61. Health Ency.: Disease: Pernicious Anemia pernicious anemia. Call Your Health Care Provider If Call for an appointmentwith your health care provider if symptoms of pernicious anemia develop. http://www.austin360.com/shared/health/adam/ency/article/000569trt.html

SEARCH: The Web Yellow Pages HOME Illustrated Health Encyclopedia Important notice Ency. home Disease P Pernicious anemia Overview Symptoms Treatment Prevention Alternative names: Addison's anemia; Biermer's anemia; Macrocytic achylic anemia; Congenital pernicious anemia; Juvenile pernicious anemia; Vitamin B12 deficiency (malabsorption) Treatment Monthly Vitamin B12 injections are the definitive treatment to correct the vitamin B12 deficiency. This therapy corrects the anemia and may correct the neurological complications if given soon enough. Since about 1 percent of vitamin B12 is absorbed even in the absence of intrinsic factor, some doctors recommend elderly patients with gastric atrophy to take oral vitamin B12 supplements in addition to monthly injections. There is also a preparation of vitamin B12 that may be given intranasally (in the nose). A well-balanced diet is essential to provide other elements such as folic acid , iron, and vitamin C for healthy blood cell development. Prognosis The outcome is usually excellent with treatment. Complications People with pernicious anemia may have gastric polyps and have twice the incidence of gastric cancer than the normal population.

62. Pernicious Anemia First Previous Next Last Index Text. Slide 26 of 37. http://www.ags.uci.edu/~bcrourke/Blood_Fluids/sld026.htm

First Previous Next Last ... Text Slide 26 of 37

63. Pernicious Anemia pernicious anemia. Failure to absorb B12 from GI tract. parietal cellssecrete glycoprotein intrinsic factor; w/o factor, B12 not absorbed; http://www.ags.uci.edu/~bcrourke/Blood_Fluids/tsld026.htm

Pernicious Anemia Failure to absorb B12 from GI tract parietal cells secrete glycoprotein intrinsic factor w/o factor, B12 not absorbed occurs with atrophic gastric mucosa chronic gastritis (ulcers) Treated either by giving intrinsic factor, or by adressing stomach condition/diet Previous slide Next slide Back to first slide View graphic version

64. Pernicious Anemia: Products And Research - GreenCanyon.com: Better Health Just A pernicious anemia Research and Products. For the best prices on the highestquality products, come visit us at www.GreenCanyon.com. pernicious anemia http://www.greencanyon.com/products/a100448c.htm

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65. Pernicious Anemia pernicious anemia. Biochemistry Selective Paper. Angel Lee. November2, 1999. Summary. Anemia is a pernicious anemia. The disease Pernicious http://www.musc.edu/BCMB/onlinepubs/molecularmedicinejournal/vol1999/pernicious_

Pernicious Anemia Biochemistry Selective Paper Angel Lee November 2, 1999 Summary. Anemia is a broad term for a group of diseases that are characterized by a decrease in hematocrit or hemglobin concentration among their many effects on the human body. This can be a result of decreased production or increased destruction of red blood cells. Defects of stem cell proliferation, cell differentiation, DNA Synthesis, hemoglobin synthesis, or any combination would cause, among their effects, the levels of red blood cell production to be lower. Associated enzyme deficiencies, abnormally shaped hemoglobin and immune system activities will also lead to excessive destruction of red blood cells. Pernicious Anemia The disease Pernicious Anemia (PA), also known as Megaloblastic Anemia, is one form with these associated systemic effects. This disease is a result of impaired absorption of Vitamin B , or Cobalamin, due to a deficiency of Intrinsic Factor and Hydrochloric Acid in gastric secretions. Generally, the disease manifests in two forms, a rare congenital form and an adult onset acquired form. Prevalence Vitamin B12 (Cobalamin) Vitamin B12 is a corrinoid, which resembles the heme of hemoglobin, however uses cobalt instead of iron. It functions as a coenzyme for only two reactions in the human body, methionine synthase and L-methylmalonyl CoA mutase. Methionine synthase is involved in the synthesis of the amino acid methionine from homocysteine. Therefore methionine can not be regenerated and levels decrease. L-methylmalonyl CoA mutase is involved in the conversion of methylmalonyl coenzyme A to succinyl CoA. The end results of the Vitamin B12 deficiency includes slow and restricted DNA synthesis

