21. Olivopontocerebellar Atrophy - Www.ezboard.com Author, Comment. Pam Pro Visitor Posts 69 (11/1/02 104947 pm) Reply,olivopontocerebellar atrophy www.emedicine.com/neuro/topic282 http://pub50.ezboard.com/fopcafrm1.showMessage?topicID=65.topic

22. Multiple System Atrophy - Www.ezboard.com 4. Research Articles by Dr. Sid Gilman Neurology 2000 Aug 22;55(4)52732 Evolutionof sporadic olivopontocerebellar atrophy into multiple system atrophy. http://pub50.ezboard.com/fopcafrm4.showMessage?topicID=2.topic

23. ClinicalTrials.gov - Linking Patients To Medical Research Search Query Details. No studies were found for olivopontocerebellar atrophy ALLFIELDS.Modify Your Search. Individual Terms, Count. olivopontocerebellar atrophy , None. http://www.clinicaltrials.gov/search/term=Olivopontocerebellar Atrophy

24. ClinicalTrials.gov - Linking Patients To Medical Research Search No studies were found for NINDS olivopontocerebellar atrophy Information Page ALLFIELDS. NINDSolivopontocerebellar atrophy Information Page , None. Page , 7. http://www.clinicaltrials.gov/search/term=NINDS Olivopontocerebellar Atrophy Inf

25. Olivopontocerebellar Atrophy olivopontocerebellar atrophy. Definition The cause of sporadic olivopontocerebellaratrophy is not known, but the disease is progressive. http://www.pennhealth.com/ency/article/000758.htm

Disease Injury Nutrition Poison ... Prevention Olivopontocerebellar atrophy Definition: Olivopontocerebellar atrophy is a neurodegenerative illness that causes certain brain areas (which may include the olivary nucleus, the pons, and the cerebellum) to shrink. Alternative Names: OPCA; Olivopontocerebellar degeneration Causes, incidence, and risk factors: This condition can be inherited but it most commonly affects people without a known family history (sporadic form). Sporadic cases tend to affect people in their 50s while familial cases usually start earlier. The cause of sporadic olivopontocerebellar atrophy is not known, but the disease is progressive. Review Date: 7/28/2002 Reviewed By: Elaine T. Kiriakopoulos, M.D., MSc, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA. Review provided by VeriMed Healthcare Network.

26. Olivopontocerebellar Atrophy olivopontocerebellar atrophy. Alternative Names OPCA; Olivopontocerebellardegeneration. Symptoms Many symptoms are associated with http://www.pennhealth.com/ency/article/000758sym.htm

Disease Injury Nutrition Poison ... Prevention Olivopontocerebellar atrophy Alternative Names: OPCA; Olivopontocerebellar degeneration Symptoms: Many symptoms are associated with olivopontocerebellar atrophy but the predominant feature is progressive ataxia (clumsiness) and difficulties with balance. There may be slurring of speech and difficulty walking. Other symptoms may include: tremor abnormal movements abnormal eye movements sexual dysfunction bowel or bladder problems stiffness or rigidity spasticity neuropathy difficulty swallowing Signs and tests: A thorough medical and neurological examination as well as a good history of symptoms and family history are necessary to make the diagnosis. There are no specific tests for this condition. An MRI of the brain may show a small cerebellum or brainstem, or atrophied olives. This is helpful in making the diagnosis but lack of these findings do not necessarily rule this condition out. Other tests may be done to rule out other diagnoses. Swallowing studies can be done to evaluate a patient's ability to swallow food and liquid safely. Review Date: 7/28/2002 Reviewed By: Elaine T. Kiriakopoulos, M.D., MSc, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA. Review provided by VeriMed Healthcare Network.

