41. Vitamin B12 Deficiency Vitamin B12 Deficiency pernicious anemia. Cobalamin Deficiency. B12 Deficiency.Book, Home Page. http://www.fpnotebook.com/HEM6.htm

Home About Links Index ... Editor's Choice Paid Advertisement (click above). Please see the privacy statement Hematology and Oncology Anemia Assorted Pages Anemia Anemia Clinical Clues Anemia Evaluation Macrocytic Anemia ... Pica Vitamin B12 Deficiency Pernicious Anemia Cobalamin Deficiency B12 Deficiency Book Home Page Cardiovascular Medicine Dental Dermatology Emergency Medicine Endocrinology Gastroenterology General Medicine Geriatric Medicine Gynecology Hematology and Oncology HIV Infectious Disease Jokes Laboratory Neonatology Nephrology Neurology Obstetrics Ophthalmology Orthopedics Otolaryngology Pediatrics Pharmacology Prevention Psychiatry Pulmonology Radiology Rheumatology Sports Medicine Surgery Urology Chapter Hematology and Oncology Index Anemia Cancer Coagulopathy Cardiovascular Medicine Dermatology Endocrinology Otolaryngology Examination Gastroenterology Hematology and Oncology Hemoglobin Hemolysis Histiocytosis HIV Infectious Disease Laboratory Leukemia General Pulmonology Lymph Marrow Neurology Obstetrics Orthopedics Pediatrics Pharmacology Platelet Prevention Procedure Psychiatry Rheumatology Surgery Symptom Evaluation Vascular Page Anemia Index Approach Approach Evaluation Approach Evaluation Labs Macrocytic Macrocytic Folate deficiency Macrocytic Pernicious Microcytic Microcytic Iron Deficiency Microcytic Sideroblastic Normocytic Chronic Disease Reticulocytosis See Also Macrocytic Anemia Vitamin B12 Causes: Vitamin B12 deficiency See Medications Affecting Cobalamin Lack of production by gastric parietal cells Malabsorption Blind Loop Syndrome (Gastrectomy and ileal resection)

42. Pernicious Anemia And Gastric Cancer pernicious anemia and Gastric Cancer. It is likely that this patient had perniciousanemia for several years and had developed an associated gastric carcinoma. http://www.mmhc.com/nhm/articles/NHM9803/Sutin.html

CASE REPORT Pernicious Anemia and Gastric Cancer By David Sutin, MD Abstract An elderly man had undergone a total gastrectomy, which had revealed a gastric adenocarcinoma. When he was seen in the clinic several months later, test results were compatible with a diagnosis of vitamin B deficiency. It is likely that this patient had pernicious anemia for several years and had developed an associated gastric carcinoma. ( Annals of Long-Term Care Case Report An elderly man presented to the geriatric clinic in early September 1997. He reported that in May 1997 he had black stool. An endoscopic evaluation at the time had shown a 20 x 20-mm gastric ulcer, the initial biopsy of which had been negative for malignancy. A second endoscopy with biopsy 2 weeks later, however, was positive for adenocarcinoma, moderately differentiated. The patient then had an abdominal computerized tomography scan, which had shown no metastasis. He had undergone a total gastrectomy, which had revealed a gastric adenocarcinoma, with metastasis in the omental tissue and in one of eight lymph nodes. The patient had done well postoperatively and was then discharged and followed in the geriatric and oncology clinics. When he was seen in the geriatric clinic, he had no complaints except for frequent flatus and occasional soft stool postoperatively and occasional dyspnea on climbing up a hill. He had a history of smoking one pack of cigarettes per day until 2 months prior to the visit, denied having any allergies, and, except for occasional Mylanta, was on no medication. He also denied any previous medical history, except as above, and had not seen a physician for 50 years. The patient lives with his son, and they alternate the shopping and the cooking responsibilities.

