1. OI: Syphilis And Neurosyphilis -- ÆGIS A comprehensive resource on Treponema pallidum, a spirochetal bacterium, from AEGIS.Category Health Reproductive Health Syphilis......Syphilis and neurosyphilis. This is part of a series on OpportunisticInfections ( OIs ). Please note that This Page Is Just A http://www.aegis.com/topics/oi/oi-syphilis.html

Syphilis and Neurosyphilis This is part of a series on Opportunistic Infections ("OIs"). Please note that This Page Is Just A Starting Point: who specializes in treating HIV. Finding The Latest Information: Advances in treating opportunistic infections can happen at any time, so the material on this page may be outdated. Some links in the see also section at the bottom of this page are actually special database links. They may contain information published after this page was written. Classification Treponema pallidum , a spirochetal bacterium. Description This is a sexually transmitted disease that has three stages: Primary syphilis symptoms: painless lesions (chancre) at the site of infection (usually penis, vulva, or vagina). These sores heal in about a month or less. Secondary syphilis symptoms: rash (condyloma lata, lymphadenopathy), fever. Late syphilis: lesions on internal organs, expecially the brain and heart. There are sometimes false positive results on syphilis tests for HIV+. Warnings: CATIE lab tests for syphilis may not be accurate standard anti-syphilis therapy may not be effective chronic infection with T. pallidum

2. Neurosyphilis neurosyphilis Considerations for a Psychiatrist. y.gif (1196 bytes). 1968;213701371.neurosyphilis Considerations for a Psychiatrist. y.gif (1196 bytes). http://www.priory.com/psych/neurosyphilis.htm

Neurosyphilis: Considerations for a Psychiatrist Mark A. Ritchie, MD Louisiana State University School of Medicine Joseph A. Perdigao, MA Louisiana State University School of Medicine Correspondence to: Mark A. Ritchie, MD Louisiana State University School of Medicine Department of Psychiatry 1542 Tulane Avenue New Orleans, Louisiana 70112-2822 (504) 568-3427, FAX (504) 568-8647 Abstract Introduction History Staging of Syphilis ... Conclusion ABSTRACT While penicillin has virtually eliminated the dramatic presentations of parenchymatous neurosyphilis, HIV, inadequate antibiotic treatment for syphilis, and the rising incidence of early syphilis among the young and urban poor, have increased the frequency of subtle, atypical and often monosymptomatic presentations of neurosyphilis. These presentations are increasingly missed as psychiatric patients receive fewer physical exams and laboratory work-ups, physicians are less experienced at diagnosing neurosyphilis, and non-physicians and non-psychiatrists care for the mentally ill. Neurologic symptoms and risks for sexually transmitted disease often signal the presence of neurosyphilis, but the disease can present with psychiatric symptoms alone, psychiatric symptoms that can mimic any other psychiatric illness. In this review of literature, the authors suggest criteria for screening and stress that a specific treponemal

3. EMedicine - Neurosyphilis : Article By Richard P Knudsen, MD neurosyphilis Syphilis (from the Greek word syphlos, meaning crippled or maimed)is a clinical challenge because of the protean manifestations associated http://www.emedicine.com/neuro/topic684.htm

document.write(''); (advertisement) Home Specialties CME PDA ... Patient Education Articles Images CME Patient Education Advanced Search Link to this site Back to: eMedicine Specialties Neurology Neurological Infections Neurosyphilis Last Updated: September 21, 2001 Rate this Article Email to a Colleague Synonyms and related keywords: neurolues, acute syphilitic meningitis, meningovascular syphilis, tabes dorsalis, general paresis, optic atrophy AUTHOR INFORMATION Section 1 of 10 Author Information Introduction Clinical Differentials ... Bibliography Author: Richard P Knudsen, MD , Adjunct Professor, Department of Neurology, Children's Hospital Regional Medical Center, University of Washington Medical Center Coauthor(s): Marcio Sotero de Menezes, MD , Assistant Professor, Department of Neurology, Division of Pediatric Neurology, Children's Hospital of Seattle, University of Washington Richard P Knudsen, MD, is a member of the following medical societies: American Academy of Neurology, American Academy of Pediatrics American Epilepsy Society Child Neurology Society , and Washington State Medical Association Editor(s): Amy A Pruitt, MD