66. Pernicious Anemia II Introduction to Blood Morphology. pernicious anemia. pernicious anemia.Megaloblasts in the bone marrow aspirate at highoil magnification. http://eduserv.hscer.washington.edu/HuBio552/hemedist/hemecases/Intro/1004.htm

Introduction to Blood Morphology Pernicious anemia Pernicious anemia. Megaloblasts in the bone marrow aspirate at high-oil magnification. Pervading both frames is the characteristic open, beaded nuclear chromatin and nuclear- cytoplasmic disproportion. (L) The large central cell is a promegaloblast. (R) The large cell below center is a basophilic megaloblast. The two cells above are polychromatophilic megaloblasts. Return to Cases Return to Index Next Image Previous Image ... Gallery of Morphology Images

67. Ask NOAH About: Anemia System, Houston TX (also in Spanish) Nutritional Deficiencies and Anemia InteliHealthMegaloblastic Anemia (See pernicious anemia) pernicious anemia Anaemia http://www.noah-health.org/english/illness/blood/anemia.html

Ask NOAH About: Anemia What is Anemia? Care and Treatment Information Resources Basic Descriptions Anemia in Children ... Organizations What Is Anemia? Basic Descriptions About Anemia - KidsHealth All About Anemia - Anemia Life Line Anaemia Due to Red Cell Loss - BUPA Anemia - KidsHealth ... Anemia - Methodist Healthcare System, Houston TX (also in Spanish Anemia: When Low Iron is the Cause - American Academy of Family Physicians (also in Spanish Anemia, General - Mayo Clinic Anemia in Young Women - InteliHealth Anemias - ... Women's Health: Anemia - American Institute of Preventive Medicine Blood Basics Blood - TeensHealth Facts About Blood - Methodist Healthcare System, Houston TX Introduction to Hematology - Puget Sound Blood Center Red Blood Cells - Puget Sound Blood Center ... Anemia in Pregnancy Anemia in Children About Anemia - KidsHealth Anemia - KidsHealth Aplastic Anemia - Lucile Packard Children's Hospital Hemolytic Anemia - Lucile Packard Children's Hospital ... Thalassemia Anemia in Teens Iron and Teens: A Guide to Anemia Prevention - Children's Hospital, Boston MA

68. Genesis Health System - Detailed Disease Info - Pernicious Anemia pernicious anemia. Definition. Hawley, Kelly. pernicious anemia How to Recognizeand Manage This Insidious Condition. American Journal of Nursing 96, no. http://www.genesishealth.com/micromedex/detaileddisease/00060440.aspx

Facility Information DeWitt Comm Hosp Genesis Medical Ctr Illini Hospital Genesis Health Grp VNA Pernicious anemia Definition Pernicious anemia is a disease in which the red blood cells are abnormally formed, due to an inability to absorb vitamin B . True pernicious anemia refers specifically to a disorder of atrophied parietal cells leading to absent intrinsic factor, resulting in an inability to absorb B Description Vitamin B , or cobalamin, plays an important role in the development of red blood cells. It is found in significant quantities in liver, meats, milk and milk products, and legumes. During the course of the digestion of foods containing B , the B becomes attached to a substance called intrinsic factor. Intrinsic factor is produced by parietal cells which line the stomach. The B -intrinsic factor complex then enters the intestine, where the vitamin is absorbed into the bloodstream. In fact, B can only be absorbed when it is attached to intrinsic factor. In pernicious anemia, the parietal cells stop producing intrinsic factor. The intestine is then completely unable to absorb B