27. 1Up Health > Olivopontocerebellar Atrophy > Causes, Incidence, And Risk Factors Comprehesive information on olivopontocerebellar atrophy (Olivopontocerebellardegeneration , OPCA). Covers info such as , alternative http://www.1uphealth.com/health/olivopontocerebellar_atrophy_info.html

1Up Health Olivopontocerebellar atrophy Alternative Medicine Clinical Trials ... Health Topics A-Z Search 1Up Health Olivopontocerebellar atrophy Information Olivopontocerebellar atrophy Causes, Incidence, and Risk Factors Alternative names : Olivopontocerebellar degeneration , OPCA Definition : Olivopontocerebellar atrophy is a neurodegenerative illness that causes certain brain areas (which may include the olivary nucleus, the pons, and the cerebellum) to shrink. Causes, Incidence, and Risk Factors This condition can be inherited but it most commonly affects people without a known family history (sporadic form). Sporadic cases tend to affect people in their 50s while familial cases usually start earlier. The cause of sporadic olivopontocerebellar atrophy is not known, but the disease is progressive. Previous Next Jump to Another Section of this Guide Definition Causes, Incidence, and Risk Factors Symptoms Diagnosis, Signs, and Tests Treatment Prognosis (Expectations) ... Calling your Health Care Provider Related Tools and Utilities Search Books on Amazon: Read Articles on eLibrary: Health Products on drugstore.com:

28. 1Up Health > Olivopontocerebellar Atrophy (Olivopontocerebellar Degeneration , O Comprehesive information on olivopontocerebellar atrophy (Olivopontocerebellardegeneration , OPCA). olivopontocerebellar atrophy Information. Guide. http://www.1uphealth.com/health/olivopontocerebellar_atrophy.html

1Up Health Alternative Medicine Clinical Trials Health News ... Health Topics A-Z Search 1Up Health Olivopontocerebellar atrophy Information Guide Alternative names : Olivopontocerebellar degeneration , OPCA Definition : Olivopontocerebellar atrophy is a neurodegenerative illness that causes certain brain areas (which may include the olivary nucleus, the pons, and the cerebellum) to shrink. Jump to a Section of this Guide Definition Causes, Incidence, and Risk Factors Symptoms Diagnosis, Signs, and Tests ... Calling your Health Care Provider Related Tools and Utilities Search Books on Amazon: Read Articles on eLibrary: Health Products on drugstore.com: Cranial MRI More More Topics Movement - uncoordinated More Search 1Up Health A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org). URAC's accreditation program is the first of its kind, requiring compliance with 53 standards of quality and accountability, verified by independent audit. A.D.A.M. is among the first to achieve this important distinction for online health information and services. Learn more about A.D.A.M.'s editorial reviewers . A.D.A.M. is also a founding member of Hi-Ethics (www.hiethics.com) and subscribes to the principles of the Health on the Net Foundation (www.hon.ch). Home Contact Us Privacy Links Directory

29. Avera Health - Olivopontocerebellar Atrophy olivopontocerebellar atrophy. Definition The cause of sporadic olivopontocerebellaratrophy is not known, but the disease is progressive. Symptoms http://www.avera.org/adam/ency/article/000758.htm

Disease Injury Nutrition Poison ... Central nervous system Olivopontocerebellar atrophy Definition: Olivopontocerebellar atrophy is a neurodegenerative illness that causes certain brain areas (which may include the olivary nucleus, the pons, and the cerebellum) to shrink. Alternative Names: OPCA; Olivopontocerebellar degeneration Causes, incidence, and risk factors: This condition can be inherited but it most commonly affects people without a known family history (sporadic form). Sporadic cases tend to affect people in their 50s while familial cases usually start earlier. The cause of sporadic olivopontocerebellar atrophy is not known, but the disease is progressive. Symptoms: Many symptoms are associated with olivopontocerebellar atrophy but the predominant feature is progressive ataxia (clumsiness) and difficulties with balance. There may be slurring of speech and difficulty walking. Other symptoms may include: tremor abnormal movements abnormal eye movements sexual dysfunction bowel or bladder problems stiffness or rigidity spasticity neuropathy difficulty swallowing Signs and tests: A thorough medical and neurological examination as well as a good history of symptoms and family history are necessary to make the diagnosis. There are no specific tests for this condition.