4. Neurosyphilis, Tabes - Medical Dictionary Of Popular Medical Terms To Help You B A definition of neurosyphilis, tabes also known as tabes dorsalis. http://www.medterms.com/script/main/art.asp?articlekey=4558

5. Syphilis & Neurosyphilis CSF Evaluation of neurosyphilis RE A young black male with HIV, headache, and positive serum RPR. Question What are the typical CSF findings in neurosyphilis? South African Medical Journal. 84(10)6824, 1994 Oct. CSF Evaluation of neurosyphilis. 4/02/01 (Beer) http://www.hivpositive.com/f-Oi/OppInfections/4-Bacterial/4-Syphilis.html

Pathogen Sites of Infection Symptoms Diagnosis ... Go to the HIVpositive.com Main Menu Pathogen: Treponema pallidum, Sites of Infection: Soon after initial infection, the organism enters the lymphatic system and/or blood stream and disseminates throughout the body. Nearly all organs can be invaded, including the central nervous system. Symptoms: Diagnosis: In early syphilis, dark field examination of exudate from lesions and direct florescent antibody tests on lesions or tissue are definitive. Non-specific serologic tests are useful for syphilis screening and for monitoring response to treatment. Specific serologic tests are used for establishing the diagnosis. They usually remain positive for life and therefore cannot be used to monitor response to treatment. CSF examination is necessary for diagnosis of neurosyphilis. In HIV-infected individuals, false-positive serological tests despite adequate therapy are possible due to polyclonal B-cell activation or auto-immune processes. Conversely, but extremely rarely, false-negative serological tests have been reported. Extraordinary means (such as direct examination of lesion material) may be necessary to establish the diagnosis in these unusual cases. Gordon et al. have concluded that cerebrospinal fluid (CSF) PCR is not a sensitive test for neurosyphilis in HIV-infected patients. Despite clinical improvements reported in a trial of intravenous penicillin G, CSF VDRL levels measured by PCR remained high in all patients examined.

6. Neurosyphilis Neuroland Neurology information for physicians health professionals Search NeuroLand http://www.neuroland.com/id/neurosyph.htm

Neuroland Neurology information Click on the brain to index page Search NeuroLand Neuro disease Notes ... Neuro Med Neurosyphilis Organism Treponema pallidum Early CNS involvement The organism invades CNS early on, 10-70% of patient with early syphilis have CSF pleocytosis, elevated CSF protein or positive CSF VDRL Early forms Asymptomatic Neurosyphilis: CSF abnormalities, neuro normal Symptomatic meningitis: clinical meningitis, may develop cranial nerve abnormalities, hydrocephalus. Most common in first year of infection. Meningovasculitis: present with strokes, peak at 7 years after primary infection. Late forms General paresis: forgetful, personality change, psychiatric symptoms. Onset usually 10-20 years after primary infection. Treatment may not improve symptoms. Tabes dorsalis: sensory loss, ataxia, bladder dysfunction. Onset of symptoms usually 15 years after initial infection. Tabes Dorsalis - Baylor Diagnosis of Neurosyphilis Serum MHA-TP or FTA-ABS positive. RPR, VDRL may be negative in late stage CSF pleocytosis with a mild elevation of CSF protein CSF VDRL: low sensitivity (22-69%), but if positive is highly specific for Neurosyphilis

7. Alteration In The Natural History Of Neurosyphilis By Concurrent Within the past 18 months, we have seen four cases of neurosyphilis at our institution(two of meningovascular syphilis, one of acute syphilitic meningitis http://www.aegis.com/pubs/aidsline/1987/sep/m8790298.html