69. Pernicious Anemia pernicious anemia Slide 29 of 33. http://meds.queensu.ca/medicine/deptmed/hemonc/macro/slide29.html

Pernicious Anemia Slide 29 of 33

70. Nutrimed Labs: PERNICIOUS ANEMIA Condition pernicious anemia. SUGGESTED NUTRITION PHYSIOLOGICAL CONSIDERATIONSpernicious anemia is basically a nutritional deficiency disease. http://www.nutrimed.com/ANEMIAP.HTM

Home Online Catalog Newsletters Therapy Index ... Contact Us Condition: PERNICIOUS ANEMIA SUGGESTED NUTRITION: Hemaplex #969 3 - per day - Stimulates hemopoiesis. Potent hematinic. Intrinsic Plus #400 3 to 6 per day - Intrinsic factor for vitamin B-12 and iron absorption. Livatrate #982 3 to 18 per day (divided dose) - Tends to improve liver function, aids in detoxification. Supplies needed iron for red blood cell production, raw liver factors, and enzymes. To order any of these products, click the blue link and use our online shopping cart. All of our products are manufactured in a US FDA approved facility. PATHOLOGICAL CONSIDERATIONS: A chronic, macrocytic anemia characterized by achlorhydria, gastro-intestinal disturbances, and neurologic syndromes. It occurs most often in Caucasians after age 50. The fundamental defect is a permanent deficiency of the intrinsic factor normally present in gastric juice. In addition to atrophy of gastric mucosa and changes in bone marrow common to all megaloblastic anemias, there is often specific neurologisc changes. Subacute combined degeneration of the spinal cord is a common finding. Degeneration may also occur in peripheral nerves, nerve plexuses of the gastro-intestinal tract, and subcortical areas in the motor region of the brain. PHYSIOLOGICAL CONSIDERATIONS: Pernicious anemia is basically a nutritional deficiency disease. Characteristic blood abnormalities can be corrected by use of folic acid. However, if there is an accompanying deficiency of vitamin B-12, an irreversible degeneration of the spinal cord may take place. The intrinsic factor normally produced by stomach mucosa is necessary in order that B-12 may be absorbed and utilized. In pernicious anemia, the stomach has become unable to produce either the intrinsic factor or hydrochloric acid. Vitamin B-6 and vitamin C increase absorption of vitamin B-12. Adequate protein is also needed as vitamin B-12 is almost always associated with animal proteins such as liver, kidney, muscle meats, etc.

71. RxMed: Illness Information - ANAPHYLAXIS The symptoms of pernicious anemia develop slowly and gradually and may not be immediatelyrecognized . Family history of pernicious anemia. Genetic factors. http://www.rxmed.com/b.main/b1.illness/b1.1.illnesses/anemia,_pernicious.html

General Illness Information Common Name: ANEMIA, PERNICIOUS Medical Term: None Specified Description: This anemia is caused by lack of vitamin B-12 (cobalamin). It is a megaloblastic anemia . In this type of anemia the bone marrow produces large abnormal blood cells (megaloblasts). It often affects adults between the ages of 50 and 60. The symptoms of pernicious anemia develop slowly and gradually and may not be immediately recognized . This is because the liver stores large amounts of vitamin B12 and so the anemia does not develop for 2 to 4 years after the body stops absorbing vitamin B12. Vitamin B-12 is found in foods of animal origin, such as meat, fish, dairy products and legumes.. Causes: Prevention: See diagnosis and treatment below. Weakness and tiredness Bleeding gums Nausea, appetite loss and weight loss Sore tongue Numbness and tingling in the hands and feet Difficulty maintaining balance Yellowish tinge to eyes and skin Shortness of breath Poor memory Headache Depression Confusion and dementia Risk Factors Improper diet, especially a vegetarian diet lacking vitamin B-12 and without supplements

72. RLS And Pernicious Anemia RLS and pernicious anemia. I would encourage everyone with this problem tocheck out whether they have a B12 deficiency or pernicious anemia. http://www.sleepnet.com/rls4/messages/276.html