43. Pernicious Anemia - User Entered Conditions At ABC Homeopathy pernicious anemia (User entered condition) There may be symptoms not related topernicious anemia, and this may not be an exhaustive list of symptoms. http://www.abchomeopathy.com/c.php/pernicious anemia

Homeopathy Common conditions Pernicious Anemia (User entered condition) Homeopathic remedies are prescribed by symptoms rather than conditions, as each case of a particular illness can manifest differently in different people. However, to make it quicker to find the symptoms related to Pernicious Anemia, the symptoms experienced by a previous vistor to our site have been grouped, by them, under the name of Pernicious Anemia. There may be symptoms not related to Pernicious Anemia, and this may not be an exhaustive list of symptoms. Pernicious Anemia For suggestions of homeopathic remedies for pernicious anemia, tick the boxes below and press the Find Remedies button at the bottom of the screen. On the next screen, you should enter any other symptoms in the search box. extremities, limbs; pain; shooting; leg; extremities, limbs; pain; shooting; leg; comes on suddenly; extremities, limbs; pain; shooting; leg; upwards; extremities, limbs; pain; shooting; leg; calf;

44. Untitled Document pernicious anemia, A Victory For Science From Whipple=s study, Minot believedthat the cause of pernicious anemia was some missing essential nutrient. http://www.csulb.edu/~acolburn/SCED496/pernicious_anemia.htm

Alan Colburn SCED 404 Home ScEd 401 ScEd 550 EDSS 450C ... Contact Pernicious Anemia, A Victory For Science Anemia is a medical condition in which the blood is low in red blood cells or hemoglobin. However, in the later part of the nineteenth century, a new form of anemia was gradually identified as a distinct medical condition, termed pernicious anemia. The victim commonly exhibited an inflamed, glossy tongue, slight jaundice or yellowing of the eyes and skin, and persistent tingling or numbness in the fingers or toes. Microscopic examination of the blood revealed cells with overly large nuclei called megaloblasts (today the hallmark sign of pernicious anemia). The anemia was almost always fatal. The survival after the onset of the disease was usually from one to three years (Hardisty 1982). For over seventy years since its first recognition, pernicious anemia remained an incurable disorder with an outlook of almost certain death. It was not until 1926 when two physicians from Boston, Doctors George R. Minot and William P. Murphy announced insights into the cure of the disease. In 1925, Minot was 40 years old and an assistant professor of medicine at Harvard University. He also had a busy practice in hematology. He recruited Murphy from Peter Bent Brigham Hospital to help him with his busy practice. Minot wanted all of his office associates to have some research experience and to have published at least one paper before starting his practice. So Minot suggested to Murphy to search for some sort of dietary supplement for patients with anemia. Minot had been interested in the dietary habits in pernicious anemia patients since he graduated from Harvard Medical School. He had noticed that the victims disliked the taste of meat and had poor eating habits (Krantz 1974).

45. 4anemia.com Living With Anemia Section A kind of megaloblastic anemia, pernicious anemia is the result of a vitaminB12 deficiency due to an inability to absorb it from the intestinal tract. http://www.4anemia.com/causes_and_types/causes_02_03.htm

Iron-Deficiency Anemia Folic-Acid-Deficiency Anemia Pernicious Anemia Aplastic Anemia ... Hemolytic Anemia A kind of megaloblastic anemia, pernicious anemia is the result of a vitamin B12 deficiency due to an inability to absorb it from the intestinal tract. Most healthy people (except for strict vegetarians) have a 3-5-year reserve of vitamin B12, which is easily absorbed from meats, in their livers. Vitamin B12 deficiency occurs when the stomach doesn't secrete a vital substance called "intrinsic factor," which is required for B12 absorption in the ileum (part of the small intestine). It also can result after the surgical removal of the stomach or ileum. Pernicious anemia often causes decreased appetite, weight loss, constipation and diarrhea, abdominal pain, swollen or painful tongue, tingling in the hands and feet, and lack of balance and coordination. Treatment usually starts with intramuscular B12 injections several times, and then less often as reserves accumulate. Ultimately, a maintenance injection rate of once a month is reached, which continues throughout life. By using this site you agree to our Legal Notice and What is Anemia?