30. Health Ency.: Disease: Olivopontocerebellar Atrophy olivopontocerebellar atrophy. earlier. The cause of sporadic olivopontocerebellaratrophy is not known, but the disease is progressive. http://www.austin360.com/shared/health/adam/ency/article/000758.html

SEARCH: The Web Yellow Pages HOME Illustrated Health Encyclopedia Important notice Ency. home Disease O Olivopontocerebellar atrophy Overview Symptoms Treatment Prevention Alternative names: OPCA; Olivopontocerebellar degeneration; Multiple systems atrophy (MSA) Definition: A neurodegenerative illness which causes certain brain areas (which may include the olivary nucleus, the pons, and the cerebellum) to shrink. Causes and Risks This condition can be inherited or it can occur in people without a family history (sporadic form). Sporadic cases are more common and tend to affect people in their 50's while familial cases may start earlier. The cause of sporadic olivopontocerebellar atrophy is not known, but the disease is progressive. Ency. home Disease O Please read this Important notice Also Check Out Home Autos Classifieds Events ... Our Sponsors By using Austin360 you accept the terms of our Visitor Agreement . Please read it. Privacy statement Registered site users: edit your profile var v=1.0; v=1.1; v=1.2;

31. Health Ency.: Disease: Olivopontocerebellar Atrophy olivopontocerebellar atrophy. Alternative names OPCA; Olivopontocerebellardegeneration; Multiple systems atrophy (MSA). Prevention. http://www.austin360.com/shared/health/adam/ency/article/000758prv.html

SEARCH: The Web Yellow Pages HOME Illustrated Health Encyclopedia Important notice Ency. home Disease O Olivopontocerebellar atrophy Overview Symptoms Treatment Prevention Alternative names: OPCA; Olivopontocerebellar degeneration; Multiple systems atrophy (MSA) Prevention There is no known way to prevent this degenerative disease. Ency. home Disease O Please read this Important notice Also Check Out Home Autos Classifieds Events ... Our Sponsors By using Austin360 you accept the terms of our Visitor Agreement . Please read it. Privacy statement Registered site users: edit your profile var v=1.0; v=1.1; v=1.2;

32. Neurobehavioral Dimensions Of Olivopontocerebellar Atrophy 5259, 1380-3395/98/2001-052$12.00 © Swets Zeitlinger. Neurobehavioral Dimensionsof olivopontocerebellar atrophy. EM Arroyo-Anllo 1 and T Botez-Marquard 1. http://www.szp.swets.nl/szp/journals/jc20152.htm

Journal of Clinical and Experimental Neuropsychology 1998, Vol.20, No.1, pp. 52-59 Neurobehavioral Dimensions of Olivopontocerebellar Atrophy E M Arroyo-Anllo and T Botez-Marquard Neurology Service, Hôtel-Dieu de Montréal and Université de Montréal, Behavioral Neurology, Neurobiology, and Neuropsychology Unit, Quebec, Canada Twenty-one patients with olivopontocerebellar atrophy (OPCA) and 21 normal controls of equivalent age, gender, and educational levels underwent a series of neurobehavioral tests thought to measure frontal lobe and parietal lobe functions as well as information processing speed. The patients with OPCA had higher reaction times and movement times, confirming the results of previous experiments. They had lower scores for some tests thought to be sensitive to dysfunction of the frontal lobe, such as hand sequencing, verbal reasoning, and proverb interpretation. Deficits in copying a simple figure and in immediate visual-spatial memory, thought to be indicative of parietal lobe dysfunction, were also discerned. These results are consistent with the hypothesis that the cerebellum is involved in visual-spatial working memory that requires rapid information processing, and that it modulates parietal lobe- and frontal lobe-mediated functions.