Sleepnet.com's Homepage Sleep Disorders Sleep Links Search RLS and Pernicious Anemia Follow Ups Post Followup Restless Legs Forum4 FAQ Posted by sue. on January 28, 2002 at 13:14:03: I would encourage everyone with this problem to check out whether they have a B12 deficiency or pernicious anemia. This is especially relevant if you have a family history of this or are from northern European descent. It doesn't happen from a lack of B12 in diet and you need the injected form of B12 as it is a stomach absorption problem. YES it is one of the reasons why people get RLS. My partner is now sleeping nights about one week after first injection. Follow Ups: Re: RLS and Pernicious Anemia Iron Deficient Re: RLS and Pernicious Anemia pinkozcat Post a Followup Name : (required. Do not use real name. No time for removal later. Search engines will find you) E-Mail : (use someone@sleepnet.com to avoid spam email, search engines,etc.) Subject : (change if you like) Comments: PLEASE ONLY CLICK THE SUBMIT FOLLOW UP BUTTON ONCE!!. Thanks, Sandman Follow Ups Post Followup Restless Legs Forum4 FAQ ... Matt Wright and DBasics Software Company

73. Re: RLS And Pernicious Anemia Re RLS and pernicious anemia. Follow Ups Post Followup Restless LegsForum4 FAQ In Reply to RLS and pernicious anemia posted by sue. http://www.sleepnet.com/rls4/messages/284.html

Sleepnet.com's Homepage Sleep Disorders Sleep Links Search Re: RLS and Pernicious Anemia Follow Ups Post Followup Restless Legs Forum4 FAQ Posted by Iron Deficient on January 30, 2002 at 09:08:10: In Reply to: RLS and Pernicious Anemia posted by sue. on January 28, 2002 at 13:14:03: I was diagnosed with an iron deficiency but was told that my B-12 was okay. Because I have been very unhappy with my doctors' care I don't know if I should just accept his answer. (He didn't give me the actual count.) I wonder if it's like iron where you may have a "normal" count but it's too low for someone with RLS or PLMD. Can you tell me what is the optimum B-12 count for someone with RLS or PLMD? Follow Ups: Re: RLS and Pernicious Anemia pinkozcat Post a Followup Name : (required. Do not use real name. No time for removal later. Search engines will find you) E-Mail : (use someone@sleepnet.com to avoid spam email, search engines,etc.) Subject : Comments: PLEASE ONLY CLICK THE SUBMIT FOLLOW UP BUTTON ONCE!!. Thanks, Sandman Follow Ups Post Followup Restless Legs Forum4 FAQ ... Matt Wright and DBasics Software Company

74. CyberSpace Search! SEARCH THE WEB. Results 1 through 4 of 4 for pernicious anemia. pernicious anemiaat DealTime Compare Prices from 1,000s of stores Find the Best Deals HERE! http://www.cyberspace.com/cgi-bin/cs_search.cgi?Terms=pernicious anemia

75. Pernicious Anemia | Principal Health News pernicious anemia. pernicious anemia How to Recognize and Manage This InsidiousCondition. American Journal of Nursing 96, no. 11 (November 1996) 52+. http://www.principalhealthnews.com/topic/pernicious

About This Site Registration FAQ Contact Us ... Site Awards You are here: Home Pernicious Anemia Pernicious Anemia Related topics: Anemias Sideroblastic Anemia Carson-DeWitt, Rosalyn S. Below: Definition Description Causes and symptoms Diagnosis ... Resources Definition Pernicious anemia is a disease in which the red blood cells are abnormally formed, due to an inability to absorb vitamin B . True pernicious anemia refers specifically to a disorder of atrophied parietal cells leading to absent intrinsic factor, resulting in an inability to absorb B Description Vitamin B , or cobalamin, plays an important role in the development of red blood cells. It is found in significant quantities in liver, meats, milk and milk products, and legumes. During the course of the digestion of foods containing B , the B becomes attached to a substance called intrinsic factor. Intrinsic factor is produced by parietal cells which line the stomach. The B -intrinsic factor complex then enters the intestine, where the vitamin is absorbed into the bloodstream. In fact, B can only be absorbed when it is attached to intrinsic factor.