Important note: Information in this article was accurate in 1987. The state of the art may have changed since the publication date. Alteration in the natural history of neurosyphilis by concurrent infection with the human immunodeficiency virus. N Engl J Med. 1987 Jun 18;316(25):1569-72. Unique Identifier : AIDSLINE MED/87228878 Johns DR; Tierney M; Felsenstein D Abstract: Neurosyphilis should probably be added to the growing list of infectious complications of the acquired immunodeficiency syndrome (AIDS) and may be the first such complication to appear. Keywords: Acquired Immunodeficiency Syndrome/*COMPLICATIONS Adult Case Report Homosexuality Human Immune Tolerance Male Meningitis/ETIOLOGY Neurosyphilis/CEREBROSPINAL FLUID/*COMPLICATIONS/DIAGNOSIS Paralysis/ETIOLOGY JOURNAL ARTICLE National Library of Medicine . Reproduced under license with the National Library of Medicine, Bethesda, MD. AEGiS is made possible through unrestricted grants from Boehringer Ingelheim iMetrikus, Inc. , the National Library of Medicine , and donations from users like you. Always watch for outdated information. This article first appeared in 1987. This material is designed to support, not replace, the relationship that exists between you and your doctor.

8. Neurosyphilis neurosyphilis. Back to previous level http://www.ohsu.edu/cliniweb/C1/C1.252.400.840.744.456.html

Neurosyphilis Back to previous level Tabes Dorsalis Search PUBMED for Tabes Dorsalis: All Review Therapy Diagnosis ... Tabes Dorsalis - Pathological Brain Photo:Virtual Hospital, U. of Iowa

9. Neurosyphilis neurosyphilis. Organism, Treponema pallidum. Early Early forms, Asymptomaticneurosyphilis CSF abnormalities, neuro normal. Symptomatic http://neuroland.com/id/neurosyph.htm

Neuroland Neurology information Click on the brain to index page Search NeuroLand Neuro disease Notes ... Neuro Med Neurosyphilis Organism Treponema pallidum Early CNS involvement The organism invades CNS early on, 10-70% of patient with early syphilis have CSF pleocytosis, elevated CSF protein or positive CSF VDRL Early forms Asymptomatic Neurosyphilis: CSF abnormalities, neuro normal Symptomatic meningitis: clinical meningitis, may develop cranial nerve abnormalities, hydrocephalus. Most common in first year of infection. Meningovasculitis: present with strokes, peak at 7 years after primary infection. Late forms General paresis: forgetful, personality change, psychiatric symptoms. Onset usually 10-20 years after primary infection. Treatment may not improve symptoms. Tabes dorsalis: sensory loss, ataxia, bladder dysfunction. Onset of symptoms usually 15 years after initial infection. Tabes Dorsalis - Baylor Diagnosis of Neurosyphilis Serum MHA-TP or FTA-ABS positive. RPR, VDRL may be negative in late stage CSF pleocytosis with a mild elevation of CSF protein CSF VDRL: low sensitivity (22-69%), but if positive is highly specific for Neurosyphilis

10. Health Ency. Disease Neurosyphilis neurosyphilis occurs in 15 to 20% of all late or tertiary syphilis infections and is a progressive, lifethreatening http://www.icflorida.com/shared/health/adam/ency/article/000703.html

11. Roche Lexikon Medizin (4. Aufl.) - Neurosyphilis Translate this page Neuro syphilis. engl. neurosyphilis. die Syphilis des Nervensystemsmit spezif. »mesodermalen« (meningealen, vaskulären) oder http://www.gesundheit.de/roche/ro25000/r26803.html

Neuro syphilis engl.: neurosyphilis die Syphilis Lues cerebri Tabes dorsalis Verwandte Themen Lues Metasyphilis Neurolues Syphilis ... Tabes dorsalis

12. MEDLINEplus Medical Encyclopedia: Neurosyphilis neurosyphilis. There are 4 different forms of neurosyphilis asymptomatic,meningovascular, tabes dorsalis, and general paresis. http://www.nlm.nih.gov/medlineplus/ency/article/000703.htm

Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Neurosyphilis Contents of this page: Illustrations Definition Causes, incidence, and risk factors Symptoms ... Prevention Illustrations Central nervous system Definition Return to top Neurosyphilis is a slowly progressive and destructive infection of the brain or spinal cord that occurs in untreated syphilis many years after the primary infection. Causes, incidence, and risk factors Return to top Neurosyphilis occurs in 15 to 20% of all late or tertiary syphilis infections and is a progressive, life-threatening complication. There are 4 different forms of neurosyphilis: asymptomatic , meningovascular, tabes dorsalis , and general paresis Asymptomatic neurosyphilis precedes symptomatic syphilis and is present in 15% of those with latent syphilis. In this case, abnormalities may be present in the cerebrospinal fluid, but no symptoms are present. In meningovascular neurosyphilis, cranial nerve palsies and pupillary abnormalities may be present with a wide variety of symptoms. This may also cause damage to blood vessels resulting in stroke. In tabes dorsalis, progressive degeneration of the spinal cord occurs causing an inability to walk.