33. Olivopontocerebellar Atrophy olivopontocerebellar atrophy,, Print this article, see olivopontocerebellardegeneration FS The Encyclopaedia of Medical Imaging Volume VI1, http://www.amershamhealth.com/medcyclopaedia/Volume VI 1/OLIVOPONTOCEREBELLAR AT

Medcyclopaedia About Medcyclopaedia Amersham Health Search for: Type a word or a phrase. All forms of the word are searchable. Advanced search Browse entry words starting with: A B C D ... Other characters Try our Medcyclopaedia Premium Edition with added tools and functionality tailored to make your working day easier. The following tools are presently available: Expanded search *For Medical Professionals only, registration required Olivopontocerebellar atrophy, see olivopontocerebellar degeneration FS The Encyclopaedia of Medical Imaging Volume VI:1 Welcome to Medcyclopaedia. This site is open to a public audience, still we want to know a little more about our visitors. Please tick off the boxes that match your profile. Do you live in Europe? Yes No Are you a medical professional? Yes No This frame will disappear when submitted Legal Contact us Making Waves

34. Olivopontocerebellar Atrophy Print this article. Find related articles By topic Neurology. By keywordsReceive HealthLink via email! Subscribe now . olivopontocerebellar atrophy. http://oci.mcw.edu/article/921445463.html

Search: search tips Email this article Print this article Find related articles: By topic: Neurology By keywords: Receive Health Link via email! Subscribe now >> Olivopontocerebellar Atrophy Olivopontocerebellar atrophy (OPCA) refers to a group of ataxias characterized by progressive neurological degeneration affecting the cerebellum, the pons, and the inferior olives. OPCA may be classified based on clinical, genetic, or neuropathological findings; thus, there are many classifications of the disorder. Among the different classifications there is wide variation in severity and age of onset. The symptoms of OPCA differ from person to person. Most patients experience difficulty with balance and coordination of the legs and arms (ataxia) and slurred speech (dysarthria). Other symptoms may include muscle spasms or weakness and stiffness of the muscles; numbness or tingling of the hands or feet; tremor (shaking) of the hand or arm; reduction or slowness of movements; loss of thinking and/or memory skills; difficulty controlling the bladder or bowels; and feeling faint when standing up. Some patients also have fatigue and/or trouble with sleep. Generally symptoms of OPCA begin in mid-adult life and progress slowly over the course of many years. There is no specific treatment for OPCA. Physicians may try different medications to treat the ataxia, tremor and rigidity that are associated with the disorder. Other treatments are directed at specific symptoms. Stiffness, spasms, sleep disorders, depression, and tremor may be improved with medication.

35. Lamb olivopontocerebellar atrophy Mark Lamb. Abstract. OlivopontocerebellarAtrophy olivopontocerebellar atrophy. olivopontocerebellar atrophy http://www.indstate.edu/thcme/anderson/ML.html

Olivopontocerebellar Atrophy Mark Lamb Abstract Olivopontocerebellar Atrophy(OPCA), is characterized by neuronal degeneration of the cerebellar cortex, the inferior olive, and the pons. The symptoms associated with it are primarily cerebellar ataxia with disturbances in equilibrium and gait. However, broader symptomology is usually seen with OPCA. Current research is focusing on three primary systems thought to be responsible for the etiology of OPCA. They are excitatory amino acid disturbances, oligodendroglial microtubular tangles, and phospholipid metabolism disorders. The only treatment for OPCA is therapy focusing on improving the dysphagia associated with the disorder. Olivopontocerebellar Atrophy Olivopontocerebellar Atrophy (OPCA) is a disease characterized primarily by the degeneration of neurons in the cerebellar cortex, pons, and inferior olive. It is a genetic disease, being either autosomal dominant or autosomal recessive in nature. This disorder, which usually occurs in the middle years of life, presents symptoms of cerebellar ataxia, equilibrium disturbance, nystagmus, dysphasia, dysarthria, and possibly intellectual deficits. According to Merritt, the pathology of OPCA includes loss of Purkinje cells, reduction of the number of neurons in the molecular and granular layers of the cerebellum, degeneration of the folia and white matter of the cerebellum, atrophy of the inferior olives and of the olivo-cerebellar connections, and atrophy of the pontine nuclei, arcuate nuclei, and brachium pontis (15). In addition to this, degeneration of the spinocerebellar tracts, corticospinal tracts, and frontal and temporal lobes has been reported (15).