76. Pernicious Anemia: A Vegetarian Danger pernicious anemia A vegetarian danger. Twice as many vegetariansas meateaters get anemia, warns Victor Herbert, MD, professor http://www.medformation.com/mf/stayhealthy.nsf/article/12551

Advanced Search [Pick a topic] Adult Medications Patient Educ. Pediatric Sports Med. Women class clinic doctor hospital job pharmacy support group Health Tip Reduce computer vision strain If you spend a lot of time looking at a computer screen and you experience the following symptoms, your screen may be one of the problems... Read more... We subscribe to the HONcode principles. Verify here Monday, March 31, 2003 Send to a Friend Pernicious anemia: A vegetarian danger Twice as many vegetarians as meat-eaters get anemia, warns Victor Herbert, M.D., professor of medicine at Mount Sinai School of Medicine and Brox Veterans Affairs Medical Center, both in New York City, and coeditor of Total Nutrition. In this case, the problem is due not only to a lack of iron but also to a lack of vitamin B12. This nutrient, which is needed for cells to divide and mature properly, comes mostly from animal foods, he explains. Consequently, strict vegetarians may get little or no B12 in their diets. The resulting condition, called pernicious anemia, isn't an immediate problem, if only because the body uses vitamin B12 sparingly. Most of us have enough in storage to last 6 years or so-"a grace period," says Carol Fleischman, M.D., assistant professor of medicine at Allegheny University Hospitals in Philadelphia. Because of this, strict vegetarians may not notice symptoms of B12 deficiency, which include fatigue and tingling in the hands and feet, for a very long time.

77. Pernicious Anemia. The Columbia Encyclopedia, Sixth Edition. 2001 The Columbia Encyclopedia, Sixth Edition. 2001. pernicious anemia.see anemia. The Columbia Encyclopedia, Sixth Edition. Copyright http://www.bartleby.com/65/x-/X-pernicio.html

Select Search All Bartleby.com All Reference Columbia Encyclopedia World History Encyclopedia World Factbook Columbia Gazetteer American Heritage Coll. Dictionary Roget's Thesauri Roget's II: Thesaurus Roget's Int'l Thesaurus Quotations Bartlett's Quotations Columbia Quotations Simpson's Quotations English Usage Modern Usage American English Fowler's King's English Strunk's Style Mencken's Language Cambridge History The King James Bible Oxford Shakespeare Gray's Anatomy Farmer's Cookbook Post's Etiquette Bulfinch's Mythology Frazer's Golden Bough All Verse Anthologies Dickinson, E. Eliot, T.S. Frost, R. Hopkins, G.M. Keats, J. Lawrence, D.H. Masters, E.L. Sandburg, C. Sassoon, S. Whitman, W. Wordsworth, W. Yeats, W.B. All Nonfiction Harvard Classics American Essays Einstein's Relativity Grant, U.S. Roosevelt, T. Wells's History Presidential Inaugurals All Fiction Shelf of Fiction Ghost Stories Short Stories Shaw, G.B. Stein, G. Stevenson, R.L. Wells, H.G. Reference Columbia Encyclopedia PREVIOUS NEXT ... BIBLIOGRAPHIC RECORD The Columbia Encyclopedia, Sixth Edition. pernicious anemia see anemia CONTENTS INDEX GUIDE ... NEXT Search Amazon: Click here to shop the Bartleby Bookstore Welcome Press Advertising ... Bartleby.com

78. MEDLINEplus Medical Encyclopedia : Pernicious Anemia Back to whats new page. MEDLINEplus medical encyclopedia perniciousanemia, This peerreviewed article on pernicious anaemia, also http://omni.ac.uk/whatsnew/detail/5018915.html