13. Neurosyphilis neurosyphilis. Definition neurosyphilis occurs in 15 to 20% of all late or tertiarysyphilis infections and is a progressive, lifethreatening complication. http://www.pennhealth.com/ency/article/000703.htm

Disease Injury Nutrition Poison ... Prevention Neurosyphilis Definition: Neurosyphilis is a slowly progressive and destructive infection of the brain or spinal cord that occurs in untreated syphilis many years after the primary infection. Causes, incidence, and risk factors: Neurosyphilis occurs in 15 to 20% of all late or tertiary syphilis infections and is a progressive, life-threatening complication. There are 4 different forms of neurosyphilis: asymptomatic , meningovascular, tabes dorsalis , and general paresis Asymptomatic neurosyphilis precedes symptomatic syphilis and is present in 15% of those with latent syphilis. In this case, abnormalities may be present in the cerebrospinal fluid, but no symptoms are present. In meningovascular neurosyphilis, cranial nerve palsies and pupillary abnormalities may be present with a wide variety of symptoms. This may also cause damage to blood vessels resulting in stroke. In tabes dorsalis, progressive degeneration of the spinal cord occurs causing an inability to walk. In general paresis

14. Neurosyphilis neurosyphilis. Prevention neurosyphilis can be prevented by the timelydiagnosis and treatment of primary syphilis and secondary syphilis. http://www.pennhealth.com/ency/article/000703prv.htm

Disease Injury Nutrition Poison ... Prevention Neurosyphilis Prevention: Neurosyphilis can be prevented by the timely diagnosis and treatment of primary syphilis and secondary syphilis . Good follow-up of these early stages to absolutely demonstrate a cure is necessary to avoid neurosyphilis from developing following incomplete treatment (either by inadequate medication or non-compliance of the individual taking the medication). Review Date: 7/19/2001 Reviewed By: Galit Kleiner-Fisman, M.D., FRCP(C), Department of Neurology, University of Toronto, Toronto, Ontario, Canada. Review provided by VeriMed Healthcare Network.

15. Health Ency.: Disease: Neurosyphilis neurosyphilis. neurosyphilis occurs in 15 to 20% of all late or tertiary syphilisinfections and is a progressive, lifethreatening complication. http://www.accessatlanta.com/shared/health/adam/ency/article/000703.html

SEARCH: The Web Yellow Pages HOME AJC.COM Illustrated Health Encyclopedia Important notice Ency. home Disease N Neurosyphilis Overview Symptoms Treatment Prevention Definition: Neurosyphilis is a slowly progressive and destructive infection of the brain or spinal cord that occurs in untreated syphilis many years after the primary infection. Causes and Risks Neurosyphilis occurs in 15 to 20% of all late or tertiary syphilis infections and is a progressive, life-threatening complication. There are 4 different forms of neurosyphilis: asymptomatic , meningovascular, tabes dorsalis , and general paresis Asymptomatic neurosyphilis precedes symptomatic syphilis and is present in 15% of those with latent syphilis. In this case, abnormalities may be present in the cerebrospinal fluid, but no symptoms are present. In meningovascular neurosyphilis, cranial nerve palsies and pupillary abnormalities may be present with a wide variety of symptoms. This may also cause damage to blood vessels resulting in stroke. In tabes dorsalis, progressive degeneration of the spinal cord occurs causing an inability to walk. In general paresis

16. 1Up Health > Neurosyphilis > Causes, Incidence, And Risk Factors Of Neurosyphili Comprehesive information on neurosyphilis . 1Up Health Diseases Conditions neurosyphilis Causes, Incidence, and Risk Factors. http://www.1uphealth.com/health/neurosyphilis_info.html