36. Opca/ds olivopontocerebellar atrophy Debra Stenacker. olivopontocerebellar atrophy(OPCA) was first described in 1900 by Dejerine and Thomas. http://www.indstate.edu/thcme/anderson/DS.html

OLIVOPONTOCEREBELLAR ATROPHY Debra Stenacker Olivopontocerebellar atrophy (OPCA) was first described in 1900 by Dejerine and Thomas. OPCA is a group of dominant inheritance and sporadic neurological disorders characterized by a chronic, progressive, cerebellar ataxia that begins in middle age. The cerebellum and its connections are the primary sites of the disease in chronic progressive disorders that often occur in familial or hereditary patterns. Postmortem studies indicate an atrophy of the cerebellum, pons, and inferior olives. This neuropathological neuronal cell loss permits classification of OPCA as a non-Alzheimer’s neurodegenerative illness. Gross postmortem inspection of the brains of patients with OPCA shows marked shrinkage of the ventral half of the pons, and disappearance of the olivary eminence on the ventral surface of the medulla. These brains also exhibit an atrophy of the cerebellum with degeneration of the middle cerebellar peduncles, and to a lesser extent, of the inferior peduncles. Thus, the cerebellum suffers mainly through atrophy of its afferent fibers. The neocerebellum and the olive undergo the primary degeneration. The purkinje cells of the cerebellar cortex are affected secondarily. Histological examination shows severe degeneration of Purkinje cells, reduction in the number of cells in the molecular and granular layers of the cerebellar cortex, severe loss of the number of cells in the pontine nuclei and olives, and demyelination of the middle cerebellar peduncle. The cerebellar nuclei are well preserved. The tegmentum of the pons, the corticospinal tracts, and the restiform body are also usually unaffected. In clinical cases involving extrapyramidal symptoms, degenerative changes in the striatum, especially the putamen, and a loss of pigmented cells in the substantia nigra may be seen. Tubular structures and crystalline inclusions may be found with the electron microscopy. More wide spread degeneration of the central nervous system has been reported in dominant autosomal cases, and may involve the spinocerebellar fibers and the posterior columns.

37. NORD - National Organization For Rare Disorders, Inc. olivopontocerebellar atrophy. View Cart/Checkout. Copyright 1988, 1990, 1994, 1997,1998 Synonyms of olivopontocerebellar atrophy Atrophy, Olivopontocerebellar; http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Olivopontocer

38. Olivopontocerebellar Atrophy - General Practice Notebook Notebook. olivopontocerebellar atrophy. Olivopontine cerebellar degenerationmay occur sporadically or as an autosomal dominant trait. http://www.gpnotebook.co.uk/cache/-113967058.htm

olivopontocerebellar atrophy Olivopontine cerebellar degeneration may occur sporadically or as an autosomal dominant trait. It is characterised by a general atrophy of the cerebellum spreading in time to involve the pons, medullary olives and other brain stem structures. It can occur at any age but onset in middle life is most common. Presentation is initially with ataxia, dysarthria, and tremor. Parkinsonian features may develop, accompanied by mild dementia, ophthalmoplegia, pyramidal tract signs and autonomic disturbance. Survival ranges from 23 - 30 years from onset. Click here for more information...