46. Glossary Definition - Pernicious Anemia pernicious anemia (purNIH-shus uh-NEE-mee-uh). http://ibscrohns.about.com/library/glossary/bldef-perniciousanemia.htm

zfp=-1 About Irritable Bowel/Crohn's Disease Search in this topic on About on the Web in Products Web Hosting Irritable Bowel/Crohn's Disease with Amber J. Tresca Your Guide to one of hundreds of sites Home Articles Forums ... Help zmhp('style="color:#fff"') Subjects ESSENTIALS Irritable Bowel Syndrome (IBS) 101 Inflammatory Bowel Disease (IBD) 101 Is Green Stool Abnormal? ... All articles on this topic Stay up-to-date! Subscribe to our newsletter. Advertising Free Credit Report Free Psychics Advertisement Pernicious Anemia (pur-NIH-shus uh-NEE-mee-uh) Back to Last Page Full Glossary Related Terms Anemia Definition: Anemia caused by a lack of vitamin B . The body needs B to make red blood cells. Common Misspellings: pernisious ahnemia, pernishious aneemia Elsewhere on the Web: Pernicious Anemia Pernicious anemia is form of anemia (low level of red blood cells) that is related to decreased body stores of vitamin B-12(cobalamin). Back to Last Page Full Glossary Recent Discussions Irritable Bowel/Crohn's Disease Join these forum conversations My daughter's butt hurts!

47. NORD - National Organization For Rare Disorders, Inc. General Discussion pernicious anemia is a rare blood disorder characterized by theinability of the body to properly utilize vitamin B12 (a cobalamin), which http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Anemia, Perni

48. The Doctor's Lounge: Pernicious Anemia (Addisonian Anemia) Review! pernicious anemia. Hematology. Medical disease review for USMLE, MRCP. A quicksummary before the exams. Hematology. pernicious anemia. (Addisonian anemia). http://www.thedoctorslounge.net/clinlounge/diseases/hematology/pernicious.htm

Home Member Search Discussion ... Contact With over 1 million users and awarded Yahoo site of the day! Start page Favorites TRANSLATE... Italian English Portugese French Spanish German Get FREE Medical Consultation! Meet the Lounge Doctors! Join the Mailing List Ask a doctor ... Membership Student Student Lounge Medical Tutorials Medical Games Discussion ... Membership Professional Discussion Specialty Medline search Guidelines search ... Membership Send TheDoctorsLounge a BIG Thank You! Back to hematological diseases index Hematology Pernicious anemia (Addisonian anemia) Autoimmune disorder in which antibodies attack the gastric mucosa (causing gastric atrophy) or intrinsic factor. This leads to inadequate absorption of intrinsic factor and hence a decrease in vitamin B12 absorption ( macrocytic anemia There is an association with other autoimmune diseases: vitiligo, Addison's disease, thyroid diseases. Clinical suspicion: macrocytic anemia due to B12 deficiency Diagnosis: Schilling test Top 100 Medical Sites Revised: January 04, 2003.

49. Bigchalk: HomeworkCentral: Pernicious Anemia (Nutrition Disorders) Looking for the best facts and sites on pernicious anemia? This HomeworkCentralsection focuses on 'Nutrition Disorders' and 'Nutrition http://www.bigchalk.com/cgi-bin/WebObjects/WOPortal.woa/Homework/High_School/Sci

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50. Bigchalk: HomeworkCentral: Pernicious Anemia (Nutrition Disorders) Looking for the best facts and sites on pernicious anemia? Physical Education Sports Fitness Nutrition Nutrition Disorders pernicious anemia. http://www.bigchalk.com/cgi-bin/WebObjects/WOPortal.woa/Homework/Teacher/Science