1Up Health Neurosyphilis Alternative Medicine Clinical Trials ... Health Topics A-Z Search 1Up Health Neurosyphilis Information Neurosyphilis Causes, Incidence, and Risk Factors Definition : Neurosyphilis is a slowly progressive and destructive infection of the brain or spinal cord that occurs in untreated syphilis many years after the primary infection. Causes, Incidence, and Risk Factors Neurosyphilis occurs in 15 to 20% of all late or tertiary syphilis infections and is a progressive, life-threatening complication. There are 4 different forms of neurosyphilis: asymptomatic , meningovascular, tabes dorsalis , and general paresis Asymptomatic neurosyphilis precedes symptomatic syphilis and is present in 15% of those with latent syphilis. In this case, abnormalities may be present in the cerebrospinal fluid, but no symptoms are present. In meningovascular neurosyphilis, cranial nerve palsies and pupillary abnormalities may be present with a wide variety of symptoms. This may also cause damage to blood vessels resulting in stroke. In tabes dorsalis, progressive degeneration of the spinal cord occurs causing an inability to walk.

17. 1Up Health > Neurosyphilis Information Comprehesive information on neurosyphilis . Search 1Up Health. Diseases Conditions . neurosyphilis Information. Guide. Definition http://www.1uphealth.com/health/neurosyphilis.html

1Up Health Alternative Medicine Clinical Trials Health News ... Health Topics A-Z Search 1Up Health Neurosyphilis Information Guide Definition : Neurosyphilis is a slowly progressive and destructive infection of the brain or spinal cord that occurs in untreated syphilis many years after the primary infection. Jump to a Section of this Guide Definition Causes, Incidence, and Risk Factors Symptoms Prevention ... Calling your Health Care Provider Related Tools and Utilities Search Books on Amazon: Read Articles on eLibrary: Health Products on drugstore.com: Dementia First trimester pregnancy General paresis Syphilis ... More More Topics Asymptomatic Confusion Depression Fever ... More Search 1Up Health A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org). URAC's accreditation program is the first of its kind, requiring compliance with 53 standards of quality and accountability, verified by independent audit. A.D.A.M. is among the first to achieve this important distinction for online health information and services. Learn more about A.D.A.M.'s editorial reviewers . A.D.A.M. is also a founding member of Hi-Ethics (www.hiethics.com) and subscribes to the principles of the Health on the Net Foundation (www.hon.ch). Home Contact Us Privacy Links Directory

18. Neurosyphilis Back Home Next. neurosyphilis. Syphilis and neurosyphilis Info onTreponema pallidum, a spirochetal bacterium, from AEGIS. Copyright http://www.ability.org.uk/Syphilis.html

"see the ability, not the disability" You to can help support the Ability Project by: Our Aims ... Z Neurosyphilis Syphilis and Neurosyphilis - Info on Treponema pallidum, a spirochetal bacterium, from AEGIS. Webmaster . Site Design by Ability "see the ability, not the disability" Acknowledgments

19. NEUROSYPHILIS neurosyphilis Penicillin is the treatment of choice. The other drugslisted below are available for patients with a genuine penicillin http://www.neuro.wustl.edu/neuromedical_treatment/nsyphlis.html

NEUROSYPHILIS Penicillin is the treatment of choice. The other drugs listed below are available for patients with a genuine penicillin allergy but their efficacy in regard to long term cure is not proven. Aqueous crystalline penicillin G 4 MU IV q4h for 14 days. Cephtriaxone Rocephin. 1 g IV or IM od for 14 days. Doxycycline 100 mg bid PO for 30 days. Tetracycline 500 mg qid PO for 30 days. Contraindicated by pregnancy and lactation.

20. Neurosyphilis neurosyphilis. Back to previous level Tabes Dorsalis Search PUBMEDfor Tabes Dorsalis All Review Therapy Diagnosis; Tabes Dorsalis http://www.ohsu.edu/cliniweb/C10/C10.228.228.674.html

Neurosyphilis Back to previous level Tabes Dorsalis Search PUBMED for Tabes Dorsalis: All Review Therapy Diagnosis ... Tabes Dorsalis - Pathological Brain Photo:Virtual Hospital, U. of Iowa

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