39. National Parkinson Foundation, Inc. olivopontocerebellar atrophy adapted from EMedicine April 15, 2002 by Dr Abe LiebermanAuthor Joseph Quinn, MD, Assistant Professor, Department of Neurology http://www.parkinson.org/newsolivo.htm

Olivopontocerebellar Atrophy adapted from E-Medicine April 15, 2002 by Dr Abe Lieberman Author: Joseph Quinn, MD, Assistant Professor, Department of Neurology, Portland VA Medical Center, Oregon Health Sciences University MRI showing atrophy of cerebellum and brainstem The brainstem includes the regions called the pons and the olives Background: In 1900, Dejerine and Thomas first introduced the term olivopontocerebellar atrophy (OPCA). Since then, the classification of idiopathic acquired ataxias has evolved a great deal. The initial cases of Dejerine and Thomas involved 2 middle-aged patients with chronic progressive cerebellar degeneration and autopsy findings of gross atrophy of the pons, cerebellum, middle cerebellar peduncle, and inferior olives. OPCA has not been proven to be a single entity. The nosology of these disorders has been extremely confusing, as the OPCAs overlap with spinocerebellar atrophies (SCAs) and multiple system atrophies (MSAs). Clinical distinction of these entities is based on the dominant feature, which may be cerebellar ataxia (observed in OPCA, SCA, and MSA), parkinsonism (observed in MSA), or autonomic failure (observed in MSA). The term OPCA has been retained to describe a form of progressive ataxia distinguished by pontine flattening and cerebellar atrophy on brain imaging studies and at autopsy. Thus defined, OPCA also may qualify as an SCA or as an MSA. While MSAs are sporadic by definition, the genetic bases of the SCAs are increasingly well defined. Since OPCA may exist as a sporadic or inherited disease, categorizing sporadic OPCA as MSA and inherited OPCA as SCA may be appropriate. Differences between sporadic and inherited OPCA in microscopic pathology support this division. When faced with an adult having progressive ataxia suggestive of OPCA, the role of the clinician includes (1) excluding readily treatable alternative diagnoses, (2) discussing the value of genetic testing with patients in whom such testing is informative, (3) managing symptoms, and (4) advising the patient and family regarding natural history and the need to plan for the future. No definitive therapy for OPCA exists.

40. N.P.F. / The Parkinson Report Good Article on MSA by the National Parkinson Foundation.Category Health Conditions and Diseases Multiple System Atrophy...... When MSA begins with imbalance, incoordination, and difficulties in speaking (dysarthria),it is often called olivopontocerebellar atrophy; as the name suggests http://www.parkinson.org/atrophy.htm

VOLUME XIX - ISSUE 2 / Spring 1998 Multiple System Atrophy By members of the National Parkinson Foundation Center of Excellence at Vanderbilt University, including David A. Robertson, Director, Nathan S. Blaser Shy-Drager Research Laboratories; Thomas L. Davis, Director, Movement Disorder Clinic; and Ariel Y. Deutch, Director, NPF Center of Excellence A lthough the cause of idiopathic Parkinson’s disease is unknown, Parkinson’s disease is probably the best characterized of the neurodegenerative disorders. The loss of dopamine in the striatum is the major contributor to the disorder. However, there are several other neurodegenerative disorders involving several different systems in the brain, in which striatal dopamine loss is also found. Among these other neurodegenerative disorders is multiple system atrophy (MSA), in which degeneration in diverse brain regions leads to problems in the control of movement, balance, blood pressure, and sexual and urinary tract function. MSA is often accompanied by some striatal dopamine loss and in certain patients typical parkinsonian symptoms are either the first noted or the most prominent. A number of areas of the brain are involved by MSA. This has led to different varieties of MSA receiving different names, depending on which area of the brain has predominant involvement. When MSA begins with imbalance, incoordination, and difficulties in speaking (dysarthria), it is often called olivopontocerebellar atrophy; as the name suggests, this form of MSA is marked by degeneration in the cerebellum, a structure involved in balance and learned motor tasks. When a patient initially has rigidity (stiffness) and slowness in initiating movements (bradykinesia) that is out of proportion to tremor, this MSA form has been called striatonigral degeneration, involving communication between nerve cells in the striatum and midbrain. In patients in whom changes in autonomic function dominates the initial presentation, particularly changes in blood pressure regulation, the MSA form is often called Shy-Drager syndrome.

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