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51. NEJM -- Sign In pernicious anemia BanHock Toh, MB, BS, D.Sc., Ian R. van Driel, Ph.D., and PaulA. Gleeson, Ph.D. The onset and progression of pernicious anemia are slow. http://content.nejm.org/cgi/content/full/337/20/1441

HOME SEARCH CURRENT ISSUE PAST ISSUES ... HELP The full text of the Journal is available online for all subscribers to the print version. For Original Articles and Special Articles, six months after publication the full text becomes available to all registered users. Registered Users User Name Password Remember my user name and password. Forgotten the password? If you do not use cookies sign in here If you have purchased access to an article or the Journal website, you may regain access here First-Time Users If you are a Journal subscriber using the Journal On-line for the first time, you must register and choose a password. If you are not a Journal subscriber subscribe here If you would like full access to the Journal Web site for 24 hours for $29, click here To regain access to Journal Web site, click here If you would like full access to this article for $10, click here To regain access to a purchased article, click here If you would like free full access to all Original Articles and Special Articles beginning six months after publication register here If you cannot get past this page

52. NEJM -- Racial Patterns In Pernicious Anemia. Early Age At Onset And Increased F Original Article from The New England Journal of Medicine Racial patternsin pernicious anemia. Next Next. Racial patterns in pernicious anemia. http://content.nejm.org/cgi/content/short/298/12/647

HOME SEARCH CURRENT ISSUE PAST ISSUES ... HELP Previous Volume 298:647-650 March 23, 1978 Number 12 Next Racial patterns in pernicious anemia. Early age at onset and increased frequency of intrinsic-factor antibody in black women R Carmel, and CS Johnson Table of Contents Find Similar Articles in the Journal Notify a friend about this article Add to Personal Archive ... Related Articles in Medline Articles in Medline by Author: Carmel, R. Johnson, C. S. Medline Citation Abstract Pernicious anemia affects primarily elderly northern Europeans, but may affect others more often than previously thought. Therefore, we analyzed the data from 156 documented cases: there were 73 patients of "European" origin, 52 black patients and 31 Latin-American patients. The mean age (+/- 1 S.D.) at presentation among black women, 53 +/- 16 years, was lower than that of all the others (P less than 0.001 in most comparisons), and seven of the 33 black women were less than 40 years old. In addition, 23 of the 24 black women tested had circulating antibody to intrinsic factor. A similar though less striking antibody prevalence (85 per cent) and age pattern (60 +/- 13 years) in Latin-American women did not reach statistical significance. No other group exceeded the usual 55 to 70 per cent prevalence of antibody. These finding suggest a different form of or a different response to the disease in black women and perhaps in Latin-American women. This article has been cited by other articles: Toh, B.-H., van Driel, I. R., Gleeson, P. A. (1997). Pernicious Anemia.

53. PERNICIOUS ANEMIA AND OTHER MEGALOBLASTIC ANEMIAS pernicious anemia AND OTHER MEGALOBLASTIC ANEMIAS. Method of deficiency.TREATMENT Cobalamin Deficiency (pernicious anemia). Therapy http://www.victorherbert.com/Conn'sCurrentTherapy2003.htm

PERNICIOUS ANEMIA AND OTHER MEGALOBLASTIC ANEMIAS. Method of Victor Herbert, M.D., J.D., M.A.C.P., F.R.S.M. (London) New York, NY. Megaloblastic (Greek: megalo=giant; blast=germ cell) anemias are those anemias resulting from pathologic slowing, by any cause, of the doubling of the nuclear DNA necessary for bone marrow nucleated cells to divide, with only minor slowing of the synthesis of cytoplasmic RNA. This nuclear-cytoplasmic dissociation becomes greater with each daughter germ cell division, until either the cells die or omit terminal division, surviving in the marrow as end stage giant red cells, white cells, and platelets. These are extruded into the peripheral blood as macroovalocytes, hypersegmented neutrophils, and giant platelets, all with a shortened life span, hence the pancytopenia (anemia, leucopenia, and thrombopenia), characteristic of full-blown megaloblastic anemia. The most common causes of megaloblastic anemia are deficiencies of vitamin B (cobalamin) and/or folate (folic acid). As with any nutrient deficiency, these two B-vitamin deficiencies may arise from any of 3 inadequacies (inadequate ingestion, absorption, or utilization), or any of 3 excesses (excessive requirement, destruction, or excretion).

