO TO TOP. Management of Quadriceps Contusion and Early myositis Ossificans. http://ortho.hyperguides.com/Tutorials/sport_med/QuadContusion/tutorial.asp

window.location="http://www.ortho.hyperguides.com/"; Quadriceps Contusions and Myositis Ossificans Christopher M. Larson, MD Pathophysiology Classification History and Physical Examination Management of Quadriceps Contusion and Early Myositis Ossificans ... References Pathophysiology External blows that cause tissue damage and vascular disruption lead to muscle contusions. An external blow creates a compression wave that travels through soft tissues and causes damage to the deep portion of muscle (vastus intermedius) as the external blow crushes the muscle against the adjacent bone. Extravasation of blood occurs within 24 hours, and bleeding is dispersed within and between muscle. By 1 week, acute inflammation results in elimination of debris and granulation tissue replaces the hematoma and necrotic muscle. Myoblastic activity increases and, by 3 weeks, dystrophic calcium and intramembranous bone can form in muscle and eventually ossify ( Slide 1 A peripheral zone of lamellar bone, an osteoid middle zone, and a central proliferation of granulation and fibrous tissue is characteristic of myositis ossificans. Slide 1 Forceful manipulation and contusion can individually lead to the development of ossification as shown in animal models.

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