Back to whats new page. MEDLINEplus medical encyclopedia : pernicious anemia This peer-reviewed article on pernicious anaemia, also known as Addison's anaemia, was updated during 2001 and is made available through the MEDLINEplus Health Information Service produced by the National Library of Medicine. This article provides background information on pernicious anaemia and discusses causes, diagnosis, clinical signs and symptoms, diagnostic tests, prognosis, and possible complications. Illustrations are provided. Patient Education Anemia, Pernicious Last modified 30/Aug/2002 [Low Graphics]

79. Pernicious Anemia - Anémie Pernicieuse - Anémie De Biermer CHRONIC ATROPHIC GASTRITIS pernicious anemia. I. Généralités. In perniciousanemia, humoral ab were found to 3 antigens of the gastric parietal cell. http://www.fortunecity.com/meltingpot/champion/627/AnemiePernicieuse.htm

web hosting domain names email addresses related sites II.Physiopathologie III.Signes cliniques IV.Facteurs de risques V. Diagnostic VI. Traitement VII. Evolution - Complications Pernicious Anemia (PA) is an anemia which occurs in the terminal stages of the chronic destructive autoimmune disease, autoimmune gastritis. The anemia results from the death of parietal cells in the body of the stomach and in the absence of gastric parietal cells, a blood-sustaining vitamin, vitamin B12, is no longer transported to its site of absorption. The term 'pernicious' described the inevitable progress and fatal outcome of the anemia and this given name by Biermer in 1972 has endured despite the knowledge that it is appropriate only to the terminal phase of the disease. I.General Considerations The primary pathologic feature of PA is progressive destruction of the normal glands of the body of the stomach. This is associated with partial or complete loss of chief cells, which secrete pepsinogens, and the parietal cells, which secrete acid and intrinsic factor. When the last is complete, failure of vitamin B12 absorption occurs. Complete loss of intrinsic factor secretion may require many years or never occur. The gastric mucosa is infiltrated, homogeneously or in patchy distribution, with various numbers of polymorphonuclear and mononuclear leukocytes - predominantly the latter. Often the gastric body mucosa is partly or wholly replaced by small intestinal mucosa (metaplasia). II.Immunologic Pathogenesis

80. Perniciuos Anemia pernicious anemia (Transcobalamin II deficiency) Pathology. pernicious anemia(PA) is caused by a lack of vitamin B 12 , otherwise known as cobalamin. http://www.diseasedir.org.uk/genetic/gene2202.htm

Pernicious anemia (Transcobalamin II deficiency) Disease type: Disorder of cobalamin (Vitamin B ) transport Chromosomes: Pathology Pernicious anemia (PA) is caused by a lack of vitamin B , otherwise known as cobalamin. Diced liver has been known since 1926 to cure PA. The active agent at this time was unknown, Eventually in 1948, the active agent was isolated, and characterised. The active agent, being vitamin B . Cobalamin is composed of a carbon ring, containing a cobolt atom in its centre. Cobalamin is involved in only two chemical reactions within the body (see figure 22.02.01). One involving the formation of methionine, and the other, the formation of succinate. These two reactions require modified versions of cobalamin, the methyltransferase requires a methylated cobalamin. Whereas the mutase requires an adenylated cobalamin. Defects in these two enzymes result in the symptoms of PA. Aetiology PA can be brought about by several possible defects. Cobalamin is absorbed across the gut by the secretion of a glycoprotein called "Intrinsic Factor" (IF). IF binds to cobalamin, and then facilitates cobnbalamins crossing into the blood stream through the IF receptor. Once in the blood, cobalamin is released by IF, and binds to transcobalamin II (TCII). This allows TCII, and cobalamin to be taken up by liver cells. Cobalamin is then modified by either adenylation, or methylation. Defects can arise in any of these pathways, particularly with IF, IF receptor, and TCII. A genetic defect in any of these will result in PA. A defect in the methylation/adenylation step results in much less severe symptoms.

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