54. Welcome To ENH.org - Health Encyclopedia: Pernicious Anemia pernicious anemia. Macrocytic achylic anemia; Congenital pernicious anemia;Juvenile pernicious anemia; Vitamin B12 deficiency (malabsorption). http://www.enh.org/Encyclopedia/ency/article/000569.asp

Disease Reference Injury Reference Test Reference Nutrition Reference ... Symptoms Reference Pernicious anemia Disease Injury Nutrition Poison ... Z Definition: A form of anemia caused by a lack of intrinsic factor , a substance needed to absorb Vitamin B12 (cobalamin) from the gastrointestinal tract. Alternative Names: Macrocytic achylic anemia; Congenital pernicious anemia; Juvenile pernicious anemia; Vitamin B12 deficiency (malabsorption) Causes, incidence, and risk factors: Intrinsic factor is a binding protein required for the absorption of Vitamin B12. Pernicious anemia results from a lack of intrinsic factor in gastric secretions which, in turn, causes inadequate Vitamin B12 absorption. Vitamin B12 deficiency results. Vitamin B12 deficiency causes a form of anemia specifically referred to as megaloblastic anemia Other causes of reductions in the level of intrinsic factor (and thus of pernicious anemia) include atrophic gastric mucosa, autoimmunity against gastric parietal cells, and autoimmunity against intrinsic factor. Absence of intrinsic factor itself is the most common cause of Vitamin B12 deficiency. Intrinsic factor is produced by cells within the stomach. In adults, the inability to make intrinsic factor can be the result of chronic gastritis or the result of gastrectomy. The onset of the disease is slow and may span decades.

55. Dorlands Medical Dictionary achrestic anemia, any of various types of megaloblastic anemia that resemblepernicious anemia but are unresponsive to therapy with vitamin B 12 . http://www.mercksource.com/pp/us/cns/cns_hl_dorlands.jspzQzpgzEzzSzppdocszSzuszS

56. Health Library Find Information On Pernicious Anemia At Find information on pernicious anemia at MerckSource. Learn more aboutPernicious pernicious anemia. Definition A form of anemia http://www.mercksource.com/pp/us/cns/cns_hl_adam.jspzQzpgzEzzSzppdocszSzuszSzcns

57. SupportPath.com: Pernicious Anemia pernicious anemia. Other topics of interest on SupportPath.com Anemia, Nutrition. NoneListed. Clinical Trials Research on pernicious anemia None Listed. http://www.supportpath.com/sl_p/pernicious_anemia.htm

Pernicious Anemia Other topics of interest on SupportPath.com: Anemia Nutrition About Us Add-A-Link ... here Online Communities / Message Boards... None Listed Online Chats... Note: Regularly scheduled chats are listed on our NEW Online Events Calendar Links in this section are primarily to chat rooms open 24/7 which may or may not be moderated. None Listed Usenet Groups... Note: Your browser must be properly configured to access Usenet groups from this site. None Listed Mailing Lists... None Listed National / International Organizations... None Listed Note: Groups are listed alphabetically by U.S. state and then country. None Listed None Listed Professional Organizations of Interest... None Listed None Listed Miscellaneous Links... None Listed Books about Pernicious Anemia and Related Topics... None Listed (The following search link is offered in association with Amazon.com Visit our Bookstore! Search: All Products Books Popular Music Classical Music Video DVD Baby Electronics Software Outdoor Living Wireless Phones Keywords: Like to add a web site to our listings? Use our Add-A-Link page.

58. Page 30 Home pernicious anemia. For more information on pernicious anemia or other autoimmunedisorders, please click on the request information icon below. http://www.aarda.org/page30.html

Pernicious Anemia Pernicious anemia (PA) is an autoimmune disease that occurs as an end stage of autoimmune gastritis which results in the destruction of gastric mucosa (moist tissue that lines the stomach). It follows long-term autoimmune gastritis (inflammation of the mucosal lining of the stomach). The autoimmune process is limited to the body of the stomach and causes gastric atrophy (wasting of tissue). The auto-reaction is against the gastric intrinsic factor (substance that makes the absorption of vitamin B-12 possible) and complement-fixing antibodies to gastric parietal cells (the binding site for vitamin B-12). Long-term destruction of the parietal cells of the gastric mucosa results in atrophy leading to the inability of the stomach to absorb and utilize vitamin B-12. Thus, PA is the end result of autoimmune gastritis. The gastric atrophy is caused by chronic inflammation from the autoimmune attack on the lining of the stomach and precedes the development of PA by many years. PA has been observed to cluster in families. For more information on pernicious anemia or other autoimmune disorders, please click on the request information icon below.

59. ENLmedical.com: Conditions And Concerns: Medical Encyclopedia: Pernicious Anemia Table of content. pernicious anemia. Causes Congenital pernicious anemiais inherited as an autosomal recessive disorder. Pernicious http://www.enlmedical.com/article/000569.htm

Medical Dictionary Naturapathic Glossary Aphrodisiacs Immune System ... Table of content Pernicious anemia Causes and Risks: People with pernicious anemia loose their ability to make intrinsic factor , a substance that enables vitamin B12 to be absorbed from the intestine. Vitamin B12 deficiency results. This condition may result from hereditary factors. Congenital pernicious anemia is inherited as an autosomal recessive disorder. Pernicious anemia is also seen in association with some autoimmune endocrine diseases such as type 1 diabetes hypoparathyroidism Addison's disease hypopituitarism , testicular dysfunction, Graves disease chronic thyroiditis myasthenia gravis secondary amenorrhea ... vitiligo , and candidiasis . Gradually the deficiency of vitamin B12 affects sensory and motor nerves, causing neurological effects. The anemia also affects the gastrointestinal system and the cardiovascular system. The disease can affect all racial groups, but the incidence is higher among people of Scandinavian or Northern European descent. Pernicious anemia usually does not appear before the age of 30, although a juvenile form of the disease can occur in children. Juvenile or congenital pernicious anemia is evident before the child is 3 years old. Risk factors are a history of autoimmune endocrine disorders, a family history of pernicious anemia, and Scandinavian or Northern European descent. The incidence is 1 out of 1,000 people.

60. H Pylori May Cause Vitamin B12 Deficiency And Pernicious Anemia 5/14/00 H Pylori May Cause Vitamin B12 Deficiency And pernicious anemia. This studydetected H. pylori in 56% of 138 patients with pernicious anemia. http://www.mercola.com/2000/may/14/h_pylori_b_12_deficiency.htm

Mercola.com Dr. Joseph Mercola All Health, No Hype FREE Weekly Health Newsletter Your Email Address: Previous Newsletters Issue 153 May 14, 2000 Doctors Can Kill You Cell Phones and Cancer Prescription Errors Uric Acid and Heart Disease ... Prevention of Premature Births Health Resources Complete Nutrition Plan Less Grains / Sugars More Omega 3 More Water ... Recommended Products H Pylori May Cause Vitamin B12 Deficiency And Pernicious Anemia Pernicious anemia is a very serious disorder, which can cause irreversible damage, resulting from a deficiency of vitamin B12. This study detected H. pylori in 56% of 138 patients with pernicious anemia. Upon treatment and eradication of the H. pylori infection, there was significant improvement of B12 status in 40% of the infected patients. The authors conclude that H. Pylori is a causative factor in many cases of B12 deficiency and that detection and eradication of it may correct the deficiency. Arch Intern Med. 2000;160:1349-1353

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